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O88869 (RASF9_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ras association domain-containing protein 9
Alternative name(s):
PAM COOH-terminal interactor protein 1
Short name=P-CIP1
Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor
Gene names
Name:Rassf9
Synonyms:Pamci, Pcip1
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in regulating vesicuar trafficking in cells. Ref.1

Subunit structure

Interacts with PAM. Ref.1

Subcellular location

Endosome. Note: Accumulates on perinuclear endosomes. Ref.1

Tissue specificity

Testis, kidney, skeletal muscle, liver, lung, brain, heart, pituitary gland, adrenal gland and ovary. Ref.1

Sequence similarities

Contains 1 Ras-associating domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PamP149253EBI-1395057,EBI-1395008

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 435435Ras association domain-containing protein 9
PRO_0000299454

Regions

Domain25 – 11995Ras-associating
Coiled coil195 – 29197 Potential

Sequences

Sequence LengthMass (Da)Tools
O88869 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 582AF0C52176E9B1

FASTA43549,545
        10         20         30         40         50         60 
MAPFGRNLLK TRHKNRSPTK DMDPEEKEIV VWVCQEEKIV CGLTKRTTSI DVIQALLEEH 

        70         80         90        100        110        120 
EATFGEKRFL LGKASDYCIV EKWRGSERAL PPLTRILKLW KAWGDEQPNM QFVLVKTDAF 

       130        140        150        160        170        180 
LPVPLWRTAE TKLVQNNEKP WELSPANYMK TLPPDKQKRI VRKTFRKLAK IRQDTGSHDR 

       190        200        210        220        230        240 
DNMECLVHLI ISQDHTIHQQ VQRMKELDME IEKCEAKIHL DRIGNDGADY VQEAYLMPRS 

       250        260        270        280        290        300 
SEEEQKLDFQ SEDNQTLEDL NDGEGVSQLE EQLQYYRALI DKLSAEIERE VKGAGTDGSE 

       310        320        330        340        350        360 
DMEGAAACEL ENSDLESVKC DLEKSMKAGL KIHSHLSGIQ REIKYSDSLL QMKAREYELL 

       370        380        390        400        410        420 
AKEFSSLHIS SKDGCQGKEN RGKEAEASSS NGEIPPLTQR VFNTYTNDTD SDTGISSNHS 

       430 
QDSETTLGDV LLLAT 

« Hide

References

[1]"P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes."
Chen L., Johnson R.C., Milgram S.L.
J. Biol. Chem. 273:33524-33532(1998) [PubMed: 9837933] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH PAM, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: Sprague-Dawley.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF056208 mRNA. Translation: AAD03249.1.
IPIIPI00213427.
RefSeqNP_075248.1. NM_022959.1.
UniGeneRn.30013.

3D structure databases

HSSPHSSP built from PDB template 2CS4 based on UniProtKB Q8NHQ8.
ProteinModelPortalO88869.
ModBaseSearch...

Protein-protein interaction databases

IntActO88869. 1 interaction.
STRINGO88869.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID65053.
KEGGrno:65053.
UCSCNM_022959. rat.

Organism-specific databases

CTD9182.
RGD621329. Rassf9.

Phylogenomic databases

eggNOGmaNOG07529.
GeneTreeENSGT00510000047164.
HOVERGENHBG053178.
InParanoidO88869.
OrthoDBEOG4T4CVG.

Gene expression databases

ArrayExpressO88869.
GenevestigatorO88869.

Family and domain databases

InterProIPR000159. Ras-assoc.
[Graphical view]
SMARTSM00314. RA. 1 hit.
[Graphical view]
PROSITEPS50200. RA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio613907.

Entry information

Entry nameRASF9_RAT
AccessionPrimary (citable) accession number: O88869
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 1, 1998
Last modified: September 21, 2011
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families