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O88932

- KCJ15_MOUSE

UniProt

O88932 - KCJ15_MOUSE

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Protein

ATP-sensitive inward rectifier potassium channel 15

Gene
Kcnj15
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei157 – 1571Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium By similarity

GO - Molecular functioni

  1. inward rectifier potassium channel activity Source: InterPro
  2. potassium channel activity Source: MGI
  3. protein binding Source: MGI

GO - Biological processi

  1. potassium ion transmembrane transport Source: GOC
  2. potassium ion transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_208837. Activation of G protein gated Potassium channels.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-sensitive inward rectifier potassium channel 15
Alternative name(s):
Inward rectifier K(+) channel Kir4.2
Potassium channel, inwardly rectifying subfamily J member 15
Gene namesi
Name:Kcnj15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1310000. Kcnj15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6363Cytoplasmic By similarityAdd
BLAST
Transmembranei64 – 8825Helical; Name=M1; By similarityAdd
BLAST
Topological domaini89 – 11325Extracellular By similarityAdd
BLAST
Intramembranei114 – 12512Helical; Pore-forming; Name=H5; By similarityAdd
BLAST
Intramembranei126 – 1327Pore-forming; By similarity
Topological domaini133 – 1419Extracellular By similarity
Transmembranei142 – 16322Helical; Name=M2; By similarityAdd
BLAST
Topological domaini164 – 375212Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375ATP-sensitive inward rectifier potassium channel 15PRO_0000154973Add
BLAST

Proteomic databases

PRIDEiO88932.

PTM databases

PhosphoSiteiO88932.

Expressioni

Gene expression databases

BgeeiO88932.
GenevestigatoriO88932.

Interactioni

Subunit structurei

Interacts with INADL By similarity.

Protein-protein interaction databases

BioGridi200898. 1 interaction.
IntActiO88932. 1 interaction.
MINTiMINT-1890790.

Structurei

3D structure databases

ProteinModelPortaliO88932.
SMRiO88932. Positions 26-340.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi127 – 1326Selectivity filter By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG289501.
HOGENOMiHOG000237326.
HOVERGENiHBG006178.
InParanoidiO88932.
KOiK05008.
OrthoDBiEOG7GFB4Z.
PhylomeDBiO88932.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003270. K_chnl_inward-rec_Kir1.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF20. PTHR11767:SF20. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01323. KIR13CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

O88932-1 [UniParc]FASTAAdd to Basket

« Hide

MDAIHLGMSS APLVKHTNGV GLKAHRPRVM SKSGHSNVRI DKVDGIYLLY    50
LQDLWTTVID MKWRYKLTLF AATFVMTWFL FGVVYYAIAF IHGDLQLGES 100
NSNHTPCIMK VDSLTGAFLF SLESQTTIGY GVRSITEECP HAIFLLVAQL 150
VITTLIEIFI TGTFLAKIAR PKKRAETIKF SHCAVISKQN GKLCLVIQVA 200
NMRKSLLIQC QLSGKLLQTH VTKEGERILL NQATVKFHVD SSSESPFLIL 250
PMTFYHVLDE TSPLRDLTPQ NLKEKEFELV VLLNATVEST SAVCQSRTSY 300
IPEEIYWGFE FVPVVSLSKN GKYVADFSQF EQIRKSPDCT FYCADSEKQK 350
LEEQYRQEDQ RERELRSLLL QQSNV 375
Length:375
Mass (Da):42,605
Last modified:November 1, 1998 - v1
Checksum:i163277597D4B2C8E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141V → W in CAB89666. 1 Publication
Sequence conflicti99 – 991E → G in CAB89666. 1 Publication
Sequence conflicti262 – 2621S → K in CAB89666. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF085696 mRNA. Translation: AAC68685.1.
AJ012368 mRNA. Translation: CAB89666.1.
AK085689 mRNA. Translation: BAC39507.1.
BC010794 mRNA. Translation: AAH10794.1.
BC057915 mRNA. Translation: AAH57915.1.
CCDSiCCDS37410.1.
RefSeqiNP_001034145.1. NM_001039056.2.
NP_001258618.1. NM_001271689.1.
NP_001258620.1. NM_001271691.1.
NP_001258622.1. NM_001271693.1.
NP_001258624.1. NM_001271695.1.
NP_062638.1. NM_019664.5.
XP_006523014.1. XM_006522951.1.
XP_006523015.1. XM_006522952.1.
XP_006523249.1. XM_006523186.1.
XP_006523250.1. XM_006523187.1.
XP_006523251.1. XM_006523188.1.
XP_006523252.1. XM_006523189.1.
XP_006523253.1. XM_006523190.1.
XP_006523254.1. XM_006523191.1.
XP_006523255.1. XM_006523192.1.
XP_006523256.1. XM_006523193.1.
UniGeneiMm.272239.
Mm.491313.

