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O88941 (MOGS_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannosyl-oligosaccharide glucosidase

EC=3.2.1.106
Alternative name(s):
Glycoprotein-processing glucosidase I
Gene names
Name:Mogs
Synonyms:Gcs1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length834 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cleaves the distal alpha 1,2-linked glucose residue from the Glc3Man9GlcNAc2 oligosaccharide precursor in a highly specific manner. Ref.2

Catalytic activity

Exohydrolysis of the non-reducing terminal glucose residues in the mannosyl-oligosaccharide Glc3Man9GlcNAc2.

Pathway

Glycan metabolism; N-glycan degradation.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type II membrane protein Ref.2.

Sequence similarities

Belongs to the glycosyl hydrolase 63 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 834834Mannosyl-oligosaccharide glucosidase
PRO_0000057712

Regions

Topological domain1 – 3636Cytoplasmic Potential
Transmembrane37 – 5721Helical; Signal-anchor for type II membrane protein; Potential
Topological domain58 – 834777Lumenal Potential
Region74 – 13663Required for endoplasmic reticulum targeting By similarity
Motif3 – 97Endoplasmic reticulum targeting

Amino acid modifications

Glycosylation6541N-linked (GlcNAc...) Ref.2

Sequences

Sequence LengthMass (Da)Tools
O88941 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: E6E1E0B58E74F178

FASTA83491,872
        10         20         30         40         50         60 
MARGERRRRA AAAEGARPLE RARGAGRRDG RAGGARGSAG GAALAVVVLA LAFGLSGRWV 

        70         80         90        100        110        120 
LAWLGVRRAL TLHPAPSALP PDSSSPAVAP EFFWGTYRPH VYFGMKTRSP KPLLTGLMWA 

       130        140        150        160        170        180 
QQGATPGTPP KLRHTCEQGD GVGPYGWEFH DGLSFGRQHI YDGALRLTTE FVKRSGGHHG 

       190        200        210        220        230        240 
GDWSWRVTVE PQASGTPSFP LVSLFFYVVT DGQEVLLPEV GAKGQLKFIS GHTSELGDFR 

       250        260        270        280        290        300 
LTLLPPTTPG DTVPKHGSYN VFWSSNPGLP LLTDMVKSHL NSWFHHRPPG ASPERYLGLP 

       310        320        330        340        350        360 
GSLKWEERGP SGQGQFLVQQ VTLKAPFSVE FVFESGSART GRDQASEQLV GGQLTRALES 

       370        380        390        400        410        420 
HAAAFKERFE RTFQLKEKGL SPEEQALGQV ALSGLLGGIG YFYGQGLVLP DTGMEGSEQK 

       430        440        450        460        470        480 
MDPSLFPPVP LFSGVPSRSF FPRGFLWDEG FHQLVVQRWD PHLTREALGH WLGLLNADGW 

       490        500        510        520        530        540 
IGREQILGDE ARARVPPEFL VQRAAHANPP TLLLPVIHML EGRAPEDLAF LRRAFPRLHA 

       550        560        570        580        590        600 
WFSWLHQSQA GPVPLSYRWR GRDLALPTLL NPKTLPSGLD DYPRASHPSA AERHLDLRCW 

       610        620        630        640        650        660 
VTLGARVLSQ LAEELGETEA AAELGPLAAS LEAAGSLDEL HWAPELGVFA DFGNHTKAVQ 

       670        680        690        700        710        720 
LKSRPPQGLV RVVGRPPARL QYVDALGYVS LFPLLLQLLE PSSPRLGPLL DVLADSRHLW 

       730        740        750        760        770        780 
SPFGLRSLSA SSLFYKQRNT EHDPPYWRGA VWLNINYLAL GALHHYGRVE GPHKVQAAKL 

       790        800        810        820        830 
YRELRANVVS NVRQQYQATG FLWEQYSDQD GRGMGCRPFQ GWTSLVLLIM AEEY 

« Hide

References

[1]Varma G.M., Vijay I.K.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
[2]"Glucosidase I, a transmembrane endoplasmic reticular glycoprotein with a luminal catalytic domain."
Shailubhai K., Pukazhenthi B.S., Saxena E.S., Varma G.M., Vijay I.K.
J. Biol. Chem. 266:16587-16593(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION AT ASN-654.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF087431 mRNA. Translation: AAC36477.1.
RefSeqNP_113937.1. NM_031749.2.
UniGeneRn.22161.

3D structure databases

ProteinModelPortalO88941.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO88941. 1 interaction.
MINTMINT-4576161.
STRING10116.ENSRNOP00000011521.

Protein family/group databases

CAZyGH63. Glycoside Hydrolase Family 63.

Proteomic databases

PaxDbO88941.
PRIDEO88941.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID78947.
KEGGrno:78947.
UCSCRGD:69240. rat.

Organism-specific databases

CTD78947.
RGD69240. Mogs.

Phylogenomic databases

eggNOGNOG305138.
HOGENOMHOG000201473.
InParanoidO88941.
KOK01228.
PhylomeDBO88941.

Enzyme and pathway databases

UniPathwayUPA00280.

Gene expression databases

GenevestigatorO88941.

Family and domain databases

InterProIPR008928. 6-hairpin_glycosidase-like.
IPR004888. Glycoside_hydrolase_63.
[Graphical view]
PANTHERPTHR10412:SF1. PTHR10412:SF1. 1 hit.
PfamPF03200. Glyco_hydro_63. 1 hit.
[Graphical view]
SUPFAMSSF48208. SSF48208. 1 hit.
ProtoNetSearch...

Other

NextBio614357.
PROO88941.

Entry information

Entry nameMOGS_RAT
AccessionPrimary (citable) accession number: O88941
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 1, 1998
Last modified: June 11, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries