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O88933

- O88933_MOUSE

UniProt

O88933 - O88933_MOUSE

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Protein
Submitted name: Homeobox protein SPX1
Gene
Esx1, Epx
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: InterPro
  2. transcription regulatory region sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. blood vessel development Source: MGI
  2. labyrinthine layer blood vessel development Source: MGI
  3. labyrinthine layer morphogenesis Source: MGI
  4. negative regulation of transcription, DNA-templated Source: Ensembl
  5. regulation of cell cycle Source: Ensembl
  6. regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Homeobox protein SPX1Imported
Submitted name:
Homeodomain protein EPXImported
Submitted name:
Protein Esx1Imported
Gene namesi
Name:Esx1Imported
Synonyms:EpxImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1096388. Esx1.

Subcellular locationi

Nucleus By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotations

Expressioni

Gene expression databases

GenevestigatoriO88933.

Family & Domainsi

Keywords - Domaini

HomeoboxUniRule annotationSAAS annotationsImported

Phylogenomic databases

GeneTreeiENSGT00750000117735.
HOVERGENiHBG052987.
InParanoidiO88933.
OMAiKPRRYRI.
TreeFamiTF315976.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88933-1 [UniParc]FASTAAdd to Basket

« Hide

MESHKKCPCC YCTDLKTFVG AVKEETLQDP QPSLSSTLLE GADYQENAES    50
ETTFYSDFGA SPKEEEVEME NSLFNSMFLE EANYQEPEGF EPSRGEAAAP 100
VAEAPQAWNG NENLGGGFLE SNAQLGEADA APVRQSLMRP LMQPVAQSSP 150
QPLPANPLQA PQQPEEQEEE EEEQPGEEQP QQEPKPRRYR ICFTPIQLQE 200
LEAFFQRVQY PDLFARVELA RRLGLPEPRV QVWFQNRRAK WRRLRRAQAF 250
RNMVPVAMSP PVGVYLDDHY GPIPIVEVIW KCYPMVPRPM HPQMMPLPPR 300
PPPGFRMPPP FRPPPLPPFP WPPVPPDAHI PNAAREYNPF PFPFPFPFPF 350
PNPFPNPNPN PNPNPNPNPN PNQNFAGPRY RY 382
Length:382
Mass (Da):43,540
Last modified:November 1, 1998 - v1
Checksum:iEC92301A84DA6175
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL672275 Genomic DNA. No translation available.
AF085715 mRNA. Translation: AAC35366.1.
AF017735 mRNA. Translation: AAD01622.1.
RefSeqiNP_031983.2. NM_007957.2.
UniGeneiMm.8017.

Genome annotation databases

EnsembliENSMUST00000074698; ENSMUSP00000074262; ENSMUSG00000023443.
GeneIDi13984.
KEGGimmu:13984.
UCSCiuc009ujs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL672275 Genomic DNA. No translation available.
AF085715 mRNA. Translation: AAC35366.1 .
AF017735 mRNA. Translation: AAD01622.1 .
RefSeqi NP_031983.2. NM_007957.2.
UniGenei Mm.8017.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000074698 ; ENSMUSP00000074262 ; ENSMUSG00000023443 .
GeneIDi 13984.
KEGGi mmu:13984.
UCSCi uc009ujs.1. mouse.

Organism-specific databases

CTDi 80712.
MGIi MGI:1096388. Esx1.

Phylogenomic databases

GeneTreei ENSGT00750000117735.
HOVERGENi HBG052987.
InParanoidi O88933.
OMAi KPRRYRI.
TreeFami TF315976.

Miscellaneous databases

NextBioi 284864.
SOURCEi Search...

Gene expression databases

Genevestigatori O88933.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Esx1, a novel X chromosome-linked homeobox gene expressed in mouse extraembryonic tissues and male germ cells."
    Li Y., Lemaire P., Behringer R.R.
    Dev. Biol. 188:85-95(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Spx1, a novel X-linked homeobox gene expressed during spermatogenesis."
    Branford W.W., Zhao G.Q., Valerius M.T., Weinstein M., Birkenmeier E.H., Rowe L.B., Potter S.S.
    Mech. Dev. 65:87-98(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Epx: a novel paired-like homeobox gene expressed in the chorion and placenta."
    Yan Y.-T., Yang L., Sciavolino P.J., Wang H., Chan D.C., Abate-Shen C., Shen M.M.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvImported.
  4. Branford W.W., Potter S.S.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  5. "A novel PF/PN motif inhibits nuclear localization and DNA binding activity of the ESX1 homeoprotein."
    Yan Y.T., Stein S.M., Ding J., Shen M.M., Abate-Shen C.
    Mol. Cell. Biol. 20:661-671(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvImported.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  7. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiO88933_MOUSE
AccessioniPrimary (citable) accession number: O88933
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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