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Protein

Hormonally up-regulated neu tumor-associated kinase

Gene

Hunk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei91 – 911ATPPROSITE-ProRule annotation
Active sitei186 – 1861Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 769ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: MGI
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • protein phosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Hormonally up-regulated neu tumor-associated kinase (EC:2.7.11.1)
Alternative name(s):
Serine/threonine-protein kinase MAK-V
Gene namesi
Name:Hunk
Synonyms:Makv
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1347352. Hunk.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 714714Hormonally up-regulated neu tumor-associated kinasePRO_0000086005Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki483 – 483Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiO88866.
PaxDbiO88866.
PRIDEiO88866.

PTM databases

iPTMnetiO88866.
PhosphoSiteiO88866.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053414.
CleanExiMM_HUNK.
GenevisibleiO88866. MM.

Interactioni

Protein-protein interaction databases

BioGridi205017. 1 interaction.
STRINGi10090.ENSMUSP00000068007.

Structurei

3D structure databases

ProteinModelPortaliO88866.
SMRiO88866. Positions 8-383.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini62 – 320259Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00840000129789.
HOGENOMiHOG000112978.
HOVERGENiHBG006086.
InParanoidiO88866.
KOiK08797.
OMAiPNRIHLE.
OrthoDBiEOG091G0I19.
PhylomeDBiO88866.
TreeFamiTF352373.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88866-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAAAGDGLL GEPAAPGGDG GAEDTTRPAA ACEGSFLPAW VSGVSRERLR
60 70 80 90 100
DFQHHKRVGN YLIGSRKLGE GSFAKVREGL HVLTGEKVAI KVIDKKRAKK
110 120 130 140 150
DTYVTKNLRR EGQIQQMIRH PNITQLLDIL ETENSYYLVM ELCPGGNLMH
160 170 180 190 200
KIYEKKRLDE AEARRYIRQL ISAVEHLHRA GVVHRDLKIE NLLLDEDNNI
210 220 230 240 250
KLIDFGLSNC AGILGYSDPF STQCGSPAYA APELLARKKY GPKIDVWSIG
260 270 280 290 300
VNMYAMLTGT LPFTVEPFSL RALYQKMVDK AMNPLPTQLS TGAVNFLRSL
310 320 330 340 350
LEPDPVKRPN IQQALANRWL NENYTGKVPC NVTYPNRISL EDLSPSVVLH
360 370 380 390 400
MTEKLGYKNS DVINTVLSNR ACHILAIYFL LNKKLERYLS GKSDIQDSIC
410 420 430 440 450
YKTQLYQIEK CRATKEPYEA SLDTWTRDFE FHAVQDKKPK EQEKRGDFLH
460 470 480 490 500
RPFSKKLDKN LPSHKQPSPS LITQLQSTKA LLKDRKASKS GFPDKDSFVC
510 520 530 540 550
RNLFRKTSDS NCVASSSMEF IPVPPPRTPR IVKKLEPHQP GPGSASILPK
560 570 580 590 600
EEPLLLDMVR SFESVDREDH IELLSPSHHY RILSSPVSLA RRNSSERTLS
610 620 630 640 650
QGLLSGSTSP LQTPLHSTLV SFAHEEKNSP PKEEGVCSPP PVPSNGLLQP
660 670 680 690 700
LGSPNCVKSR GRFPMMGIGQ MLRKRHQSLQ PSSERSLDAS MSPLQPTAPS
710
SLSFDMADGV KGQC
Length:714
Mass (Da):79,603
Last modified:November 1, 1998 - v1
Checksum:iD35A53E7A8D9BD1F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti697 – 6971T → I in AAF35282 (PubMed:10662544).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055919 mRNA. Translation: AAC61489.1.
AF167987 mRNA. Translation: AAF35282.1.
CCDSiCCDS28315.1.
RefSeqiNP_056570.1. NM_015755.2.
UniGeneiMm.125874.

Genome annotation databases

EnsembliENSMUST00000065856; ENSMUSP00000068007; ENSMUSG00000053414.
GeneIDi26559.
KEGGimmu:26559.
UCSCiuc007zwi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055919 mRNA. Translation: AAC61489.1.
AF167987 mRNA. Translation: AAF35282.1.
CCDSiCCDS28315.1.
RefSeqiNP_056570.1. NM_015755.2.
UniGeneiMm.125874.

3D structure databases

ProteinModelPortaliO88866.
SMRiO88866. Positions 8-383.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205017. 1 interaction.
STRINGi10090.ENSMUSP00000068007.

PTM databases

iPTMnetiO88866.
PhosphoSiteiO88866.

Proteomic databases

MaxQBiO88866.
PaxDbiO88866.
PRIDEiO88866.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065856; ENSMUSP00000068007; ENSMUSG00000053414.
GeneIDi26559.
KEGGimmu:26559.
UCSCiuc007zwi.1. mouse.

Organism-specific databases

CTDi30811.
MGIiMGI:1347352. Hunk.

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00840000129789.
HOGENOMiHOG000112978.
HOVERGENiHBG006086.
InParanoidiO88866.
KOiK08797.
OMAiPNRIHLE.
OrthoDBiEOG091G0I19.
PhylomeDBiO88866.
TreeFamiTF352373.

Enzyme and pathway databases

BRENDAi2.7.11.1. 3474.

Miscellaneous databases

PROiO88866.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053414.
CleanExiMM_HUNK.
GenevisibleiO88866. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHUNK_MOUSE
AccessioniPrimary (citable) accession number: O88866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.