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O88932 (KCJ15_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-sensitive inward rectifier potassium channel 15
Alternative name(s):
Inward rectifier K(+) channel Kir4.2
Potassium channel, inwardly rectifying subfamily J member 15
Gene names
Name:Kcnj15
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Subunit structure

Interacts with INADL By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ15 subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375ATP-sensitive inward rectifier potassium channel 15
PRO_0000154973

Regions

Topological domain1 – 6363Cytoplasmic By similarity
Transmembrane64 – 8825Helical; Name=M1; By similarity
Topological domain89 – 11325Extracellular By similarity
Intramembrane114 – 12512Helical; Pore-forming; Name=H5; By similarity
Intramembrane126 – 1327Pore-forming; By similarity
Topological domain133 – 1419Extracellular By similarity
Transmembrane142 – 16322Helical; Name=M2; By similarity
Topological domain164 – 375212Cytoplasmic By similarity
Motif127 – 1326Selectivity filter By similarity

Sites

Site1571Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium By similarity

Experimental info

Sequence conflict141V → W in CAB89666. Ref.2
Sequence conflict991E → G in CAB89666. Ref.2
Sequence conflict2621S → K in CAB89666. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O88932 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 163277597D4B2C8E

FASTA37542,605
        10         20         30         40         50         60 
MDAIHLGMSS APLVKHTNGV GLKAHRPRVM SKSGHSNVRI DKVDGIYLLY LQDLWTTVID 

        70         80         90        100        110        120 
MKWRYKLTLF AATFVMTWFL FGVVYYAIAF IHGDLQLGES NSNHTPCIMK VDSLTGAFLF 

       130        140        150        160        170        180 
SLESQTTIGY GVRSITEECP HAIFLLVAQL VITTLIEIFI TGTFLAKIAR PKKRAETIKF 

       190        200        210        220        230        240 
SHCAVISKQN GKLCLVIQVA NMRKSLLIQC QLSGKLLQTH VTKEGERILL NQATVKFHVD 

       250        260        270        280        290        300 
SSSESPFLIL PMTFYHVLDE TSPLRDLTPQ NLKEKEFELV VLLNATVEST SAVCQSRTSY 

       310        320        330        340        350        360 
IPEEIYWGFE FVPVVSLSKN GKYVADFSQF EQIRKSPDCT FYCADSEKQK LEEQYRQEDQ 

       370 
RERELRSLLL QQSNV 

« Hide

References

« Hide 'large scale' references
[1]"Expression of an inward rectifier current from a Kir 4 family K+ channel gene cloned from mouse liver."
Pearson W.L., Dourado M., Schreiber M., Nichols C.G., Salkoff L.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Developmentally regulated expression of the murine ortholog of the potassium channel KIR4.2 (KCNJ15)."
Thiery E., Gosset P., Damotte D., Delezoide A.-L., de Saint-Sauveur N., Vayssettes C., Creau N.
Mech. Dev. 95:313-316(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF085696 mRNA. Translation: AAC68685.1.
AJ012368 mRNA. Translation: CAB89666.1.
AK085689 mRNA. Translation: BAC39507.1.
BC010794 mRNA. Translation: AAH10794.1.
BC057915 mRNA. Translation: AAH57915.1.
CCDSCCDS37410.1.
RefSeqNP_001034145.1. NM_001039056.2.
NP_001258618.1. NM_001271689.1.
NP_001258620.1. NM_001271691.1.
NP_001258622.1. NM_001271693.1.
NP_001258624.1. NM_001271695.1.
NP_062638.1. NM_019664.5.
XP_006523014.1. XM_006522951.1.
XP_006523015.1. XM_006522952.1.
XP_006523249.1. XM_006523186.1.
XP_006523250.1. XM_006523187.1.
XP_006523251.1. XM_006523188.1.
XP_006523252.1. XM_006523189.1.
XP_006523253.1. XM_006523190.1.
XP_006523254.1. XM_006523191.1.
XP_006523255.1. XM_006523192.1.
XP_006523256.1. XM_006523193.1.
UniGeneMm.272239.
Mm.491313.

3D structure databases

ProteinModelPortalO88932.
SMRO88932. Positions 26-340.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200898. 1 interaction.
IntActO88932. 1 interaction.
MINTMINT-1890790.

Chemistry

GuidetoPHARMACOLOGY439.

PTM databases

PhosphoSiteO88932.

Proteomic databases

PRIDEO88932.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000113854; ENSMUSP00000109485; ENSMUSG00000062609.
ENSMUST00000113855; ENSMUSP00000109486; ENSMUSG00000062609.
ENSMUST00000113856; ENSMUSP00000109487; ENSMUSG00000062609.
GeneID16516.
KEGGmmu:16516.
UCSCuc008abs.1. mouse.

Organism-specific databases

CTD3772.
MGIMGI:1310000. Kcnj15.

Phylogenomic databases

eggNOGNOG289501.
HOGENOMHOG000237326.
HOVERGENHBG006178.
InParanoidO88932.
KOK05008.
OrthoDBEOG7GFB4Z.
PhylomeDBO88932.

Gene expression databases

BgeeO88932.
GenevestigatorO88932.

Family and domain databases

Gene3D2.60.40.1400. 1 hit.
InterProIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003270. K_chnl_inward-rec_Kir1.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF20. PTHR11767:SF20. 1 hit.
PfamPF01007. IRK. 1 hit.
[Graphical view]
PIRSFPIRSF005465. GIRK_kir. 1 hit.
PRINTSPR01323. KIR13CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMSSF81296. SSF81296. 1 hit.
ProtoNetSearch...

Other

ChiTaRSKCNJ15. mouse.
NextBio289873.
PROO88932.
SOURCESearch...

Entry information

Entry nameKCJ15_MOUSE
AccessionPrimary (citable) accession number: O88932
Secondary accession number(s): Q9JK34
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot