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O88902

- PTN23_RAT

UniProt

O88902 - PTN23_RAT

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Protein

Tyrosine-protein phosphatase non-receptor type 23

Gene

Ptpn23

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1255 – 12551Phosphocysteine intermediateCurated

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. cilium morphogenesis Source: UniProtKB
  2. protein transport Source: UniProtKB-KW
  3. regulation of cell migration Source: InterPro
  4. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cilium biogenesis/degradation, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 23 (EC:3.1.3.48)
Alternative name(s):
His domain-containing protein tyrosine phosphatase
Short name:
HD-PTP
Protein tyrosine phosphatase TD14
Short name:
PTP-TD14
Gene namesi
Name:Ptpn23
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi619892. Ptpn23.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Cytoplasmic vesicle 1 Publication. Endosome By similarity. Cytoplasmcytoskeletoncilium basal body By similarity

GO - Cellular componenti

  1. ciliary basal body Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. cytoplasmic vesicle Source: UniProtKB-KW
  4. early endosome Source: UniProtKB
  5. endosome Source: UniProtKB
  6. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1255 – 12551C → S: Abolishes suppressive effect on Ha-ras induced transformation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 1499›1499Tyrosine-protein phosphatase non-receptor type 23PRO_0000094779Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei986 – 9861PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO88902.
PRIDEiO88902.

PTM databases

PhosphoSiteiO88902.

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in brain, testis and kidney, and lowest levels in skeletal muscle.2 Publications

Gene expression databases

GenevestigatoriO88902.

Interactioni

Subunit structurei

Interacts with GRAP2 and GRB2. Interacts with UBAP1 and CHMP4B (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052992.

Structurei

3D structure databases

ProteinModelPortaliO88902.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 219219BRO1PROSITE-ProRule annotationAdd
BLAST
Repeati75 – 10834TPR 1Add
BLAST
Repeati199 – 23234TPR 2Add
BLAST
Repeati788 – 78921
Repeati790 – 79122
Repeati792 – 79323
Repeati794 – 79524
Repeati796 – 79725
Repeati798 – 79926
Repeati800 – 80127
Repeati802 – 80328
Repeati804 – 80529
Repeati806 – 807210
Repeati808 – 809211
Repeati810 – 811212
Repeati812 – 813213
Repeati814 – 815214
Repeati816 – 817215
Repeati818 – 819216
Repeati820 – 821217
Repeati822 – 823218
Repeati824 – 825219
Repeati826 – 827220
Domaini1055 – 1315261Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni598 – 993396HisAdd
BLAST
Regioni788 – 8274020 X 2 AA approximate tandem repeats of P-QAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili278 – 30528Sequence AnalysisAdd
BLAST
Coiled coili377 – 46488Sequence AnalysisAdd
BLAST
Coiled coili506 – 53732Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi544 – 971428Pro-richAdd
BLAST
Compositional biasi1379 – 143658Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 BRO1 domain.PROSITE-ProRule annotation
Contains 2 TPR repeats.Curated
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000012993.
HOVERGENiHBG082231.
InParanoidiO88902.
PhylomeDBiO88902.

Family and domain databases

Gene3Di1.25.40.280. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR025304. ALIX_V_dom.
IPR004328. BRO1_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR028770. PTPN23.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PANTHERiPTHR19134:SF27. PTHR19134:SF27. 1 hit.
PfamiPF13949. ALIX_LYPXL_bnd. 1 hit.
PF03097. BRO1. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01041. BRO1. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51180. BRO1. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

O88902-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
LNVNLMLGQA QECLLEKSML DNRKSFLVAR ISAQVVDYYK EACRALENPD
60 70 80 90 100
TASLLGRIQK DWKKLVQMKI YYFAAVAHLH MGKQAEEQQK FGERVAYFQS
110 120 130 140 150
ALDKLNEAIK LAKGQPDTVQ DALRFAMDVI GGKYNSAKKD NDFIYHEAVP
160 170 180 190 200
ALDTLQPVKG APLVKPLPVN PTDPAVTGPD IFAKLVPMAA HEASSLYSEE
210 220 230 240 250
KAKLLREMLA KIEDKNEVLD QFMDSMQLDP DTVDNLDAYN HIPPQLMEKC
260 270 280 290 300
AALSVRPDTV KNLVQSMQVL SGVFTDVEAS LKDIRDLLEE DELQEQKLQE
310 320 330 340 350
TLGQAGAGPG PSVTKAELGE VRREWAKYTE VHEKASFTNS ELHRAMNLHV
360 370 380 390 400
GNLRLLSGPL DQVRAALPTP ALTPEDKAVL QNLKRILAKV QEMRDQRVSL
410 420 430 440 450
EQQLRELIQK DDITASLVTT DHSEMKKLFE EQLKKYDQLK VYLEQNLAAQ
460 470 480 490 500
DNVLRALTEA NVQYAAVRRV LSELDQKWNS TLQTLVASYE AYEDLMKKSQ
510 520 530 540 550
EGKDFYADLE SKVAALLERA QSLCRAQEAA RQQLLDRELK KKAPPPRPTA
560 570 580 590 600
PKPLLSRREE GEAAEAGDQP EELRSLPPDM MAGPRLPDPF LGTAAPLHFS
610 620 630 640 650
PGPFPGSTGP ATHYLSGPLP PGTYSGPTQL MQPRAAVPMA PGPVLYPAPV
660 670 680 690 700
YTSELGLVPR SSPQHGIVSS PYAGVGPPQP IVGLPSAPPP QFSGPELAMD
710 720 730 740 750
VRPATTTVDS VQAPISSHMA LRPGPAPAPP QPCFPVPQPV PQSVPQPQPL
760 770 780 790 800
PTPYTYSIGT KQHLTGPLPQ HHFPPGIPTS FPAPRIGPQP PPQLQPQPQP
810 820 830 840 850
QPQPQPPPQP QPQPQPQPQP QPQPQPQRPV FGPQPTQQPL PFQHPHLFPS
860 870 880 890 900
QAPGILTPPP PYPFTPQPGV LGQPPPTRHT QLYPGPPPDT LPPHSGALPF
910 920 930 940 950
PSPGPPHPHP TLAYGPAPSP RPLGPQATPV SIRGPPPANQ PAPSPHLVPS
960 970 980 990 1000
PAPSPGPGPV PSRPPTAEPP PCLRRGAAAA DLLSSSPESQ HGGTQPPGGG
1010 1020 1030 1040 1050
QPLLQPTKVD AAERPTAQAL RLIEQDPYEH PERLQKLQQE LESFRGQLGD
1060 1070 1080 1090 1100
AGALDAVWRE LQEAQEHDAR GRSIAIARCY SLKNRHQDVM PYDSNRVVLR
1110 1120 1130 1140 1150
SGKDDYINAS CVEGLSPYCP PLVATQRPLP GTAADFWLMV HEQKVSVIVM
1160 1170 1180 1190 1200
LVSEAEMEKQ KVARYFPIER GQPMVHGALS VALSSVRTTD THVERVLSLQ
1210 1220 1230 1240 1250
FRDQSLKRSL VHLHFPTWPE LGLPDSPGNL LRFIQEVHAH YLHQRPLHTP
1260 1270 1280 1290 1300
IVVHCSSGVG RTGAFALLYA AVQEVEAGSR IPELPQLVRR MRQQRKHMLQ
1310 1320 1330 1340 1350
EKLHLKFCHE ALVRHVEQVL QRHGVPPPGK PVASMSVSQK SHLPQDSQDL
1360 1370 1380 1390 1400
VLGGDVPISS IQATIAKLSI RPLGGLDSPA ASLPSLVEPP GLPPASLPEP
1410 1420 1430 1440 1450
TPAPPSSPPP PSSPLPEPPQ PEEEPSVPEA PSLGPPSSSL ELLASLTPEA
1460 1470 1480 1490
FSLDSSLRGK QRMSKQNFLQ AHNGQGLRAA QPTDDPLSLL DPLWTLNKT
Length:1,499
Mass (Da):163,454
Last modified:June 21, 2005 - v2
Checksum:i9F9BF8C8DE517123
GO

Sequence cautioni

The sequence AAC62959.1 differs from that shown. Reason: Frameshift at positions 1302 and 1364. Curated
The sequence AAC62959.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Sequence conflicti1280 – 12801R → G in AAF13172. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077000 mRNA. Translation: AAC62959.1. Sequence problems.
AF175208 mRNA. Translation: AAF13172.1.
PIRiT14355.
UniGeneiRn.54442.

Genome annotation databases

UCSCiRGD:619892. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077000 mRNA. Translation: AAC62959.1 . Sequence problems.
AF175208 mRNA. Translation: AAF13172.1 .
PIRi T14355.
UniGenei Rn.54442.

3D structure databases

ProteinModelPortali O88902.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000052992.

PTM databases

PhosphoSitei O88902.

Proteomic databases

PaxDbi O88902.
PRIDEi O88902.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:619892. rat.

Organism-specific databases

RGDi 619892. Ptpn23.

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000012993.
HOVERGENi HBG082231.
InParanoidi O88902.
PhylomeDBi O88902.

Miscellaneous databases

NextBioi 13948318.
PROi O88902.

Gene expression databases

Genevestigatori O88902.

Family and domain databases

Gene3Di 1.25.40.280. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR025304. ALIX_V_dom.
IPR004328. BRO1_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR028770. PTPN23.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
PANTHERi PTHR19134:SF27. PTHR19134:SF27. 1 hit.
Pfami PF13949. ALIX_LYPXL_bnd. 1 hit.
PF03097. BRO1. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM01041. BRO1. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS51180. BRO1. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel putative protein-tyrosine phosphatase contains a BRO1-like domain and suppresses Ha-ras-mediated transformation."
    Cao L., Zhang L., Ruiz-Lozano P., Yang Q., Chien K.R., Graham R.M., Zhou M.
    J. Biol. Chem. 273:21077-21083(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, MUTAGENESIS OF CYS-1255, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Corrections in cDNA sequence of the rat protein tyrosine phosphatase TD14 (PTP-TD14): identification of a base insertion and a base deletion in the sequence database."
    Nicolas G., Galand C., Malbert-Colas L., Lecomte M.-C.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1248-1499.
    Strain: Sprague-Dawley.
    Tissue: Kidney.
  3. "HD-PTP: a novel protein tyrosine phosphatase gene on human chromosome 3p21.3."
    Toyooka S., Ouchida M., Jitsumori Y., Tsukuda K., Sakai A., Nakamura A., Shimizu N., Shimizu K.
    Biochem. Biophys. Res. Commun. 278:671-678(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPTN23_RAT
AccessioniPrimary (citable) accession number: O88902
Secondary accession number(s): Q9QZP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: October 29, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3