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O88854 (GALR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galanin receptor type 2

Short name=GAL2-R
Short name=GALR-2
Gene names
Name:Galr2
Synonyms:Galnr2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the hormone galanin and for GALP. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 371371Galanin receptor type 2
PRO_0000069467

Regions

Topological domain1 – 2727Extracellular Potential
Transmembrane28 – 4821Helical; Name=1; Potential
Topological domain49 – 5911Cytoplasmic Potential
Transmembrane60 – 8021Helical; Name=2; Potential
Topological domain81 – 9818Extracellular Potential
Transmembrane99 – 12022Helical; Name=3; Potential
Topological domain121 – 14020Cytoplasmic Potential
Transmembrane141 – 16121Helical; Name=4; Potential
Topological domain162 – 18625Extracellular Potential
Transmembrane187 – 20721Helical; Name=5; Potential
Topological domain208 – 23629Cytoplasmic Potential
Transmembrane237 – 25721Helical; Name=6; Potential
Topological domain258 – 2592Extracellular Potential
Transmembrane260 – 28021Helical; Name=7; Potential
Topological domain281 – 37191Cytoplasmic Potential

Amino acid modifications

Glycosylation21N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 174 By similarity

Experimental info

Sequence conflict1301L → M in AAC36589. Ref.1
Sequence conflict184 – 1885RAMDL → PWNS Ref.2
Sequence conflict192 – 1932VF → CL in AAC95468. Ref.2
Sequence conflict2211A → V in AAC95468. Ref.2
Sequence conflict345 – 36016SEAAG…ALPNC → KRGSRAPRPRTRTSQT Ref.2

Sequences

Sequence LengthMass (Da)Tools
O88854 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: C59F6560AF2EFD34

FASTA37140,516
        10         20         30         40         50         60 
MNGSDSQGAE DSSQEGGGGW QPEAVLVPLF FALIFLVGAV GNALVLAVLL RGGQAVSTTN 

        70         80         90        100        110        120 
LFILNLGVAD LCFILCCVPF QATIYTLDDW VFGSLLCKAV HFLIFLTMHA SSFTLAAVSL 

       130        140        150        160        170        180 
DRYLAIRYPL HSRELRTPRN ALAAIGLIWG LALLFSGPYL SYYSQSQLAN LTVCHPAWSA 

       190        200        210        220        230        240 
PRRRAMDLCT FVFSYLLPVL VLSLTYARTL HYLWRTVDPV AAGSGSQRAK RKVTRMIVIV 

       250        260        270        280        290        300 
AVLFCLCWMP HHALILCVWF GRFPLTRATY ALRILSHLVS YANSCVNPIV YALVSKHFRK 

       310        320        330        340        350        360 
GFRKICAGLL RRAPRRASGR VCILAPGNHS GGMLEPESTD LTQVSEAAGP LVPAPALPNC 

       370 
TTLSRTLDPA C 

« Hide

References

« Hide 'large scale' references
[1]"Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3."
Kolakowski L.F. Jr., O'Neill G.P., Howard A.D., Broussard S.R., Sullivan K.A., Feighner S.D., Sawzdargo M., Nguyen T., Kargman S., Shiao L.-L., Hreniuk D.L., Tan C.P., Evans J., Abramovitz M., Chateauneuf A., Coulombe N., Ng G., Johnson M.P. expand/collapse author list , Tharian A., Khoshbouei H., George S.R., Smith R.G., O'Dowd B.F.
J. Neurochem. 71:2239-2251(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 129/Sv.
[2]"The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization."
Pang L., Hashemi T., Lee H.J., Maguire M., Graziano M.P., Bayne M., Hawes B., Wong G., Wang S.
J. Neurochem. 71:2252-2259(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/Sv.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF042784 Genomic DNA. Translation: AAC36589.1.
AF077375 mRNA. Translation: AAC95468.1.
AL645861 Genomic DNA. Translation: CAM16797.1.
CH466558 Genomic DNA. Translation: EDL34569.1.
BC116980 mRNA. Translation: AAI16981.1.
BC116982 mRNA. Translation: AAI16983.1.
RefSeqNP_034384.3. NM_010254.4.
UniGeneMm.57149.

3D structure databases

ProteinModelPortalO88854.
SMRO88854. Positions 23-305.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000054062.

Chemistry

GuidetoPHARMACOLOGY244.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO88854.

Proteomic databases

PRIDEO88854.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000055872; ENSMUSP00000054062; ENSMUSG00000020793.
GeneID14428.
KEGGmmu:14428.
UCSCuc007mkr.2. mouse.

Organism-specific databases

CTD8811.
MGIMGI:1337018. Galr2.

Phylogenomic databases

eggNOGNOG320953.
GeneTreeENSGT00620000087530.
HOGENOMHOG000230487.
HOVERGENHBG101447.
InParanoidQ14A53.
KOK04231.
OMAFRKICAG.
OrthoDBEOG7327PK.
TreeFamTF315737.

Gene expression databases

BgeeO88854.
CleanExMM_GALR2.
GenevestigatorO88854.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR003907. GAL2_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01419. GALANIN2R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio286037.
PROO88854.
SOURCESearch...

Entry information

Entry nameGALR2_MOUSE
AccessionPrimary (citable) accession number: O88854
Secondary accession number(s): Q14A53, Q9Z2B0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries