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O88932

- KCJ15_MOUSE

UniProt

O88932 - KCJ15_MOUSE

Protein

ATP-sensitive inward rectifier potassium channel 15

Gene

Kcnj15

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei157 – 1571Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

    GO - Molecular functioni

    1. inward rectifier potassium channel activity Source: InterPro
    2. potassium channel activity Source: MGI
    3. protein binding Source: MGI

    GO - Biological processi

    1. potassium ion transmembrane transport Source: GOC
    2. potassium ion transport Source: MGI

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_208837. Activation of G protein gated Potassium channels.
    REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-sensitive inward rectifier potassium channel 15
    Alternative name(s):
    Inward rectifier K(+) channel Kir4.2
    Potassium channel, inwardly rectifying subfamily J member 15
    Gene namesi
    Name:Kcnj15
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1310000. Kcnj15.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375ATP-sensitive inward rectifier potassium channel 15PRO_0000154973Add
    BLAST

    Proteomic databases

    PRIDEiO88932.

    PTM databases

    PhosphoSiteiO88932.

    Expressioni

    Gene expression databases

    BgeeiO88932.
    GenevestigatoriO88932.

    Interactioni

    Subunit structurei

    Interacts with INADL.By similarity

    Protein-protein interaction databases

    BioGridi200898. 1 interaction.
    IntActiO88932. 1 interaction.
    MINTiMINT-1890790.

    Structurei

    3D structure databases

    ProteinModelPortaliO88932.
    SMRiO88932. Positions 26-340.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6363CytoplasmicBy similarityAdd
    BLAST
    Topological domaini89 – 11325ExtracellularBy similarityAdd
    BLAST
    Topological domaini133 – 1419ExtracellularBy similarity
    Topological domaini164 – 375212CytoplasmicBy similarityAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei114 – 12512Helical; Pore-forming; Name=H5By similarityAdd
    BLAST
    Intramembranei126 – 1327Pore-formingBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei64 – 8825Helical; Name=M1By similarityAdd
    BLAST
    Transmembranei142 – 16322Helical; Name=M2By similarityAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi127 – 1326Selectivity filterBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG289501.
    HOGENOMiHOG000237326.
    HOVERGENiHBG006178.
    InParanoidiO88932.
    KOiK05008.
    OrthoDBiEOG7GFB4Z.
    PhylomeDBiO88932.

    Family and domain databases

    Gene3Di2.60.40.1400. 1 hit.
    InterProiIPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR003270. K_chnl_inward-rec_Kir1.3.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view]
    PANTHERiPTHR11767. PTHR11767. 1 hit.
    PTHR11767:SF20. PTHR11767:SF20. 1 hit.
    PfamiPF01007. IRK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005465. GIRK_kir. 1 hit.
    PRINTSiPR01323. KIR13CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMiSSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O88932-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDAIHLGMSS APLVKHTNGV GLKAHRPRVM SKSGHSNVRI DKVDGIYLLY    50
    LQDLWTTVID MKWRYKLTLF AATFVMTWFL FGVVYYAIAF IHGDLQLGES 100
    NSNHTPCIMK VDSLTGAFLF SLESQTTIGY GVRSITEECP HAIFLLVAQL 150
    VITTLIEIFI TGTFLAKIAR PKKRAETIKF SHCAVISKQN GKLCLVIQVA 200
    NMRKSLLIQC QLSGKLLQTH VTKEGERILL NQATVKFHVD SSSESPFLIL 250
    PMTFYHVLDE TSPLRDLTPQ NLKEKEFELV VLLNATVEST SAVCQSRTSY 300
    IPEEIYWGFE FVPVVSLSKN GKYVADFSQF EQIRKSPDCT FYCADSEKQK 350
    LEEQYRQEDQ RERELRSLLL QQSNV 375
    Length:375
    Mass (Da):42,605
    Last modified:November 1, 1998 - v1
    Checksum:i163277597D4B2C8E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141V → W in CAB89666. (PubMed:10906485)Curated
    Sequence conflicti99 – 991E → G in CAB89666. (PubMed:10906485)Curated
    Sequence conflicti262 – 2621S → K in CAB89666. (PubMed:10906485)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF085696 mRNA. Translation: AAC68685.1.
    AJ012368 mRNA. Translation: CAB89666.1.
    AK085689 mRNA. Translation: BAC39507.1.
    BC010794 mRNA. Translation: AAH10794.1.
    BC057915 mRNA. Translation: AAH57915.1.
    CCDSiCCDS37410.1.
    RefSeqiNP_001034145.1. NM_001039056.2.
    NP_001258618.1. NM_001271689.1.
    NP_001258620.1. NM_001271691.1.
    NP_001258622.1. NM_001271693.1.
    NP_001258624.1. NM_001271695.1.
    NP_062638.1. NM_019664.5.
    XP_006523014.1. XM_006522951.1.
    XP_006523015.1. XM_006522952.1.
    XP_006523249.1. XM_006523186.1.
    XP_006523250.1. XM_006523187.1.
    XP_006523251.1. XM_006523188.1.
    XP_006523252.1. XM_006523189.1.
    XP_006523253.1. XM_006523190.1.
    XP_006523254.1. XM_006523191.1.
    XP_006523255.1. XM_006523192.1.
    XP_006523256.1. XM_006523193.1.
    UniGeneiMm.272239.
    Mm.491313.

