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O88870

- BEST1_MOUSE

UniProt

O88870 - BEST1_MOUSE

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Protein
Bestrophin-1
Gene
Best1, Bmd1, Vmd2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Forms calcium-sensitive chloride channels. Permeable to bicarbonate By similarity.

GO - Molecular functioni

  1. chloride channel activity Source: UniProtKB-KW

GO - Biological processi

  1. detection of light stimulus involved in visual perception Source: MGI
  2. regulation of calcium ion transport Source: MGI
  3. transepithelial chloride transport Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium, Chloride

Enzyme and pathway databases

ReactomeiREACT_196640. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Bestrophin-1
Alternative name(s):
Vitelliform macular dystrophy protein 2 homolog
Gene namesi
Name:Best1
Synonyms:Bmd1, Vmd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1346332. Best1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei26 – 4621Helical; Reviewed prediction
Add
BLAST
Topological domaini47 – 7024Extracellular Reviewed prediction
Add
BLAST
Transmembranei71 – 9121Helical; Reviewed prediction
Add
BLAST
Topological domaini92 – 17887Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei179 – 19921Helical; Reviewed prediction
Add
BLAST
Topological domaini200 – 22829Extracellular Reviewed prediction
Add
BLAST
Intramembranei229 – 24921 Reviewed prediction
Add
BLAST
Topological domaini250 – 27021Extracellular Reviewed prediction
Add
BLAST
Transmembranei271 – 29121Helical; Reviewed prediction
Add
BLAST
Topological domaini292 – 551260Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB
  2. chloride channel complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Bestrophin-1
PRO_0000143116Add
BLAST

Post-translational modificationi

Phosphorylated by PP2A By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiO88870.

PTM databases

PhosphoSiteiO88870.

Expressioni

Gene expression databases

BgeeiO88870.
CleanExiMM_BEST1.
GenevestigatoriO88870.

Interactioni

Subunit structurei

Tetramer or pentamers. May interact with PPP2CB and PPP2R1B By similarity.

Structurei

3D structure databases

ProteinModelPortaliO88870.

Family & Domainsi

Sequence similaritiesi

Belongs to the bestrophin family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG315004.
GeneTreeiENSGT00390000002997.
HOGENOMiHOG000115678.
HOVERGENiHBG044928.
InParanoidiB2RSY6.
KOiK13878.
OMAiRSGYHSA.
OrthoDBiEOG7N0C43.
TreeFamiTF315803.

Family and domain databases

InterProiIPR000615. Bestrophin.
IPR021134. Bestrophin/UPF0187.
[Graphical view]
PANTHERiPTHR10736. PTHR10736. 1 hit.
PfamiPF01062. Bestrophin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88870-1 [UniParc]FASTAAdd to Basket

« Hide

MTITYTNKVA NARLGSFSSL LLCWRGSIYK LLYGEFLVFI FLYYSIRGLY    50
RMVLSSDQQL LFEKLALYCD SYIQLIPISF VLGFYVTLVV SRWWSQYENL 100
PWPDRLMIQV SSFVEGKDEE GRLLRRTLIR YAILGQVLIL RSISTSVYKR 150
FPTLHHLVLA GFMTHGEHKQ LQKLGLPHNT FWVPWVWFAN LSMKAYLGGR 200
IRDTVLLQSL MNEVCTLRTQ CGQLYAYDWI SIPLVYTQVV TVAVYSFFLA 250
CLIGRQFLNP NKDYPGHEMD LVVPVFTILQ FLFYMGWLKV AEQLINPFGE 300
DDDDFETNWI IDRNLQVSLL SVDGMHQNLP PMERDMYWNE AAPQPPYTAA 350
SARSRRHSFM GSTFNISLKK EDLELWSKEE ADTDKKESGY SSTIGCFLGL 400
QPKNYHLPLK DLKTKLLCSK NPLLEGQCKD ANQKNQKDVW KFKGLDFLKC 450
VPRFKRRGSH CGPQAPSSHP TEQSAPSSSD TGDGPSTDYQ EICHMKKKTV 500
EFNLNIPESP TEHLQQRRLD QMSTNIQALM KEHAESYPYR DEAGTKPVLY 550
E 551
Length:551
Mass (Da):63,684
Last modified:July 27, 2011 - v3
Checksum:i0898D6DE08FEEFB9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti255 – 2551R → K in AAS09922. 1 Publication
Sequence conflicti255 – 2551R → K in AAC64345. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY450427 mRNA. Translation: AAS09922.1.
BC139060 mRNA. Translation: AAI39061.1.
BC139061 mRNA. Translation: AAI39062.1.
AF057171 mRNA. Translation: AAC64345.1.
CCDSiCCDS29568.1.
RefSeqiNP_036043.2. NM_011913.2.
UniGeneiMm.31577.

Genome annotation databases

EnsembliENSMUST00000117346; ENSMUSP00000113053; ENSMUSG00000037418.
GeneIDi24115.
KEGGimmu:24115.
UCSCiuc008gou.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY450427 mRNA. Translation: AAS09922.1 .
BC139060 mRNA. Translation: AAI39061.1 .
BC139061 mRNA. Translation: AAI39062.1 .
AF057171 mRNA. Translation: AAC64345.1 .
CCDSi CCDS29568.1.
RefSeqi NP_036043.2. NM_011913.2.
UniGenei Mm.31577.

3D structure databases

ProteinModelPortali O88870.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O88870.

Proteomic databases

PRIDEi O88870.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000117346 ; ENSMUSP00000113053 ; ENSMUSG00000037418 .
GeneIDi 24115.
KEGGi mmu:24115.
UCSCi uc008gou.2. mouse.

Organism-specific databases

CTDi 7439.
MGIi MGI:1346332. Best1.

Phylogenomic databases

eggNOGi NOG315004.
GeneTreei ENSGT00390000002997.
HOGENOMi HOG000115678.
HOVERGENi HBG044928.
InParanoidi B2RSY6.
KOi K13878.
OMAi RSGYHSA.
OrthoDBi EOG7N0C43.
TreeFami TF315803.

Enzyme and pathway databases

Reactomei REACT_196640. Stimuli-sensing channels.

Miscellaneous databases

NextBioi 304147.
PROi O88870.
SOURCEi Search...

Gene expression databases

Bgeei O88870.
CleanExi MM_BEST1.
Genevestigatori O88870.

Family and domain databases

InterProi IPR000615. Bestrophin.
IPR021134. Bestrophin/UPF0187.
[Graphical view ]
PANTHERi PTHR10736. PTHR10736. 1 hit.
Pfami PF01062. Bestrophin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the murine Vmd2 RFP-TM gene family."
    Kraemer F., Stoehr H., Weber B.H.F.
    Cytogenet. Genome Res. 105:107-114(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 178-258.

Entry informationi

Entry nameiBEST1_MOUSE
AccessioniPrimary (citable) accession number: O88870
Secondary accession number(s): B2RSY6, Q6H1V0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi