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Protein

Homeodomain-interacting protein kinase 1

Gene

Hipk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.4 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei219 – 2191ATPCurated
Active sitei315 – 3151Proton acceptorCurated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi196 – 2049ATPCurated

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB-KW
  • transcription corepressor activity Source: UniProtKB

GO - Biological processi

  • adherens junction assembly Source: CACAO
  • anterior/posterior pattern specification Source: MGI
  • embryonic camera-type eye morphogenesis Source: DFLAT
  • embryonic retina morphogenesis in camera-type eye Source: DFLAT
  • endothelial cell apoptotic process Source: MGI
  • extrinsic apoptotic signaling pathway Source: MGI
  • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: MGI
  • iris morphogenesis Source: DFLAT
  • lens induction in camera-type eye Source: DFLAT
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • neuron differentiation Source: DFLAT
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of DNA binding Source: UniProtKB
  • protein phosphorylation Source: UniProtKB
  • regulation of tumor necrosis factor-mediated signaling pathway Source: MGI
  • retina layer formation Source: DFLAT
  • smoothened signaling pathway Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeodomain-interacting protein kinase 1 (EC:2.7.11.1)
Alternative name(s):
Nuclear body-associated kinase 2
Protein kinase Myak
Gene namesi
Name:Hipk1
Synonyms:Kiaa0630, Myak, Nbak2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1314873. Hipk1.

Subcellular locationi

  • Nucleus
  • Cytoplasm

  • Note: Predominantly nuclear. Translocates from nucleus to cytoplasm in response to stress stimuli via SENP1-mediated desumoylation.

GO - Cellular componenti

  • cytoplasm Source: DFLAT
  • nuclear speck Source: MGI
  • nucleus Source: UniProtKB
  • PML body Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Small eyes with deficient lens, abnormal retinal lamination, and thickened retinas.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi219 – 2191K → A: Abolishes enzymatic activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12101210Homeodomain-interacting protein kinase 1PRO_0000085994Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki25 – 25Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki25 – 25Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei872 – 8721PhosphoserineBy similarity
Cross-linki1203 – 1203Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationi

Phosphorylated and activated by JNK1 (By similarity). Autophosphorylated.By similarity
Sumoylated. When conjugated it is directed to nuclear speckles. SENP1-mediated desumoylation is mediated by TNF in response to stress stimuli, triggering transient translocation from nucleus to cytoplasm.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO88904.
PaxDbiO88904.
PRIDEiO88904.

PTM databases

iPTMnetiO88904.
PhosphoSiteiO88904.

Expressioni

Tissue specificityi

Ubiquitously expressed, with high levels in reproductive tissues. Expressed in the epithelial layer of mammary gland, uterus and epididymis, in the corpus luteum, and in post-meiotic round spermatids.2 Publications

Developmental stagei

Highest at E12, where it is expressed primarily in the central nervous system. Highly induced during primary fetal liver erythropoiesis. Expressed in the inner retina during late embryogenesis, predominantly in cytoplasm.3 Publications

Gene expression databases

BgeeiO88904.
CleanExiMM_HIPK1.
GenevisibleiO88904. MM.

Interactioni

Subunit structurei

Interacts with Nkx1-2, Nkx2-5, MYB, PARK7, DAXX and p53/TP53. Part of a cytoplasmic complex made of HIPK1, DAB2IP and MAP3K5 in response to TNF. This complex formation promotes MAP3K5-JNK activation and subsequent apoptosis.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DAXXQ9UER73EBI-692945,EBI-77321From a different organism.
DaxxO356133EBI-692945,EBI-77304
Mdm2P238043EBI-692945,EBI-641788
Rassf5Q5EBH15EBI-692945,EBI-960530

Protein-protein interaction databases

BioGridi200306. 2 interactions.
IntActiO88904. 5 interactions.
MINTiMINT-8308057.
STRINGi10090.ENSMUSP00000029438.

