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O88902

- PTN23_RAT

UniProt

O88902 - PTN23_RAT

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Protein
Tyrosine-protein phosphatase non-receptor type 23
Gene
Ptpn23
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis By similarity.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1255 – 12551Phosphocysteine intermediate Inferred

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cilium morphogenesis Source: UniProtKB
  2. protein transport Source: UniProtKB-KW
  3. regulation of cell migration Source: InterPro
  4. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cilium biogenesis/degradation, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 23 (EC:3.1.3.48)
Alternative name(s):
His domain-containing protein tyrosine phosphatase
Short name:
HD-PTP
Protein tyrosine phosphatase TD14
Short name:
PTP-TD14
Gene namesi
Name:Ptpn23
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi619892. Ptpn23.

Subcellular locationi

Nucleus By similarity. Cytoplasm By similarity. Cytoplasmic vesicle. Endosome By similarity. Cytoplasmcytoskeletoncilium basal body By similarity 1 Publication

GO - Cellular componenti

  1. ciliary basal body Source: UniProtKB
  2. cytoplasm Source: UniProtKB
  3. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
  4. early endosome Source: UniProtKB
  5. endosome Source: UniProtKB
  6. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1255 – 12551C → S: Abolishes suppressive effect on Ha-ras induced transformation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 1499›1499Tyrosine-protein phosphatase non-receptor type 23
PRO_0000094779Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei986 – 9861Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO88902.
PRIDEiO88902.

PTM databases

PhosphoSiteiO88902.

Expressioni

Tissue specificityi

Ubiquitously expressed, with highest levels in brain, testis and kidney, and lowest levels in skeletal muscle.2 Publications

Gene expression databases

GenevestigatoriO88902.

Interactioni

Subunit structurei

Interacts with GRAP2 and GRB2. Interacts with UBAP1 and CHMP4B By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052992.

Structurei

3D structure databases

ProteinModelPortaliO88902.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 219219BRO1
Add
BLAST
Repeati75 – 10834TPR 1
Add
BLAST
Repeati199 – 23234TPR 2
Add
BLAST
Repeati788 – 78921
Repeati790 – 79122
Repeati792 – 79323
Repeati794 – 79524
Repeati796 – 79725
Repeati798 – 79926
Repeati800 – 80127
Repeati802 – 80328
Repeati804 – 80529
Repeati806 – 807210
Repeati808 – 809211
Repeati810 – 811212
Repeati812 – 813213
Repeati814 – 815214
Repeati816 – 817215
Repeati818 – 819216
Repeati820 – 821217
Repeati822 – 823218
Repeati824 – 825219
Repeati826 – 827220
Domaini1055 – 1315261Tyrosine-protein phosphatase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni598 – 993396His
Add
BLAST
Regioni788 – 8274020 X 2 AA approximate tandem repeats of P-Q
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili278 – 30528 Reviewed prediction
Add
BLAST
Coiled coili377 – 46488 Reviewed prediction
Add
BLAST
Coiled coili506 – 53732 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi544 – 971428Pro-rich
Add
BLAST
Compositional biasi1379 – 143658Pro-rich
Add
BLAST

Sequence similaritiesi

Contains 1 BRO1 domain.
Contains 2 TPR repeats.

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000012993.
HOVERGENiHBG082231.
InParanoidiO88902.
PhylomeDBiO88902.

Family and domain databases

Gene3Di1.25.40.280. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR025304. ALIX_V_dom.
IPR004328. BRO1_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR028770. PTPN23.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PANTHERiPTHR19134:SF27. PTHR19134:SF27. 1 hit.
PfamiPF13949. ALIX_LYPXL_bnd. 1 hit.
PF03097. BRO1. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM01041. BRO1. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51180. BRO1. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

