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O88879

- APAF_MOUSE

UniProt

O88879 - APAF_MOUSE

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Protein

Apoptotic protease-activating factor 1

Gene
Apaf1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase 9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei265 – 2651ATP

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi154 – 1618ATP Reviewed prediction

GO - Molecular functioni

  1. ADP binding Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. cysteine-type endopeptidase activator activity involved in apoptotic process Source: MGI
  4. identical protein binding Source: MGI

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  2. activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: RefGenome
  3. brain development Source: MGI
  4. defense response Source: InterPro
  5. forebrain development Source: MGI
  6. multicellular organismal development Source: MGI
  7. neural tube closure Source: MGI
  8. neuron apoptotic process Source: MGI
  9. positive regulation of apoptotic signaling pathway Source: MGI
  10. regulation of apoptotic DNA fragmentation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

ATP-binding, Calcium, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_206522. Formation of apoptosome.
REACT_225157. Activation of caspases through apoptosome-mediated cleavage.

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptotic protease-activating factor 1
Short name:
APAF-1
Gene namesi
Name:Apaf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1306796. Apaf1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. apoptosome Source: RefGenome
  2. cytosol Source: MGI
  3. Golgi apparatus Source: Ensembl
  4. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi265 – 2651R → S: No stimulation of CASP9 activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12491249Apoptotic protease-activating factor 1PRO_0000050845Add
BLAST

Proteomic databases

MaxQBiO88879.
PaxDbiO88879.
PRIDEiO88879.

PTM databases

PhosphoSiteiO88879.

Expressioni

Tissue specificityi

Highly expressed in lung and spleen, weakly in brain and kidney and not detectable in liver.

Developmental stagei

High levels in embryonic brain and liver from E11.5 to E17.5 day.

Gene expression databases

ArrayExpressiO88879.
BgeeiO88879.
CleanExiMM_APAF1.
GenevestigatoriO88879.

Interactioni

Subunit structurei

Monomer. Oligomerizes to a heptameric ring, known as the apoptosome, upon binding of cytochrome c and dATP. Oligomeric Apaf-1 and pro-caspase-9 bind to each other via their respective NH2-terminal CARD domains and consecutively mature caspase-9 is released from the complex By similarity. Interacts with UACA. It may also interact with Bcl-XL. Interacts with APIP. Interacts (via CARD and NACHT domains) with NAIP/BIRC1 (via NACHT domain) By similarity.3 Publications

Protein-protein interaction databases

BioGridi198139. 1 interaction.
IntActiO88879. 1 interaction.
MINTiMINT-104429.

Structurei

Secondary structure

1
1249
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi109 – 1168
Helixi130 – 14112
Turni142 – 1454
Beta strandi148 – 1536
Helixi160 – 1678
Helixi171 – 1744
Turni175 – 1773
Beta strandi182 – 1865
Helixi192 – 20615
Turni207 – 2093
Helixi220 – 23011
Beta strandi232 – 2354
Beta strandi239 – 2446
Helixi248 – 2514
Beta strandi259 – 2668
Turni267 – 2726
Helixi288 – 29912
Helixi309 – 3168
Turni317 – 3193
Helixi321 – 33313
Beta strandi334 – 3363
Helixi338 – 3469
Helixi361 – 37313
Turni377 – 3793
Helixi380 – 3856
Helixi386 – 3883
Helixi397 – 4048
Helixi408 – 42013
Beta strandi425 – 43612
Helixi439 – 44810
Helixi450 – 4523
Helixi453 – 46513
Turni470 – 4723
Helixi480 – 49314
Helixi497 – 5048
Helixi507 – 51711
Helixi520 – 5289
Turni529 – 5324
Helixi540 – 55213
Turni553 – 5564
Beta strandi557 – 5593
Helixi563 – 5686
Helixi575 – 58511
Beta strandi589 – 5913
Helixi598 – 6003
Beta strandi608 – 6114
Beta strandi618 – 6236
Beta strandi627 – 6348
Beta strandi639 – 6435
Turni644 – 6463
Beta strandi649 – 6535
Beta strandi660 – 6656
Beta strandi669 – 6768
Beta strandi679 – 6857
Turni686 – 6883
Beta strandi691 – 6966
Beta strandi702 – 7076
Beta strandi709 – 7124
Beta strandi715 – 7206
Beta strandi725 – 7295
Beta strandi732 – 7398
Beta strandi746 – 7516
Beta strandi757 – 77115
Helixi772 – 7743
Beta strandi777 – 7826
Beta strandi810 – 8178
Beta strandi820 – 8256
Turni826 – 8283
Beta strandi831 – 8366
Beta strandi838 – 8414
Beta strandi845 – 8484
Beta strandi854 – 8585
Beta strandi860 – 8623
Beta strandi864 – 8685
Turni869 – 8724
Beta strandi873 – 8786
Beta strandi885 – 8906
Beta strandi894 – 9018
Beta strandi906 – 9105
Helixi911 – 9155
Beta strandi919 – 93113
Beta strandi934 – 95320
Beta strandi956 – 9594
Beta strandi964 – 9696
Beta strandi973 – 9808
Beta strandi986 – 9894
Turni990 – 9923
Beta strandi996 – 9983
Beta strandi1009 – 10113
Beta strandi1013 – 10164
Beta strandi1018 – 10214
Beta strandi1023 – 10308
Turni1032 – 10343
Beta strandi1047 – 10526
Beta strandi1054 – 107118
Turni1072 – 10754
Beta strandi1079 – 10824
Beta strandi1091 – 10933
Beta strandi1095 – 10995
Beta strandi1101 – 11033
Beta strandi1114 – 11185
Beta strandi1130 – 11356
Beta strandi1137 – 114610
Beta strandi1153 – 11597
Beta strandi1183 – 11864
Beta strandi1193 – 120311
Beta strandi1205 – 12073
Beta strandi1228 – 12303
Beta strandi1233 – 12364
Beta strandi1242 – 12454

