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O88902

- PTN23_RAT

UniProt

O88902 - PTN23_RAT

Protein

Tyrosine-protein phosphatase non-receptor type 23

Gene

Ptpn23

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1255 – 12551Phosphocysteine intermediateCurated

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cilium morphogenesis Source: UniProtKB
    2. protein transport Source: UniProtKB-KW
    3. regulation of cell migration Source: InterPro
    4. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cilium biogenesis/degradation, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 23 (EC:3.1.3.48)
    Alternative name(s):
    His domain-containing protein tyrosine phosphatase
    Short name:
    HD-PTP
    Protein tyrosine phosphatase TD14
    Short name:
    PTP-TD14
    Gene namesi
    Name:Ptpn23
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi619892. Ptpn23.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity. Cytoplasmic vesicle 1 Publication. Endosome By similarity. Cytoplasmcytoskeletoncilium basal body By similarity

    GO - Cellular componenti

    1. ciliary basal body Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    4. early endosome Source: UniProtKB
    5. endosome Source: UniProtKB
    6. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1255 – 12551C → S: Abolishes suppressive effect on Ha-ras induced transformation. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 1499›1499Tyrosine-protein phosphatase non-receptor type 23PRO_0000094779Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei986 – 9861PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiO88902.
    PRIDEiO88902.

    PTM databases

    PhosphoSiteiO88902.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed, with highest levels in brain, testis and kidney, and lowest levels in skeletal muscle.2 Publications

    Gene expression databases

    GenevestigatoriO88902.

    Interactioni

    Subunit structurei

    Interacts with GRAP2 and GRB2. Interacts with UBAP1 and CHMP4B By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000052992.

    Structurei

    3D structure databases

    ProteinModelPortaliO88902.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 219219BRO1PROSITE-ProRule annotationAdd
    BLAST
    Repeati75 – 10834TPR 1Add
    BLAST
    Repeati199 – 23234TPR 2Add
    BLAST
    Repeati788 – 78921
    Repeati790 – 79122
    Repeati792 – 79323
    Repeati794 – 79524
    Repeati796 – 79725
    Repeati798 – 79926
    Repeati800 – 80127
    Repeati802 – 80328
    Repeati804 – 80529
    Repeati806 – 807210
    Repeati808 – 809211
    Repeati810 – 811212
    Repeati812 – 813213
    Repeati814 – 815214
    Repeati816 – 817215
    Repeati818 – 819216
    Repeati820 – 821217
    Repeati822 – 823218
    Repeati824 – 825219
    Repeati826 – 827220
    Domaini1055 – 1315261Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni598 – 993396HisAdd
    BLAST
    Regioni788 – 8274020 X 2 AA approximate tandem repeats of P-QAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili278 – 30528Sequence AnalysisAdd
    BLAST
    Coiled coili377 – 46488Sequence AnalysisAdd
    BLAST
    Coiled coili506 – 53732Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi544 – 971428Pro-richAdd
    BLAST
    Compositional biasi1379 – 143658Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BRO1 domain.PROSITE-ProRule annotation
    Contains 2 TPR repeats.Curated
    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000012993.
    HOVERGENiHBG082231.
    InParanoidiO88902.
    PhylomeDBiO88902.

    Family and domain databases

    Gene3Di1.25.40.280. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR025304. ALIX_V_dom.
    IPR004328. BRO1_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR028770. PTPN23.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PANTHERiPTHR19134:SF27. PTHR19134:SF27. 1 hit.
    PfamiPF13949. ALIX_LYPXL_bnd. 1 hit.
    PF03097. BRO1. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM01041. BRO1. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS51180. BRO1. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    O88902-1 [UniParc]FASTAAdd to Basket

