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Protein

Adhesion G protein-coupled receptor L2

Gene

Adgrl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis.1 Publication

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • G-protein coupled receptor activity Source: RGD

GO - Biological processi

  • brain development Source: RGD
  • cell surface receptor signaling pathway Source: InterPro

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
LigandLectin

Protein family/group databases

MEROPSiP02.009

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor L2
Alternative name(s):
Calcium-independent alpha-latrotoxin receptor 2
Short name:
CIRL-2
Latrophilin-2
Gene namesi
Name:Adgrl2
Synonyms:Cirl2, Cl2, Lphn2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620835 Adgrl2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 855ExtracellularCuratedAdd BLAST830
Transmembranei856 – 876Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini877 – 884CytoplasmicCurated8
Transmembranei885 – 905Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini906 – 911ExtracellularCurated6
Transmembranei912 – 932Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini933 – 956CytoplasmicCuratedAdd BLAST24
Transmembranei957 – 977Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini978 – 994ExtracellularCuratedAdd BLAST17
Transmembranei995 – 1015Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini1016 – 1065CytoplasmicCuratedAdd BLAST50
Transmembranei1066 – 1086Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1087 – 1090ExtracellularCurated4
Transmembranei1091 – 1111Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1112 – 1487CytoplasmicCuratedAdd BLAST376

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi207

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001291126 – 1487Adhesion G protein-coupled receptor L2Add BLAST1462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi140 ↔ 322PROSITE-ProRule annotation
Glycosylationi335N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi524N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi633N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi735N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi748N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi791N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi796N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi817N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1402PhosphoserineBy similarity1
Modified residuei1437PhosphoserineBy similarity1
Modified residuei1458PhosphoserineCombined sources1

Post-translational modificationi

Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei828 – 829CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO88923
PRIDEiO88923

PTM databases

iPTMnetiO88923
PhosphoSitePlusiO88923

Expressioni

Tissue specificityi

Expressed ubiquitously with highest concentrations found in placenta, kidney, spleen, ovary, heart and lung.1 Publication

Interactioni

Subunit structurei

Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042136

Structurei

3D structure databases

ProteinModelPortaliO88923
SMRiO88923
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 130SUEL-type lectinPROSITE-ProRule annotationAdd BLAST90
Domaini139 – 398Olfactomedin-likePROSITE-ProRule annotationAdd BLAST260
Domaini789 – 840GPSPROSITE-ProRule annotationAdd BLAST52

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3545 Eukaryota
KOG4193 Eukaryota
KOG4729 Eukaryota
ENOG410XSD2 LUCA
HOVERGENiHBG052337
InParanoidiO88923
KOiK04593
PhylomeDBiO88923

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003924 GPCR_2_latrophilin
IPR003334 GPCR_2_latrophilin_rcpt_C
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR031240 Latrophilin-2
IPR000922 Lectin_gal-bd_dom
IPR003112 Olfac-like_dom
PANTHERiPTHR12011:SF61 PTHR12011:SF61, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF16489 GAIN, 1 hit
PF02140 Gal_Lectin, 1 hit
PF01825 GPS, 1 hit
PF02793 HRM, 1 hit
PF02354 Latrophilin, 1 hit
PF02191 OLF, 1 hit
PRINTSiPR00249 GPCRSECRETIN
PR01444 LATROPHILIN
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00284 OLF, 1 hit
PROSITEiView protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51132 OLF, 1 hit
PS50228 SUEL_LECTIN, 1 hit

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O88923-7) [UniParc]FASTAAdd to basket
Also known as: CL2A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSSGCRMRS LWFIMIISFS PNTEGFSRAA LPFGLVRREL SCEGYSIDLR
60 70 80 90 100
CPGSDVIMIE SANYGRTDDK ICDADPFQME NTDCYLPDAF KIMTQRCNNR
110 120 130 140 150
TQCVVVTGSD VFPDPCPGTY KYLEVQYECV PYMEQKVFVC PGTLKAIVDS
160 170 180 190 200
PSIYEAEQKA GAWCKDPLQA ADKIYFMPWT PYRTDTLIEY ASLEDFQNSR
210 220 230 240 250
QTTTYKLPNR VDGTGFVVYD GAVFFNKERT RNIVKFDLRT RIKSGEAIIN
260 270 280 290 300
YANYHDTSPY RWGGKTDIDL AVDENGLWVI YATEQNNGMI VISQLNPYTL
310 320 330 340 350
RFEATWETTY DKRAASNAFM ICGVLYVVRS VYQDNESEAG KNVIDYIYNT
360 370 380 390 400
RLSRGEHVDV PFPNQYQYIA AVDYNPRDNQ LYVWNNNFIL RYSLEFGPPD
410 420 430 440 450
PAQVPTTAVT ITSSAELFKT TVSTTSSTSQ RGPVSSTVAG PQEGSRGTKP
460 470 480 490 500
PPAVSTTKIP PVTNIFPLPE RFCEALEMKG IKWPQTQRGM MVERPCPKGT
510 520 530 540 550
RGTASYLCMA STGTWNPKGP DLSNCTSHWV NQLAQKIRSG ENAASLANEL
560 570 580 590 600
AKHTKGTVFA GDVSSSVRLM EQLVDILDAQ LQELKPSEKD SAGRSYNKLQ
610 620 630 640 650
KREKTCRAYL KAIVDTVDNL LRAETLDCWK HMNSSEQAHT ATMLLDTLEE
660 670 680 690 700
GAFVLADNLL EPTRVSMPTD NIVLEVAVLS TEGQVQDFTF HLGFKGAFSS
710 720 730 740 750
IQLSANTVKQ NSRNGLAKVV FIIYRSLGPF LSTENATVKL GADLLGRNST
760 770 780 790 800
IAVNSHVLSV SINKESSRVY LTDPVLFSMP HIDSDNYFNA NCSFWNYSER
810 820 830 840 850
TMMGYWSTQG CKLVDTNKTR TTCACSHLTN FAILMAHREI VYKDGVHKLL
860 870 880 890 900
LTVITWVGIV VSLVCLAICI FTFCFFRGLQ SDRNTIHKNL CINLFIAEFI
910 920 930 940 950
FLIGIDKTQY TIACPVFAGL LHFFFLAAFS WMCLEGVQLY LMLVEVFESE
960 970 980 990 1000
YSRKKYYYVA GYLFPATVVG VSAAIDSKSY GTLEACWLHV DNYFIWSFIG
1010 1020 1030 1040 1050
PVTFIILLNI IFLVITLCKM VKHSNTLKPD SSRLENINNY RVCDGYYNTD
1060 1070 1080 1090 1100
LPGYEDNKPF IKSWVLGAFA LLCLLGLTWS FGLLFVNEET VVMAYLFTAF
1110 1120 1130 1140 1150
NAFQGLFIFI FHCALQKKVR KEYAKCFRHW YCCGGLPTES PHSSVKASTS
1160 1170 1180 1190 1200
RTSARYSSGT QSRIRRMWND TVRKQSESSF ISGDINSTST LNQGMTGNYL
1210 1220 1230 1240 1250
LTNPLLRPHG TNNPYNTLLA ETVVCNAPSA PVFNSPGHSL NNTRDTSAMD
1260 1270 1280 1290 1300
TLPLNGNFNN SYSLRKADYH DGVQVVDCGL SLNDTAFEKM IISELVHNNL
1310 1320 1330 1340 1350
RGSNKTHNLE LKLPVKPVIG GSSSEDDAIV ADASSLMHGD NPGLEFRHKE
1360 1370 1380 1390 1400
LEAPLIPQRT HSLLYQPQKK VKPEATDSYV SQLTAEADEH LQSPNRDSLY
1410 1420 1430 1440 1450
TSMPNLRDSP YPESSPDMAE DLSPSRRSEN EDIYYKSMPN LGAGRQLQMC
1460 1470 1480
YQISRGNSDG YIIPINKEGC IPEGDVREGQ MQLVTSL
Length:1,487
Mass (Da):166,729
Last modified:April 26, 2004 - v2
Checksum:i56179F1A95471B00
GO
Isoform 2 (identifier: O88923-1) [UniParc]FASTAAdd to basket
Also known as: CL2BC

The sequence of this isoform differs from the canonical sequence as follows:
     1054-1062: Missing.

Show »
Length:1,478
Mass (Da):165,593
Checksum:iCBB1ED1B00F70407
GO
Isoform 3 (identifier: O88923-2) [UniParc]FASTAAdd to basket
Also known as: CL2AA

The sequence of this isoform differs from the canonical sequence as follows:
     1038-1038: N → K
     1039-1053: Missing.
     1054-1062: Missing.
     1183-1193: Missing.

Show »
Length:1,452
Mass (Da):162,744
Checksum:i3D29320F1A736660
GO
Isoform 4 (identifier: O88923-3) [UniParc]FASTAAdd to basket
Also known as: CL2AB

The sequence of this isoform differs from the canonical sequence as follows:
     1038-1038: N → K
     1039-1053: Missing.
     1054-1062: Missing.
     1194-1236: Missing.

Show »
Length:1,420
Mass (Da):159,323
Checksum:i30E8DB4FD4717BF2
GO
Isoform 5 (identifier: O88923-4) [UniParc]FASTAAdd to basket
Also known as: CL2AC

The sequence of this isoform differs from the canonical sequence as follows:
     1038-1038: N → K
     1039-1053: Missing.
     1054-1062: Missing.

Show »
Length:1,463
Mass (Da):163,875
Checksum:iD5DFAC02CC1FC3A1
GO
Isoform 6 (identifier: O88923-5) [UniParc]FASTAAdd to basket
Also known as: CL2BA

The sequence of this isoform differs from the canonical sequence as follows:
     1054-1062: Missing.
     1183-1193: Missing.

Show »
Length:1,467
Mass (Da):164,462
Checksum:i700420D1FD770513
GO
Isoform 7 (identifier: O88923-6) [UniParc]FASTAAdd to basket
Also known as: CL2BB

The sequence of this isoform differs from the canonical sequence as follows:
     1054-1062: Missing.
     1194-1236: Missing.

Show »
Length:1,435
Mass (Da):161,041
Checksum:i593833C7D30AD2D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti977S → Y in AAC62654 (PubMed:9830014).Curated1
Sequence conflicti977S → Y in AAC62655 (PubMed:9830014).Curated1
Sequence conflicti977S → Y in AAC62656 (PubMed:9830014).Curated1
Sequence conflicti977S → Y in AAC62657 (PubMed:9830014).Curated1
Sequence conflicti977S → Y in AAC62658 (PubMed:9830014).Curated1
Sequence conflicti977S → Y in AAC62659 (PubMed:9830014).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0504291038N → K in isoform 3, isoform 4 and isoform 5. 1 Publication1
Alternative sequenceiVSP_0504301039 – 1053Missing in isoform 3, isoform 4 and isoform 5. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0101121054 – 1062Missing in isoform 2, isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7. 1 Publication9
Alternative sequenceiVSP_0504281183 – 1193Missing in isoform 6 and isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_0504271194 – 1236Missing in isoform 7 and isoform 4. 1 PublicationAdd BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF063102 mRNA Translation: AAC77815.1
AF081148 mRNA Translation: AAC62654.1
AF081149 mRNA Translation: AAC62655.1
AF081150 mRNA Translation: AAC62656.1
AF081151 mRNA Translation: AAC62657.1
AF081152 mRNA Translation: AAC62658.1
AF081153 mRNA Translation: AAC62659.1
PIRiT14324
T17157
T17158
T17159
T17160
T17185
T46611
RefSeqiNP_001177404.2, NM_001190475.2
NP_001289137.1, NM_001302208.1
NP_001289138.1, NM_001302209.1
NP_001289139.1, NM_001302210.1
NP_001289140.1, NM_001302211.1
NP_001289141.1, NM_001302212.1
NP_599235.3, NM_134408.3
UniGeneiRn.12089

Genome annotation databases

GeneIDi171447
KEGGirno:171447

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAGRL2_RAT
AccessioniPrimary (citable) accession number: O88923
Secondary accession number(s): O88918
, O88919, O88920, O88921, O88922, Q9Z174
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 26, 2004
Last modified: May 23, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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