UniProtKB - O88898 (P63_MOUSE)
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Tumor protein 63
Tp63
Functioni
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 244 | ZincBy similarity | 1 | |
Metal bindingi | 247 | ZincBy similarity | 1 | |
Metal bindingi | 308 | ZincBy similarity | 1 | |
Metal bindingi | 312 | ZincBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 170 – 362 | By similarityAdd BLAST | 193 |
GO - Molecular functioni
- chromatin binding Source: MGI
- damaged DNA binding Source: MGI
- DNA binding Source: MGI
- DNA binding transcription factor activity Source: MGI
- double-stranded DNA binding Source: GO_Central
- identical protein binding Source: IntAct
- MDM2/MDM4 family protein binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- p53 binding Source: MGI
- sequence-specific DNA binding Source: MGI
- transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI
- transcription factor activity, transcription factor binding Source: MGI
- transcription regulatory region DNA binding Source: InterPro
- WW domain binding Source: MGI
GO - Biological processi
- anatomical structure formation involved in morphogenesis Source: MGI
- animal organ morphogenesis Source: MGI
- apoptotic process Source: MGI
- cell aging Source: MGI
- cell differentiation Source: MGI
- cell proliferation Source: MGI
- cellular response to DNA damage stimulus Source: MGI
- cellular response to UV Source: GO_Central
- chromatin remodeling Source: MGI
- cloacal septation Source: MGI
- cranial skeletal system development Source: MGI
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: GO_Central
- ectoderm and mesoderm interaction Source: MGI
- embryonic forelimb morphogenesis Source: MGI
- embryonic hindlimb morphogenesis Source: MGI
- embryonic limb morphogenesis Source: MGI
- epidermal cell differentiation Source: MGI
- epidermal cell division Source: MGI
- epidermis development Source: MGI
- epithelial cell development Source: MGI
- epithelial cell differentiation Source: MGI
- establishment of planar polarity Source: MGI
- establishment of skin barrier Source: UniProtKB
- female genitalia morphogenesis Source: MGI
- hair follicle development Source: MGI
- hair follicle morphogenesis Source: MGI
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: MGI
- keratinocyte differentiation Source: MGI
- keratinocyte proliferation Source: MGI
- mitotic G1 DNA damage checkpoint Source: GO_Central
- morphogenesis of a polarized epithelium Source: MGI
- multicellular organism aging Source: MGI
- multicellular organism development Source: MGI
- negative regulation of apoptotic process Source: MGI
- negative regulation of cellular senescence Source: MGI
- negative regulation of intracellular estrogen receptor signaling pathway Source: CAFA
- negative regulation of keratinocyte differentiation Source: MGI
- negative regulation of mesoderm development Source: MGI
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- neuron apoptotic process Source: MGI
- Notch signaling pathway Source: UniProtKB-KW
- odontogenesis of dentin-containing tooth Source: MGI
- pattern specification process Source: MGI
- polarized epithelial cell differentiation Source: MGI
- positive regulation of apoptotic signaling pathway Source: MGI
- positive regulation of cell cycle G1/S phase transition Source: MGI
- positive regulation of fibroblast apoptotic process Source: MGI
- positive regulation of keratinocyte proliferation Source: MGI
- positive regulation of mesenchymal cell proliferation Source: MGI
- positive regulation of Notch signaling pathway Source: MGI
- positive regulation of osteoblast differentiation Source: MGI
- positive regulation of somatic stem cell population maintenance Source: CAFA
