Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O88855

- LT4R1_MOUSE

UniProt

O88855 - LT4R1_MOUSE

Protein

Leukotriene B4 receptor 1

Gene

Ltb4r

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

    GO - Molecular functioni

    1. leukotriene B4 receptor activity Source: MGI

    GO - Biological processi

    1. inflammatory response Source: Ensembl
    2. signal transduction Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leukotriene B4 receptor 1
    Short name:
    LTB4-R 1
    Short name:
    LTB4-R1
    Gene namesi
    Name:Ltb4r
    Synonyms:Bltr, Ltb4r1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1309472. Ltb4r1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351Leukotriene B4 receptor 1PRO_0000069709Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiO88855.

    PTM databases

    PhosphoSiteiO88855.

    Expressioni

    Tissue specificityi

    Highly expressed on activated leukocytes, including eosinophils.

    Gene expression databases

    ArrayExpressiO88855.
    BgeeiO88855.
    CleanExiMM_LTB4R1.
    GenevestigatoriO88855.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliO88855.
    SMRiO88855. Positions 22-286.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini45 – 5612CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini78 – 9316ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini116 – 14025CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini162 – 17918ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini201 – 22222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini244 – 26825ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini290 – 35162CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4423Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei94 – 11522Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei180 – 20021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei223 – 24321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG329990.
    GeneTreeiENSGT00730000110302.
    HOGENOMiHOG000008594.
    HOVERGENiHBG104134.
    InParanoidiO88855.
    KOiK04296.
    OMAiGCRLCHY.
    OrthoDBiEOG738056.
    PhylomeDBiO88855.
    TreeFamiTF330976.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003981. Leukotriene_B4_rcpt.
    IPR003983. Leukotriene_B4_typ-1_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01477. LTB1RECEPTOR.
    PR01476. LTBRECEPTOR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O88855-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAANTTSPAA PSSPGGMSLS LLPIVLLSVA LAVGLPGNSF VVWSILKRMQ    50
    KRTVTALLVL NLALADLAVL LTAPFFLHFL ARGTWSFREM GCRLCHYVCG 100
    ISMYASVLLI TIMSLDRSLA VARPFMSQKV RTKAFARWVL AGIWVVSFLL 150
    AIPVLVYRTV KWNNRTLICA PNYPNKEHKV FHLLFEAITG FLLPFLAVVA 200
    SYSDIGRRLQ ARRFRRSRRT GRLVVLIILA FAAFWLPYHL VNLVEAGRTV 250
    AGWDKNSPAG QRLRLARYVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF 300
    VVKLLEGTGS EVSSTRRGGT LVQTPKDTPA CPEPGPTDSF MTSSTIPESS 350
    K 351
    Length:351
    Mass (Da):38,252
    Last modified:November 1, 1998 - v1
    Checksum:iB5B9AA94156BCD00
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF044030 mRNA. Translation: AAC61677.1.
    AF110104 mRNA. Translation: AAD09817.1.
    AF077673 Genomic DNA. Translation: AAD43002.1.
    BC064063 mRNA. Translation: AAH64063.1.
    CCDSiCCDS27129.1.
    RefSeqiNP_032545.1. NM_008519.2.
    UniGeneiMm.20853.

    Genome annotation databases

    EnsembliENSMUST00000057569; ENSMUSP00000051368; ENSMUSG00000046908.
    GeneIDi16995.
    KEGGimmu:16995.
    UCSCiuc007uar.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF044030 mRNA. Translation: AAC61677.1 .
    AF110104 mRNA. Translation: AAD09817.1 .
    AF077673 Genomic DNA. Translation: AAD43002.1 .
    BC064063 mRNA. Translation: AAH64063.1 .
    CCDSi CCDS27129.1.
    RefSeqi NP_032545.1. NM_008519.2.
    UniGenei Mm.20853.

    3D structure databases

    ProteinModelPortali O88855.
    SMRi O88855. Positions 22-286.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi O88855.
    ChEMBLi CHEMBL2657.
    GuidetoPHARMACOLOGYi 267.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O88855.

    Proteomic databases

    PRIDEi O88855.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000057569 ; ENSMUSP00000051368 ; ENSMUSG00000046908 .
    GeneIDi 16995.
    KEGGi mmu:16995.
    UCSCi uc007uar.2. mouse.

    Organism-specific databases

    CTDi 16995.
    MGIi MGI:1309472. Ltb4r1.

    Phylogenomic databases

    eggNOGi NOG329990.
    GeneTreei ENSGT00730000110302.
    HOGENOMi HOG000008594.
    HOVERGENi HBG104134.
    InParanoidi O88855.
    KOi K04296.
    OMAi GCRLCHY.
    OrthoDBi EOG738056.
    PhylomeDBi O88855.
    TreeFami TF330976.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 291096.
    PROi O88855.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O88855.
    Bgeei O88855.
    CleanExi MM_LTB4R1.
    Genevestigatori O88855.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR003981. Leukotriene_B4_rcpt.
    IPR003983. Leukotriene_B4_typ-1_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01477. LTB1RECEPTOR.
    PR01476. LTBRECEPTOR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils."
      Huang W.-W., Garcia-Zepeda E.A., Sauty A., Oettgen H.C., Rothenberg M.E., Luster A.D.
      J. Exp. Med. 188:1063-1074(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Expression cloning of a murine leukotriene B4 receptor."
      Jensen B.S., Mollerup J.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    3. "Leukotriene binding, signaling, and analysis of HIV coreceptor function in mouse and human leukotriene B4 receptor-transfected cells."
      Martin V., Ronde P., Unett D., Wong A., Hoffman T.L., Edinger A.L., Doms R.W., Funk C.D.
      J. Biol. Chem. 274:8597-8603(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
      Tissue: Liver.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiLT4R1_MOUSE
    AccessioniPrimary (citable) accession number: O88855
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3