O88902-1 [UniParc]FASTAAdd to Basket

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LNVNLMLGQA QECLLEKSML DNRKSFLVAR ISAQVVDYYK EACRALENPD     50
TASLLGRIQK DWKKLVQMKI YYFAAVAHLH MGKQAEEQQK FGERVAYFQS 100
ALDKLNEAIK LAKGQPDTVQ DALRFAMDVI GGKYNSAKKD NDFIYHEAVP 150
ALDTLQPVKG APLVKPLPVN PTDPAVTGPD IFAKLVPMAA HEASSLYSEE 200
KAKLLREMLA KIEDKNEVLD QFMDSMQLDP DTVDNLDAYN HIPPQLMEKC 250
AALSVRPDTV KNLVQSMQVL SGVFTDVEAS LKDIRDLLEE DELQEQKLQE 300
TLGQAGAGPG PSVTKAELGE VRREWAKYTE VHEKASFTNS ELHRAMNLHV 350
GNLRLLSGPL DQVRAALPTP ALTPEDKAVL QNLKRILAKV QEMRDQRVSL 400
EQQLRELIQK DDITASLVTT DHSEMKKLFE EQLKKYDQLK VYLEQNLAAQ 450
DNVLRALTEA NVQYAAVRRV LSELDQKWNS TLQTLVASYE AYEDLMKKSQ 500
EGKDFYADLE SKVAALLERA QSLCRAQEAA RQQLLDRELK KKAPPPRPTA 550
PKPLLSRREE GEAAEAGDQP EELRSLPPDM MAGPRLPDPF LGTAAPLHFS 600
PGPFPGSTGP ATHYLSGPLP PGTYSGPTQL MQPRAAVPMA PGPVLYPAPV 650
YTSELGLVPR SSPQHGIVSS PYAGVGPPQP IVGLPSAPPP QFSGPELAMD 700
VRPATTTVDS VQAPISSHMA LRPGPAPAPP QPCFPVPQPV PQSVPQPQPL 750
PTPYTYSIGT KQHLTGPLPQ HHFPPGIPTS FPAPRIGPQP PPQLQPQPQP 800
QPQPQPPPQP QPQPQPQPQP QPQPQPQRPV FGPQPTQQPL PFQHPHLFPS 850
QAPGILTPPP PYPFTPQPGV LGQPPPTRHT QLYPGPPPDT LPPHSGALPF 900
PSPGPPHPHP TLAYGPAPSP RPLGPQATPV SIRGPPPANQ PAPSPHLVPS 950
PAPSPGPGPV PSRPPTAEPP PCLRRGAAAA DLLSSSPESQ HGGTQPPGGG 1000
QPLLQPTKVD AAERPTAQAL RLIEQDPYEH PERLQKLQQE LESFRGQLGD 1050
AGALDAVWRE LQEAQEHDAR GRSIAIARCY SLKNRHQDVM PYDSNRVVLR 1100
SGKDDYINAS CVEGLSPYCP PLVATQRPLP GTAADFWLMV HEQKVSVIVM 1150
LVSEAEMEKQ KVARYFPIER GQPMVHGALS VALSSVRTTD THVERVLSLQ 1200
FRDQSLKRSL VHLHFPTWPE LGLPDSPGNL LRFIQEVHAH YLHQRPLHTP 1250
IVVHCSSGVG RTGAFALLYA AVQEVEAGSR IPELPQLVRR MRQQRKHMLQ 1300
EKLHLKFCHE ALVRHVEQVL QRHGVPPPGK PVASMSVSQK SHLPQDSQDL 1350
VLGGDVPISS IQATIAKLSI RPLGGLDSPA ASLPSLVEPP GLPPASLPEP 1400
TPAPPSSPPP PSSPLPEPPQ PEEEPSVPEA PSLGPPSSSL ELLASLTPEA 1450
FSLDSSLRGK QRMSKQNFLQ AHNGQGLRAA QPTDDPLSLL DPLWTLNKT 1499
Length:1,499
Mass (Da):163,454
Last modified:June 21, 2005 - v2
Checksum:i9F9BF8C8DE517123
GO

Sequence cautioni

The sequence AAC62959.1 differs from that shown. Reason: Frameshift at positions 1302 and 1364.
The sequence AAC62959.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1280 – 12801R → G in AAF13172. 1 Publication

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF077000 mRNA. Translation: AAC62959.1. Sequence problems.
AF175208 mRNA. Translation: AAF13172.1.
PIRiT14355.
UniGeneiRn.54442.

Genome annotation databases

UCSCiRGD:619892. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF077000 mRNA. Translation: AAC62959.1 . Sequence problems.
AF175208 mRNA. Translation: AAF13172.1 .
PIRi T14355.
UniGenei Rn.54442.

3D structure databases

ProteinModelPortali O88902.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000052992.

PTM databases

PhosphoSitei O88902.

Proteomic databases

PaxDbi O88902.
PRIDEi O88902.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:619892. rat.

Organism-specific databases

RGDi 619892. Ptpn23.

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000012993.
HOVERGENi HBG082231.
InParanoidi O88902.
PhylomeDBi O88902.

Miscellaneous databases

NextBioi 13948318.
PROi O88902.

Gene expression databases

Genevestigatori O88902.

Family and domain databases

Gene3Di 1.25.40.280. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR025304. ALIX_V_dom.
IPR004328. BRO1_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR028770. PTPN23.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
PANTHERi PTHR19134:SF27. PTHR19134:SF27. 1 hit.
Pfami PF13949. ALIX_LYPXL_bnd. 1 hit.
PF03097. BRO1. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM01041. BRO1. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS51180. BRO1. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel putative protein-tyrosine phosphatase contains a BRO1-like domain and suppresses Ha-ras-mediated transformation."
    Cao L., Zhang L., Ruiz-Lozano P., Yang Q., Chien K.R., Graham R.M., Zhou M.
    J. Biol. Chem. 273:21077-21083(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, MUTAGENESIS OF CYS-1255, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "Corrections in cDNA sequence of the rat protein tyrosine phosphatase TD14 (PTP-TD14): identification of a base insertion and a base deletion in the sequence database."
    Nicolas G., Galand C., Malbert-Colas L., Lecomte M.-C.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1248-1499.
    Strain: Sprague-Dawley.
    Tissue: Kidney.
  3. "HD-PTP: a novel protein tyrosine phosphatase gene on human chromosome 3p21.3."
    Toyooka S., Ouchida M., Jitsumori Y., Tsukuda K., Sakai A., Nakamura A., Shimizu N., Shimizu K.
    Biochem. Biophys. Res. Commun. 278:671-678(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPTN23_RAT
AccessioniPrimary (citable) accession number: O88902
Secondary accession number(s): Q9QZP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 21, 2005
Last modified: June 11, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi