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Protein

Hormonally up-regulated neu tumor-associated kinase

Gene

Hunk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei91ATPPROSITE-ProRule annotation1
Active sitei186Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 76ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: MGI
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • intracellular signal transduction Source: GO_Central
  • protein phosphorylation Source: MGI

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Hormonally up-regulated neu tumor-associated kinase (EC:2.7.11.1)
Alternative name(s):
Serine/threonine-protein kinase MAK-V
Gene namesi
Name:Hunk
Synonyms:Makv
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1347352. Hunk.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000860051 – 714Hormonally up-regulated neu tumor-associated kinaseAdd BLAST714

Proteomic databases

MaxQBiO88866.
PaxDbiO88866.
PRIDEiO88866.

PTM databases

iPTMnetiO88866.
PhosphoSitePlusiO88866.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053414.
CleanExiMM_HUNK.
GenevisibleiO88866. MM.

Interactioni

Protein-protein interaction databases

BioGridi205017. 1 interactor.
STRINGi10090.ENSMUSP00000068007.

Structurei

3D structure databases

ProteinModelPortaliO88866.
SMRiO88866.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 320Protein kinasePROSITE-ProRule annotationAdd BLAST259

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00880000137920.
HOGENOMiHOG000112978.
HOVERGENiHBG006086.
InParanoidiO88866.
KOiK08797.
OMAiEFHAVQD.
OrthoDBiEOG091G0I19.
PhylomeDBiO88866.
TreeFamiTF352373.

Family and domain databases

CDDicd14070. STKc_HUNK. 1 hit.
InterProiView protein in InterPro
IPR034671. Hunk.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

O88866-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAAAGDGLL GEPAAPGGDG GAEDTTRPAA ACEGSFLPAW VSGVSRERLR
60 70 80 90 100
DFQHHKRVGN YLIGSRKLGE GSFAKVREGL HVLTGEKVAI KVIDKKRAKK
110 120 130 140 150
DTYVTKNLRR EGQIQQMIRH PNITQLLDIL ETENSYYLVM ELCPGGNLMH
160 170 180 190 200
KIYEKKRLDE AEARRYIRQL ISAVEHLHRA GVVHRDLKIE NLLLDEDNNI
210 220 230 240 250
KLIDFGLSNC AGILGYSDPF STQCGSPAYA APELLARKKY GPKIDVWSIG
260 270 280 290 300
VNMYAMLTGT LPFTVEPFSL RALYQKMVDK AMNPLPTQLS TGAVNFLRSL
310 320 330 340 350
LEPDPVKRPN IQQALANRWL NENYTGKVPC NVTYPNRISL EDLSPSVVLH
360 370 380 390 400
MTEKLGYKNS DVINTVLSNR ACHILAIYFL LNKKLERYLS GKSDIQDSIC
410 420 430 440 450
YKTQLYQIEK CRATKEPYEA SLDTWTRDFE FHAVQDKKPK EQEKRGDFLH
460 470 480 490 500
RPFSKKLDKN LPSHKQPSPS LITQLQSTKA LLKDRKASKS GFPDKDSFVC
510 520 530 540 550
RNLFRKTSDS NCVASSSMEF IPVPPPRTPR IVKKLEPHQP GPGSASILPK
560 570 580 590 600
EEPLLLDMVR SFESVDREDH IELLSPSHHY RILSSPVSLA RRNSSERTLS
610 620 630 640 650
QGLLSGSTSP LQTPLHSTLV SFAHEEKNSP PKEEGVCSPP PVPSNGLLQP
660 670 680 690 700
LGSPNCVKSR GRFPMMGIGQ MLRKRHQSLQ PSSERSLDAS MSPLQPTAPS
710
SLSFDMADGV KGQC
Length:714
Mass (Da):79,603
Last modified:November 1, 1998 - v1
Checksum:iD35A53E7A8D9BD1F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti697T → I in AAF35282 (PubMed:10662544).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055919 mRNA. Translation: AAC61489.1.
AF167987 mRNA. Translation: AAF35282.1.
CCDSiCCDS28315.1.
RefSeqiNP_056570.1. NM_015755.2.
UniGeneiMm.125874.

Genome annotation databases

EnsembliENSMUST00000065856; ENSMUSP00000068007; ENSMUSG00000053414.
GeneIDi26559.
KEGGimmu:26559.
UCSCiuc007zwi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055919 mRNA. Translation: AAC61489.1.
AF167987 mRNA. Translation: AAF35282.1.
CCDSiCCDS28315.1.
RefSeqiNP_056570.1. NM_015755.2.
UniGeneiMm.125874.

3D structure databases

ProteinModelPortaliO88866.
SMRiO88866.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205017. 1 interactor.
STRINGi10090.ENSMUSP00000068007.

PTM databases

iPTMnetiO88866.
PhosphoSitePlusiO88866.

Proteomic databases

MaxQBiO88866.
PaxDbiO88866.
PRIDEiO88866.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065856; ENSMUSP00000068007; ENSMUSG00000053414.
GeneIDi26559.
KEGGimmu:26559.
UCSCiuc007zwi.1. mouse.

Organism-specific databases

CTDi30811.
MGIiMGI:1347352. Hunk.

Phylogenomic databases

eggNOGiKOG0583. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00880000137920.
HOGENOMiHOG000112978.
HOVERGENiHBG006086.
InParanoidiO88866.
KOiK08797.
OMAiEFHAVQD.
OrthoDBiEOG091G0I19.
PhylomeDBiO88866.
TreeFamiTF352373.

Enzyme and pathway databases

BRENDAi2.7.11.1. 3474.

Miscellaneous databases

PROiPR:O88866.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053414.
CleanExiMM_HUNK.
GenevisibleiO88866. MM.

Family and domain databases

CDDicd14070. STKc_HUNK. 1 hit.
InterProiView protein in InterPro
IPR034671. Hunk.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHUNK_MOUSE
AccessioniPrimary (citable) accession number: O88866
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: June 7, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.