Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O88941

- MOGS_RAT

UniProt

O88941 - MOGS_RAT

Protein

Mannosyl-oligosaccharide glucosidase

Gene

Mogs

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cleaves the distal alpha 1,2-linked glucose residue from the Glc3Man9GlcNAc2 oligosaccharide precursor in a highly specific manner.1 Publication

    Catalytic activityi

    Exohydrolysis of the non-reducing terminal glucose residues in the mannosyl-oligosaccharide Glc3Man9GlcNAc2.

    Pathwayi

    GO - Molecular functioni

    1. mannosyl-oligosaccharide glucosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. oligosaccharide metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    UniPathwayiUPA00280.

    Protein family/group databases

    CAZyiGH63. Glycoside Hydrolase Family 63.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannosyl-oligosaccharide glucosidase (EC:3.2.1.106)
    Alternative name(s):
    Glycoprotein-processing glucosidase I
    Gene namesi
    Name:Mogs
    Synonyms:Gcs1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi69240. Mogs.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Single-pass type II membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 834834Mannosyl-oligosaccharide glucosidasePRO_0000057712Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi654 – 6541N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO88941.
    PRIDEiO88941.

    Expressioni

    Gene expression databases

    GenevestigatoriO88941.

    Interactioni

    Protein-protein interaction databases

    IntActiO88941. 1 interaction.
    MINTiMINT-4576161.
    STRINGi10116.ENSRNOP00000011521.

    Structurei

    3D structure databases

    ProteinModelPortaliO88941.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3636CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini58 – 834777LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5721Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni74 – 13663Required for endoplasmic reticulum targetingBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi3 – 97Endoplasmic reticulum targeting

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 63 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG305138.
    HOGENOMiHOG000201473.
    InParanoidiO88941.
    KOiK01228.
    PhylomeDBiO88941.

    Family and domain databases

    InterProiIPR008928. 6-hairpin_glycosidase-like.
    IPR004888. Glycoside_hydrolase_63.
    [Graphical view]
    PANTHERiPTHR10412:SF1. PTHR10412:SF1. 1 hit.
    PfamiPF03200. Glyco_hydro_63. 1 hit.
    [Graphical view]
    SUPFAMiSSF48208. SSF48208. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O88941-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARGERRRRA AAAEGARPLE RARGAGRRDG RAGGARGSAG GAALAVVVLA    50
    LAFGLSGRWV LAWLGVRRAL TLHPAPSALP PDSSSPAVAP EFFWGTYRPH 100
    VYFGMKTRSP KPLLTGLMWA QQGATPGTPP KLRHTCEQGD GVGPYGWEFH 150
    DGLSFGRQHI YDGALRLTTE FVKRSGGHHG GDWSWRVTVE PQASGTPSFP 200
    LVSLFFYVVT DGQEVLLPEV GAKGQLKFIS GHTSELGDFR LTLLPPTTPG 250
    DTVPKHGSYN VFWSSNPGLP LLTDMVKSHL NSWFHHRPPG ASPERYLGLP 300
    GSLKWEERGP SGQGQFLVQQ VTLKAPFSVE FVFESGSART GRDQASEQLV 350
    GGQLTRALES HAAAFKERFE RTFQLKEKGL SPEEQALGQV ALSGLLGGIG 400
    YFYGQGLVLP DTGMEGSEQK MDPSLFPPVP LFSGVPSRSF FPRGFLWDEG 450
    FHQLVVQRWD PHLTREALGH WLGLLNADGW IGREQILGDE ARARVPPEFL 500
    VQRAAHANPP TLLLPVIHML EGRAPEDLAF LRRAFPRLHA WFSWLHQSQA 550
    GPVPLSYRWR GRDLALPTLL NPKTLPSGLD DYPRASHPSA AERHLDLRCW 600
    VTLGARVLSQ LAEELGETEA AAELGPLAAS LEAAGSLDEL HWAPELGVFA 650
    DFGNHTKAVQ LKSRPPQGLV RVVGRPPARL QYVDALGYVS LFPLLLQLLE 700
    PSSPRLGPLL DVLADSRHLW SPFGLRSLSA SSLFYKQRNT EHDPPYWRGA 750
    VWLNINYLAL GALHHYGRVE GPHKVQAAKL YRELRANVVS NVRQQYQATG 800
    FLWEQYSDQD GRGMGCRPFQ GWTSLVLLIM AEEY 834
    Length:834
    Mass (Da):91,872
    Last modified:November 1, 1998 - v1
    Checksum:iE6E1E0B58E74F178
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF087431 mRNA. Translation: AAC36477.1.
    RefSeqiNP_113937.1. NM_031749.2.
    UniGeneiRn.22161.

    Genome annotation databases

    GeneIDi78947.
    KEGGirno:78947.
    UCSCiRGD:69240. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF087431 mRNA. Translation: AAC36477.1 .
    RefSeqi NP_113937.1. NM_031749.2.
    UniGenei Rn.22161.

    3D structure databases

    ProteinModelPortali O88941.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O88941. 1 interaction.
    MINTi MINT-4576161.
    STRINGi 10116.ENSRNOP00000011521.

    Protein family/group databases

    CAZyi GH63. Glycoside Hydrolase Family 63.

    Proteomic databases

    PaxDbi O88941.
    PRIDEi O88941.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 78947.
    KEGGi rno:78947.
    UCSCi RGD:69240. rat.

    Organism-specific databases

    CTDi 78947.
    RGDi 69240. Mogs.

    Phylogenomic databases

    eggNOGi NOG305138.
    HOGENOMi HOG000201473.
    InParanoidi O88941.
    KOi K01228.
    PhylomeDBi O88941.

    Enzyme and pathway databases

    UniPathwayi UPA00280 .

    Miscellaneous databases

    NextBioi 614357.
    PROi O88941.

    Gene expression databases

    Genevestigatori O88941.

    Family and domain databases

    InterProi IPR008928. 6-hairpin_glycosidase-like.
    IPR004888. Glycoside_hydrolase_63.
    [Graphical view ]
    PANTHERi PTHR10412:SF1. PTHR10412:SF1. 1 hit.
    Pfami PF03200. Glyco_hydro_63. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48208. SSF48208. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Varma G.M., Vijay I.K.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
    2. "Glucosidase I, a transmembrane endoplasmic reticular glycoprotein with a luminal catalytic domain."
      Shailubhai K., Pukazhenthi B.S., Saxena E.S., Varma G.M., Vijay I.K.
      J. Biol. Chem. 266:16587-16593(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION AT ASN-654.

    Entry informationi

    Entry nameiMOGS_RAT
    AccessioniPrimary (citable) accession number: O88941
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3