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- post-anal tail morphogenesis Source: MGI
- prostate gland development Source: MGI
- prostatic bud formation Source: MGI
- protein homotetramerization Source: MGI
- proximal/distal pattern formation Source: MGI
- regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
- regulation of epidermal cell division Source: UniProtKB
- regulation of neuron apoptotic process Source: GO_Central
- replicative cell aging Source: Ensembl
- response to gamma radiation Source: GO_Central
- response to X-ray Source: GO_Central
- skeletal system development Source: MGI
- skin epidermis development Source: MGI
- skin morphogenesis Source: MGI
- smooth muscle tissue development Source: MGI
- spermatogenesis Source: Ensembl
- squamous basal epithelial stem cell differentiation involved in prostate gland acinus development Source: MGI
- sympathetic nervous system development Source: MGI
- urinary bladder development Source: MGI
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Apoptosis, Notch signaling pathway, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-6804759. Regulation of TP53 Activity through Association with Co-factors. |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor protein 63Short name: p63 Alternative name(s): Transformation-related protein 63 Short name: TP63 Tumor protein p73-like Short name: p73L |
Gene namesi | Name:Tp63 Synonyms:P63, P73l, Tp73l, Trp63 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1330810. Trp63. |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 543 | Y → F: Abolishes interaction with WWP1. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185730 | 1 – 680 | Tumor protein 63Add BLAST | 680 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 676 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
PaxDbi | O88898. |
PRIDEi | O88898. |
PTM databases
iPTMneti | O88898. |
PhosphoSitePlusi | O88898. |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000022510. |
CleanExi | MM_TRP63. |
ExpressionAtlasi | O88898. baseline and differential. |
Genevisiblei | O88898. MM. |
Interactioni
Subunit structurei
Binary interactionsi
GO - Molecular functioni
- identical protein binding Source: IntAct
- MDM2/MDM4 family protein binding Source: MGI
- p53 binding Source: MGI
- WW domain binding Source: MGI
Protein-protein interaction databases
BioGridi | 204325. 3 interactors. |
ELMi | O88898. |
IntActi | O88898. 7 interactors. |
MINTi | O88898. |
STRINGi | 10090.ENSMUSP00000110965. |
Structurei
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5N2O | NMR | - | A | 545-609 | [»] | |
ProteinModelPortali | O88898. | |||||
SMRi | O88898. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 541 – 607 | SAMAdd BLAST | 67 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 107 | Transcription activationBy similarityAdd BLAST | 107 | |
Regioni | 352 – 388 | Interaction with HIPK2By similarityAdd BLAST | 37 | |
Regioni | 394 – 443 | OligomerizationBy similarityAdd BLAST | 50 | |
Regioni | 610 – 680 | Transactivation inhibitionBy similarityAdd BLAST | 71 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 437 – 444 | Poly-Gln | 8 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG410IGE4. Eukaryota. ENOG410XV9W. LUCA. |
GeneTreei | ENSGT00390000015092. |
HOVERGENi | HBG005201. |
InParanoidi | O88898. |
KOi | K10149. |
OMAi | GIMEHRQ. |
OrthoDBi | EOG091G0XY5. |
PhylomeDBi | O88898. |
TreeFami | TF106101. |
Family and domain databases
CDDi | cd08367. P53. 1 hit. cd09572. SAM_tumor-p63. 1 hit. |
Gene3Di | 2.60.40.720. 1 hit. 4.10.170.10. 1 hit. |
InterProi | View protein in InterPro IPR008967. p53-like_TF_DNA-bd. IPR012346. p53/RUNT-type_TF_DNA-bd_sf. IPR011615. p53_DNA-bd. IPR036674. p53_tetramer_sf. IPR010991. p53_tetrameristn. IPR002117. p53_tumour_suppressor. IPR001660. SAM. IPR013761. SAM/pointed_sf. IPR032645. Tp63. IPR037611. Tumor-p63_SAM. |
PANTHERi | PTHR11447. PTHR11447. 1 hit. PTHR11447:SF8. PTHR11447:SF8. 1 hit. |
Pfami | View protein in Pfam PF00870. P53. 1 hit. PF07710. P53_tetramer. 1 hit. PF07647. SAM_2. 1 hit. |
PRINTSi | PR00386. P53SUPPRESSR. |
SMARTi | View protein in SMART SM00454. SAM. 1 hit. |
SUPFAMi | SSF47719. SSF47719. 1 hit. SSF47769. SSF47769. 1 hit. SSF49417. SSF49417. 1 hit. |
PROSITEi | View protein in PROSITE PS00348. P53. 1 hit. |
s (6)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MNFETSRCAT LQYCPDPYIQ RFIETPAHFS WKESYYRSAM SQSTQTSEFL
60 70 80 90 100
SPEVFQHIWD FLEQPICSVQ PIELNFVDEP SENGATNKIE ISMDCIRMQD
110 120 130 140 150
SDLSDPMWPQ YTNLGLLNSM DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA
160 170 180 190 200
QPSSTFDALS PSPAIPSNTD YPGPHSFDVS FQQSSTAKSA TWTYSTELKK
210 220 230 240 250
LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV VKRCPNHELS
260 270 280 290 300
REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT
310 320 330 340 350
TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR
360 370 380 390 400
DRKADEDSIR KQQVSDSAKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL
410 420 430 440 450
LYLPVRGRET YEMLLKIKES LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ
460 470 480 490 500
TSMQSQSSYG NSSPPLNKMN SMNKLPSVSQ LINPQQRNAL TPTTMPEGMG
510 520 530 540 550
ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP PPYPTDCSIV
560 570 580 590 600
SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG
610 620 630 640 650
ILDHRQLHDF SSPPHLLRTP SGASTVSVGS SETRGERVID AVRFTLRQTI
660 670 680
SFPPRDEWND FNFDMDSRRN KQQRIKEEGE
The sequence of this isoform differs from the canonical sequence as follows:
1-108: MNFETSRCAT...QDSDLSDPMW → MLYLENNAQTQFSE
551-680: SFLARLGCSS...KQQRIKEEGE → RIWQV
The sequence of this isoform differs from the canonical sequence as follows:
373-377: GTKRP → A
450-680: QTSMQSQSSY...KQQRIKEEGE → HLLSACFRNE...SNPPNHSVYP
The sequence of this isoform differs from the canonical sequence as follows:
1-108: MNFETSRCAT...QDSDLSDPMW → MLYLENNAQTQFSE
373-377: GTKRP → A
450-680: QTSMQSQSSY...KQQRIKEEGE → HLLSACFRNE...SNPPNHSVYP
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012471 | 1 – 108 | MNFET…SDPMW → MLYLENNAQTQFSE in isoform 2, isoform 4 and isoform 6. 3 PublicationsAdd BLAST | 108 | |
Alternative sequenceiVSP_012472 | 373 – 377 | GTKRP → A in isoform 5 and isoform 6. 1 Publication | 5 | |
Alternative sequenceiVSP_012473 | 450 – 680 | QTSMQ…KEEGE → HLLSACFRNELVEPRGEAPT QSDVFFRHSNPPNHSVYP in isoform 5 and isoform 6. 1 PublicationAdd BLAST | 231 | |
Alternative sequenceiVSP_012474 | 551 – 680 | SFLAR…KEEGE → RIWQV in isoform 3 and isoform 4. 2 PublicationsAdd BLAST | 130 |
Sequence databases
Genome annotation databases
Ensembli | ENSMUST00000040231; ENSMUSP00000038117; ENSMUSG00000022510. [O88898-2] ENSMUST00000065523; ENSMUSP00000067005; ENSMUSG00000022510. [O88898-3] ENSMUST00000115308; ENSMUSP00000110963; ENSMUSG00000022510. [O88898-5] ENSMUST00000115310; ENSMUSP00000110965; ENSMUSG00000022510. [O88898-1] |
GeneIDi | 22061. |
KEGGi | mmu:22061. |
UCSCi | uc007yuo.2. mouse. [O88898-5] uc007yup.2. mouse. [O88898-1] uc007yuq.2. mouse. [O88898-3] uc007yut.2. mouse. [O88898-6] uc007yuu.2. mouse. [O88898-2] uc007yuv.2. mouse. [O88898-4] |
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | P63_MOUSE | |
Accessioni | O88898Primary (citable) accession number: O88898 Secondary accession number(s): O88897 Q9QWZ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 4, 2005 |
Last sequence update: | November 1, 1998 | |
Last modified: | March 28, 2018 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |