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O88876

- DHRS3_MOUSE

UniProt

O88876 - DHRS3_MOUSE

Protein

Short-chain dehydrogenase/reductase 3

Gene

Dhrs3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (10 May 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.By similarity

    Catalytic activityi

    All-trans-retinol + NADP+ = all-trans-retinal + NADPH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei175 – 1751SubstrateBy similarity
    Active sitei188 – 1881Proton acceptorBy similarity

    GO - Molecular functioni

    1. NADP-retinol dehydrogenase activity Source: UniProtKB-EC
    2. retinol dehydrogenase activity Source: MGI

    GO - Biological processi

    1. bone morphogenesis Source: MGI
    2. cardiac septum morphogenesis Source: MGI
    3. negative regulation of retinoic acid receptor signaling pathway Source: MGI
    4. outflow tract morphogenesis Source: MGI
    5. palate development Source: MGI
    6. regulation of ossification Source: MGI
    7. retinoid metabolic process Source: MGI

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    ReactomeiREACT_196617. The retinoid cycle in cones (daylight vision).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Short-chain dehydrogenase/reductase 3 (EC:1.1.1.300)
    Alternative name(s):
    Retinal short-chain dehydrogenase/reductase 1
    Short name:
    retSDR1
    Gene namesi
    Name:Dhrs3
    Synonyms:Rsdr1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1315215. Dhrs3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 302302Short-chain dehydrogenase/reductase 3PRO_0000054645Add
    BLAST

    Proteomic databases

    PaxDbiO88876.
    PRIDEiO88876.

    PTM databases

    PhosphoSiteiO88876.

    Expressioni

    Tissue specificityi

    In the embryo, expressed in developing osteogenic and chondrogenic tissues of vertebra, rib, tooth and limb bud.1 Publication

    Gene expression databases

    ArrayExpressiO88876.
    BgeeiO88876.
    CleanExiMM_DHRS3.
    GenevestigatoriO88876.

    Structurei

    3D structure databases

    ProteinModelPortaliO88876.
    SMRiO88876. Positions 34-290.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei170 – 19021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei195 – 21521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei258 – 27821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1028.
    GeneTreeiENSGT00540000069900.
    HOVERGENiHBG051352.
    InParanoidiO88876.
    KOiK11146.
    OMAiWTMHALI.
    OrthoDBiEOG7Z3F50.
    PhylomeDBiO88876.
    TreeFamiTF312837.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O88876-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVWKWLGALV VFPLQMIYLV TKAAVGMVLP PKLRDLSRES VLITGGGRGI    50
    GRHLAREFAE RGARKIVLWG RTEKCLKETT EEIRQMGTEC HYFICDVGNR 100
    EEVYQMAKAV REKVGDITIL VNNAAVVHGK SLMDSDDDAL LKSQHVNTLG 150
    QFWTTKAFLP RMLELQNGHI VCLNSVLALS AIPGAIDYCT SKASAFAFME 200
    SLTLGLLDCP GVSATTVLPF HTSTEMFQGM RVRFPNLFPP LKPETVARRT 250
    VDAVQQNQAL LLLPWTMNIL IILKSILPQA ALEEIHRFSG TYTCMNTFKG 300
    RT 302
    Length:302
    Mass (Da):33,652
    Last modified:May 10, 2004 - v2
    Checksum:iE530F36877C3C610
    GO
    Isoform 2 (identifier: O88876-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-26: Missing.
         114-153: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:236
    Mass (Da):26,431
    Checksum:i49DD2E6FC940669A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti68 – 681L → F in AAH10972. (PubMed:15489334)Curated
    Sequence conflicti234 – 2341F → L(PubMed:9705317)Curated
    Sequence conflicti234 – 2341F → L1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2626Missing in isoform 2. 1 PublicationVSP_050734Add
    BLAST
    Alternative sequencei114 – 15340Missing in isoform 2. 1 PublicationVSP_050735Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF061743 mRNA. Translation: AAC63265.1.
    X95281 mRNA. Translation: CAA64602.1.
    AF179241
    , AF179238, AF179239, AF179240 Genomic DNA. Translation: AAD55403.1.
    AK032958 mRNA. Translation: BAC28098.1.
    AK151419 mRNA. Translation: BAE30384.1.
    BC008980 mRNA. Translation: AAH08980.1.
    BC010972 mRNA. Translation: AAH10972.1.
    BC013540 mRNA. Translation: AAH13540.1.
    CCDSiCCDS18912.1. [O88876-1]
    RefSeqiNP_001165895.1. NM_001172424.1.
    NP_035433.1. NM_011303.6. [O88876-1]
    UniGeneiMm.14063.

    Genome annotation databases

    EnsembliENSMUST00000105744; ENSMUSP00000101370; ENSMUSG00000066026. [O88876-2]
    ENSMUST00000154208; ENSMUSP00000122552; ENSMUSG00000066026. [O88876-1]
    GeneIDi20148.
    KEGGimmu:20148.
    UCSCiuc008vrn.2. mouse. [O88876-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF061743 mRNA. Translation: AAC63265.1 .
    X95281 mRNA. Translation: CAA64602.1 .
    AF179241
    , AF179238 , AF179239 , AF179240 Genomic DNA. Translation: AAD55403.1 .
    AK032958 mRNA. Translation: BAC28098.1 .
    AK151419 mRNA. Translation: BAE30384.1 .
    BC008980 mRNA. Translation: AAH08980.1 .
    BC010972 mRNA. Translation: AAH10972.1 .
    BC013540 mRNA. Translation: AAH13540.1 .
    CCDSi CCDS18912.1. [O88876-1 ]
    RefSeqi NP_001165895.1. NM_001172424.1.
    NP_035433.1. NM_011303.6. [O88876-1 ]
    UniGenei Mm.14063.

    3D structure databases

    ProteinModelPortali O88876.
    SMRi O88876. Positions 34-290.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O88876.

    Proteomic databases

    PaxDbi O88876.
    PRIDEi O88876.

    Protocols and materials databases

    DNASUi 20148.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000105744 ; ENSMUSP00000101370 ; ENSMUSG00000066026 . [O88876-2 ]
    ENSMUST00000154208 ; ENSMUSP00000122552 ; ENSMUSG00000066026 . [O88876-1 ]
    GeneIDi 20148.
    KEGGi mmu:20148.
    UCSCi uc008vrn.2. mouse. [O88876-1 ]

    Organism-specific databases

    CTDi 9249.
    MGIi MGI:1315215. Dhrs3.

    Phylogenomic databases

    eggNOGi COG1028.
    GeneTreei ENSGT00540000069900.
    HOVERGENi HBG051352.
    InParanoidi O88876.
    KOi K11146.
    OMAi WTMHALI.
    OrthoDBi EOG7Z3F50.
    PhylomeDBi O88876.
    TreeFami TF312837.

    Enzyme and pathway databases

    Reactomei REACT_196617. The retinoid cycle in cones (daylight vision).

    Miscellaneous databases

    NextBioi 297657.
    PROi O88876.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O88876.
    Bgeei O88876.
    CleanExi MM_DHRS3.
    Genevestigatori O88876.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000126. 11-beta-HSD1. 1 hit.
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal."
      Haeseleer F., Huang J., Lebioda L., Saari J.C., Palczewski K.
      J. Biol. Chem. 273:21790-21799(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Retina.
    2. "Bmp-2 downstream targets in mesenchymal development identified by subtractive cloning from recombinant mesenchymal progenitors (C3H10T1/2)."
      Baechner D., Ahrens M., Schroeder D., Hoffmann A., Lauber J., Betat N., Steinert P., Flohe L., Gross G.
      Dev. Dyn. 213:398-411(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Mesenchymal cell.
    3. "Structure of retinal short-chain dehydrogenase/reductase retSDR1 gene."
      Haeseleer F., Palczewski K.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
      Tissue: Retina.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Bone marrow and Mesonephros.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Colon, Kidney and Mammary gland.

    Entry informationi

    Entry nameiDHRS3_MOUSE
    AccessioniPrimary (citable) accession number: O88876
    Secondary accession number(s): Q3UAD1
    , Q91WR0, Q91XC3, Q922A6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3