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Protein

Tumor protein 63

Gene

Tp63

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates transcription of the p21 promoter (By similarity). Activates RIPK4 transcription. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge.By similarity5 Publications

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi244ZincBy similarity1
Metal bindingi247ZincBy similarity1
Metal bindingi308ZincBy similarity1
Metal bindingi312ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi170 – 362By similarityAdd BLAST193

GO - Molecular functioni

  • chromatin binding Source: MGI
  • damaged DNA binding Source: MGI
  • DNA binding Source: MGI
  • double-stranded DNA binding Source: GO_Central
  • identical protein binding Source: IntAct
  • metal ion binding Source: UniProtKB-KW
  • p53 binding Source: GO_Central
  • sequence-specific DNA binding Source: MGI
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: MGI
  • transcription factor activity, transcription factor binding Source: MGI
  • transcription regulatory region DNA binding Source: InterPro
  • WW domain binding Source: MGI

GO - Biological processi

  • anatomical structure formation involved in morphogenesis Source: MGI
  • animal organ morphogenesis Source: MGI
  • apoptotic process Source: MGI
  • cell aging Source: MGI
  • cell differentiation Source: MGI
  • cellular response to UV Source: GO_Central
  • chromatin remodeling Source: MGI
  • cloacal septation Source: MGI
  • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: GO_Central
  • ectoderm and mesoderm interaction Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • epidermal cell division Source: MGI
  • epidermis development Source: MGI
  • epithelial cell development Source: MGI
  • epithelial cell differentiation Source: MGI
  • establishment of planar polarity Source: MGI
  • establishment of skin barrier Source: UniProtKB
  • female genitalia morphogenesis Source: MGI
  • hair follicle development Source: MGI
  • hair follicle morphogenesis Source: MGI
  • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: MGI
  • keratinocyte differentiation Source: MGI
  • keratinocyte proliferation Source: MGI
  • mitotic G1 DNA damage checkpoint Source: GO_Central
  • morphogenesis of a polarized epithelium Source: MGI
  • multicellular organism aging Source: MGI
  • multicellular organism development Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of keratinocyte differentiation Source: MGI
  • negative regulation of mesoderm development Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • neuron apoptotic process Source: MGI
  • Notch signaling pathway Source: UniProtKB-KW
  • odontogenesis of dentin-containing tooth Source: MGI
  • pattern specification process Source: MGI
  • polarized epithelial cell differentiation Source: MGI
  • positive regulation of apoptotic signaling pathway Source: MGI
  • positive regulation of fibroblast apoptotic process Source: MGI
  • positive regulation of keratinocyte proliferation Source: MGI
  • positive regulation of mesenchymal cell proliferation Source: MGI
  • positive regulation of Notch signaling pathway Source: MGI
  • positive regulation of osteoblast differentiation Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • post-anal tail morphogenesis Source: MGI
  • prostate gland development Source: MGI
  • prostatic bud formation Source: MGI
  • protein homotetramerization Source: MGI
  • proximal/distal pattern formation Source: MGI
  • regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • regulation of epidermal cell division Source: UniProtKB
  • regulation of neuron apoptotic process Source: GO_Central
  • replicative cell aging Source: Ensembl
  • response to gamma radiation Source: GO_Central
  • response to X-ray Source: GO_Central
  • skeletal system development Source: MGI
  • skin morphogenesis Source: MGI
  • smooth muscle tissue development Source: MGI
  • spermatogenesis Source: Ensembl
  • squamous basal epithelial stem cell differentiation involved in prostate gland acinus development Source: MGI
  • sympathetic nervous system development Source: MGI
  • urinary bladder development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Apoptosis, Notch signaling pathway, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-6804759. Regulation of TP53 Activity through Association with Co-factors.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein 63
Short name:
p63
Alternative name(s):
Transformation-related protein 63
Short name:
TP63
Tumor protein p73-like
Short name:
p73L
Gene namesi
Name:Tp63
Synonyms:P63, P73l, Tp73l, Trp63
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1330810. Trp63.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi543Y → F: Abolishes interaction with WWP1. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001857301 – 680Tumor protein 63Add BLAST680

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki676Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity

Post-translational modificationi

May be sumoylated.By similarity
Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiO88898.
PRIDEiO88898.

PTM databases

iPTMnetiO88898.
PhosphoSitePlusiO88898.

Expressioni

Tissue specificityi

Widely expressed, notably in thymus, prostate, placenta and skeletal muscle, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast and prostate express high levels of DeltaN-type isoforms.1 Publication

Developmental stagei

TA*-type isoforms are expressed from E7.5, prior to the onset of epithelial stratification, while DeltaN-type isoforms are expressed from E9.5.1 Publication

Inductioni

Induced by DNA damaging agents.1 Publication

Gene expression databases

BgeeiENSMUSG00000022510.
CleanExiMM_TRP63.
ExpressionAtlasiO88898. baseline and differential.
GenevisibleiO88898. MM.

Interactioni

Subunit structurei

Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Interacts with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Interacts with PDS5A. Interacts (via activation domain) with NOC2L (By similarity). Interacts with WWP1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-2338025,EBI-2338025
Cables1Q9ESJ12EBI-2338025,EBI-604411
KAT2BQ928313EBI-2338228,EBI-477430From a different organism.
NQO1P155592EBI-2338228,EBI-3989435From a different organism.
TP53P046372EBI-2338025,EBI-366083From a different organism.

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • p53 binding Source: GO_Central
  • WW domain binding Source: MGI

Protein-protein interaction databases

BioGridi204325. 3 interactors.
IntActiO88898. 7 interactors.
MINTiMINT-4585054.
STRINGi10090.ENSMUSP00000110965.

Structurei

3D structure databases

ProteinModelPortaliO88898.
SMRiO88898.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini541 – 607SAMAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 107Transcription activationBy similarityAdd BLAST107
Regioni352 – 388Interaction with HIPK2By similarityAdd BLAST37
Regioni394 – 443OligomerizationBy similarityAdd BLAST50
Regioni610 – 680Transactivation inhibitionBy similarityAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi437 – 444Poly-Gln8

Domaini

The transactivation inhibitory domain (TID) can interact with, and inhibit the activity of the N-terminal transcriptional activation domain of TA*-type isoforms.By similarity

Sequence similaritiesi

Belongs to the p53 family.Curated

Phylogenomic databases

eggNOGiENOG410IGE4. Eukaryota.
ENOG410XV9W. LUCA.
GeneTreeiENSGT00390000015092.
HOVERGENiHBG005201.
InParanoidiO88898.
KOiK10149.
OMAiVPSSHCT.
OrthoDBiEOG091G0XY5.
PhylomeDBiO88898.
TreeFamiTF106101.

Family and domain databases

CDDicd08367. P53. 1 hit.
Gene3Di1.10.150.50. 1 hit.
2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR002117. p53_tumour_suppressor.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR032645. Tp63.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 2 hits.
PTHR11447:SF8. PTHR11447:SF8. 2 hits.
PfamiPF00870. P53. 1 hit.
PF07710. P53_tetramer. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF47769. SSF47769. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiPS00348. P53. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O88898-1) [UniParc]FASTAAdd to basket
Also known as: TA*-alpha, TA*p63alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNFETSRCAT LQYCPDPYIQ RFIETPAHFS WKESYYRSAM SQSTQTSEFL
60 70 80 90 100
SPEVFQHIWD FLEQPICSVQ PIELNFVDEP SENGATNKIE ISMDCIRMQD
110 120 130 140 150
SDLSDPMWPQ YTNLGLLNSM DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA
160 170 180 190 200
QPSSTFDALS PSPAIPSNTD YPGPHSFDVS FQQSSTAKSA TWTYSTELKK
210 220 230 240 250
LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV VKRCPNHELS
260 270 280 290 300
REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT
310 320 330 340 350
TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR
360 370 380 390 400
DRKADEDSIR KQQVSDSAKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL
410 420 430 440 450
LYLPVRGRET YEMLLKIKES LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ
460 470 480 490 500
TSMQSQSSYG NSSPPLNKMN SMNKLPSVSQ LINPQQRNAL TPTTMPEGMG
510 520 530 540 550
ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP PPYPTDCSIV
560 570 580 590 600
SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG
610 620 630 640 650
ILDHRQLHDF SSPPHLLRTP SGASTVSVGS SETRGERVID AVRFTLRQTI
660 670 680
SFPPRDEWND FNFDMDSRRN KQQRIKEEGE
Note: Produced by alternative promoter usage.
Length:680
Mass (Da):76,789
Last modified:November 1, 1998 - v1
Checksum:i8DFF0284F247C68A
GO
Isoform 2 (identifier: O88898-2) [UniParc]FASTAAdd to basket
Also known as: DeltaN-alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MNFETSRCAT...QDSDLSDPMW → MLYLENNAQTQFSE

Note: Produced by alternative promoter usage.
Show »
Length:586
Mass (Da):65,789
Checksum:i622E24085B8BDCB7
GO
Isoform 3 (identifier: O88898-3) [UniParc]FASTAAdd to basket
Also known as: TA*-beta, TA*p63beta

The sequence of this isoform differs from the canonical sequence as follows:
     551-680: SFLARLGCSS...KQQRIKEEGE → RIWQV

Note: Produced by alternative splicing of isoform 1.
Show »
Length:555
Mass (Da):62,455
Checksum:i059E034046EB8987
GO
Isoform 4 (identifier: O88898-4) [UniParc]FASTAAdd to basket
Also known as: DeltaN-beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MNFETSRCAT...QDSDLSDPMW → MLYLENNAQTQFSE
     551-680: SFLARLGCSS...KQQRIKEEGE → RIWQV

Note: Produced by alternative splicing of isoform 2.
Show »
Length:461
Mass (Da):51,455
Checksum:i7613296F2F85DBC8
GO
Isoform 5 (identifier: O88898-5) [UniParc]FASTAAdd to basket
Also known as: TA*-gamma, TA*p63gamma

The sequence of this isoform differs from the canonical sequence as follows:
     373-377: GTKRP → A
     450-680: QTSMQSQSSY...KQQRIKEEGE → HLLSACFRNE...SNPPNHSVYP

Note: Produced by alternative splicing of isoform 1.
Show »
Length:483
Mass (Da):54,970
Checksum:iA90ED0C110C50EAD
GO
Isoform 6 (identifier: O88898-6) [UniParc]FASTAAdd to basket
Also known as: DeltaN-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: MNFETSRCAT...QDSDLSDPMW → MLYLENNAQTQFSE
     373-377: GTKRP → A
     450-680: QTSMQSQSSY...KQQRIKEEGE → HLLSACFRNE...SNPPNHSVYP

Note: Produced by alternative splicing of isoform 2.
Show »
Length:389
Mass (Da):43,970
Checksum:iFE6B4A859C5F00BB
GO

Sequence cautioni

The sequence BAC33397 differs from that shown. Intron retention.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0124711 – 108MNFET…SDPMW → MLYLENNAQTQFSE in isoform 2, isoform 4 and isoform 6. 3 PublicationsAdd BLAST108
Alternative sequenceiVSP_012472373 – 377GTKRP → A in isoform 5 and isoform 6. 1 Publication5
Alternative sequenceiVSP_012473450 – 680QTSMQ…KEEGE → HLLSACFRNELVEPRGEAPT QSDVFFRHSNPPNHSVYP in isoform 5 and isoform 6. 1 PublicationAdd BLAST231
Alternative sequenceiVSP_012474551 – 680SFLAR…KEEGE → RIWQV in isoform 3 and isoform 4. 2 PublicationsAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075434 mRNA. Translation: AAC62639.1.
AF075435 mRNA. Translation: AAC62640.1.
AF075436 mRNA. Translation: AAC62641.1.
AF075437 mRNA. Translation: AAC62642.1.
AF075438 mRNA. Translation: AAC62643.1.
AF075439 mRNA. Translation: AAC62644.1.
AB010152 mRNA. Translation: BAA32432.1.
AF533892 Genomic DNA. Translation: AAP87982.1.
AF533892 Genomic DNA. Translation: AAP87985.1.
AF533892 Genomic DNA. Translation: AAP87983.1.
AF533892 Genomic DNA. Translation: AAP87984.1.
AF533892 Genomic DNA. Translation: AAP87986.1.
AF533892 Genomic DNA. Translation: AAP87987.1.
AK048623 mRNA. Translation: BAC33397.1. Sequence problems.
CCDSiCCDS28085.1. [O88898-2]
CCDS49808.1. [O88898-5]
CCDS49809.1. [O88898-1]
CCDS49810.1. [O88898-3]
RefSeqiNP_001120731.1. NM_001127259.1. [O88898-1]
NP_001120732.1. NM_001127260.1. [O88898-3]
NP_001120733.1. NM_001127261.1. [O88898-5]
NP_001120734.1. NM_001127262.1. [O88898-4]
NP_001120736.1. NM_001127264.1.
NP_001120737.1. NM_001127265.1. [O88898-6]
NP_035771.1. NM_011641.2. [O88898-2]
UniGeneiMm.20894.

Genome annotation databases

EnsembliENSMUST00000040231; ENSMUSP00000038117; ENSMUSG00000022510. [O88898-2]
ENSMUST00000065523; ENSMUSP00000067005; ENSMUSG00000022510. [O88898-3]
ENSMUST00000115308; ENSMUSP00000110963; ENSMUSG00000022510. [O88898-5]
ENSMUST00000115310; ENSMUSP00000110965; ENSMUSG00000022510. [O88898-1]
GeneIDi22061.
KEGGimmu:22061.
UCSCiuc007yuo.2. mouse. [O88898-5]
uc007yup.2. mouse. [O88898-1]
uc007yuq.2. mouse. [O88898-3]
uc007yut.2. mouse. [O88898-6]
uc007yuu.2. mouse. [O88898-2]
uc007yuv.2. mouse. [O88898-4]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF075434 mRNA. Translation: AAC62639.1.
AF075435 mRNA. Translation: AAC62640.1.
AF075436 mRNA. Translation: AAC62641.1.
AF075437 mRNA. Translation: AAC62642.1.
AF075438 mRNA. Translation: AAC62643.1.
AF075439 mRNA. Translation: AAC62644.1.
AB010152 mRNA. Translation: BAA32432.1.
AF533892 Genomic DNA. Translation: AAP87982.1.
AF533892 Genomic DNA. Translation: AAP87985.1.
AF533892 Genomic DNA. Translation: AAP87983.1.
AF533892 Genomic DNA. Translation: AAP87984.1.
AF533892 Genomic DNA. Translation: AAP87986.1.
AF533892 Genomic DNA. Translation: AAP87987.1.
AK048623 mRNA. Translation: BAC33397.1. Sequence problems.
CCDSiCCDS28085.1. [O88898-2]
CCDS49808.1. [O88898-5]
CCDS49809.1. [O88898-1]
CCDS49810.1. [O88898-3]
RefSeqiNP_001120731.1. NM_001127259.1. [O88898-1]
NP_001120732.1. NM_001127260.1. [O88898-3]
NP_001120733.1. NM_001127261.1. [O88898-5]
NP_001120734.1. NM_001127262.1. [O88898-4]
NP_001120736.1. NM_001127264.1.
NP_001120737.1. NM_001127265.1. [O88898-6]
NP_035771.1. NM_011641.2. [O88898-2]
UniGeneiMm.20894.

3D structure databases

ProteinModelPortaliO88898.
SMRiO88898.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204325. 3 interactors.
IntActiO88898. 7 interactors.
MINTiMINT-4585054.
STRINGi10090.ENSMUSP00000110965.

PTM databases

iPTMnetiO88898.
PhosphoSitePlusiO88898.

Proteomic databases

PaxDbiO88898.
PRIDEiO88898.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040231; ENSMUSP00000038117; ENSMUSG00000022510. [O88898-2]
ENSMUST00000065523; ENSMUSP00000067005; ENSMUSG00000022510. [O88898-3]
ENSMUST00000115308; ENSMUSP00000110963; ENSMUSG00000022510. [O88898-5]
ENSMUST00000115310; ENSMUSP00000110965; ENSMUSG00000022510. [O88898-1]
GeneIDi22061.
KEGGimmu:22061.
UCSCiuc007yuo.2. mouse. [O88898-5]
uc007yup.2. mouse. [O88898-1]
uc007yuq.2. mouse. [O88898-3]
uc007yut.2. mouse. [O88898-6]
uc007yuu.2. mouse. [O88898-2]
uc007yuv.2. mouse. [O88898-4]

Organism-specific databases

CTDi22061.
MGIiMGI:1330810. Trp63.

Phylogenomic databases

eggNOGiENOG410IGE4. Eukaryota.
ENOG410XV9W. LUCA.
GeneTreeiENSGT00390000015092.
HOVERGENiHBG005201.
InParanoidiO88898.
KOiK10149.
OMAiVPSSHCT.
OrthoDBiEOG091G0XY5.
PhylomeDBiO88898.
TreeFamiTF106101.

Enzyme and pathway databases

ReactomeiR-MMU-6804759. Regulation of TP53 Activity through Association with Co-factors.

Miscellaneous databases

PROiO88898.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022510.
CleanExiMM_TRP63.
ExpressionAtlasiO88898. baseline and differential.
GenevisibleiO88898. MM.

Family and domain databases

CDDicd08367. P53. 1 hit.
Gene3Di1.10.150.50. 1 hit.
2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR002117. p53_tumour_suppressor.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR032645. Tp63.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 2 hits.
PTHR11447:SF8. PTHR11447:SF8. 2 hits.
PfamiPF00870. P53. 1 hit.
PF07710. P53_tetramer. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SMARTiSM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF47769. SSF47769. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiPS00348. P53. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP63_MOUSE
AccessioniPrimary (citable) accession number: O88898
Secondary accession number(s): O88897
, O88899, O89097, Q8C826, Q9QWY9, Q9QWZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.