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O88908 (SOAT2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sterol O-acyltransferase 2
EC=2.3.1.26
Alternative name(s):
Acyl-coenzyme A:cholesterol acyltransferase 2
Short name=ACAT-2
Cholesterol acyltransferase 2
Gene names
Name:Soat2
Synonyms:Acact-2, Acat2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length525 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.

Catalytic activity

Acyl-CoA + cholesterol = CoA + cholesterol ester.

Subunit structure

May form homo- or heterodimers By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 525525Sterol O-acyltransferase 2
PRO_0000207646

Regions

Transmembrane123 – 14321Helical; Potential
Transmembrane154 – 17421Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane265 – 28521Helical; Potential
Transmembrane307 – 32721Helical; Potential
Transmembrane350 – 37021Helical; Potential
Transmembrane440 – 46021Helical; Potential
Transmembrane475 – 49521Helical; Potential

Sites

Active site4371 Potential

Experimental info

Sequence conflict931Q → P in AAC64057. Ref.1
Sequence conflict961H → R in AAC64057. Ref.1
Sequence conflict104 – 1052IT → VA in AAC64057. Ref.1
Sequence conflict131 – 1322CV → WF in AAC64057. Ref.1
Sequence conflict1751S → Y in AAC64057. Ref.1
Sequence conflict2621G → R in AAC64057. Ref.1
Sequence conflict5191R → Q in AAC64057. Ref.1
Sequence conflict5251P → T in AAC64057. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O88908 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: F1C2DFEB5AB6CCA8

FASTA52560,597
        10         20         30         40         50         60 
MQPKVPQLRR REGLGEEQEK GARGGEGNAR THGTPDLVQW TRHMEAVKTQ FLEQAQRELA 

        70         80         90        100        110        120 
ELLDRALWEA MQAYPKQDRP LPSAAPDSTS KTQELHPGKR KVFITRKSLI DELMEVQHFR 

       130        140        150        160        170        180 
TIYHMFIAGL CVLIISTLAI DFIDEGRLML EFDLLLFSFG QLPLALMTWV PMFLSTLLVP 

       190        200        210        220        230        240 
YQTLWLWARP RAGGAWMLGA SLGCVLLAAH AVVLCVLPVH VSVRHELPPA SRCVLVFEQV 

       250        260        270        280        290        300 
RLLMKSYSFL RETVPGIFCV RGGKGISPPS FSSYLYFLFC PTLIYRETYP RTPSIRWNYV 

       310        320        330        340        350        360 
AKNFAQVLGC LLYACFILGR LCVPVFANMS REPFSTRALL LSILHATGPG IFMLLLIFFA 

       370        380        390        400        410        420 
FLHCWLNAFA EMLRFGDRMF YRDWWNSTSF SNYYRTWNVV VHDWLYSYVY QDGLWLLGRR 

       430        440        450        460        470        480 
ARGVAMLGVF LVSAVVHEYI FCFVLGFFYP VMLMLFLVFG GLLNFTMNDR HTGPAWNILM 

       490        500        510        520 
WTFLFMGQGI QVSLYCQEWY ARRHCPLPQT TFWGMVTPRS WSCHP

« Hide

References

« Hide 'large scale' references
[1]"ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization."
Cases S., Novak S., Zheng Y.-W., Myers H.M., Lear S.R., Sande E., Welch C.B., Lusis A.J., Spencer T.A., Krause B.R., Erickson S.K., Farese R.V. Jr.
J. Biol. Chem. 273:26755-26764(1998) [PubMed: 9756919] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF078751 mRNA. Translation: AAC64057.1.
CH466550 Genomic DNA. Translation: EDL04004.1.
BC025931 mRNA. Translation: AAH25931.1.
IPIIPI00136247.
RefSeqNP_666176.1. NM_146064.1.
UniGeneMm.358862.

3D structure databases

ProteinModelPortalO88908.
ModBaseSearch...

Protein-protein interaction databases

STRINGO88908.

Proteomic databases

PRIDEO88908.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023806; ENSMUSP00000023806; ENSMUSG00000023045.
GeneID223920.
KEGGmmu:223920.

Organism-specific databases

CTD8435.
MGIMGI:1332226. Soat2.

Phylogenomic databases

eggNOGroNOG13755.
HOGENOMHBG446698.
HOVERGENHBG058198.
InParanoidO88908.
OrthoDBEOG4548ZG.

Enzyme and pathway databases

BRENDA2.3.1.26. 3474.

Gene expression databases

ArrayExpressO88908.
BgeeO88908.
CleanExMM_ACAT2.
MM_SOAT2.
GenevestigatorO88908.
GermOnlineENSMUSG00000023045. Mus musculus.

Family and domain databases

InterProIPR004299. MBOAT_fam.
IPR014371. Oat_ACAT_DAG_ARE.
[Graphical view]
KOK00637.
PANTHERPTHR10408. PTHR10408. 1 hit.
PfamPF03062. MBOAT. 1 hit.
[Graphical view]
PIRSFPIRSF000439. Oat_ACAT_DAG_ARE. 1 hit.
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameSOAT2_MOUSE
AccessionPrimary (citable) accession number: O88908
Secondary accession number(s): Q8R0Y9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 27, 2011
Last modified: January 25, 2012
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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