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O88941

- MOGS_RAT

UniProt

O88941 - MOGS_RAT

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Protein

Mannosyl-oligosaccharide glucosidase

Gene
Mogs, Gcs1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Cleaves the distal alpha 1,2-linked glucose residue from the Glc3Man9GlcNAc2 oligosaccharide precursor in a highly specific manner.1 Publication

Catalytic activityi

Exohydrolysis of the non-reducing terminal glucose residues in the mannosyl-oligosaccharide Glc3Man9GlcNAc2.

Pathwayi

GO - Molecular functioni

  1. mannosyl-oligosaccharide glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. oligosaccharide metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00280.

Protein family/group databases

CAZyiGH63. Glycoside Hydrolase Family 63.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannosyl-oligosaccharide glucosidase (EC:3.2.1.106)
Alternative name(s):
Glycoprotein-processing glucosidase I
Gene namesi
Name:Mogs
Synonyms:Gcs1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi69240. Mogs.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type II membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei37 – 5721Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini58 – 834777Lumenal Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 834834Mannosyl-oligosaccharide glucosidasePRO_0000057712Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi654 – 6541N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO88941.
PRIDEiO88941.

Expressioni

Gene expression databases

GenevestigatoriO88941.

Interactioni

Protein-protein interaction databases

IntActiO88941. 1 interaction.
MINTiMINT-4576161.
STRINGi10116.ENSRNOP00000011521.

Structurei

3D structure databases

ProteinModelPortaliO88941.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni74 – 13663Required for endoplasmic reticulum targeting By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi3 – 97Endoplasmic reticulum targeting

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG305138.
HOGENOMiHOG000201473.
InParanoidiO88941.
KOiK01228.
PhylomeDBiO88941.

Family and domain databases

InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR004888. Glycoside_hydrolase_63.
[Graphical view]
PANTHERiPTHR10412:SF1. PTHR10412:SF1. 1 hit.
PfamiPF03200. Glyco_hydro_63. 1 hit.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.

Sequencei

Sequence statusi: Complete.

O88941-1 [UniParc]FASTAAdd to Basket

« Hide

MARGERRRRA AAAEGARPLE RARGAGRRDG RAGGARGSAG GAALAVVVLA    50
LAFGLSGRWV LAWLGVRRAL TLHPAPSALP PDSSSPAVAP EFFWGTYRPH 100
VYFGMKTRSP KPLLTGLMWA QQGATPGTPP KLRHTCEQGD GVGPYGWEFH 150
DGLSFGRQHI YDGALRLTTE FVKRSGGHHG GDWSWRVTVE PQASGTPSFP 200
LVSLFFYVVT DGQEVLLPEV GAKGQLKFIS GHTSELGDFR LTLLPPTTPG 250
DTVPKHGSYN VFWSSNPGLP LLTDMVKSHL NSWFHHRPPG ASPERYLGLP 300
GSLKWEERGP SGQGQFLVQQ VTLKAPFSVE FVFESGSART GRDQASEQLV 350
GGQLTRALES HAAAFKERFE RTFQLKEKGL SPEEQALGQV ALSGLLGGIG 400
YFYGQGLVLP DTGMEGSEQK MDPSLFPPVP LFSGVPSRSF FPRGFLWDEG 450
FHQLVVQRWD PHLTREALGH WLGLLNADGW IGREQILGDE ARARVPPEFL 500
VQRAAHANPP TLLLPVIHML EGRAPEDLAF LRRAFPRLHA WFSWLHQSQA 550
GPVPLSYRWR GRDLALPTLL NPKTLPSGLD DYPRASHPSA AERHLDLRCW 600
VTLGARVLSQ LAEELGETEA AAELGPLAAS LEAAGSLDEL HWAPELGVFA 650
DFGNHTKAVQ LKSRPPQGLV RVVGRPPARL QYVDALGYVS LFPLLLQLLE 700
PSSPRLGPLL DVLADSRHLW SPFGLRSLSA SSLFYKQRNT EHDPPYWRGA 750
VWLNINYLAL GALHHYGRVE GPHKVQAAKL YRELRANVVS NVRQQYQATG 800
FLWEQYSDQD GRGMGCRPFQ GWTSLVLLIM AEEY 834
Length:834
Mass (Da):91,872
Last modified:November 1, 1998 - v1
Checksum:iE6E1E0B58E74F178
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF087431 mRNA. Translation: AAC36477.1.
RefSeqiNP_113937.1. NM_031749.2.
UniGeneiRn.22161.

Genome annotation databases

GeneIDi78947.
KEGGirno:78947.
UCSCiRGD:69240. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF087431 mRNA. Translation: AAC36477.1 .
RefSeqi NP_113937.1. NM_031749.2.
UniGenei Rn.22161.

3D structure databases

ProteinModelPortali O88941.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O88941. 1 interaction.
MINTi MINT-4576161.
STRINGi 10116.ENSRNOP00000011521.

Protein family/group databases

CAZyi GH63. Glycoside Hydrolase Family 63.

Proteomic databases

PaxDbi O88941.
PRIDEi O88941.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 78947.
KEGGi rno:78947.
UCSCi RGD:69240. rat.

Organism-specific databases

CTDi 78947.
RGDi 69240. Mogs.

Phylogenomic databases

eggNOGi NOG305138.
HOGENOMi HOG000201473.
InParanoidi O88941.
KOi K01228.
PhylomeDBi O88941.

Enzyme and pathway databases

UniPathwayi UPA00280 .

Miscellaneous databases

NextBioi 614357.
PROi O88941.

Gene expression databases

Genevestigatori O88941.

Family and domain databases

InterProi IPR008928. 6-hairpin_glycosidase-like.
IPR004888. Glycoside_hydrolase_63.
[Graphical view ]
PANTHERi PTHR10412:SF1. PTHR10412:SF1. 1 hit.
Pfami PF03200. Glyco_hydro_63. 1 hit.
[Graphical view ]
SUPFAMi SSF48208. SSF48208. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Varma G.M., Vijay I.K.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "Glucosidase I, a transmembrane endoplasmic reticular glycoprotein with a luminal catalytic domain."
    Shailubhai K., Pukazhenthi B.S., Saxena E.S., Varma G.M., Vijay I.K.
    J. Biol. Chem. 266:16587-16593(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION AT ASN-654.

Entry informationi

Entry nameiMOGS_RAT
AccessioniPrimary (citable) accession number: O88941
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 1, 1998
Last modified: June 11, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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