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O88933

- O88933_MOUSE

UniProt

O88933 - O88933_MOUSE

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Protein
Submitted name:

Homeobox protein SPX1

Gene

Esx1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
  2. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl

GO - Biological processi

  1. blood vessel development Source: MGI
  2. labyrinthine layer blood vessel development Source: MGI
  3. labyrinthine layer morphogenesis Source: MGI
  4. regulation of cell cycle Source: Ensembl
  5. regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Homeobox protein SPX1Imported
Submitted name:
Homeodomain protein EPXImported
Submitted name:
Protein Esx1Imported
Gene namesi
Name:Esx1Imported
Synonyms:EpxImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1096388. Esx1.

Subcellular locationi

Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriO88933.

Family & Domainsi

Keywords - Domaini

HomeoboxUniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118908.
HOVERGENiHBG052987.
KOiK18491.
OMAiKPRRYRI.
TreeFamiTF315976.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88933-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESHKKCPCC YCTDLKTFVG AVKEETLQDP QPSLSSTLLE GADYQENAES
60 70 80 90 100
ETTFYSDFGA SPKEEEVEME NSLFNSMFLE EANYQEPEGF EPSRGEAAAP
110 120 130 140 150
VAEAPQAWNG NENLGGGFLE SNAQLGEADA APVRQSLMRP LMQPVAQSSP
160 170 180 190 200
QPLPANPLQA PQQPEEQEEE EEEQPGEEQP QQEPKPRRYR ICFTPIQLQE
210 220 230 240 250
LEAFFQRVQY PDLFARVELA RRLGLPEPRV QVWFQNRRAK WRRLRRAQAF
260 270 280 290 300
RNMVPVAMSP PVGVYLDDHY GPIPIVEVIW KCYPMVPRPM HPQMMPLPPR
310 320 330 340 350
PPPGFRMPPP FRPPPLPPFP WPPVPPDAHI PNAAREYNPF PFPFPFPFPF
360 370 380
PNPFPNPNPN PNPNPNPNPN PNQNFAGPRY RY
Length:382
Mass (Da):43,540
Last modified:November 1, 1998 - v1
Checksum:iEC92301A84DA6175
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL672275 Genomic DNA. No translation available.
AF085715 mRNA. Translation: AAC35366.1.
AF017735 mRNA. Translation: AAD01622.1.
RefSeqiNP_031983.2. NM_007957.2.
UniGeneiMm.8017.

Genome annotation databases

EnsembliENSMUST00000074698; ENSMUSP00000074262; ENSMUSG00000023443.
GeneIDi13984.
KEGGimmu:13984.
UCSCiuc009ujs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL672275 Genomic DNA. No translation available.
AF085715 mRNA. Translation: AAC35366.1 .
AF017735 mRNA. Translation: AAD01622.1 .
RefSeqi NP_031983.2. NM_007957.2.
UniGenei Mm.8017.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000074698 ; ENSMUSP00000074262 ; ENSMUSG00000023443 .
GeneIDi 13984.
KEGGi mmu:13984.
UCSCi uc009ujs.1. mouse.

Organism-specific databases

CTDi 80712.
MGIi MGI:1096388. Esx1.

Phylogenomic databases

GeneTreei ENSGT00760000118908.
HOVERGENi HBG052987.
KOi K18491.
OMAi KPRRYRI.
TreeFami TF315976.

Miscellaneous databases

NextBioi 284864.
SOURCEi Search...

Gene expression databases

Genevestigatori O88933.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Esx1, a novel X chromosome-linked homeobox gene expressed in mouse extraembryonic tissues and male germ cells."
    Li Y., Lemaire P., Behringer R.R.
    Dev. Biol. 188:85-95(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Spx1, a novel X-linked homeobox gene expressed during spermatogenesis."
    Branford W.W., Zhao G.Q., Valerius M.T., Weinstein M., Birkenmeier E.H., Rowe L.B., Potter S.S.
    Mech. Dev. 65:87-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Epx: a novel paired-like homeobox gene expressed in the chorion and placenta."
    Yan Y.-T., Yang L., Sciavolino P.J., Wang H., Chan D.C., Abate-Shen C., Shen M.M.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvImported.
  4. Branford W.W., Potter S.S.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  5. "A novel PF/PN motif inhibits nuclear localization and DNA binding activity of the ESX1 homeoprotein."
    Yan Y.T., Stein S.M., Ding J., Shen M.M., Abate-Shen C.
    Mol. Cell. Biol. 20:661-671(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvImported.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  7. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiO88933_MOUSE
AccessioniPrimary (citable) accession number: O88933
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3