Genome annotation databases

EnsembliENSMUST00000113854; ENSMUSP00000109485; ENSMUSG00000062609.
ENSMUST00000113855; ENSMUSP00000109486; ENSMUSG00000062609.
ENSMUST00000113856; ENSMUSP00000109487; ENSMUSG00000062609.
GeneIDi16516.
KEGGimmu:16516.
UCSCiuc008abs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF085696 mRNA. Translation: AAC68685.1 .
AJ012368 mRNA. Translation: CAB89666.1 .
AK085689 mRNA. Translation: BAC39507.1 .
BC010794 mRNA. Translation: AAH10794.1 .
BC057915 mRNA. Translation: AAH57915.1 .
CCDSi CCDS37410.1.
RefSeqi NP_001034145.1. NM_001039056.2.
NP_001258618.1. NM_001271689.1.
NP_001258620.1. NM_001271691.1.
NP_001258622.1. NM_001271693.1.
NP_001258624.1. NM_001271695.1.
NP_062638.1. NM_019664.5.
XP_006523014.1. XM_006522951.1.
XP_006523015.1. XM_006522952.1.
XP_006523249.1. XM_006523186.1.
XP_006523250.1. XM_006523187.1.
XP_006523251.1. XM_006523188.1.
XP_006523252.1. XM_006523189.1.
XP_006523253.1. XM_006523190.1.
XP_006523254.1. XM_006523191.1.
XP_006523255.1. XM_006523192.1.
XP_006523256.1. XM_006523193.1.
UniGenei Mm.272239.
Mm.491313.

3D structure databases

ProteinModelPortali O88932.
SMRi O88932. Positions 26-340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200898. 1 interaction.
IntActi O88932. 1 interaction.
MINTi MINT-1890790.

Chemistry

GuidetoPHARMACOLOGYi 439.

PTM databases

PhosphoSitei O88932.

Proteomic databases

PRIDEi O88932.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000113854 ; ENSMUSP00000109485 ; ENSMUSG00000062609 .
ENSMUST00000113855 ; ENSMUSP00000109486 ; ENSMUSG00000062609 .
ENSMUST00000113856 ; ENSMUSP00000109487 ; ENSMUSG00000062609 .
GeneIDi 16516.
KEGGi mmu:16516.
UCSCi uc008abs.1. mouse.

Organism-specific databases

CTDi 3772.
MGIi MGI:1310000. Kcnj15.

Phylogenomic databases

eggNOGi NOG289501.
HOGENOMi HOG000237326.
HOVERGENi HBG006178.
InParanoidi O88932.
KOi K05008.
OrthoDBi EOG7GFB4Z.
PhylomeDBi O88932.

Enzyme and pathway databases

Reactomei REACT_208837. Activation of G protein gated Potassium channels.
REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

Miscellaneous databases

ChiTaRSi KCNJ15. mouse.
NextBioi 289873.
PROi O88932.
SOURCEi Search...

Gene expression databases

Bgeei O88932.
Genevestigatori O88932.

Family and domain databases

Gene3Di 2.60.40.1400. 1 hit.
InterProi IPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003270. K_chnl_inward-rec_Kir1.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view ]
PANTHERi PTHR11767. PTHR11767. 1 hit.
PTHR11767:SF20. PTHR11767:SF20. 1 hit.
Pfami PF01007. IRK. 1 hit.
[Graphical view ]
PIRSFi PIRSF005465. GIRK_kir. 1 hit.
PRINTSi PR01323. KIR13CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMi SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of an inward rectifier current from a Kir 4 family K+ channel gene cloned from mouse liver."
    Pearson W.L., Dourado M., Schreiber M., Nichols C.G., Salkoff L.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Developmentally regulated expression of the murine ortholog of the potassium channel KIR4.2 (KCNJ15)."
    Thiery E., Gosset P., Damotte D., Delezoide A.-L., de Saint-Sauveur N., Vayssettes C., Creau N.
    Mech. Dev. 95:313-316(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiKCJ15_MOUSE
AccessioniPrimary (citable) accession number: O88932
Secondary accession number(s): Q9JK34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi