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O88855

- LT4R1_MOUSE

UniProt

O88855 - LT4R1_MOUSE

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Protein

Leukotriene B4 receptor 1

Gene

Ltb4r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

GO - Molecular functioni

  1. leukotriene B4 receptor activity Source: MGI

GO - Biological processi

  1. inflammatory response Source: Ensembl
  2. signal transduction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_230951. Leukotriene receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene B4 receptor 1
Short name:
LTB4-R 1
Short name:
LTB4-R1
Gene namesi
Name:Ltb4r
Synonyms:Bltr, Ltb4r1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1309472. Ltb4r1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121ExtracellularSequence AnalysisAdd
BLAST
Transmembranei22 – 4423Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini45 – 5612CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 9316ExtracellularSequence AnalysisAdd
BLAST
Transmembranei94 – 11522Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini116 – 14025CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini162 – 17918ExtracellularSequence AnalysisAdd
BLAST
Transmembranei180 – 20021Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini201 – 22222CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei223 – 24321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini244 – 26825ExtracellularSequence AnalysisAdd
BLAST
Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini290 – 35162CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Leukotriene B4 receptor 1PRO_0000069709Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiO88855.

PTM databases

PhosphoSiteiO88855.

Expressioni

Tissue specificityi

Highly expressed on activated leukocytes, including eosinophils.

Gene expression databases

BgeeiO88855.
CleanExiMM_LTB4R1.
ExpressionAtlasiO88855. baseline and differential.
GenevestigatoriO88855.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliO88855.
SMRiO88855. Positions 22-286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG329990.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000008594.
HOVERGENiHBG104134.
InParanoidiO88855.
KOiK04296.
OMAiGCRLCHY.
OrthoDBiEOG738056.
PhylomeDBiO88855.
TreeFamiTF330976.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003983. Leukotriene_B4_typ-1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01477. LTB1RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88855-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAANTTSPAA PSSPGGMSLS LLPIVLLSVA LAVGLPGNSF VVWSILKRMQ
60 70 80 90 100
KRTVTALLVL NLALADLAVL LTAPFFLHFL ARGTWSFREM GCRLCHYVCG
110 120 130 140 150
ISMYASVLLI TIMSLDRSLA VARPFMSQKV RTKAFARWVL AGIWVVSFLL
160 170 180 190 200
AIPVLVYRTV KWNNRTLICA PNYPNKEHKV FHLLFEAITG FLLPFLAVVA
210 220 230 240 250
SYSDIGRRLQ ARRFRRSRRT GRLVVLIILA FAAFWLPYHL VNLVEAGRTV
260 270 280 290 300
AGWDKNSPAG QRLRLARYVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF
310 320 330 340 350
VVKLLEGTGS EVSSTRRGGT LVQTPKDTPA CPEPGPTDSF MTSSTIPESS

K
Length:351
Mass (Da):38,252
Last modified:November 1, 1998 - v1
Checksum:iB5B9AA94156BCD00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044030 mRNA. Translation: AAC61677.1.
AF110104 mRNA. Translation: AAD09817.1.
AF077673 Genomic DNA. Translation: AAD43002.1.
BC064063 mRNA. Translation: AAH64063.1.
CCDSiCCDS27129.1.
RefSeqiNP_032545.1. NM_008519.2.
UniGeneiMm.20853.

Genome annotation databases

EnsembliENSMUST00000057569; ENSMUSP00000051368; ENSMUSG00000046908.
GeneIDi16995.
KEGGimmu:16995.
UCSCiuc007uar.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044030 mRNA. Translation: AAC61677.1 .
AF110104 mRNA. Translation: AAD09817.1 .
AF077673 Genomic DNA. Translation: AAD43002.1 .
BC064063 mRNA. Translation: AAH64063.1 .
CCDSi CCDS27129.1.
RefSeqi NP_032545.1. NM_008519.2.
UniGenei Mm.20853.

3D structure databases

ProteinModelPortali O88855.
SMRi O88855. Positions 22-286.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi O88855.
ChEMBLi CHEMBL2657.
GuidetoPHARMACOLOGYi 267.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O88855.

Proteomic databases

PRIDEi O88855.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000057569 ; ENSMUSP00000051368 ; ENSMUSG00000046908 .
GeneIDi 16995.
KEGGi mmu:16995.
UCSCi uc007uar.2. mouse.

Organism-specific databases

CTDi 16995.
MGIi MGI:1309472. Ltb4r1.

Phylogenomic databases

eggNOGi NOG329990.
GeneTreei ENSGT00760000118990.
HOGENOMi HOG000008594.
HOVERGENi HBG104134.
InParanoidi O88855.
KOi K04296.
OMAi GCRLCHY.
OrthoDBi EOG738056.
PhylomeDBi O88855.
TreeFami TF330976.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.
REACT_230951. Leukotriene receptors.

Miscellaneous databases

NextBioi 291096.
PROi O88855.
SOURCEi Search...

Gene expression databases

Bgeei O88855.
CleanExi MM_LTB4R1.
ExpressionAtlasi O88855. baseline and differential.
Genevestigatori O88855.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003983. Leukotriene_B4_typ-1_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01477. LTB1RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils."
    Huang W.-W., Garcia-Zepeda E.A., Sauty A., Oettgen H.C., Rothenberg M.E., Luster A.D.
    J. Exp. Med. 188:1063-1074(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Expression cloning of a murine leukotriene B4 receptor."
    Jensen B.S., Mollerup J.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. "Leukotriene binding, signaling, and analysis of HIV coreceptor function in mouse and human leukotriene B4 receptor-transfected cells."
    Martin V., Ronde P., Unett D., Wong A., Hoffman T.L., Edinger A.L., Doms R.W., Funk C.D.
    J. Biol. Chem. 274:8597-8603(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
    Tissue: Liver.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiLT4R1_MOUSE
AccessioniPrimary (citable) accession number: O88855
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1998
Last modified: November 26, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3