O88855 (LT4R1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leukotriene B4 receptor 1
Short name=LTB4-R 1
Short name=LTB4-R1

Gene names

Name:	Ltb4r
Synonyms:	Bltr, Ltb4r1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Highly expressed on activated leukocytes, including eosinophils.
Post-translational modification	Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	inflammatory response Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	leukotriene B4 receptor activity Inferred from direct assay PubMed 15866883. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Leukotriene B4 receptor 1		PRO_0000069709
Regions
	Topological domain	1 – 21	21	Extracellular Potential
	Transmembrane	22 – 44	23	Helical; Name=1; Potential
	Topological domain	45 – 56	12	Cytoplasmic Potential
	Transmembrane	57 – 77	21	Helical; Name=2; Potential
	Topological domain	78 – 93	16	Extracellular Potential
	Transmembrane	94 – 115	22	Helical; Name=3; Potential
	Topological domain	116 – 140	25	Cytoplasmic Potential
	Transmembrane	141 – 161	21	Helical; Name=4; Potential
	Topological domain	162 – 179	18	Extracellular Potential
	Transmembrane	180 – 200	21	Helical; Name=5; Potential
	Topological domain	201 – 222	22	Cytoplasmic Potential
	Transmembrane	223 – 243	21	Helical; Name=6; Potential
	Topological domain	244 – 268	25	Extracellular Potential
	Transmembrane	269 – 289	21	Helical; Name=7; Potential
	Topological domain	290 – 351	62	Cytoplasmic Potential
Amino acid modifications
	Modified residue	320	1	Phosphothreonine Ref.5
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	164	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O88855 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: B5B9AA94156BCD00	FASTA	351	38,252
	10 20 30 40 50 60 MAANTTSPAA PSSPGGMSLS LLPIVLLSVA LAVGLPGNSF VVWSILKRMQ KRTVTALLVL 70 80 90 100 110 120 NLALADLAVL LTAPFFLHFL ARGTWSFREM GCRLCHYVCG ISMYASVLLI TIMSLDRSLA 130 140 150 160 170 180 VARPFMSQKV RTKAFARWVL AGIWVVSFLL AIPVLVYRTV KWNNRTLICA PNYPNKEHKV 190 200 210 220 230 240 FHLLFEAITG FLLPFLAVVA SYSDIGRRLQ ARRFRRSRRT GRLVVLIILA FAAFWLPYHL 250 260 270 280 290 300 VNLVEAGRTV AGWDKNSPAG QRLRLARYVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF 310 320 330 340 350 VVKLLEGTGS EVSSTRRGGT LVQTPKDTPA CPEPGPTDSF MTSSTIPESS K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils." Huang W.-W., Garcia-Zepeda E.A., Sauty A., Oettgen H.C., Rothenberg M.E., Luster A.D. J. Exp. Med. 188:1063-1074(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Expression cloning of a murine leukotriene B4 receptor." Jensen B.S., Mollerup J. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J. Tissue: Mammary gland.
[3]	"Leukotriene binding, signaling, and analysis of HIV coreceptor function in mouse and human leukotriene B4 receptor-transfected cells." Martin V., Ronde P., Unett D., Wong A., Hoffman T.L., Edinger A.L., Doms R.W., Funk C.D. J. Biol. Chem. 274:8597-8603(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv. Tissue: Liver.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Mammary gland.
[5]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-320, MASS SPECTROMETRY. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF044030 mRNA. Translation: AAC61677.1. AF110104 mRNA. Translation: AAD09817.1. AF077673 Genomic DNA. Translation: AAD43002.1. BC064063 mRNA. Translation: AAH64063.1.
IPI	IPI00135285.
RefSeq	NP_032545.1. NM_008519.2.
UniGene	Mm.20853.
3D structure databases
ProteinModelPortal	O88855.
SMR	O88855. Positions 24-289.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O88855.
Proteomic databases
PRIDE	O88855.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000057569; ENSMUSP00000051368; ENSMUSG00000046908.
GeneID	16995.
KEGG	mmu:16995.
UCSC	uc007uar.2. mouse.
Organism-specific databases
CTD	16995.
MGI	MGI:1309472. Ltb4r1.
Phylogenomic databases
eggNOG	NOG329990.
GeneTree	ENSGT00630000089620.
HOGENOM	HOG000008594.
HOVERGEN	HBG104134.
InParanoid	O88855.
KO	K04296.
OMA	PGNSFVV.
OrthoDB	EOG4RV2SB.
Gene expression databases
ArrayExpress	O88855.
Bgee	O88855.
CleanEx	MM_LTB4R1.
Genevestigator	O88855.
GermOnline	ENSMUSG00000046908. Mus musculus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR003981. Leukotriene_B4_rcpt. IPR003983. Leukotriene_B4_typ-1_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01477. LTB1RECEPTOR. PR01476. LTBRECEPTOR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	O88855.
ChEMBL	CHEMBL2657.
NextBio	291096.
SOURCE	Search...

Entry information

Entry name

LT4R1_MOUSE

Accession

Primary (citable) accession number: O88855

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	November 1, 1998
Last modified:	May 29, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program