Structurei

3D structure databases

ProteinModelPortaliO88904.
SMRiO88904. Positions 188-518.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini190 – 518329Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni885 – 1093209Interaction with TP53Add
BLAST
Regioni891 – 998108Required for localization to nuclear specklesBy similarityAdd
BLAST
Regioni902 – 92625SUMO interaction motifs (SIM); required for nuclear localization and kinase activityBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi844 – 8474Nuclear localization signal 1 (NLS1)By similarity

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0667. Eukaryota.
ENOG410XPET. LUCA.
GeneTreeiENSGT00760000119032.
HOGENOMiHOG000231785.
HOVERGENiHBG051908.
InParanoidiO88904.
KOiK08826.
OMAiTDWRNAH.
OrthoDBiEOG7034GK.
PhylomeDBiO88904.
TreeFamiTF105417.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O88904-1) [UniParc]FASTAAdd to basket

Also known as: 2b, Myak-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASQLQVFSP PSVSSSAFCS AKKLKIEPSG WDVSGQSSND KYYTHSKTLP
60 70 80 90 100
ATQGQASSSH QVANFNLPAY DQGLLLPAPA VEHIVVTAAD SSGSAATATF
110 120 130 140 150
QSSQTLTHRS NVSLLEPYQK CGLKRKSEEV ESNGSVQIIE EHPPLMLQNR
160 170 180 190 200
TVVGAAATTT TVTTKSSSSS GEGDYQLVQH EILCSMTNSY EVLEFLGRGT
210 220 230 240 250
FGQVAKCWKR STKEIVAIKI LKNHPSYARQ GQIEVSILSR LSSENADEYN
260 270 280 290 300
FVRSYECFQH KNHTCLVFEM LEQNLYDFLK QNKFSPLPLK YIRPILQQVA
310 320 330 340 350
TALMKLKSLG LIHADLKPEN IMLVDPVRQP YRVKVIDFGS ASHVSKAVCS
360 370 380 390 400
TYLQSRYYRA PEIILGLPFC EAIDMWSLGC VIAELFLGWP LYPGASEYDQ
410 420 430 440 450
IRYISQTQGL PAEYLLSAGT KTTRFFNRDP NLGYPLWRLK TPEEHELETG
460 470 480 490 500
IKSKEARKYI FNCLDDMAQV NMSTDLEGTD MLAEKADRRE YIDLLKKMLT
510 520 530 540 550
IDADKRITPL KTLNHQFVTM SHLLDFPHSS HVKSCFQNME ICKRRVHMYD
560 570 580 590 600
TVSQIKSPFT THVAPNTSTN LTMSFSNQLN TVHNQASVLA SSSTAAAATL
610 620 630 640 650
SLANSDVSLL NYQSALYPSS AAPVPGVAQQ GVSLQPGTTQ ICTQTDPFQQ
660 670 680 690 700
TFIVCPPAFQ TGLQATTKHS GFPVRMDNAV PIVPQAPAAQ PLQIQSGVLT
710 720 730 740 750
QGSCTPLMVA TLHPQVATIT PQYAVPFTLS CAAGRPALVE QTAAVLQAWP
760 770 780 790 800
GGTQQILLPS AWQQLPGVAL HNSVQPAAVI PEAMGSSQQL ADWRNAHSHG
810 820 830 840 850
NQYSTIMQQP SLLTNHVTLA TAQPLNVGVA HVVRQQQSSS LPSKKNKQSA
860 870 880 890 900
PVSSKSSLEV LPSQVYSLVG SSPLRTTSSY NSLVPVQDQH QPIIIPDTPS
910 920 930 940 950
PPVSVITIRS DTDEEEDNKY KPNSSSLKAR SNVISYVTVN DSPDSDSSLS
960 970 980 990 1000
SPHPTDTLSA LRGNSGTLLE GPGRPAADGI GTRTIIVPPL KTQLGDCTVA
1010 1020 1030 1040 1050
TQASGLLSSK TKPVASVSGQ SSGCCITPTG YRAQRGGASA VQPLNLSQNQ
1060 1070 1080 1090 1100
QSSSASTSQE RSSNPAPRRQ QAFVAPLSQA PYAFQHGSPL HSTGHPHLAP
1110 1120 1130 1140 1150
APAHLPSQPH LYTYAAPTSA AALGSTSSIA HLFSPQGSSR HAAAYTTHPS
1160 1170 1180 1190 1200
TLVHQVPVSV GPSLLTSASV APAQYQHQFA TQSYIGSSRG STIYTGYPLS
1210
PTKISQYSYL
Length:1,210
Mass (Da):130,723
Last modified:March 15, 2005 - v2
Checksum:i26D264B883220640
GO
Isoform 2 (identifier: O88904-2) [UniParc]FASTAAdd to basket

Also known as: 2a

The sequence of this isoform differs from the canonical sequence as follows:
     702-746: Missing.

