ID   O88933_MOUSE            Unreviewed;       382 AA.
AC   O88933;
DT   01-NOV-1998, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1998, sequence version 1.
DT   27-MAR-2024, entry version 170.
DE   SubName: Full=Extraembryonic, spermatogenesis, homeobox 1 {ECO:0000313|Ensembl:ENSMUSP00000074262.3};
DE   SubName: Full=Homeobox protein SPX1 {ECO:0000313|EMBL:AAC35366.1};
DE   SubName: Full=Homeodomain protein EPX {ECO:0000313|EMBL:AAD01622.1};
GN   Name=Esx1 {ECO:0000313|Ensembl:ENSMUSP00000074262.3,
GN   ECO:0000313|MGI:MGI:1096388};
GN   Synonyms=Epx {ECO:0000313|EMBL:AAD01622.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAC35366.1};
RN   [1] {ECO:0000313|EMBL:AAC35366.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=9245514; DOI=10.1006/dbio.1997.8640;
RA   Li Y., Lemaire P., Behringer R.R.;
RT   "Esx1, a novel X chromosome-linked homeobox gene expressed in mouse
RT   extraembryonic tissues and male germ cells.";
RL   Dev. Biol. 188:85-95(1997).
RN   [2] {ECO:0000313|EMBL:AAC35366.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=9256347; DOI=10.1016/S0925-4773(97)00058-0;
RA   Branford W.W., Zhao G.Q., Valerius M.T., Weinstein M., Birkenmeier E.H.,
RA   Rowe L.B., Potter S.S.;
RT   "Spx1, a novel X-linked homeobox gene expressed during spermatogenesis.";
RL   Mech. Dev. 65:87-98(1997).
RN   [3] {ECO:0000313|EMBL:AAD01622.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=129/Sv {ECO:0000313|EMBL:AAD01622.1};
RA   Yan Y.-T., Yang L., Sciavolino P.J., Wang H., Chan D.C., Abate-Shen C.,
RA   Shen M.M.;
RT   "Epx: a novel paired-like homeobox gene expressed in the chorion and
RT   placenta.";
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AAC35366.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Branford W.W., Potter S.S.;
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:AAD01622.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=129/Sv {ECO:0000313|EMBL:AAD01622.1};
RX   PubMed=10611245; DOI=10.1128/MCB.20.2.661-671.2000;
RA   Yan Y.T., Stein S.M., Ding J., Shen M.M., Abate-Shen C.;
RT   "A novel PF/PN motif inhibits nuclear localization and DNA binding activity
RT   of the ESX1 homeoprotein.";
RL   Mol. Cell. Biol. 20:661-671(2000).
RN   [6] {ECO:0000313|Ensembl:ENSMUSP00000074262.3, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000074262.3,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [7] {ECO:0000313|Ensembl:ENSMUSP00000074262.3}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000074262.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR   EMBL; AF085715; AAC35366.1; -; mRNA.
DR   EMBL; AF017735; AAD01622.1; -; mRNA.
DR   RefSeq; NP_031983.2; NM_007957.2.
DR   STRING; 10090.ENSMUSP00000074262; -.
DR   PaxDb; 10090-ENSMUSP00000074262; -.
DR   ProteomicsDB; 329013; -.
DR   Antibodypedia; 15003; 150 antibodies from 28 providers.
DR   DNASU; 13984; -.
DR   Ensembl; ENSMUST00000074698.3; ENSMUSP00000074262.3; ENSMUSG00000023443.14.
DR   GeneID; 13984; -.
DR   KEGG; mmu:13984; -.
DR   UCSC; uc009ujs.1; mouse.
DR   AGR; MGI:1096388; -.
DR   CTD; 80712; -.
DR   MGI; MGI:1096388; Esx1.
DR   VEuPathDB; HostDB:ENSMUSG00000023443; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00940000163297; -.
DR   OMA; LFARMEL; -.
DR   OrthoDB; 3042435at2759; -.
DR   TreeFam; TF315976; -.
DR   BioGRID-ORCS; 13984; 1 hit in 78 CRISPR screens.
DR   Proteomes; UP000000589; Chromosome X.
DR   Bgee; ENSMUSG00000023443; Expressed in yolk sac and 59 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR   GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:MGI.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0001568; P:blood vessel development; IMP:MGI.
DR   GO; GO:0060716; P:labyrinthine layer blood vessel development; IMP:MGI.
DR   GO; GO:0060713; P:labyrinthine layer morphogenesis; IMP:MGI.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; ISO:MGI.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR   GO; GO:0051726; P:regulation of cell cycle; ISO:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000047; HTH_motif.
DR   PANTHER; PTHR24329; HOMEOBOX PROTEIN ARISTALESS; 1.
DR   PANTHER; PTHR24329:SF340; HOMEOBOX PROTEIN ESX1; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:O88933,
KW   ECO:0007829|ProteomicsDB:O88933};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          184..244
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        186..245
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          144..187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        351..372
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   382 AA;  43540 MW;  EC92301A84DA6175 CRC64;
     MESHKKCPCC YCTDLKTFVG AVKEETLQDP QPSLSSTLLE GADYQENAES ETTFYSDFGA
     SPKEEEVEME NSLFNSMFLE EANYQEPEGF EPSRGEAAAP VAEAPQAWNG NENLGGGFLE
     SNAQLGEADA APVRQSLMRP LMQPVAQSSP QPLPANPLQA PQQPEEQEEE EEEQPGEEQP
     QQEPKPRRYR ICFTPIQLQE LEAFFQRVQY PDLFARVELA RRLGLPEPRV QVWFQNRRAK
     WRRLRRAQAF RNMVPVAMSP PVGVYLDDHY GPIPIVEVIW KCYPMVPRPM HPQMMPLPPR
     PPPGFRMPPP FRPPPLPPFP WPPVPPDAHI PNAAREYNPF PFPFPFPFPF PNPFPNPNPN
     PNPNPNPNPN PNQNFAGPRY RY
//