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Protein

Mannosyl-oligosaccharide glucosidase

Gene

Mogs

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cleaves the distal alpha 1,2-linked glucose residue from the Glc3Man9GlcNAc2 oligosaccharide precursor in a highly specific manner.1 Publication

Catalytic activityi

Exohydrolysis of the non-reducing terminal glucose residues in the mannosyl-oligosaccharide Glc3Man9GlcNAc2.

Pathwayi

GO - Molecular functioni

  1. mannosyl-oligosaccharide glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. oligosaccharide metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

UniPathwayiUPA00280.

Protein family/group databases

CAZyiGH63. Glycoside Hydrolase Family 63.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannosyl-oligosaccharide glucosidase (EC:3.2.1.106)
Alternative name(s):
Glycoprotein-processing glucosidase I
Gene namesi
Name:Mogs
Synonyms:Gcs1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi69240. Mogs.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Single-pass type II membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei37 – 5721Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini58 – 834777LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 834834Mannosyl-oligosaccharide glucosidasePRO_0000057712Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi654 – 6541N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO88941.
PRIDEiO88941.

Expressioni

Gene expression databases

GenevestigatoriO88941.

Interactioni

Protein-protein interaction databases

IntActiO88941. 1 interaction.
MINTiMINT-4576161.
STRINGi10116.ENSRNOP00000011521.

Structurei

3D structure databases

ProteinModelPortaliO88941.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni74 – 13663Required for endoplasmic reticulum targetingBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi3 – 97Endoplasmic reticulum targeting

Sequence similaritiesi

Belongs to the glycosyl hydrolase 63 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG305138.
HOGENOMiHOG000201473.
InParanoidiO88941.
KOiK01228.
PhylomeDBiO88941.

Family and domain databases

InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR004888. Glycoside_hydrolase_63.
[Graphical view]
PANTHERiPTHR10412:SF1. PTHR10412:SF1. 1 hit.
PfamiPF03200. Glyco_hydro_63. 1 hit.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.

Sequencei

Sequence statusi: Complete.

O88941-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARGERRRRA AAAEGARPLE RARGAGRRDG RAGGARGSAG GAALAVVVLA
60 70 80 90 100
LAFGLSGRWV LAWLGVRRAL TLHPAPSALP PDSSSPAVAP EFFWGTYRPH
110 120 130 140 150
VYFGMKTRSP KPLLTGLMWA QQGATPGTPP KLRHTCEQGD GVGPYGWEFH
160 170 180 190 200
DGLSFGRQHI YDGALRLTTE FVKRSGGHHG GDWSWRVTVE PQASGTPSFP
210 220 230 240 250
LVSLFFYVVT DGQEVLLPEV GAKGQLKFIS GHTSELGDFR LTLLPPTTPG
260 270 280 290 300
DTVPKHGSYN VFWSSNPGLP LLTDMVKSHL NSWFHHRPPG ASPERYLGLP
310 320 330 340 350
GSLKWEERGP SGQGQFLVQQ VTLKAPFSVE FVFESGSART GRDQASEQLV
360 370 380 390 400
GGQLTRALES HAAAFKERFE RTFQLKEKGL SPEEQALGQV ALSGLLGGIG
410 420 430 440 450
YFYGQGLVLP DTGMEGSEQK MDPSLFPPVP LFSGVPSRSF FPRGFLWDEG
460 470 480 490 500
FHQLVVQRWD PHLTREALGH WLGLLNADGW IGREQILGDE ARARVPPEFL
510 520 530 540 550
VQRAAHANPP TLLLPVIHML EGRAPEDLAF LRRAFPRLHA WFSWLHQSQA
560 570 580 590 600
GPVPLSYRWR GRDLALPTLL NPKTLPSGLD DYPRASHPSA AERHLDLRCW
610 620 630 640 650
VTLGARVLSQ LAEELGETEA AAELGPLAAS LEAAGSLDEL HWAPELGVFA
660 670 680 690 700
DFGNHTKAVQ LKSRPPQGLV RVVGRPPARL QYVDALGYVS LFPLLLQLLE
710 720 730 740 750
PSSPRLGPLL DVLADSRHLW SPFGLRSLSA SSLFYKQRNT EHDPPYWRGA
760 770 780 790 800
VWLNINYLAL GALHHYGRVE GPHKVQAAKL YRELRANVVS NVRQQYQATG
810 820 830
FLWEQYSDQD GRGMGCRPFQ GWTSLVLLIM AEEY
Length:834
Mass (Da):91,872
Last modified:November 1, 1998 - v1
Checksum:iE6E1E0B58E74F178
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087431 mRNA. Translation: AAC36477.1.
RefSeqiNP_113937.1. NM_031749.2.
UniGeneiRn.22161.

Genome annotation databases

GeneIDi78947.
KEGGirno:78947.
UCSCiRGD:69240. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087431 mRNA. Translation: AAC36477.1.
RefSeqiNP_113937.1. NM_031749.2.
UniGeneiRn.22161.

3D structure databases

ProteinModelPortaliO88941.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88941. 1 interaction.
MINTiMINT-4576161.
STRINGi10116.ENSRNOP00000011521.

Protein family/group databases

CAZyiGH63. Glycoside Hydrolase Family 63.

Proteomic databases

PaxDbiO88941.
PRIDEiO88941.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi78947.
KEGGirno:78947.
UCSCiRGD:69240. rat.

Organism-specific databases

CTDi78947.
RGDi69240. Mogs.

Phylogenomic databases

eggNOGiNOG305138.
HOGENOMiHOG000201473.
InParanoidiO88941.
KOiK01228.
PhylomeDBiO88941.

Enzyme and pathway databases

UniPathwayiUPA00280.

Miscellaneous databases

NextBioi614357.
PROiO88941.

Gene expression databases

GenevestigatoriO88941.

Family and domain databases

InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR004888. Glycoside_hydrolase_63.
[Graphical view]
PANTHERiPTHR10412:SF1. PTHR10412:SF1. 1 hit.
PfamiPF03200. Glyco_hydro_63. 1 hit.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Varma G.M., Vijay I.K.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "Glucosidase I, a transmembrane endoplasmic reticular glycoprotein with a luminal catalytic domain."
    Shailubhai K., Pukazhenthi B.S., Saxena E.S., Varma G.M., Vijay I.K.
    J. Biol. Chem. 266:16587-16593(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION AT ASN-654.

Entry informationi

Entry nameiMOGS_RAT
AccessioniPrimary (citable) accession number: O88941
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 1, 1998
Last modified: January 7, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.