    Genome annotation databases

    EnsembliENSMUST00000113854; ENSMUSP00000109485; ENSMUSG00000062609.
    ENSMUST00000113855; ENSMUSP00000109486; ENSMUSG00000062609.
    ENSMUST00000113856; ENSMUSP00000109487; ENSMUSG00000062609.
    GeneIDi16516.
    KEGGimmu:16516.
    UCSCiuc008abs.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF085696 mRNA. Translation: AAC68685.1 .
    AJ012368 mRNA. Translation: CAB89666.1 .
    AK085689 mRNA. Translation: BAC39507.1 .
    BC010794 mRNA. Translation: AAH10794.1 .
    BC057915 mRNA. Translation: AAH57915.1 .
    CCDSi CCDS37410.1.
    RefSeqi NP_001034145.1. NM_001039056.2.
    NP_001258618.1. NM_001271689.1.
    NP_001258620.1. NM_001271691.1.
    NP_001258622.1. NM_001271693.1.
    NP_001258624.1. NM_001271695.1.
    NP_062638.1. NM_019664.5.
    XP_006523014.1. XM_006522951.1.
    XP_006523015.1. XM_006522952.1.
    XP_006523249.1. XM_006523186.1.
    XP_006523250.1. XM_006523187.1.
    XP_006523251.1. XM_006523188.1.
    XP_006523252.1. XM_006523189.1.
    XP_006523253.1. XM_006523190.1.
    XP_006523254.1. XM_006523191.1.
    XP_006523255.1. XM_006523192.1.
    XP_006523256.1. XM_006523193.1.
    UniGenei Mm.272239.
    Mm.491313.

    3D structure databases

    ProteinModelPortali O88932.
    SMRi O88932. Positions 26-340.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200898. 1 interaction.
    IntActi O88932. 1 interaction.
    MINTi MINT-1890790.

    Chemistry

    GuidetoPHARMACOLOGYi 439.

    PTM databases

    PhosphoSitei O88932.

    Proteomic databases

    PRIDEi O88932.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000113854 ; ENSMUSP00000109485 ; ENSMUSG00000062609 .
    ENSMUST00000113855 ; ENSMUSP00000109486 ; ENSMUSG00000062609 .
    ENSMUST00000113856 ; ENSMUSP00000109487 ; ENSMUSG00000062609 .
    GeneIDi 16516.
    KEGGi mmu:16516.
    UCSCi uc008abs.1. mouse.

    Organism-specific databases

    CTDi 3772.
    MGIi MGI:1310000. Kcnj15.

    Phylogenomic databases

    eggNOGi NOG289501.
    HOGENOMi HOG000237326.
    HOVERGENi HBG006178.
    InParanoidi O88932.
    KOi K05008.
    OrthoDBi EOG7GFB4Z.
    PhylomeDBi O88932.

    Enzyme and pathway databases

    Reactomei REACT_208837. Activation of G protein gated Potassium channels.
    REACT_226457. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.

    Miscellaneous databases

    ChiTaRSi KCNJ15. mouse.
    NextBioi 289873.
    PROi O88932.
    SOURCEi Search...

    Gene expression databases

    Bgeei O88932.
    Genevestigatori O88932.

    Family and domain databases

    Gene3Di 2.60.40.1400. 1 hit.
    InterProi IPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR003270. K_chnl_inward-rec_Kir1.3.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view ]
    PANTHERi PTHR11767. PTHR11767. 1 hit.
    PTHR11767:SF20. PTHR11767:SF20. 1 hit.
    Pfami PF01007. IRK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005465. GIRK_kir. 1 hit.
    PRINTSi PR01323. KIR13CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMi SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Expression of an inward rectifier current from a Kir 4 family K+ channel gene cloned from mouse liver."
      Pearson W.L., Dourado M., Schreiber M., Nichols C.G., Salkoff L.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Developmentally regulated expression of the murine ortholog of the potassium channel KIR4.2 (KCNJ15)."
      Thiery E., Gosset P., Damotte D., Delezoide A.-L., de Saint-Sauveur N., Vayssettes C., Creau N.
      Mech. Dev. 95:313-316(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney.

    Entry informationi

    Entry nameiKCJ15_MOUSE
    AccessioniPrimary (citable) accession number: O88932
    Secondary accession number(s): Q9JK34
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3