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Protein

ATP-sensitive inward rectifier potassium channel 15

Gene

Kcnj15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei157Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity1

GO - Molecular functioni

  • inward rectifier potassium channel activity Source: GO_Central
  • potassium channel activity Source: MGI

GO - Biological processi

  • potassium ion import Source: GO_Central
  • potassium ion transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-MMU-1296041. Activation of G protein gated Potassium channels.
R-MMU-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 15
Alternative name(s):
Inward rectifier K(+) channel Kir4.2
Potassium channel, inwardly rectifying subfamily J member 15
Gene namesi
Name:Kcnj15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1310000. Kcnj15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 63CytoplasmicBy similarityAdd BLAST63
Transmembranei64 – 88Helical; Name=M1By similarityAdd BLAST25
Topological domaini89 – 113ExtracellularBy similarityAdd BLAST25
Intramembranei114 – 125Helical; Pore-forming; Name=H5By similarityAdd BLAST12
Intramembranei126 – 132Pore-formingBy similarity7
Topological domaini133 – 141ExtracellularBy similarity9
Transmembranei142 – 163Helical; Name=M2By similarityAdd BLAST22
Topological domaini164 – 375CytoplasmicBy similarityAdd BLAST212

GO - Cellular componenti

  • integral component of membrane Source: MGI
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi439.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001549731 – 375ATP-sensitive inward rectifier potassium channel 15Add BLAST375

Proteomic databases

PaxDbiO88932.
PRIDEiO88932.

PTM databases

iPTMnetiO88932.
PhosphoSitePlusiO88932.

Expressioni

Gene expression databases

BgeeiENSMUSG00000062609.
ExpressionAtlasiO88932. baseline and differential.
GenevisibleiO88932. MM.

Interactioni

Subunit structurei

Interacts with PATJ.By similarity

Protein-protein interaction databases

BioGridi200898. 2 interactors.
IntActiO88932. 1 interactor.
MINTiMINT-1890790.
STRINGi10090.ENSMUSP00000045218.

Structurei

3D structure databases

ProteinModelPortaliO88932.
SMRiO88932.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi127 – 132Selectivity filterBy similarity6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3827. Eukaryota.
ENOG410XQ62. LUCA.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237326.
HOVERGENiHBG006178.
InParanoidiO88932.
KOiK05008.
PhylomeDBiO88932.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003270. K_chnl_inward-rec_Kir1.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF20. PTHR11767:SF20. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01323. KIR13CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

O88932-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAIHLGMSS APLVKHTNGV GLKAHRPRVM SKSGHSNVRI DKVDGIYLLY
60 70 80 90 100
LQDLWTTVID MKWRYKLTLF AATFVMTWFL FGVVYYAIAF IHGDLQLGES
110 120 130 140 150
NSNHTPCIMK VDSLTGAFLF SLESQTTIGY GVRSITEECP HAIFLLVAQL
160 170 180 190 200
VITTLIEIFI TGTFLAKIAR PKKRAETIKF SHCAVISKQN GKLCLVIQVA
210 220 230 240 250
NMRKSLLIQC QLSGKLLQTH VTKEGERILL NQATVKFHVD SSSESPFLIL
260 270 280 290 300
PMTFYHVLDE TSPLRDLTPQ NLKEKEFELV VLLNATVEST SAVCQSRTSY
310 320 330 340 350
IPEEIYWGFE FVPVVSLSKN GKYVADFSQF EQIRKSPDCT FYCADSEKQK
360 370
LEEQYRQEDQ RERELRSLLL QQSNV
Length:375
Mass (Da):42,605
Last modified:November 1, 1998 - v1
Checksum:i163277597D4B2C8E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14V → W in CAB89666 (PubMed:10906485).Curated1
Sequence conflicti99E → G in CAB89666 (PubMed:10906485).Curated1
Sequence conflicti262S → K in CAB89666 (PubMed:10906485).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085696 mRNA. Translation: AAC68685.1.
AJ012368 mRNA. Translation: CAB89666.1.
AK085689 mRNA. Translation: BAC39507.1.
BC010794 mRNA. Translation: AAH10794.1.
BC057915 mRNA. Translation: AAH57915.1.
CCDSiCCDS37410.1.
RefSeqiNP_001034145.1. NM_001039056.2.
NP_001258618.1. NM_001271689.1.
NP_001258620.1. NM_001271691.1.
NP_001258622.1. NM_001271693.1.
NP_001258624.1. NM_001271695.1.
NP_062638.1. NM_019664.5.
XP_006523014.1. XM_006522951.3.
XP_006523015.1. XM_006522952.3.
XP_017172374.1. XM_017316885.1.
UniGeneiMm.272239.
Mm.491313.

Genome annotation databases

EnsembliENSMUST00000113854; ENSMUSP00000109485; ENSMUSG00000062609.
ENSMUST00000113855; ENSMUSP00000109486; ENSMUSG00000062609.
ENSMUST00000113856; ENSMUSP00000109487; ENSMUSG00000062609.
GeneIDi16516.
KEGGimmu:16516.
UCSCiuc008abs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085696 mRNA. Translation: AAC68685.1.
AJ012368 mRNA. Translation: CAB89666.1.
AK085689 mRNA. Translation: BAC39507.1.
BC010794 mRNA. Translation: AAH10794.1.
BC057915 mRNA. Translation: AAH57915.1.
CCDSiCCDS37410.1.
RefSeqiNP_001034145.1. NM_001039056.2.
NP_001258618.1. NM_001271689.1.
NP_001258620.1. NM_001271691.1.
NP_001258622.1. NM_001271693.1.
NP_001258624.1. NM_001271695.1.
NP_062638.1. NM_019664.5.
XP_006523014.1. XM_006522951.3.
XP_006523015.1. XM_006522952.3.
XP_017172374.1. XM_017316885.1.
UniGeneiMm.272239.
Mm.491313.

3D structure databases

ProteinModelPortaliO88932.
SMRiO88932.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200898. 2 interactors.
IntActiO88932. 1 interactor.
MINTiMINT-1890790.
STRINGi10090.ENSMUSP00000045218.

Chemistry databases

GuidetoPHARMACOLOGYi439.

PTM databases

iPTMnetiO88932.
PhosphoSitePlusiO88932.

Proteomic databases

PaxDbiO88932.
PRIDEiO88932.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113854; ENSMUSP00000109485; ENSMUSG00000062609.
ENSMUST00000113855; ENSMUSP00000109486; ENSMUSG00000062609.
ENSMUST00000113856; ENSMUSP00000109487; ENSMUSG00000062609.
GeneIDi16516.
KEGGimmu:16516.
UCSCiuc008abs.2. mouse.

Organism-specific databases

CTDi3772.
MGIiMGI:1310000. Kcnj15.

Phylogenomic databases

eggNOGiKOG3827. Eukaryota.
ENOG410XQ62. LUCA.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237326.
HOVERGENiHBG006178.
InParanoidiO88932.
KOiK05008.
PhylomeDBiO88932.

Enzyme and pathway databases

ReactomeiR-MMU-1296041. Activation of G protein gated Potassium channels.
R-MMU-997272. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

ChiTaRSiKcnj15. mouse.
PROiO88932.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062609.
ExpressionAtlasiO88932. baseline and differential.
GenevisibleiO88932. MM.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003270. K_chnl_inward-rec_Kir1.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF20. PTHR11767:SF20. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01323. KIR13CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCJ15_MOUSE
AccessioniPrimary (citable) accession number: O88932
Secondary accession number(s): Q9JK34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.