    « Hide

    LNVNLMLGQA QECLLEKSML DNRKSFLVAR ISAQVVDYYK EACRALENPD     50
    TASLLGRIQK DWKKLVQMKI YYFAAVAHLH MGKQAEEQQK FGERVAYFQS 100
    ALDKLNEAIK LAKGQPDTVQ DALRFAMDVI GGKYNSAKKD NDFIYHEAVP 150
    ALDTLQPVKG APLVKPLPVN PTDPAVTGPD IFAKLVPMAA HEASSLYSEE 200
    KAKLLREMLA KIEDKNEVLD QFMDSMQLDP DTVDNLDAYN HIPPQLMEKC 250
    AALSVRPDTV KNLVQSMQVL SGVFTDVEAS LKDIRDLLEE DELQEQKLQE 300
    TLGQAGAGPG PSVTKAELGE VRREWAKYTE VHEKASFTNS ELHRAMNLHV 350
    GNLRLLSGPL DQVRAALPTP ALTPEDKAVL QNLKRILAKV QEMRDQRVSL 400
    EQQLRELIQK DDITASLVTT DHSEMKKLFE EQLKKYDQLK VYLEQNLAAQ 450
    DNVLRALTEA NVQYAAVRRV LSELDQKWNS TLQTLVASYE AYEDLMKKSQ 500
    EGKDFYADLE SKVAALLERA QSLCRAQEAA RQQLLDRELK KKAPPPRPTA 550
    PKPLLSRREE GEAAEAGDQP EELRSLPPDM MAGPRLPDPF LGTAAPLHFS 600
    PGPFPGSTGP ATHYLSGPLP PGTYSGPTQL MQPRAAVPMA PGPVLYPAPV 650
    YTSELGLVPR SSPQHGIVSS PYAGVGPPQP IVGLPSAPPP QFSGPELAMD 700
    VRPATTTVDS VQAPISSHMA LRPGPAPAPP QPCFPVPQPV PQSVPQPQPL 750
    PTPYTYSIGT KQHLTGPLPQ HHFPPGIPTS FPAPRIGPQP PPQLQPQPQP 800
    QPQPQPPPQP QPQPQPQPQP QPQPQPQRPV FGPQPTQQPL PFQHPHLFPS 850
    QAPGILTPPP PYPFTPQPGV LGQPPPTRHT QLYPGPPPDT LPPHSGALPF 900
    PSPGPPHPHP TLAYGPAPSP RPLGPQATPV SIRGPPPANQ PAPSPHLVPS 950
    PAPSPGPGPV PSRPPTAEPP PCLRRGAAAA DLLSSSPESQ HGGTQPPGGG 1000
    QPLLQPTKVD AAERPTAQAL RLIEQDPYEH PERLQKLQQE LESFRGQLGD 1050
    AGALDAVWRE LQEAQEHDAR GRSIAIARCY SLKNRHQDVM PYDSNRVVLR 1100
    SGKDDYINAS CVEGLSPYCP PLVATQRPLP GTAADFWLMV HEQKVSVIVM 1150
    LVSEAEMEKQ KVARYFPIER GQPMVHGALS VALSSVRTTD THVERVLSLQ 1200
    FRDQSLKRSL VHLHFPTWPE LGLPDSPGNL LRFIQEVHAH YLHQRPLHTP 1250
    IVVHCSSGVG RTGAFALLYA AVQEVEAGSR IPELPQLVRR MRQQRKHMLQ 1300
    EKLHLKFCHE ALVRHVEQVL QRHGVPPPGK PVASMSVSQK SHLPQDSQDL 1350
    VLGGDVPISS IQATIAKLSI RPLGGLDSPA ASLPSLVEPP GLPPASLPEP 1400
    TPAPPSSPPP PSSPLPEPPQ PEEEPSVPEA PSLGPPSSSL ELLASLTPEA 1450
    FSLDSSLRGK QRMSKQNFLQ AHNGQGLRAA QPTDDPLSLL DPLWTLNKT 1499
    Length:1,499
    Mass (Da):163,454
    Last modified:June 21, 2005 - v2
    Checksum:i9F9BF8C8DE517123
    GO

    Sequence cautioni

    The sequence AAC62959.1 differs from that shown. Reason: Frameshift at positions 1302 and 1364.
    The sequence AAC62959.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Sequence conflicti1280 – 12801R → G in AAF13172. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF077000 mRNA. Translation: AAC62959.1. Sequence problems.
    AF175208 mRNA. Translation: AAF13172.1.
    PIRiT14355.
    UniGeneiRn.54442.

    Genome annotation databases

    UCSCiRGD:619892. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF077000 mRNA. Translation: AAC62959.1 . Sequence problems.
    AF175208 mRNA. Translation: AAF13172.1 .
    PIRi T14355.
    UniGenei Rn.54442.

    3D structure databases

    ProteinModelPortali O88902.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000052992.

    PTM databases

    PhosphoSitei O88902.

    Proteomic databases

    PaxDbi O88902.
    PRIDEi O88902.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:619892. rat.

    Organism-specific databases

    RGDi 619892. Ptpn23.

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000012993.
    HOVERGENi HBG082231.
    InParanoidi O88902.
    PhylomeDBi O88902.

    Miscellaneous databases

    NextBioi 13948318.
    PROi O88902.

    Gene expression databases

    Genevestigatori O88902.

    Family and domain databases

    Gene3Di 1.25.40.280. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR025304. ALIX_V_dom.
    IPR004328. BRO1_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR028770. PTPN23.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    PANTHERi PTHR19134:SF27. PTHR19134:SF27. 1 hit.
    Pfami PF13949. ALIX_LYPXL_bnd. 1 hit.
    PF03097. BRO1. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM01041. BRO1. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS51180. BRO1. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel putative protein-tyrosine phosphatase contains a BRO1-like domain and suppresses Ha-ras-mediated transformation."
      Cao L., Zhang L., Ruiz-Lozano P., Yang Q., Chien K.R., Graham R.M., Zhou M.
      J. Biol. Chem. 273:21077-21083(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, MUTAGENESIS OF CYS-1255, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Brain.
    2. "Corrections in cDNA sequence of the rat protein tyrosine phosphatase TD14 (PTP-TD14): identification of a base insertion and a base deletion in the sequence database."
      Nicolas G., Galand C., Malbert-Colas L., Lecomte M.-C.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1248-1499.
      Strain: Sprague-Dawley.
      Tissue: Kidney.
    3. "HD-PTP: a novel protein tyrosine phosphatase gene on human chromosome 3p21.3."
      Toyooka S., Ouchida M., Jitsumori Y., Tsukuda K., Sakai A., Nakamura A., Shimizu N., Shimizu K.
      Biochem. Biophys. Res. Commun. 278:671-678(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPTN23_RAT
    AccessioniPrimary (citable) accession number: O88902
    Secondary accession number(s): Q9QZP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3