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Protein

Leukotriene B4 receptor 1

Gene

Ltb4r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-391906. Leukotriene receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene B4 receptor 1
Short name:
LTB4-R 1
Short name:
LTB4-R1
Gene namesi
Name:Ltb4r
Synonyms:Bltr, Ltb4r1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1309472. Ltb4r1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21ExtracellularSequence analysisAdd BLAST21
Transmembranei22 – 44Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini45 – 56CytoplasmicSequence analysisAdd BLAST12
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 93ExtracellularSequence analysisAdd BLAST16
Transmembranei94 – 115Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini116 – 140CytoplasmicSequence analysisAdd BLAST25
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 179ExtracellularSequence analysisAdd BLAST18
Transmembranei180 – 200Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini201 – 222CytoplasmicSequence analysisAdd BLAST22
Transmembranei223 – 243Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini244 – 268ExtracellularSequence analysisAdd BLAST25
Transmembranei269 – 289Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini290 – 351CytoplasmicSequence analysisAdd BLAST62

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2657.
GuidetoPHARMACOLOGYi267.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697091 – 351Leukotriene B4 receptor 1Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi164N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiO88855.
PaxDbiO88855.
PRIDEiO88855.

PTM databases

iPTMnetiO88855.
PhosphoSitePlusiO88855.

Expressioni

Tissue specificityi

Highly expressed on activated leukocytes, including eosinophils.

Gene expression databases

BgeeiENSMUSG00000046908.
CleanExiMM_LTB4R1.
ExpressionAtlasiO88855. baseline and differential.
GenevisibleiO88855. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051368.

Chemistry databases

BindingDBiO88855.

Structurei

3D structure databases

ProteinModelPortaliO88855.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00840000129842.
HOGENOMiHOG000008594.
HOVERGENiHBG104134.
InParanoidiO88855.
KOiK04296.
OMAiGCRLCHY.
OrthoDBiEOG091G0FBQ.
PhylomeDBiO88855.
TreeFamiTF330976.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003983. Leukotriene_B4_typ-1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01477. LTB1RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88855-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANTTSPAA PSSPGGMSLS LLPIVLLSVA LAVGLPGNSF VVWSILKRMQ
60 70 80 90 100
KRTVTALLVL NLALADLAVL LTAPFFLHFL ARGTWSFREM GCRLCHYVCG
110 120 130 140 150
ISMYASVLLI TIMSLDRSLA VARPFMSQKV RTKAFARWVL AGIWVVSFLL
160 170 180 190 200
AIPVLVYRTV KWNNRTLICA PNYPNKEHKV FHLLFEAITG FLLPFLAVVA
210 220 230 240 250
SYSDIGRRLQ ARRFRRSRRT GRLVVLIILA FAAFWLPYHL VNLVEAGRTV
260 270 280 290 300
AGWDKNSPAG QRLRLARYVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF
310 320 330 340 350
VVKLLEGTGS EVSSTRRGGT LVQTPKDTPA CPEPGPTDSF MTSSTIPESS

K
Length:351
Mass (Da):38,252
Last modified:November 1, 1998 - v1
Checksum:iB5B9AA94156BCD00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044030 mRNA. Translation: AAC61677.1.
AF110104 mRNA. Translation: AAD09817.1.
AF077673 Genomic DNA. Translation: AAD43002.1.
BC064063 mRNA. Translation: AAH64063.1.
CCDSiCCDS27129.1.
RefSeqiNP_032545.1. NM_008519.2.
UniGeneiMm.20853.

Genome annotation databases

EnsembliENSMUST00000057569; ENSMUSP00000051368; ENSMUSG00000046908.
GeneIDi16995.
KEGGimmu:16995.
UCSCiuc007uar.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044030 mRNA. Translation: AAC61677.1.
AF110104 mRNA. Translation: AAD09817.1.
AF077673 Genomic DNA. Translation: AAD43002.1.
BC064063 mRNA. Translation: AAH64063.1.
CCDSiCCDS27129.1.
RefSeqiNP_032545.1. NM_008519.2.
UniGeneiMm.20853.

3D structure databases

ProteinModelPortaliO88855.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051368.

Chemistry databases

BindingDBiO88855.
ChEMBLiCHEMBL2657.
GuidetoPHARMACOLOGYi267.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO88855.
PhosphoSitePlusiO88855.

Proteomic databases

EPDiO88855.
PaxDbiO88855.
PRIDEiO88855.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057569; ENSMUSP00000051368; ENSMUSG00000046908.
GeneIDi16995.
KEGGimmu:16995.
UCSCiuc007uar.2. mouse.

Organism-specific databases

CTDi16995.
MGIiMGI:1309472. Ltb4r1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00840000129842.
HOGENOMiHOG000008594.
HOVERGENiHBG104134.
InParanoidiO88855.
KOiK04296.
OMAiGCRLCHY.
OrthoDBiEOG091G0FBQ.
PhylomeDBiO88855.
TreeFamiTF330976.

Enzyme and pathway databases

ReactomeiR-MMU-391906. Leukotriene receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiO88855.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046908.
CleanExiMM_LTB4R1.
ExpressionAtlasiO88855. baseline and differential.
GenevisibleiO88855. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003983. Leukotriene_B4_typ-1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01477. LTB1RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLT4R1_MOUSE
AccessioniPrimary (citable) accession number: O88855
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.