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3SFZX-ray3.00A1-1249[»]
3SHFX-ray3.55A1-1249[»]
ProteinModelPortaliO88879.
SMRiO88879. Positions 1-586.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9090CARDAdd
BLAST
Domaini106 – 415310NB-ARCAdd
BLAST
Repeati613 – 65240WD 1-1Add
BLAST
Repeati655 – 69440WD 1-2Add
BLAST
Repeati697 – 73842WD 1-3Add
BLAST
Repeati741 – 78040WD 1-4Add
BLAST
Repeati796 – 83742WD 1-5Add
BLAST
Repeati838 – 87740WD 1-6Add
BLAST
Repeati880 – 91031WD 1-7Add
BLAST
Repeati922 – 95837WD 2-1Add
BLAST
Repeati959 – 99840WD 2-2Add
BLAST
Repeati1001 – 104040WD 2-3Add
BLAST
Repeati1042 – 108039WD 2-4Add
BLAST
Repeati1083 – 112240WD 2-5Add
BLAST
Repeati1125 – 116440WD 2-6Add
BLAST
Repeati1176 – 121338WD 2-7Add
BLAST
Repeati1214 – 124936WD 2-8Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni910 – 92112Interpropeller linkerAdd
BLAST

Domaini

The CARD domain mediates interaction with APIP.1 Publication
The monomeric form is autoinhibited in a closed conformation through a bound ADP at the nucleotide binding site. Exchange of ADP for ATP and binding of cytochrome c trigger a large conformational change where the first WD repeat region swings out, allowing the NB-ARC domain to rotate and expose the contact areas for oligomerization.1 Publication

Sequence similaritiesi

Contains 1 CARD domain.
Contains 1 NB-ARC domain.
Contains 15 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00750000117677.
HOVERGENiHBG018730.
InParanoidiA2RRK8.
KOiK02084.
OMAiETKKVCK.
OrthoDBiEOG7XWPMS.
PhylomeDBiO88879.
TreeFamiTF323866.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
2.130.10.10. 2 hits.
3.40.50.300. 1 hit.
InterProiIPR017251. Apoptotic_pept-activating_1.
IPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR000767. Disease_R.
IPR020472. G-protein_beta_WD-40_rep.
IPR002182. NB-ARC.
IPR027417. P-loop_NTPase.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00931. NB-ARC. 1 hit.
PF00400. WD40. 10 hits.
[Graphical view]
PIRSFiPIRSF037646. Apop_pept_activating-1. 1 hit.
PRINTSiPR00364. DISEASERSIST.
PR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 13 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF50978. SSF50978. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 9 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O88879-1) [UniParc]FASTAAdd to Basket

Also known as: Apaf-1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDAKARNCLL QHREALEKDI KTSYIMDHMI SNGVLSVIEE EKVKSQATQY     50
QRAAALIKMI LNKDNCAYIS FYNALLHEGY KDLAALLQSG LPLVSSSSGK 100
DTDGGITSFV RTVLCEGGVP QRPVIFVTRK KLVHAIQQKL WKLNGEPGWV 150
TIYGMAGCGK SVLAAEAVRD HSLLEGCFSG GVHWVSIGKQ DKSGLLMKLQ 200
NLCMRLDQEE SFSQRLPLNI EEAKDRLRVL MLRKHPRSLL ILDDVWDPWV 250
LKAFDNQCQI LLTTRDKSVT DSVMGPKHVV PVESGLGREK GLEILSLFVN 300
MKKEDLPAEA HSIIKECKGS PLVVSLIGAL LRDFPNRWAY YLRQLQNKQF 350
KRIRKSSSYD YEALDEAMSI SVEMLREDIK DYYTDLSILQ KDVKVPTKVL 400
CVLWDLETEE VEDILQEFVN KSLLFCNRNG KSFCYYLHDL QVDFLTEKNR 450
SQLQDLHRKM VTQFQRYYQP HTLSPDQEDC MYWYNFLAYH MASANMHKEL 500
CALMFSLDWI KAKTELVGPA HLIHEFVAYR HILDEKDCAV CENFQEFLSL 550
NGHLLGRQPF PNIVQLGLCE PETSEVYRQA KLQAKQEGDT GRLYLEWINK 600
KTIKNLSRLV VRPHTDAVYH ACFSQDGQRI ASCGADKTLQ VFKAETGEKL 650
LDIKAHEDEV LCCAFSSDDS YIATCSADKK VKIWDSATGK LVHTYDEHSE 700
QVNCCHFTNK SNHLLLATGS NDFFLKLWDL NQKECRNTMF GHTNSVNHCR 750
FSPDDELLAS CSADGTLRLW DVRSANERKS INVKRFFLSS EDPPEDVEVI 800
VKCCSWSADG DKIIVAAKNK VLLFDIHTSG LLAEIHTGHH STIQYCDFSP 850
YDHLAVIALS QYCVELWNID SRLKVADCRG HLSWVHGVMF SPDGSSFLTA 900
SDDQTIRVWE TKKVCKNSAI VLKQEIDVVF QENETMVLAV DNIRGLQLIA 950
GKTGQIDYLP EAQVSCCCLS PHLEYVAFGD EDGAIKIIEL PNNRVFSSGV 1000
GHKKAVRHIQ FTADGKTLIS SSEDSVIQVW NWQTGDYVFL QAHQETVKDF 1050
RLLQDSRLLS WSFDGTVKVW NVITGRIERD FTCHQGTVLS CAISSDATKF 1100
SSTSADKTAK IWSFDLLSPL HELKGHNGCV RCSAFSLDGI LLATGDDNGE 1150
IRIWNVSDGQ LLHSCAPISV EEGTATHGGW VTDVCFSPDS KTLVSAGGYL 1200
KWWNVATGDS SQTFYTNGTN LKKIHVSPDF RTYVTVDNLG ILYILQVLE 1249

Note: Major isoform.

Length:1,249
Mass (Da):141,003
Last modified:July 27, 2011 - v3
Checksum:iAA639E407F9ABC24
GO
Isoform 2 (identifier: O88879-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-110: GKDTDGGITSFV → A

Show »
Length:1,238
Mass (Da):139,896
Checksum:iCC9BE41A95B20ADF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei99 – 11012GKDTD…ITSFV → A in isoform 2. VSP_006763Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti209 – 2091E → D in AAC62458. 1 Publication
Sequence conflicti592 – 5921R → P in AAC62458. 1 Publication
Sequence conflicti710 – 7101K → S in AAC62458. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064071 mRNA. Translation: AAC62458.1.
BC131683 mRNA. Translation: AAI31684.1.
BC131684 mRNA. Translation: AAI31685.1.
CCDSiCCDS36030.1. [O88879-1]
CCDS70095.1. [O88879-2]
RefSeqiNP_001036023.1. NM_001042558.1. [O88879-1]
NP_033814.2. NM_009684.2. [O88879-1]
UniGeneiMm.220289.

