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Protein

Amyloid-beta A4 precursor protein-binding family A member 3

Gene

Apba3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • chemical synaptic transmission Source: MGI
  • in utero embryonic development Source: MGI
  • negative regulation of catalytic activity Source: MGI
  • protein transport Source: UniProtKB-KW
  • regulation of gene expression Source: MGI

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid-beta A4 precursor protein-binding family A member 3
Alternative name(s):
Adapter protein X11gamma
Neuron-specific X11L2 protein
Neuronal Munc18-1-interacting protein 3
Short name:
Mint-3
Gene namesi
Name:Apba3
Synonyms:Mint3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1888527. Apba3.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000646211 – 571Amyloid-beta A4 precursor protein-binding family A member 3Add BLAST571

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei168PhosphoserineBy similarity1
Modified residuei369PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO88888.
PeptideAtlasiO88888.
PRIDEiO88888.

PTM databases

iPTMnetiO88888.
PhosphoSitePlusiO88888.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000004931.
GenevisibleiO88888. MM.

Interactioni

Subunit structurei

Binds to the cytoplasmic domain of amyloid protein (APP). Interacts with HIF1AN (via N-terminus) (By similarity). Interacts with NECAB3; seems to mediate the interaction between NECAB3 and HIF1AN (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050995.

Structurei

3D structure databases

ProteinModelPortaliO88888.
SMRiO88888.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini214 – 378PIDPROSITE-ProRule annotationAdd BLAST165
Domaini391 – 477PDZ 1PROSITE-ProRule annotationAdd BLAST87
Domaini482 – 556PDZ 2PROSITE-ProRule annotationAdd BLAST75

Domaini

Composed of an N-terminal domain, a middle phosphotyrosine-binding domain (PID/PTB) that mediates binding with the cytoplasmic domain of the amyloid-beta precursor protein, and two C-terminal PDZ domains thought to attach proteins to the plasma membrane.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3605. Eukaryota.
ENOG410XSBD. LUCA.
GeneTreeiENSGT00390000013578.
HOGENOMiHOG000033981.
HOVERGENiHBG050523.
InParanoidiO88888.
OMAiHNGDLDH.
OrthoDBiEOG091G0PDJ.
PhylomeDBiO88888.
TreeFamiTF315245.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR030531. Apba3.
IPR001478. PDZ.
IPR011993. PH_dom-like.
IPR006020. PTB/PI_dom.
PANTHERiPTHR12345:SF24. PTHR12345:SF24. 1 hit.
PfamiView protein in Pfam
PF00595. PDZ. 2 hits.
PF00640. PID. 1 hit.
SMARTiView protein in SMART
SM00228. PDZ. 2 hits.
SM00462. PTB. 1 hit.
SUPFAMiSSF50156. SSF50156. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS50106. PDZ. 2 hits.
PS01179. PID. 1 hit.

Sequencei

Sequence statusi: Complete.

O88888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFLPGPQHP PGPPTMDLEE PKGPEVPSEN HPSNTQSALG PGGPVTLSEM
60 70 80 90 100
ELDTSSVQEL VQQLEALPSD LGGPFPDGAP CPLHIATGQG LATQENPDAG
110 120 130 140 150
GLLSAEAGGD DLLGLLRDEA SSPAQSVPQD PAQTAPRLLQ PPEDPDGDPG
160 170 180 190 200
WMEGASAEPA DSRSSSSSPE PWLETAPLVT QQEPPVGTQS RETLASCPAV
210 220 230 240 250
TEVPGPCGPE ELMDGVIFGA KYLGSTQLLS ERSPAPSTRM GQAQEAMDRV
260 270 280 290 300
KAPEGETQPM VEVDIFISTK RVKVLAADSQ DALMDHALQT ISYIADIGPV
310 320 330 340 350
LVLMARRRLA RRTTPQDRQR RLYKMLCHVF HSEDAQLIAQ AIGQAFSIAY
360 370 380 390 400
SQFLQENRID PSQVGTQPST AASHPHNGDL DHFCNSQNCR EVCIQKRPGE
410 420 430 440 450
GLGVALVESG WGSLLPTAVI ANLLHGGPAE RCGALSIGDR VTAINGTSLV
460 470 480 490 500
GLSLAACQAA VREVRRLSSV TLSIIHCPPV TTAVIRRPHV REQLGFCVED
510 520 530 540 550
GIICSLLRGG AAERGGVRVG HRIIEVNGQS VVAMPHARII QLLTETREIH
560 570
IKTMPAATYR LLTGQEQPVY L
Length:571
Mass (Da):60,718
Last modified:November 1, 1998 - v1
Checksum:i1BBAC7BD1CCF3BCA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti238T → A in BAC32549 (PubMed:16141072).Curated1
Sequence conflicti381D → G in BAC32549 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070975 mRNA. Translation: AAC78837.1.
AK045965 mRNA. Translation: BAC32549.1.
AK170182 mRNA. Translation: BAE41620.1.
CH466553 Genomic DNA. Translation: EDL31434.1.
BC005423 mRNA. Translation: AAH05423.1.
BC009666 mRNA. Translation: AAH09666.1.
CCDSiCCDS24050.1.
RefSeqiNP_061228.1. NM_018758.2.
XP_006513968.1. XM_006513905.1.
XP_006513969.1. XM_006513906.3.
UniGeneiMm.293931.

Genome annotation databases

EnsembliENSMUST00000057798; ENSMUSP00000050995; ENSMUSG00000004931.
ENSMUST00000220297; ENSMUSP00000151985; ENSMUSG00000004931.
GeneIDi57267.
KEGGimmu:57267.
UCSCiuc007ggz.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiAPBA3_MOUSE
AccessioniPrimary (citable) accession number: O88888
Secondary accession number(s): Q3TDI1, Q8BR09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: September 27, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot