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O88933

- O88933_MOUSE

UniProt

O88933 - O88933_MOUSE

Protein
Submitted name:

Homeobox protein SPX1

Gene

Esx1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro
    2. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. blood vessel development Source: MGI
    2. labyrinthine layer blood vessel development Source: MGI
    3. labyrinthine layer morphogenesis Source: MGI
    4. negative regulation of transcription, DNA-templated Source: Ensembl
    5. regulation of cell cycle Source: Ensembl
    6. regulation of transcription from RNA polymerase II promoter Source: MGI

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Homeobox protein SPX1Imported
    Submitted name:
    Homeodomain protein EPXImported
    Submitted name:
    Protein Esx1Imported
    Gene namesi
    Name:Esx1Imported
    Synonyms:EpxImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1096388. Esx1.

    Subcellular locationi

    Nucleus UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    NucleusUniRule annotationSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriO88933.

    Family & Domainsi

    Keywords - Domaini

    HomeoboxUniRule annotationSAAS annotationImported

    Phylogenomic databases

    GeneTreeiENSGT00750000117735.
    HOVERGENiHBG052987.
    InParanoidiO88933.
    OMAiKPRRYRI.
    TreeFamiTF315976.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O88933-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESHKKCPCC YCTDLKTFVG AVKEETLQDP QPSLSSTLLE GADYQENAES    50
    ETTFYSDFGA SPKEEEVEME NSLFNSMFLE EANYQEPEGF EPSRGEAAAP 100
    VAEAPQAWNG NENLGGGFLE SNAQLGEADA APVRQSLMRP LMQPVAQSSP 150
    QPLPANPLQA PQQPEEQEEE EEEQPGEEQP QQEPKPRRYR ICFTPIQLQE 200
    LEAFFQRVQY PDLFARVELA RRLGLPEPRV QVWFQNRRAK WRRLRRAQAF 250
    RNMVPVAMSP PVGVYLDDHY GPIPIVEVIW KCYPMVPRPM HPQMMPLPPR 300
    PPPGFRMPPP FRPPPLPPFP WPPVPPDAHI PNAAREYNPF PFPFPFPFPF 350
    PNPFPNPNPN PNPNPNPNPN PNQNFAGPRY RY 382
    Length:382
    Mass (Da):43,540
    Last modified:November 1, 1998 - v1
    Checksum:iEC92301A84DA6175
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL672275 Genomic DNA. No translation available.
    AF085715 mRNA. Translation: AAC35366.1.
    AF017735 mRNA. Translation: AAD01622.1.
    RefSeqiNP_031983.2. NM_007957.2.
    UniGeneiMm.8017.

    Genome annotation databases

    EnsembliENSMUST00000074698; ENSMUSP00000074262; ENSMUSG00000023443.
    GeneIDi13984.
    KEGGimmu:13984.
    UCSCiuc009ujs.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL672275 Genomic DNA. No translation available.
    AF085715 mRNA. Translation: AAC35366.1 .
    AF017735 mRNA. Translation: AAD01622.1 .
    RefSeqi NP_031983.2. NM_007957.2.
    UniGenei Mm.8017.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000074698 ; ENSMUSP00000074262 ; ENSMUSG00000023443 .
    GeneIDi 13984.
    KEGGi mmu:13984.
    UCSCi uc009ujs.1. mouse.

    Organism-specific databases

    CTDi 80712.
    MGIi MGI:1096388. Esx1.

    Phylogenomic databases

    GeneTreei ENSGT00750000117735.
    HOVERGENi HBG052987.
    InParanoidi O88933.
    OMAi KPRRYRI.
    TreeFami TF315976.

    Miscellaneous databases

    NextBioi 284864.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori O88933.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Esx1, a novel X chromosome-linked homeobox gene expressed in mouse extraembryonic tissues and male germ cells."
      Li Y., Lemaire P., Behringer R.R.
      Dev. Biol. 188:85-95(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Spx1, a novel X-linked homeobox gene expressed during spermatogenesis."
      Branford W.W., Zhao G.Q., Valerius M.T., Weinstein M., Birkenmeier E.H., Rowe L.B., Potter S.S.
      Mech. Dev. 65:87-98(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Epx: a novel paired-like homeobox gene expressed in the chorion and placenta."
      Yan Y.-T., Yang L., Sciavolino P.J., Wang H., Chan D.C., Abate-Shen C., Shen M.M.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvImported.
    4. Branford W.W., Potter S.S.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    5. "A novel PF/PN motif inhibits nuclear localization and DNA binding activity of the ESX1 homeoprotein."
      Yan Y.T., Stein S.M., Ding J., Shen M.M., Abate-Shen C.
      Mol. Cell. Biol. 20:661-671(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvImported.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    7. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiO88933_MOUSE
    AccessioniPrimary (citable) accession number: O88933
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1998
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3