Genome annotation databases

EnsembliENSMUST00000020157; ENSMUSP00000020157; ENSMUSG00000019979. [O88879-1]
ENSMUST00000159110; ENSMUSP00000125291; ENSMUSG00000019979. [O88879-1]
GeneIDi11783.
KEGGimmu:11783.
UCSCiuc007gtg.1. mouse. [O88879-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064071 mRNA. Translation: AAC62458.1 .
BC131683 mRNA. Translation: AAI31684.1 .
BC131684 mRNA. Translation: AAI31685.1 .
CCDSi CCDS36030.1. [O88879-1 ]
CCDS70095.1. [O88879-2 ]
RefSeqi NP_001036023.1. NM_001042558.1. [O88879-1 ]
NP_033814.2. NM_009684.2. [O88879-1 ]
UniGenei Mm.220289.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3SFZ X-ray 3.00 A 1-1249 [» ]
3SHF X-ray 3.55 A 1-1249 [» ]
ProteinModelPortali O88879.
SMRi O88879. Positions 1-586.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198139. 1 interaction.
IntActi O88879. 1 interaction.
MINTi MINT-104429.

PTM databases

PhosphoSitei O88879.

Proteomic databases

MaxQBi O88879.
PaxDbi O88879.
PRIDEi O88879.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020157 ; ENSMUSP00000020157 ; ENSMUSG00000019979 . [O88879-1 ]
ENSMUST00000159110 ; ENSMUSP00000125291 ; ENSMUSG00000019979 . [O88879-1 ]
GeneIDi 11783.
KEGGi mmu:11783.
UCSCi uc007gtg.1. mouse. [O88879-1 ]

Organism-specific databases

CTDi 317.
MGIi MGI:1306796. Apaf1.

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00750000117677.
HOVERGENi HBG018730.
InParanoidi A2RRK8.
KOi K02084.
OMAi ETKKVCK.
OrthoDBi EOG7XWPMS.
PhylomeDBi O88879.
TreeFami TF323866.

Enzyme and pathway databases

Reactomei REACT_206522. Formation of apoptosome.
REACT_225157. Activation of caspases through apoptosome-mediated cleavage.

Miscellaneous databases

ChiTaRSi APAF1. mouse.
NextBioi 279591.
PROi O88879.
SOURCEi Search...

Gene expression databases

ArrayExpressi O88879.
Bgeei O88879.
CleanExi MM_APAF1.
Genevestigatori O88879.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
2.130.10.10. 2 hits.
3.40.50.300. 1 hit.
InterProi IPR017251. Apoptotic_pept-activating_1.
IPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR000767. Disease_R.
IPR020472. G-protein_beta_WD-40_rep.
IPR002182. NB-ARC.
IPR027417. P-loop_NTPase.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
PF00931. NB-ARC. 1 hit.
PF00400. WD40. 10 hits.
[Graphical view ]
PIRSFi PIRSF037646. Apop_pept_activating-1. 1 hit.
PRINTSi PR00364. DISEASERSIST.
PR00320. GPROTEINBRPT.
SMARTi SM00320. WD40. 13 hits.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
SSF50978. SSF50978. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEi PS50209. CARD. 1 hit.
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 9 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development."
    Cecconi F., Alvarez-Bolado G., Meyer B.I., Roth K.A., Gruss P.
    Cell 94:727-737(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: Swiss Webster / NIH.
    Tissue: Embryo.
  2. "A comparison of the expression and properties of Apaf-1 and Apaf-1L."
    Walke D.W., Morgan J.I.
    Brain Res. 886:73-81(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Spleen.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein."
    Cho D.-H., Hong Y.-M., Lee H.-J., Woo H.-N., Pyo J.-O., Mak T.W., Jung Y.-K.
    J. Biol. Chem. 279:39942-39950(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH APIP, DOMAIN.
  5. "Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of stress-induced apoptosis."
    Sakai T., Liu L., Teng X., Mukai-Sakai R., Shimada H., Kaji R., Mitani T., Matsumoto M., Toida K., Ishimura K., Shishido Y., Mak T.W., Fukui K.
    J. Biol. Chem. 279:41131-41140(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH UACA.
  6. "Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis."
    Reubold T.F., Wohlgemuth S., Eschenburg S.
    Structure 19:1074-1083(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS), WD REPEATS, SUBUNIT, MUTAGENESIS OF ARG-265.

Entry informationi

Entry nameiAPAF_MOUSE
AccessioniPrimary (citable) accession number: O88879
Secondary accession number(s): A2RRK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Physiological concentrations of calcium ions negatively affect the assembly of apoptosome by inhibiting nucleotide exchange in the monomeric form By similarity.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi