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Protein

Hormonally up-regulated neu tumor-associated kinase

Gene

Hunk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91ATPPROSITE-ProRule annotation1
Active sitei186Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 76ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: MGI
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • protein phosphorylation Source: MGI

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 3474

Names & Taxonomyi

Protein namesi
Recommended name:
Hormonally up-regulated neu tumor-associated kinase (EC:2.7.11.1)
Alternative name(s):
Serine/threonine-protein kinase MAK-V
Gene namesi
Name:Hunk
Synonyms:Makv
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1347352 Hunk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000860051 – 714Hormonally up-regulated neu tumor-associated kinaseAdd BLAST714

Proteomic databases

MaxQBiO88866
PaxDbiO88866
PRIDEiO88866

PTM databases

iPTMnetiO88866
PhosphoSitePlusiO88866

Expressioni

Gene expression databases

BgeeiENSMUSG00000053414
CleanExiMM_HUNK
GenevisibleiO88866 MM

Interactioni

Protein-protein interaction databases

BioGridi205017, 1 interactor
STRINGi10090.ENSMUSP00000068007

Structurei

3D structure databases

ProteinModelPortaliO88866
SMRiO88866
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 320Protein kinasePROSITE-ProRule annotationAdd BLAST259

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00900000140868
HOGENOMiHOG000112978
HOVERGENiHBG006086
InParanoidiO88866
KOiK08797
OMAiDKNLPSH
OrthoDBiEOG091G0I19
PhylomeDBiO88866
TreeFamiTF352373

Family and domain databases

CDDicd14070 STKc_HUNK, 1 hit
InterProiView protein in InterPro
IPR034671 Hunk
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

O88866-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAAAGDGLL GEPAAPGGDG GAEDTTRPAA ACEGSFLPAW VSGVSRERLR
60 70 80 90 100
DFQHHKRVGN YLIGSRKLGE GSFAKVREGL HVLTGEKVAI KVIDKKRAKK
110 120 130 140 150
DTYVTKNLRR EGQIQQMIRH PNITQLLDIL ETENSYYLVM ELCPGGNLMH
160 170 180 190 200
KIYEKKRLDE AEARRYIRQL ISAVEHLHRA GVVHRDLKIE NLLLDEDNNI
210 220 230 240 250
KLIDFGLSNC AGILGYSDPF STQCGSPAYA APELLARKKY GPKIDVWSIG
260 270 280 290 300
VNMYAMLTGT LPFTVEPFSL RALYQKMVDK AMNPLPTQLS TGAVNFLRSL
310 320 330 340 350
LEPDPVKRPN IQQALANRWL NENYTGKVPC NVTYPNRISL EDLSPSVVLH
360 370 380 390 400
MTEKLGYKNS DVINTVLSNR ACHILAIYFL LNKKLERYLS GKSDIQDSIC
410 420 430 440 450
YKTQLYQIEK CRATKEPYEA SLDTWTRDFE FHAVQDKKPK EQEKRGDFLH
460 470 480 490 500
RPFSKKLDKN LPSHKQPSPS LITQLQSTKA LLKDRKASKS GFPDKDSFVC
510 520 530 540 550
RNLFRKTSDS NCVASSSMEF IPVPPPRTPR IVKKLEPHQP GPGSASILPK
560 570 580 590 600
EEPLLLDMVR SFESVDREDH IELLSPSHHY RILSSPVSLA RRNSSERTLS
610 620 630 640 650
QGLLSGSTSP LQTPLHSTLV SFAHEEKNSP PKEEGVCSPP PVPSNGLLQP
660 670 680 690 700
LGSPNCVKSR GRFPMMGIGQ MLRKRHQSLQ PSSERSLDAS MSPLQPTAPS
710
SLSFDMADGV KGQC
Length:714
Mass (Da):79,603
Last modified:November 1, 1998 - v1
Checksum:iD35A53E7A8D9BD1F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti697T → I in AAF35282 (PubMed:10662544).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055919 mRNA Translation: AAC61489.1
AF167987 mRNA Translation: AAF35282.1
CCDSiCCDS28315.1
RefSeqiNP_056570.1, NM_015755.2
UniGeneiMm.125874

Genome annotation databases

EnsembliENSMUST00000065856; ENSMUSP00000068007; ENSMUSG00000053414
GeneIDi26559
KEGGimmu:26559
UCSCiuc007zwi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHUNK_MOUSE
AccessioniPrimary (citable) accession number: O88866
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health