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Protein

MAGUK p55 subfamily member 3

Gene

Mpp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
MAGUK p55 subfamily member 3
Alternative name(s):
Discs large homolog 3
Protein MPP3
Gene namesi
Name:Mpp3
Synonyms:Dlgh3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1328354. Mpp3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568MAGUK p55 subfamily member 3PRO_0000094576Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei307 – 3071PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO88910.
PaxDbiO88910.
PRIDEiO88910.

PTM databases

PhosphoSiteiO88910.

Expressioni

Tissue specificityi

Expressed in brain, skeletal muscle, testis, kidney, and lung.

Interactioni

Subunit structurei

May interact with HTR2A. Interacts (via PDZ domain) with CADM1 (via C-terminus). Interacts with HTR4.2 Publications

Protein-protein interaction databases

IntActiO88910. 3 interactions.
MINTiMINT-4102357.
STRINGi10090.ENSMUSP00000055469.

Structurei

3D structure databases

ProteinModelPortaliO88910.
SMRiO88910. Positions 7-116, 133-560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 6055L27 1PROSITE-ProRule annotationAdd
BLAST
Domaini61 – 11858L27 2PROSITE-ProRule annotationAdd
BLAST
Domaini137 – 21882PDZPROSITE-ProRule annotationAdd
BLAST
Domaini226 – 29671SH3PROSITE-ProRule annotationAdd
BLAST
Domaini385 – 568184Guanylate kinase-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MAGUK family.Curated
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 2 L27 domains.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG0609. Eukaryota.
COG0194. LUCA.
HOVERGENiHBG001858.
InParanoidiO88910.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88910-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVLSEDSGL HETLALLTSQ LRPDSNHREE MGFLRDVFSE KSLSYLMKIH
60 70 80 90 100
EKLRYYERQS PTPVLHSAMA LAEDVMEELQ AASVHSDERE LLQLLSTPHL
110 120 130 140 150
RAVLMVHDTV AQKNFDPVLP PLPDNIDEDF EEESVKIVRL VKNKEPLGAT
160 170 180 190 200
IRRDEHSGAV VVARIMRGGA ADRSGLVHVG DELREVNGIA VLHKRPDEIS
210 220 230 240 250
QILAQSQGSI TLKIIPATQE EDRFKDSKVF MRALFHYDPR EDRAIPCQEA
260 270 280 290 300
GLPFQRRQVL EVVSQDDPTW WQAKRVGDTN LRAGLIPSKQ FQERRLSYRR
310 320 330 340 350
TTGTLPSPQN FKKPPYDQPC DKETCDCDGY FKGHYVAGLR RSFRLGCRER
360 370 380 390 400
LGGSQEAKVP TGAESQVLLT YEEVARYQHQ PGERPRLVVL IGSLGAHLHE
410 420 430 440 450
LKQRVVAEDP QQFAVAVPHT TRPRKSHERD GVEYHFVSKQ AFEADVHHNK
460 470 480 490 500
FLEHGEYKEN LYGTSLEAIQ AVMAKNKVCL VDVEPEALRH LRTPEFKPYV
510 520 530 540 550
IFVKPAIQER RKTPPVSPDS EDIASSLDEQ QQEMAASAAF IDQHYGHLID
560
TVLVRQDLQE PAASSELS
Length:568
Mass (Da):64,401
Last modified:July 27, 2011 - v2
Checksum:i078EC699D9DB0C93
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31V → I in AAD12762 (PubMed:9838122).Curated
Sequence conflicti329 – 3291G → E in AAD12762 (PubMed:9838122).Curated
Sequence conflicti429 – 4291R → I in AAD12762 (PubMed:9838122).Curated
Sequence conflicti450 – 4501K → R in AAD12762 (PubMed:9838122).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079366 mRNA. Translation: AAD12762.1.
AL591145 Genomic DNA. No translation available.
UniGeneiMm.20449.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF079366 mRNA. Translation: AAD12762.1.
AL591145 Genomic DNA. No translation available.
UniGeneiMm.20449.

3D structure databases

ProteinModelPortaliO88910.
SMRiO88910. Positions 7-116, 133-560.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88910. 3 interactions.
MINTiMINT-4102357.
STRINGi10090.ENSMUSP00000055469.

PTM databases

PhosphoSiteiO88910.

Proteomic databases

MaxQBiO88910.
PaxDbiO88910.
PRIDEiO88910.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1328354. Mpp3.

Phylogenomic databases

eggNOGiKOG0609. Eukaryota.
COG0194. LUCA.
HOVERGENiHBG001858.
InParanoidiO88910.

Miscellaneous databases

ChiTaRSiMpp3. mouse.
PROiO88910.
SOURCEiSearch...

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like_dom.
IPR020590. Guanylate_kinase_CS.
IPR014775. L27_C.
IPR004172. L27_dom.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
PF02828. L27. 2 hits.
PF00595. PDZ. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
SM00569. L27. 2 hits.
SM00228. PDZ. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF101288. SSF101288. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50156. SSF50156. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS51022. L27. 2 hits.
PS50106. PDZ. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA sequence and chromosomal localization of mouse Dlgh3 gene adjacent to the BRCA1 tumor suppressor locus."
    Lin L., Peters L.L., Ciciotte S.L., Chishti A.H.
    Biochim. Biophys. Acta 1443:211-216(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins."
    Becamel C., Gavarini S., Chanrion B., Alonso G., Galeotti N., Dumuis A., Bockaert J., Marin P.
    J. Biol. Chem. 279:20257-20266(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HTR2A.
  4. "New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting."
    Joubert L., Hanson B., Barthet G., Sebben M., Claeysen S., Hong W., Marin P., Dumuis A., Bockaert J.
    J. Cell Sci. 117:5367-5379(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HTR4.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiMPP3_MOUSE
AccessioniPrimary (citable) accession number: O88910
Secondary accession number(s): E9Q5S2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: July 27, 2011
Last modified: April 13, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.