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Protein

SH2 domain-containing protein 1A

Gene

Sh2d1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (By similarity). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions (PubMed:22683124). Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation (PubMed:19648922). In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (PubMed:22683124). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.By similarity1 Publication4 Publications

GO - Molecular functioni

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • cell-cell signaling Source: MGI
  • cellular defense response Source: InterPro
  • humoral immune response Source: MGI
  • innate immune response Source: UniProtKB-KW
  • positive regulation of natural killer cell mediated cytotoxicity Source: MGI

Keywordsi

Biological processAdaptive immunity, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing protein 1A
Alternative name(s):
Signaling lymphocytic activation molecule-associated protein
Short name:
SLAM-associated protein
T-cell signal transduction molecule SAP
Gene namesi
Name:Sh2d1a
Synonyms:Xlp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1328352 Sh2d1a

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi32R → K: No effect on interaction with FYN SH3 domain. 1 Publication1
Mutagenesisi68T → I: No effect on interaction with FYN SH3 domain. 1 Publication1
Mutagenesisi70P → A: No effect on interaction with FYN SH3 domain. 1 Publication1
Mutagenesisi74 – 75KR → AA: Disrupts interaction with FYN SH3 domain. 1 Publication2
Mutagenesisi78 – 79RK → AA: Disrupts interaction with FYN SH3 domain. 1 Publication2
Mutagenesisi78R → A: No effect on NK cell development, impairs promotion of NK cell cytotoxicity and IFN-gamma production in response to hematopoietic cells. 1 Publication1
Mutagenesisi90P → K: No effect on interaction with FYN SH3 domain. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000977231 – 126SH2 domain-containing protein 1AAdd BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei89N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO88890
PRIDEiO88890

PTM databases

iPTMnetiO88890
PhosphoSitePlusiO88890

Expressioni

Tissue specificityi

T-cells.

Gene expression databases

BgeeiENSMUSG00000005696
CleanExiMM_SH2D1A
ExpressionAtlasiO88890 baseline and differential
GenevisibleiO88890 MM

Interactioni

Subunit structurei

Interacts with CD84, CD244, LY9, SLAMF1 and FYN (By similarity). Interacts with NTRK1, NTRK2 and NTRK3.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Slamf1Q9QUM43EBI-7910438,EBI-7910086

GO - Molecular functioni

Protein-protein interaction databases

CORUMiO88890
IntActiO88890, 3 interactors
MINTiO88890
STRINGi10090.ENSMUSP00000005839

Structurei

3D structure databases

ProteinModelPortaliO88890
SMRiO88890
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 104SH2PROSITE-ProRule annotationAdd BLAST99

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni67 – 92Interaction with FYN SH3 domain1 PublicationAdd BLAST26

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG0565 Eukaryota
COG5411 LUCA
GeneTreeiENSGT00510000046904
HOGENOMiHOG000231700
HOVERGENiHBG003702
InParanoidiO88890
KOiK07990
OMAiCLCVLCK
OrthoDBiEOG091G0ULG
PhylomeDBiO88890
TreeFamiTF343096

Family and domain databases

CDDicd10400 SH2_SAP1a, 1 hit
Gene3Di3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR017289 SH2_prot_1A
IPR035876 SH2D1A_SH2
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PIRSFiPIRSF037828 SH2_p1A, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: O88890-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDAVTVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYQGY
60 70 80 90 100
IYTYRVSQTE TGSWSAETAP GVHKRFFRKV KNLISAFQKP DQGIVTPLQY
110 120
PVEKSSGRGP QAPTGRRDSD ICLNAP
Length:126
Mass (Da):13,904
Last modified:November 1, 1998 - v1
Checksum:iD78FA7CE425AA680
GO
Isoform Short (identifier: O88890-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-46: Missing.

Show »
Length:123
Mass (Da):13,588
Checksum:iD44BC29EA4A82439
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00439144 – 46Missing in isoform Short. Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072903 mRNA Translation: AAC62629.1
AF097633 mRNA Translation: AAC95999.1
AF097632 mRNA Translation: AAC95998.1
AF154505, AF154503, AF154504 Genomic DNA Translation: AAF14526.1
AL831716 Genomic DNA Translation: CAM19525.1
CCDSiCCDS30099.1 [O88890-1]
CCDS85770.1 [O88890-2]
RefSeqiNP_001300617.1, NM_001313688.1
NP_001300618.1, NM_001313689.1 [O88890-2]
NP_001300620.1, NM_001313691.1
NP_035494.1, NM_011364.4 [O88890-1]
UniGeneiMm.441197

Genome annotation databases

EnsembliENSMUST00000005839; ENSMUSP00000005839; ENSMUSG00000005696 [O88890-1]
ENSMUST00000115070; ENSMUSP00000110722; ENSMUSG00000005696 [O88890-2]
ENSMUST00000189753; ENSMUSP00000141070; ENSMUSG00000005696 [O88890-1]
GeneIDi20400
KEGGimmu:20400
UCSCiuc009tbb.1 mouse [O88890-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSH21A_MOUSE
AccessioniPrimary (citable) accession number: O88890
Secondary accession number(s): A2ANL8, Q9QWV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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