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Protein

Musculin

Gene

Msc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription repressor that blocks myogenesis and activation of E-box dependent muscle genes.

GO - Molecular functioni

GO - Biological processi

  • branchiomeric skeletal muscle development Source: UniProtKB
  • cellular response to leukemia inhibitory factor Source: MGI
  • diaphragm development Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • palate development Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Musculin
Alternative name(s):
Myogenic repressor
Gene namesi
Name:Msc
Synonyms:Myor
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1333884. Msc.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi110 – 112RER → LEG: Loss of DNA-binding. 1 Publication3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272841 – 201MusculinAdd BLAST201

Proteomic databases

PaxDbiO88940.
PRIDEiO88940.

PTM databases

PhosphoSitePlusiO88940.

Expressioni

Developmental stagei

Expression in embryos is largely restricted to embryonic skeletal muscle lineage. First detected at 9.5 dpc in cells within the first and second branchial arches. At 10.5 dpc, expression was also observed in the myotomal compartment of rostral somites and by 11.5 dpc in myotomes along the whole anterio-posterior axis, as well as in cells within the developing forelimbs and hindlimbs. At 12.5-14.5 dpc, expression was confined to the skeletal muscle lineage (head, neck, trunk, limbs and diaphragm but not cardiac and smooth muscle). At 15 dpc, a peak expression was seen in neonatal limbs.1 Publication

Gene expression databases

BgeeiENSMUSG00000025930.
CleanExiMM_MSC.
ExpressionAtlasiO88940. baseline and differential.
GenevisibleiO88940. MM.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer. Forms a heterodimer with TCF3.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027062.

Structurei

3D structure databases

ProteinModelPortaliO88940.
SMRiO88940.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 154bHLHPROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi66 – 71Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi48 – 55Glu-rich (acidic)8
Compositional biasi76 – 86Gly-richAdd BLAST11

Phylogenomic databases

eggNOGiKOG4029. Eukaryota.
ENOG411227D. LUCA.
GeneTreeiENSGT00710000106684.
HOGENOMiHOG000261670.
HOVERGENiHBG105298.
InParanoidiO88940.
KOiK09072.
OMAiEERCTLG.
OrthoDBiEOG091G0N6P.
PhylomeDBiO88940.
TreeFamiTF350742.

Family and domain databases

CDDicd00083. HLH. 1 hit.
Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
PfamiView protein in Pfam
PF00010. HLH. 1 hit.
SMARTiView protein in SMART
SM00353. HLH. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.

Sequencei

Sequence statusi: Complete.

O88940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGSVSDPE DSEMRGLQRV YPAPASKRPP LLRMERGYGS PSDISSAEEE
60 70 80 90 100
DGEEEPGSLG AAGGCKRKRL RGADAGGAGG RAGGAGKKPL PPKGSAAECK
110 120 130 140 150
QSQRNAANAR ERARMRVLSK AFSRLKTSLP WVPPDTKLSK LDTLRLASSY
160 170 180 190 200
IAHLRQLLQE DRYEDSYVHP VNLTWPFVVS GRPDSDSKDV SAANRLCGTS

A
Length:201
Mass (Da):21,538
Last modified:November 1, 1998 - v1
Checksum:i04C757F710C69E32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087035 mRNA. Translation: AAC69869.1.
AF108216 mRNA. Translation: AAD10053.1.
BC103592 mRNA. Translation: AAI03593.1.
BC103593 mRNA. Translation: AAI03594.1.
BC103594 mRNA. Translation: AAI03595.1.
BC103623 mRNA. Translation: AAI03624.1.
CCDSiCCDS14825.1.
RefSeqiNP_034957.1. NM_010827.2.
UniGeneiMm.5820.

Genome annotation databases

EnsembliENSMUST00000027062; ENSMUSP00000027062; ENSMUSG00000025930.
GeneIDi17681.
KEGGimmu:17681.
UCSCiuc007aja.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiMUSC_MOUSE
AccessioniPrimary (citable) accession number: O88940
Secondary accession number(s): Q3ZAZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1998
Last modified: August 30, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot