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Protein

Sterol O-acyltransferase 2

Gene

Soat2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.

Catalytic activityi

Acyl-CoA + cholesterol = CoA + cholesterol ester.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei437 – 4371Sequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism

Enzyme and pathway databases

BRENDAi2.3.1.26. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol O-acyltransferase 2 (EC:2.3.1.26)
Alternative name(s):
Acyl-coenzyme A:cholesterol acyltransferase 2
Short name:
ACAT-2
Cholesterol acyltransferase 2
Gene namesi
Name:Soat2
Synonyms:Acact-2, Acat2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1332226. Soat2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 122122CytoplasmicSequence analysisAdd
BLAST
Transmembranei123 – 14119HelicalSequence analysisAdd
BLAST
Topological domaini142 – 16019LumenalSequence analysisAdd
BLAST
Transmembranei161 – 17919HelicalSequence analysisAdd
BLAST
Topological domaini180 – 20324CytoplasmicSequence analysisAdd
BLAST
Transmembranei204 – 22219HelicalSequence analysisAdd
BLAST
Topological domaini223 – 343121LumenalSequence analysisAdd
BLAST
Transmembranei344 – 36623HelicalSequence analysisAdd
BLAST
Topological domaini367 – 478112CytoplasmicSequence analysisAdd
BLAST
Transmembranei479 – 49719HelicalSequence analysisAdd
BLAST
Topological domaini498 – 52528LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Sterol O-acyltransferase 2PRO_0000207646Add
BLAST

Proteomic databases

EPDiO88908.
PaxDbiO88908.
PRIDEiO88908.

PTM databases

iPTMnetiO88908.
PhosphoSiteiO88908.
SwissPalmiO88908.

Expressioni

Gene expression databases

BgeeiENSMUSG00000023045.
CleanExiMM_ACAT2.
MM_SOAT2.
ExpressionAtlasiO88908. baseline and differential.
GenevisibleiO88908. MM.

Interactioni

Subunit structurei

May form homo- or heterodimers.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023806.

Structurei

3D structure databases

ProteinModelPortaliO88908.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0380. Eukaryota.
COG5056. LUCA.
GeneTreeiENSGT00530000063122.
HOGENOMiHOG000020782.
HOVERGENiHBG058198.
InParanoidiO88908.
KOiK00637.
OMAiRHCPLPQ.
OrthoDBiEOG091G0991.
TreeFamiTF315226.

Family and domain databases

InterProiIPR004299. MBOAT_fam.
IPR014371. Oat_ACAT_DAG_ARE.
IPR030687. Sterol_acyltranf_meta.
[Graphical view]
PANTHERiPTHR10408. PTHR10408. 1 hit.
PfamiPF03062. MBOAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000439. Oat_ACAT_DAG_ARE. 1 hit.
PIRSF500230. Sterol_acyltranf_ACAT. 1 hit.

Sequencei

Sequence statusi: Complete.

O88908-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPKVPQLRR REGLGEEQEK GARGGEGNAR THGTPDLVQW TRHMEAVKTQ
60 70 80 90 100
FLEQAQRELA ELLDRALWEA MQAYPKQDRP LPSAAPDSTS KTQELHPGKR
110 120 130 140 150
KVFITRKSLI DELMEVQHFR TIYHMFIAGL CVLIISTLAI DFIDEGRLML
160 170 180 190 200
EFDLLLFSFG QLPLALMTWV PMFLSTLLVP YQTLWLWARP RAGGAWMLGA
210 220 230 240 250
SLGCVLLAAH AVVLCVLPVH VSVRHELPPA SRCVLVFEQV RLLMKSYSFL
260 270 280 290 300
RETVPGIFCV RGGKGISPPS FSSYLYFLFC PTLIYRETYP RTPSIRWNYV
310 320 330 340 350
AKNFAQVLGC LLYACFILGR LCVPVFANMS REPFSTRALL LSILHATGPG
360 370 380 390 400
IFMLLLIFFA FLHCWLNAFA EMLRFGDRMF YRDWWNSTSF SNYYRTWNVV
410 420 430 440 450
VHDWLYSYVY QDGLWLLGRR ARGVAMLGVF LVSAVVHEYI FCFVLGFFYP
460 470 480 490 500
VMLMLFLVFG GLLNFTMNDR HTGPAWNILM WTFLFMGQGI QVSLYCQEWY
510 520
ARRHCPLPQT TFWGMVTPRS WSCHP
Length:525
Mass (Da):60,597
Last modified:July 27, 2011 - v2
Checksum:iF1C2DFEB5AB6CCA8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931Q → P in AAC64057 (PubMed:9756919).Curated
Sequence conflicti96 – 961H → R in AAC64057 (PubMed:9756919).Curated
Sequence conflicti104 – 1052IT → VA in AAC64057 (PubMed:9756919).Curated
Sequence conflicti131 – 1322CV → WF in AAC64057 (PubMed:9756919).Curated
Sequence conflicti175 – 1751S → Y in AAC64057 (PubMed:9756919).Curated
Sequence conflicti262 – 2621G → R in AAC64057 (PubMed:9756919).Curated
Sequence conflicti519 – 5191R → Q in AAC64057 (PubMed:9756919).Curated
Sequence conflicti525 – 5251P → T in AAC64057 (PubMed:9756919).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078751 mRNA. Translation: AAC64057.1.
CH466550 Genomic DNA. Translation: EDL04004.1.
BC025931 mRNA. Translation: AAH25931.1.
CCDSiCCDS27872.1.
RefSeqiNP_666176.1. NM_146064.1.
UniGeneiMm.358862.

Genome annotation databases

EnsembliENSMUST00000023806; ENSMUSP00000023806; ENSMUSG00000023045.
GeneIDi223920.
KEGGimmu:223920.
UCSCiuc007xut.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078751 mRNA. Translation: AAC64057.1.
CH466550 Genomic DNA. Translation: EDL04004.1.
BC025931 mRNA. Translation: AAH25931.1.
CCDSiCCDS27872.1.
RefSeqiNP_666176.1. NM_146064.1.
UniGeneiMm.358862.

3D structure databases

ProteinModelPortaliO88908.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023806.

PTM databases

iPTMnetiO88908.
PhosphoSiteiO88908.
SwissPalmiO88908.

Proteomic databases

EPDiO88908.
PaxDbiO88908.
PRIDEiO88908.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023806; ENSMUSP00000023806; ENSMUSG00000023045.
GeneIDi223920.
KEGGimmu:223920.
UCSCiuc007xut.1. mouse.

Organism-specific databases

CTDi8435.
MGIiMGI:1332226. Soat2.

Phylogenomic databases

eggNOGiKOG0380. Eukaryota.
COG5056. LUCA.
GeneTreeiENSGT00530000063122.
HOGENOMiHOG000020782.
HOVERGENiHBG058198.
InParanoidiO88908.
KOiK00637.
OMAiRHCPLPQ.
OrthoDBiEOG091G0991.
TreeFamiTF315226.

Enzyme and pathway databases

BRENDAi2.3.1.26. 3474.

Miscellaneous databases

PROiO88908.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023045.
CleanExiMM_ACAT2.
MM_SOAT2.
ExpressionAtlasiO88908. baseline and differential.
GenevisibleiO88908. MM.

Family and domain databases

InterProiIPR004299. MBOAT_fam.
IPR014371. Oat_ACAT_DAG_ARE.
IPR030687. Sterol_acyltranf_meta.
[Graphical view]
PANTHERiPTHR10408. PTHR10408. 1 hit.
PfamiPF03062. MBOAT. 1 hit.
[Graphical view]
PIRSFiPIRSF000439. Oat_ACAT_DAG_ARE. 1 hit.
PIRSF500230. Sterol_acyltranf_ACAT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSOAT2_MOUSE
AccessioniPrimary (citable) accession number: O88908
Secondary accession number(s): Q8R0Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.