Show »
Length:1,165
Mass (Da):126,144
Checksum:iC082CA8CD6BB206C
GO
Isoform 3 (identifier: O88904-3) [UniParc]FASTAAdd to basket

Also known as: Myak-S

The sequence of this isoform differs from the canonical sequence as follows:
     661-719: TGLQATTKHS...ATLHPQVATI → KSEQAEGNEG...KAFWIPCEDG
     720-1209: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:720
Mass (Da):79,448
Checksum:iFEEEFF23976995DD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti732 – 7321Missing in AAC63010 (PubMed:9748262).Curated
Sequence conflicti921 – 9211K → E in AAC63010 (PubMed:9748262).Curated
Sequence conflicti953 – 9531H → Y in BAC65615 (PubMed:12693553).Curated
Sequence conflicti954 – 9541P → S in AAC63010 (PubMed:9748262).Curated
Sequence conflicti954 – 9541P → S in BAC65615 (PubMed:12693553).Curated
Sequence conflicti1134 – 11341S → F in AAC63010 (PubMed:9748262).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei661 – 71959TGLQA…QVATI → KSEQAEGNEGLGETESSPGG QESGSGVSQGETTGGAQEQI HNPWTTSNNKAFWIPCEDG in isoform 3. 1 PublicationVSP_013132Add
BLAST
Alternative sequencei702 – 74645Missing in isoform 2. 1 PublicationVSP_013133Add
BLAST
Alternative sequencei720 – 1209490Missing in isoform 3. 1 PublicationVSP_013134Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077658 mRNA. Translation: AAC63010.1.
AF071070 mRNA. Translation: AAD41592.1.
AF071071 mRNA. Translation: AAD41593.1.
AF170303 mRNA. Translation: AAD52568.1.
AF170304 mRNA. Translation: AAD52569.1.
BC145697 mRNA. Translation: AAI45698.1.
BC145699 mRNA. Translation: AAI45700.1.
AK122333 mRNA. Translation: BAC65615.1.
CCDSiCCDS38576.1. [O88904-1]
CCDS79992.1. [O88904-2]
PIRiT14357.
RefSeqiNP_001288233.1. NM_001301304.1. [O88904-1]
NP_001288235.1. NM_001301306.1. [O88904-2]
NP_034562.2. NM_010432.2. [O88904-1]
UniGeneiMm.20827.

Genome annotation databases

EnsembliENSMUST00000029438; ENSMUSP00000029438; ENSMUSG00000008730. [O88904-1]
ENSMUST00000106845; ENSMUSP00000102458; ENSMUSG00000008730. [O88904-2]
ENSMUST00000118317; ENSMUSP00000113998; ENSMUSG00000008730. [O88904-1]
GeneIDi15257.
KEGGimmu:15257.
UCSCiuc008qtg.2. mouse. [O88904-1]
uc012cve.1. mouse. [O88904-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077658 mRNA. Translation: AAC63010.1.
AF071070 mRNA. Translation: AAD41592.1.
AF071071 mRNA. Translation: AAD41593.1.
AF170303 mRNA. Translation: AAD52568.1.
AF170304 mRNA. Translation: AAD52569.1.
BC145697 mRNA. Translation: AAI45698.1.
BC145699 mRNA. Translation: AAI45700.1.
AK122333 mRNA. Translation: BAC65615.1.
CCDSiCCDS38576.1. [O88904-1]
CCDS79992.1. [O88904-2]
PIRiT14357.
RefSeqiNP_001288233.1. NM_001301304.1. [O88904-1]
NP_001288235.1. NM_001301306.1. [O88904-2]
NP_034562.2. NM_010432.2. [O88904-1]
UniGeneiMm.20827.

3D structure databases

ProteinModelPortaliO88904.
SMRiO88904. Positions 188-518.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200306. 2 interactions.
IntActiO88904. 5 interactions.
MINTiMINT-8308057.
STRINGi10090.ENSMUSP00000029438.

PTM databases

iPTMnetiO88904.
PhosphoSiteiO88904.

Proteomic databases

MaxQBiO88904.
PaxDbiO88904.
PRIDEiO88904.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029438; ENSMUSP00000029438; ENSMUSG00000008730. [O88904-1]
ENSMUST00000106845; ENSMUSP00000102458; ENSMUSG00000008730. [O88904-2]
ENSMUST00000118317; ENSMUSP00000113998; ENSMUSG00000008730. [O88904-1]
GeneIDi15257.
KEGGimmu:15257.
UCSCiuc008qtg.2. mouse. [O88904-1]
uc012cve.1. mouse. [O88904-2]

Organism-specific databases

CTDi204851.
MGIiMGI:1314873. Hipk1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0667. Eukaryota.
ENOG410XPET. LUCA.
GeneTreeiENSGT00760000119032.
HOGENOMiHOG000231785.
HOVERGENiHBG051908.
InParanoidiO88904.
KOiK08826.
OMAiTDWRNAH.
OrthoDBiEOG7034GK.
PhylomeDBiO88904.
TreeFamiTF105417.

Miscellaneous databases

NextBioi287873.
PROiO88904.
SOURCEiSearch...

Gene expression databases

BgeeiO88904.
CleanExiMM_HIPK1.
GenevisibleiO88904. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors."
    Kim Y.H., Choi C.Y., Lee S.-J., Conti M.A., Kim Y.
    J. Biol. Chem. 273:25875-25879(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH NKX1-2 AND NKX2-5.
    Strain: BALB/cJ.
  2. "Murine Myak, a member of a family of yeast YAK1-related genes, is highly expressed in hormonally modulated epithelia in the reproductive system and in the embryonic central nervous system."
    Shang E., Wang X., Huang J., Yoshida W., Kuroiwa A., Wolgemuth D.J.
    Mol. Reprod. Dev. 55:372-378(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: CD-1.
    Tissue: Testis.
  3. "Protein kinases associated with PML/CBP nuclear bodies and filamentous threads regulate transcription and inhibit cell growth."
    Sather S.L., Johnson N.L., Johnson G.L.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  5. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 608-1209 (ISOFORM 1).
    Tissue: Brain.
  6. "Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity."
    Ecsedy J.A., Michaelson J.S., Leder P.
    Mol. Cell. Biol. 23:950-960(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH DAXX, AUTOPHOSPHORYLATION, MUTAGENESIS OF LYS-219.
  7. "Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)."
    Kondo S., Lu Y., Debbas M., Lin A.W., Sarosi I., Itie A., Wakeham A., Tuan J., Saris C., Elliott G., Ma W., Benchimol S., Lowe S.W., Mak T.W., Thukral S.K.
    Proc. Natl. Acad. Sci. U.S.A. 100:5431-5436(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TP53, AUTOPHOSPHORYLATION, FUNCTION.
  8. "Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation."
    Aikawa Y., Nguyen L.A., Isono K., Takakura N., Tagata Y., Schmitz M.L., Koseki H., Kitabayashi I.
    EMBO J. 25:3955-3965(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN ANGIOGENESIS.
  9. "SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis."
    Li X., Luo Y., Yu L., Lin Y., Luo D., Zhang H., He Y., Kim Y.-O., Kim Y., Tang S., Min W.
    Cell Death Differ. 15:739-750(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DESUMOYLATION BY SENP1, SUBCELLULAR LOCATION.
  10. "Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation."
    Hattangadi S.M., Burke K.A., Lodish H.F.
    Blood 115:4853-4861(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
  11. "Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis."
    Inoue T., Kagawa T., Inoue-Mochita M., Isono K., Ohtsu N., Nobuhisa I., Fukushima M., Tanihara H., Taga T.
    FEBS Lett. 584:3233-3238(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN EYE DEVELOPMENT, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiHIPK1_MOUSE
AccessioniPrimary (citable) accession number: O88904
Secondary accession number(s): A6H5Z7
, Q80TV5, Q9QUQ8, Q9QZR3, Q9WVN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 15, 2005
Last modified: May 11, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.