Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Galanin receptor type 2

Gene

Galr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the hormone galanin, GALP and spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 2
Short name:
GAL2-R
Short name:
GALR-2
Gene namesi
Name:Galr2
Synonyms:Galnr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1337018 Galr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 59CytoplasmicSequence analysisAdd BLAST11
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 98ExtracellularSequence analysisAdd BLAST18
Transmembranei99 – 120Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini121 – 140CytoplasmicSequence analysisAdd BLAST20
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 186ExtracellularSequence analysisAdd BLAST25
Transmembranei187 – 207Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini208 – 236CytoplasmicSequence analysisAdd BLAST29
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 259ExtracellularSequence analysis2
Transmembranei260 – 280Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini281 – 371CytoplasmicSequence analysisAdd BLAST91

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi244

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694671 – 371Galanin receptor type 2Add BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 174PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88854
PRIDEiO88854

PTM databases

PhosphoSitePlusiO88854

Expressioni

Gene expression databases

BgeeiENSMUSG00000020793
CleanExiMM_GALR2
GenevisibleiO88854 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054062

Structurei

3D structure databases

ProteinModelPortaliO88854
SMRiO88854
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00860000133695
HOGENOMiHOG000230487
HOVERGENiHBG101447
InParanoidiO88854
KOiK04231
OMAiFRKICAG
OrthoDBiEOG091G0ZDG
TreeFamiTF315737

Family and domain databases

InterProiView protein in InterPro
IPR003907 GAL2_rcpt
IPR000405 Galanin_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01419 GALANIN2R
PR00663 GALANINR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O88854-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGSDSQGAE DSSQEGGGGW QPEAVLVPLF FALIFLVGAV GNALVLAVLL
60 70 80 90 100
RGGQAVSTTN LFILNLGVAD LCFILCCVPF QATIYTLDDW VFGSLLCKAV
110 120 130 140 150
HFLIFLTMHA SSFTLAAVSL DRYLAIRYPL HSRELRTPRN ALAAIGLIWG
160 170 180 190 200
LALLFSGPYL SYYSQSQLAN LTVCHPAWSA PRRRAMDLCT FVFSYLLPVL
210 220 230 240 250
VLSLTYARTL HYLWRTVDPV AAGSGSQRAK RKVTRMIVIV AVLFCLCWMP
260 270 280 290 300
HHALILCVWF GRFPLTRATY ALRILSHLVS YANSCVNPIV YALVSKHFRK
310 320 330 340 350
GFRKICAGLL RRAPRRASGR VCILAPGNHS GGMLEPESTD LTQVSEAAGP
360 370
LVPAPALPNC TTLSRTLDPA C
Length:371
Mass (Da):40,516
Last modified:July 27, 2011 - v2
Checksum:iC59F6560AF2EFD34
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130L → M in AAC36589 (PubMed:9832121).Curated1
Sequence conflicti184 – 188RAMDL → PWNS (PubMed:9832122).Curated5
Sequence conflicti192 – 193VF → CL in AAC95468 (PubMed:9832122).Curated2
Sequence conflicti221A → V in AAC95468 (PubMed:9832122).Curated1
Sequence conflicti345 – 360SEAAG…ALPNC → KRGSRAPRPRTRTSQT (PubMed:9832122).CuratedAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042784 Genomic DNA Translation: AAC36589.1
AF077375 mRNA Translation: AAC95468.1
AL645861 Genomic DNA Translation: CAM16797.1
CH466558 Genomic DNA Translation: EDL34569.1
BC116980 mRNA Translation: AAI16981.1
BC116982 mRNA Translation: AAI16983.1
CCDSiCCDS25663.1
RefSeqiNP_034384.3, NM_010254.4
UniGeneiMm.57149

Genome annotation databases

EnsembliENSMUST00000055872; ENSMUSP00000054062; ENSMUSG00000020793
GeneIDi14428
KEGGimmu:14428
UCSCiuc007mkr.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGALR2_MOUSE
AccessioniPrimary (citable) accession number: O88854
Secondary accession number(s): Q14A53, Q9Z2B0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health