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Protein

Short-chain dehydrogenase/reductase 3

Gene

Dhrs3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.By similarity

Catalytic activityi

All-trans-retinol + NADP+ = all-trans-retinal + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei175SubstrateBy similarity1
Active sitei188Proton acceptorBy similarity1

GO - Molecular functioni

  • NADP-retinol dehydrogenase activity Source: UniProtKB-EC
  • retinol dehydrogenase activity Source: MGI

GO - Biological processi

  • bone morphogenesis Source: MGI
  • cardiac septum morphogenesis Source: MGI
  • negative regulation of retinoic acid receptor signaling pathway Source: MGI
  • outflow tract morphogenesis Source: MGI
  • regulation of ossification Source: MGI
  • retinoid metabolic process Source: MGI
  • roof of mouth development Source: MGI

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

ReactomeiR-MMU-2187335 The retinoid cycle in cones (daylight vision)
R-MMU-5365859 RA biosynthesis pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Short-chain dehydrogenase/reductase 3 (EC:1.1.1.300)
Alternative name(s):
Retinal short-chain dehydrogenase/reductase 1
Short name:
retSDR1
Gene namesi
Name:Dhrs3
Synonyms:Rsdr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1315215 Dhrs3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546451 – 302Short-chain dehydrogenase/reductase 3Add BLAST302

Proteomic databases

MaxQBiO88876
PaxDbiO88876
PRIDEiO88876

PTM databases

iPTMnetiO88876
PhosphoSitePlusiO88876

Expressioni

Tissue specificityi

In the embryo, expressed in developing osteogenic and chondrogenic tissues of vertebra, rib, tooth and limb bud.1 Publication

Gene expression databases

BgeeiENSMUSG00000066026
CleanExiMM_DHRS3
ExpressionAtlasiO88876 baseline and differential
GenevisibleiO88876 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000122552

Structurei

3D structure databases

ProteinModelPortaliO88876
SMRiO88876
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1201 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00910000143991
HOVERGENiHBG051352
InParanoidiO88876
KOiK11146
OMAiWTMHALI
OrthoDBiEOG091G0825
PhylomeDBiO88876
TreeFamiTF312837

Family and domain databases

InterProiView protein in InterPro
IPR032969 DHRS3
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PANTHERiPTHR24322:SF483 PTHR24322:SF483, 1 hit
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O88876-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVWKWLGALV VFPLQMIYLV TKAAVGMVLP PKLRDLSRES VLITGGGRGI
60 70 80 90 100
GRHLAREFAE RGARKIVLWG RTEKCLKETT EEIRQMGTEC HYFICDVGNR
110 120 130 140 150
EEVYQMAKAV REKVGDITIL VNNAAVVHGK SLMDSDDDAL LKSQHVNTLG
160 170 180 190 200
QFWTTKAFLP RMLELQNGHI VCLNSVLALS AIPGAIDYCT SKASAFAFME
210 220 230 240 250
SLTLGLLDCP GVSATTVLPF HTSTEMFQGM RVRFPNLFPP LKPETVARRT
260 270 280 290 300
VDAVQQNQAL LLLPWTMNIL IILKSILPQA ALEEIHRFSG TYTCMNTFKG

RT
Length:302
Mass (Da):33,652
Last modified:May 10, 2004 - v2
Checksum:iE530F36877C3C610
GO
Isoform 2 (identifier: O88876-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.
     114-153: Missing.

Note: No experimental confirmation available.
Show »
Length:236
Mass (Da):26,431
Checksum:i49DD2E6FC940669A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68L → F in AAH10972 (PubMed:15489334).Curated1
Sequence conflicti234F → L (PubMed:9705317).Curated1
Sequence conflicti234F → L (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0507341 – 26Missing in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_050735114 – 153Missing in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF061743 mRNA Translation: AAC63265.1
X95281 mRNA Translation: CAA64602.1
AF179241
, AF179238, AF179239, AF179240 Genomic DNA Translation: AAD55403.1
AK032958 mRNA Translation: BAC28098.1
AK151419 mRNA Translation: BAE30384.1
BC008980 mRNA Translation: AAH08980.1
BC010972 mRNA Translation: AAH10972.1
BC013540 mRNA Translation: AAH13540.1
CCDSiCCDS18912.1 [O88876-1]
RefSeqiNP_035433.1, NM_011303.6 [O88876-1]
UniGeneiMm.14063
Mm.181278

Genome annotation databases

EnsembliENSMUST00000105744; ENSMUSP00000101370; ENSMUSG00000066026 [O88876-2]
ENSMUST00000154208; ENSMUSP00000122552; ENSMUSG00000066026 [O88876-1]
GeneIDi20148
KEGGimmu:20148
UCSCiuc008vrm.2 mouse [O88876-2]
uc008vrn.2 mouse [O88876-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDHRS3_MOUSE
AccessioniPrimary (citable) accession number: O88876
Secondary accession number(s): Q3UAD1
, Q91WR0, Q91XC3, Q922A6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: May 23, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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