Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leukotriene B4 receptor 1

Gene

Ltb4r

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.

GO - Molecular functioni

  1. leukotriene B4 receptor activity Source: MGI

GO - Biological processi

  1. inflammatory response Source: Ensembl
  2. signal transduction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_230951. Leukotriene receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukotriene B4 receptor 1
Short name:
LTB4-R 1
Short name:
LTB4-R1
Gene namesi
Name:Ltb4r
Synonyms:Bltr, Ltb4r1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1309472. Ltb4r1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121ExtracellularSequence AnalysisAdd
BLAST
Transmembranei22 – 4423Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini45 – 5612CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 9316ExtracellularSequence AnalysisAdd
BLAST
Transmembranei94 – 11522Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini116 – 14025CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini162 – 17918ExtracellularSequence AnalysisAdd
BLAST
Transmembranei180 – 20021Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini201 – 22222CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei223 – 24321Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini244 – 26825ExtracellularSequence AnalysisAdd
BLAST
Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini290 – 35162CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Leukotriene B4 receptor 1PRO_0000069709Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes desensitization.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiO88855.

PTM databases

PhosphoSiteiO88855.

Expressioni

Tissue specificityi

Highly expressed on activated leukocytes, including eosinophils.

Gene expression databases

BgeeiO88855.
CleanExiMM_LTB4R1.
ExpressionAtlasiO88855. baseline and differential.
GenevestigatoriO88855.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliO88855.
SMRiO88855. Positions 22-286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG329990.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000008594.
HOVERGENiHBG104134.
InParanoidiO88855.
KOiK04296.
OMAiLCHYVCG.
OrthoDBiEOG738056.
PhylomeDBiO88855.
TreeFamiTF330976.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003983. Leukotriene_B4_typ-1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01477. LTB1RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88855-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAANTTSPAA PSSPGGMSLS LLPIVLLSVA LAVGLPGNSF VVWSILKRMQ
60 70 80 90 100
KRTVTALLVL NLALADLAVL LTAPFFLHFL ARGTWSFREM GCRLCHYVCG
110 120 130 140 150
ISMYASVLLI TIMSLDRSLA VARPFMSQKV RTKAFARWVL AGIWVVSFLL
160 170 180 190 200
AIPVLVYRTV KWNNRTLICA PNYPNKEHKV FHLLFEAITG FLLPFLAVVA
210 220 230 240 250
SYSDIGRRLQ ARRFRRSRRT GRLVVLIILA FAAFWLPYHL VNLVEAGRTV
260 270 280 290 300
AGWDKNSPAG QRLRLARYVL IALAFLSSSV NPVLYACAGG GLLRSAGVGF
310 320 330 340 350
VVKLLEGTGS EVSSTRRGGT LVQTPKDTPA CPEPGPTDSF MTSSTIPESS

K
Length:351
Mass (Da):38,252
Last modified:November 1, 1998 - v1
Checksum:iB5B9AA94156BCD00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044030 mRNA. Translation: AAC61677.1.
AF110104 mRNA. Translation: AAD09817.1.
AF077673 Genomic DNA. Translation: AAD43002.1.
BC064063 mRNA. Translation: AAH64063.1.
CCDSiCCDS27129.1.
RefSeqiNP_032545.1. NM_008519.2.
UniGeneiMm.20853.

Genome annotation databases

EnsembliENSMUST00000057569; ENSMUSP00000051368; ENSMUSG00000046908.
GeneIDi16995.
KEGGimmu:16995.
UCSCiuc007uar.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044030 mRNA. Translation: AAC61677.1.
AF110104 mRNA. Translation: AAD09817.1.
AF077673 Genomic DNA. Translation: AAD43002.1.
BC064063 mRNA. Translation: AAH64063.1.
CCDSiCCDS27129.1.
RefSeqiNP_032545.1. NM_008519.2.
UniGeneiMm.20853.

3D structure databases

ProteinModelPortaliO88855.
SMRiO88855. Positions 22-286.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiO88855.
ChEMBLiCHEMBL2657.
GuidetoPHARMACOLOGYi267.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO88855.

Proteomic databases

PRIDEiO88855.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057569; ENSMUSP00000051368; ENSMUSG00000046908.
GeneIDi16995.
KEGGimmu:16995.
UCSCiuc007uar.2. mouse.

Organism-specific databases

CTDi16995.
MGIiMGI:1309472. Ltb4r1.

Phylogenomic databases

eggNOGiNOG329990.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000008594.
HOVERGENiHBG104134.
InParanoidiO88855.
KOiK04296.
OMAiLCHYVCG.
OrthoDBiEOG738056.
PhylomeDBiO88855.
TreeFamiTF330976.

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_230951. Leukotriene receptors.

Miscellaneous databases

NextBioi291096.
PROiO88855.
SOURCEiSearch...

Gene expression databases

BgeeiO88855.
CleanExiMM_LTB4R1.
ExpressionAtlasiO88855. baseline and differential.
GenevestigatoriO88855.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003981. Leukotriene_B4_rcpt.
IPR003983. Leukotriene_B4_typ-1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01477. LTB1RECEPTOR.
PR01476. LTBRECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils."
    Huang W.-W., Garcia-Zepeda E.A., Sauty A., Oettgen H.C., Rothenberg M.E., Luster A.D.
    J. Exp. Med. 188:1063-1074(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Expression cloning of a murine leukotriene B4 receptor."
    Jensen B.S., Mollerup J.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. "Leukotriene binding, signaling, and analysis of HIV coreceptor function in mouse and human leukotriene B4 receptor-transfected cells."
    Martin V., Ronde P., Unett D., Wong A., Hoffman T.L., Edinger A.L., Doms R.W., Funk C.D.
    J. Biol. Chem. 274:8597-8603(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
    Tissue: Liver.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.

Entry informationi

Entry nameiLT4R1_MOUSE
AccessioniPrimary (citable) accession number: O88855
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1998
Last modified: January 7, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.