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O88902 (PTN23_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase non-receptor type 23

EC=3.1.3.48
Alternative name(s):
His domain-containing protein tyrosine phosphatase
Short name=HD-PTP
Protein tyrosine phosphatase TD14
Short name=PTP-TD14
Gene names
Name:Ptpn23
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1499 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis By similarity. Ref.1

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subunit structure

Interacts with GRAP2 and GRB2. Interacts with UBAP1 and CHMP4B By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Cytoplasmic vesicle. Endosome By similarity. Cytoplasmcytoskeletoncilium basal body By similarity Ref.1.

Tissue specificity

Ubiquitously expressed, with highest levels in brain, testis and kidney, and lowest levels in skeletal muscle. Ref.1 Ref.3

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 BRO1 domain.

Contains 2 TPR repeats.

Contains 1 tyrosine-protein phosphatase domain.

Sequence caution

The sequence AAC62959.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAC62959.1 differs from that shown. Reason: Frameshift at positions 1302 and 1364.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 1499›1499Tyrosine-protein phosphatase non-receptor type 23
PRO_0000094779

Regions

Domain1 – 219219BRO1
Repeat75 – 10834TPR 1
Repeat199 – 23234TPR 2
Repeat788 – 78921
Repeat790 – 79122
Repeat792 – 79323
Repeat794 – 79524
Repeat796 – 79725
Repeat798 – 79926
Repeat800 – 80127
Repeat802 – 80328
Repeat804 – 80529
Repeat806 – 807210
Repeat808 – 809211
Repeat810 – 811212
Repeat812 – 813213
Repeat814 – 815214
Repeat816 – 817215
Repeat818 – 819216
Repeat820 – 821217
Repeat822 – 823218
Repeat824 – 825219
Repeat826 – 827220
Domain1055 – 1315261Tyrosine-protein phosphatase
Region598 – 993396His
Region788 – 8274020 X 2 AA approximate tandem repeats of P-Q
Coiled coil278 – 30528 Potential
Coiled coil377 – 46488 Potential
Coiled coil506 – 53732 Potential
Compositional bias544 – 971428Pro-rich
Compositional bias1379 – 143658Pro-rich

Sites

Active site12551Phosphocysteine intermediate Probable

Amino acid modifications

Modified residue9861Phosphoserine By similarity

Experimental info

Mutagenesis12551C → S: Abolishes suppressive effect on Ha-ras induced transformation. Ref.1
Sequence conflict12801R → G in AAF13172. Ref.2
Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
O88902 [UniParc].

Last modified June 21, 2005. Version 2.
Checksum: 9F9BF8C8DE517123

FASTA1,499163,454
        10         20         30         40         50         60 
LNVNLMLGQA QECLLEKSML DNRKSFLVAR ISAQVVDYYK EACRALENPD TASLLGRIQK 

        70         80         90        100        110        120 
DWKKLVQMKI YYFAAVAHLH MGKQAEEQQK FGERVAYFQS ALDKLNEAIK LAKGQPDTVQ 

       130        140        150        160        170        180 
DALRFAMDVI GGKYNSAKKD NDFIYHEAVP ALDTLQPVKG APLVKPLPVN PTDPAVTGPD 

       190        200        210        220        230        240 
IFAKLVPMAA HEASSLYSEE KAKLLREMLA KIEDKNEVLD QFMDSMQLDP DTVDNLDAYN 

       250        260        270        280        290        300 
HIPPQLMEKC AALSVRPDTV KNLVQSMQVL SGVFTDVEAS LKDIRDLLEE DELQEQKLQE 

       310        320        330        340        350        360 
TLGQAGAGPG PSVTKAELGE VRREWAKYTE VHEKASFTNS ELHRAMNLHV GNLRLLSGPL 

       370        380        390        400        410        420 
DQVRAALPTP ALTPEDKAVL QNLKRILAKV QEMRDQRVSL EQQLRELIQK DDITASLVTT 

       430        440        450        460        470        480 
DHSEMKKLFE EQLKKYDQLK VYLEQNLAAQ DNVLRALTEA NVQYAAVRRV LSELDQKWNS 

       490        500        510        520        530        540 
TLQTLVASYE AYEDLMKKSQ EGKDFYADLE SKVAALLERA QSLCRAQEAA RQQLLDRELK 

       550        560        570        580        590        600 
KKAPPPRPTA PKPLLSRREE GEAAEAGDQP EELRSLPPDM MAGPRLPDPF LGTAAPLHFS 

       610        620        630        640        650        660 
PGPFPGSTGP ATHYLSGPLP PGTYSGPTQL MQPRAAVPMA PGPVLYPAPV YTSELGLVPR 

       670        680        690        700        710        720 
SSPQHGIVSS PYAGVGPPQP IVGLPSAPPP QFSGPELAMD VRPATTTVDS VQAPISSHMA 

       730        740        750        760        770        780 
LRPGPAPAPP QPCFPVPQPV PQSVPQPQPL PTPYTYSIGT KQHLTGPLPQ HHFPPGIPTS 

       790        800        810        820        830        840 
FPAPRIGPQP PPQLQPQPQP QPQPQPPPQP QPQPQPQPQP QPQPQPQRPV FGPQPTQQPL 

       850        860        870        880        890        900 
PFQHPHLFPS QAPGILTPPP PYPFTPQPGV LGQPPPTRHT QLYPGPPPDT LPPHSGALPF 

       910        920        930        940        950        960 
PSPGPPHPHP TLAYGPAPSP RPLGPQATPV SIRGPPPANQ PAPSPHLVPS PAPSPGPGPV 

       970        980        990       1000       1010       1020 
PSRPPTAEPP PCLRRGAAAA DLLSSSPESQ HGGTQPPGGG QPLLQPTKVD AAERPTAQAL 

      1030       1040       1050       1060       1070       1080 
RLIEQDPYEH PERLQKLQQE LESFRGQLGD AGALDAVWRE LQEAQEHDAR GRSIAIARCY 

      1090       1100       1110       1120       1130       1140 
SLKNRHQDVM PYDSNRVVLR SGKDDYINAS CVEGLSPYCP PLVATQRPLP GTAADFWLMV 

      1150       1160       1170       1180       1190       1200 
HEQKVSVIVM LVSEAEMEKQ KVARYFPIER GQPMVHGALS VALSSVRTTD THVERVLSLQ 

      1210       1220       1230       1240       1250       1260 
FRDQSLKRSL VHLHFPTWPE LGLPDSPGNL LRFIQEVHAH YLHQRPLHTP IVVHCSSGVG 

      1270       1280       1290       1300       1310       1320 
RTGAFALLYA AVQEVEAGSR IPELPQLVRR MRQQRKHMLQ EKLHLKFCHE ALVRHVEQVL 

      1330       1340       1350       1360       1370       1380 
QRHGVPPPGK PVASMSVSQK SHLPQDSQDL VLGGDVPISS IQATIAKLSI RPLGGLDSPA 

      1390       1400       1410       1420       1430       1440 
ASLPSLVEPP GLPPASLPEP TPAPPSSPPP PSSPLPEPPQ PEEEPSVPEA PSLGPPSSSL 

      1450       1460       1470       1480       1490 
ELLASLTPEA FSLDSSLRGK QRMSKQNFLQ AHNGQGLRAA QPTDDPLSLL DPLWTLNKT 

« Hide

References

[1]"A novel putative protein-tyrosine phosphatase contains a BRO1-like domain and suppresses Ha-ras-mediated transformation."
Cao L., Zhang L., Ruiz-Lozano P., Yang Q., Chien K.R., Graham R.M., Zhou M.
J. Biol. Chem. 273:21077-21083(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, MUTAGENESIS OF CYS-1255, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Brain.
[2]"Corrections in cDNA sequence of the rat protein tyrosine phosphatase TD14 (PTP-TD14): identification of a base insertion and a base deletion in the sequence database."
Nicolas G., Galand C., Malbert-Colas L., Lecomte M.-C.
Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1248-1499.
Strain: Sprague-Dawley.
Tissue: Kidney.
[3]"HD-PTP: a novel protein tyrosine phosphatase gene on human chromosome 3p21.3."
Toyooka S., Ouchida M., Jitsumori Y., Tsukuda K., Sakai A., Nakamura A., Shimizu N., Shimizu K.
Biochem. Biophys. Res. Commun. 278:671-678(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF077000 mRNA. Translation: AAC62959.1. Sequence problems.
AF175208 mRNA. Translation: AAF13172.1.
PIRT14355.
UniGeneRn.54442.

3D structure databases

ProteinModelPortalO88902.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000052992.

PTM databases

PhosphoSiteO88902.

Proteomic databases

PaxDbO88902.
PRIDEO88902.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:619892. rat.

Organism-specific databases

RGD619892. Ptpn23.

Phylogenomic databases

eggNOGCOG5599.
HOGENOMHOG000012993.
HOVERGENHBG082231.
InParanoidO88902.
PhylomeDBO88902.

Gene expression databases

GenevestigatorO88902.

Family and domain databases

Gene3D1.25.40.280. 1 hit.
3.90.190.10. 1 hit.
InterProIPR025304. ALIX_V_dom.
IPR004328. BRO1_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR028770. PTPN23.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PANTHERPTHR19134:SF27. PTHR19134:SF27. 1 hit.
PfamPF13949. ALIX_LYPXL_bnd. 1 hit.
PF03097. BRO1. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM01041. BRO1. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
PROSITEPS51180. BRO1. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio13948318.
PROO88902.

Entry information

Entry namePTN23_RAT
AccessionPrimary (citable) accession number: O88902
Secondary accession number(s): Q9QZP8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: June 11, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families