Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Musculin

Gene

Msc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription repressor that blocks myogenesis and activation of E-box dependent muscle genes.

GO - Molecular functioni

GO - Biological processi

  • branchiomeric skeletal muscle development Source: UniProtKB
  • diaphragm development Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • palate development Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Musculin
Alternative name(s):
Myogenic repressor
Gene namesi
Name:Msc
Synonyms:Myor
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1333884. Msc.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi110 – 1123RER → LEG: Loss of DNA-binding. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201MusculinPRO_0000127284Add
BLAST

Proteomic databases

PaxDbiO88940.
PRIDEiO88940.

PTM databases

PhosphoSiteiO88940.

Expressioni

Developmental stagei

Expression in embryos is largely restricted to embryonic skeletal muscle lineage. First detected at 9.5 dpc in cells within the first and second branchial arches. At 10.5 dpc, expression was also observed in the myotomal compartment of rostral somites and by 11.5 dpc in myotomes along the whole anterio-posterior axis, as well as in cells within the developing forelimbs and hindlimbs. At 12.5-14.5 dpc, expression was confined to the skeletal muscle lineage (head, neck, trunk, limbs and diaphragm but not cardiac and smooth muscle). At 15 dpc, a peak expression was seen in neonatal limbs.1 Publication

Gene expression databases

BgeeiENSMUSG00000025930.
CleanExiMM_MSC.
ExpressionAtlasiO88940. baseline and differential.
GenevisibleiO88940. MM.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer. Forms a heterodimer with TCF3.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027062.

Structurei

3D structure databases

ProteinModelPortaliO88940.
SMRiO88940. Positions 102-159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini102 – 15453bHLHPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi66 – 716Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi48 – 558Glu-rich (acidic)
Compositional biasi76 – 8611Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00710000106684.
HOGENOMiHOG000261670.
HOVERGENiHBG105298.
InParanoidiO88940.
KOiK09072.
OMAiQRGYPVP.
OrthoDBiEOG091G0N6P.
PhylomeDBiO88940.
TreeFamiTF350742.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGSVSDPE DSEMRGLQRV YPAPASKRPP LLRMERGYGS PSDISSAEEE
60 70 80 90 100
DGEEEPGSLG AAGGCKRKRL RGADAGGAGG RAGGAGKKPL PPKGSAAECK
110 120 130 140 150
QSQRNAANAR ERARMRVLSK AFSRLKTSLP WVPPDTKLSK LDTLRLASSY
160 170 180 190 200
IAHLRQLLQE DRYEDSYVHP VNLTWPFVVS GRPDSDSKDV SAANRLCGTS

A
Length:201
Mass (Da):21,538
Last modified:November 1, 1998 - v1
Checksum:i04C757F710C69E32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087035 mRNA. Translation: AAC69869.1.
AF108216 mRNA. Translation: AAD10053.1.
BC103592 mRNA. Translation: AAI03593.1.
BC103593 mRNA. Translation: AAI03594.1.
BC103594 mRNA. Translation: AAI03595.1.
BC103623 mRNA. Translation: AAI03624.1.
CCDSiCCDS14825.1.
RefSeqiNP_034957.1. NM_010827.2.
UniGeneiMm.5820.

Genome annotation databases

EnsembliENSMUST00000027062; ENSMUSP00000027062; ENSMUSG00000025930.
GeneIDi17681.
KEGGimmu:17681.
UCSCiuc007aja.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087035 mRNA. Translation: AAC69869.1.
AF108216 mRNA. Translation: AAD10053.1.
BC103592 mRNA. Translation: AAI03593.1.
BC103593 mRNA. Translation: AAI03594.1.
BC103594 mRNA. Translation: AAI03595.1.
BC103623 mRNA. Translation: AAI03624.1.
CCDSiCCDS14825.1.
RefSeqiNP_034957.1. NM_010827.2.
UniGeneiMm.5820.

3D structure databases

ProteinModelPortaliO88940.
SMRiO88940. Positions 102-159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027062.

PTM databases

PhosphoSiteiO88940.

Proteomic databases

PaxDbiO88940.
PRIDEiO88940.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027062; ENSMUSP00000027062; ENSMUSG00000025930.
GeneIDi17681.
KEGGimmu:17681.
UCSCiuc007aja.2. mouse.

Organism-specific databases

CTDi9242.
MGIiMGI:1333884. Msc.

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00710000106684.
HOGENOMiHOG000261670.
HOVERGENiHBG105298.
InParanoidiO88940.
KOiK09072.
OMAiQRGYPVP.
OrthoDBiEOG091G0N6P.
PhylomeDBiO88940.
TreeFamiTF350742.

Miscellaneous databases

PROiO88940.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025930.
CleanExiMM_MSC.
ExpressionAtlasiO88940. baseline and differential.
GenevisibleiO88940. MM.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUSC_MOUSE
AccessioniPrimary (citable) accession number: O88940
Secondary accession number(s): Q3ZAZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.