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O88855 (LT4R1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leukotriene B4 receptor 1

Short name=LTB4-R 1
Short name=LTB4-R1
Gene names
Name:Ltb4r
Synonyms:Bltr, Ltb4r1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Highly expressed on activated leukocytes, including eosinophils.

Post-translational modification

Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Leukotriene B4 receptor 1
PRO_0000069709

Regions

Topological domain1 – 2121Extracellular Potential
Transmembrane22 – 4423Helical; Name=1; Potential
Topological domain45 – 5612Cytoplasmic Potential
Transmembrane57 – 7721Helical; Name=2; Potential
Topological domain78 – 9316Extracellular Potential
Transmembrane94 – 11522Helical; Name=3; Potential
Topological domain116 – 14025Cytoplasmic Potential
Transmembrane141 – 16121Helical; Name=4; Potential
Topological domain162 – 17918Extracellular Potential
Transmembrane180 – 20021Helical; Name=5; Potential
Topological domain201 – 22222Cytoplasmic Potential
Transmembrane223 – 24321Helical; Name=6; Potential
Topological domain244 – 26825Extracellular Potential
Transmembrane269 – 28921Helical; Name=7; Potential
Topological domain290 – 35162Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation1641N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O88855 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: B5B9AA94156BCD00

FASTA35138,252
        10         20         30         40         50         60 
MAANTTSPAA PSSPGGMSLS LLPIVLLSVA LAVGLPGNSF VVWSILKRMQ KRTVTALLVL 

        70         80         90        100        110        120 
NLALADLAVL LTAPFFLHFL ARGTWSFREM GCRLCHYVCG ISMYASVLLI TIMSLDRSLA 

       130        140        150        160        170        180 
VARPFMSQKV RTKAFARWVL AGIWVVSFLL AIPVLVYRTV KWNNRTLICA PNYPNKEHKV 

       190        200        210        220        230        240 
FHLLFEAITG FLLPFLAVVA SYSDIGRRLQ ARRFRRSRRT GRLVVLIILA FAAFWLPYHL 

       250        260        270        280        290        300 
VNLVEAGRTV AGWDKNSPAG QRLRLARYVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF 

       310        320        330        340        350 
VVKLLEGTGS EVSSTRRGGT LVQTPKDTPA CPEPGPTDSF MTSSTIPESS K 

« Hide

References

« Hide 'large scale' references
[1]"Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils."
Huang W.-W., Garcia-Zepeda E.A., Sauty A., Oettgen H.C., Rothenberg M.E., Luster A.D.
J. Exp. Med. 188:1063-1074(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Expression cloning of a murine leukotriene B4 receptor."
Jensen B.S., Mollerup J.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J.
Tissue: Mammary gland.
[3]"Leukotriene binding, signaling, and analysis of HIV coreceptor function in mouse and human leukotriene B4 receptor-transfected cells."
Martin V., Ronde P., Unett D., Wong A., Hoffman T.L., Edinger A.L., Doms R.W., Funk C.D.
J. Biol. Chem. 274:8597-8603(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
Tissue: Liver.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF044030 mRNA. Translation: AAC61677.1.
AF110104 mRNA. Translation: AAD09817.1.
AF077673 Genomic DNA. Translation: AAD43002.1.
BC064063 mRNA. Translation: AAH64063.1.
RefSeqNP_032545.1. NM_008519.2.
UniGeneMm.20853.

3D structure databases

ProteinModelPortalO88855.
SMRO88855. Positions 24-289.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBO88855.
ChEMBLCHEMBL2657.
GuidetoPHARMACOLOGY267.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO88855.

Proteomic databases

PRIDEO88855.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000057569; ENSMUSP00000051368; ENSMUSG00000046908.
GeneID16995.
KEGGmmu:16995.
UCSCuc007uar.2. mouse.

Organism-specific databases

CTD16995.
MGIMGI:1309472. Ltb4r1.

Phylogenomic databases

eggNOGNOG329990.
GeneTreeENSGT00730000110302.
HOGENOMHOG000008594.
HOVERGENHBG104134.
InParanoidO88855.
KOK04296.
OMAGCRLCHY.
OrthoDBEOG738056.
PhylomeDBO88855.
TreeFamTF330976.

Gene expression databases

ArrayExpressO88855.
BgeeO88855.
CleanExMM_LTB4R1.
GenevestigatorO88855.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003983. Leukotriene_B4_typ-1_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01477. LTB1RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio291096.
PROO88855.
SOURCESearch...

Entry information

Entry nameLT4R1_MOUSE
AccessionPrimary (citable) accession number: O88855
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries