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O88854

- GALR2_MOUSE

UniProt

O88854 - GALR2_MOUSE

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Protein
Galanin receptor type 2
Gene
Galr2, Galnr2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for the hormone galanin, GALP and spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).

GO - Molecular functioni

  1. galanin receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. negative regulation of adenylate cyclase activity Source: InterPro
  2. neuron projection development Source: MGI
  3. positive regulation of cytosolic calcium ion concentration Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 2
Short name:
GAL2-R
Short name:
GALR-2
Gene namesi
Name:Galr2
Synonyms:Galnr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1337018. Galr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727Extracellular Reviewed prediction
Add
BLAST
Transmembranei28 – 4821Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini49 – 5911Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei60 – 8021Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini81 – 9818Extracellular Reviewed prediction
Add
BLAST
Transmembranei99 – 12022Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini121 – 14020Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei141 – 16121Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini162 – 18625Extracellular Reviewed prediction
Add
BLAST
Transmembranei187 – 20721Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini208 – 23629Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei237 – 25721Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini258 – 2592Extracellular Reviewed prediction
Transmembranei260 – 28021Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini281 – 37191Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Galanin receptor type 2
PRO_0000069467Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi97 ↔ 174 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO88854.

PTM databases

PhosphoSiteiO88854.

Expressioni

Gene expression databases

BgeeiO88854.
CleanExiMM_GALR2.
GenevestigatoriO88854.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054062.

Structurei

3D structure databases

ProteinModelPortaliO88854.
SMRiO88854. Positions 23-305.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320953.
GeneTreeiENSGT00620000087530.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
InParanoidiQ14A53.
KOiK04231.
OMAiFRKICAG.
OrthoDBiEOG7327PK.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR003907. GAL2_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01419. GALANIN2R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88854-1 [UniParc]FASTAAdd to Basket

« Hide

MNGSDSQGAE DSSQEGGGGW QPEAVLVPLF FALIFLVGAV GNALVLAVLL    50
RGGQAVSTTN LFILNLGVAD LCFILCCVPF QATIYTLDDW VFGSLLCKAV 100
HFLIFLTMHA SSFTLAAVSL DRYLAIRYPL HSRELRTPRN ALAAIGLIWG 150
LALLFSGPYL SYYSQSQLAN LTVCHPAWSA PRRRAMDLCT FVFSYLLPVL 200
VLSLTYARTL HYLWRTVDPV AAGSGSQRAK RKVTRMIVIV AVLFCLCWMP 250
HHALILCVWF GRFPLTRATY ALRILSHLVS YANSCVNPIV YALVSKHFRK 300
GFRKICAGLL RRAPRRASGR VCILAPGNHS GGMLEPESTD LTQVSEAAGP 350
LVPAPALPNC TTLSRTLDPA C 371
Length:371
Mass (Da):40,516
Last modified:July 27, 2011 - v2
Checksum:iC59F6560AF2EFD34
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301L → M in AAC36589. 1 Publication
Sequence conflicti184 – 1885RAMDL → PWNS1 Publication
Sequence conflicti192 – 1932VF → CL in AAC95468. 1 Publication
Sequence conflicti221 – 2211A → V in AAC95468. 1 Publication
Sequence conflicti345 – 36016SEAAG…ALPNC → KRGSRAPRPRTRTSQT1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF042784 Genomic DNA. Translation: AAC36589.1.
AF077375 mRNA. Translation: AAC95468.1.
AL645861 Genomic DNA. Translation: CAM16797.1.
CH466558 Genomic DNA. Translation: EDL34569.1.
BC116980 mRNA. Translation: AAI16981.1.
BC116982 mRNA. Translation: AAI16983.1.
CCDSiCCDS25663.1.
RefSeqiNP_034384.3. NM_010254.4.
UniGeneiMm.57149.

Genome annotation databases

EnsembliENSMUST00000055872; ENSMUSP00000054062; ENSMUSG00000020793.
GeneIDi14428.
KEGGimmu:14428.
UCSCiuc007mkr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF042784 Genomic DNA. Translation: AAC36589.1 .
AF077375 mRNA. Translation: AAC95468.1 .
AL645861 Genomic DNA. Translation: CAM16797.1 .
CH466558 Genomic DNA. Translation: EDL34569.1 .
BC116980 mRNA. Translation: AAI16981.1 .
BC116982 mRNA. Translation: AAI16983.1 .
CCDSi CCDS25663.1.
RefSeqi NP_034384.3. NM_010254.4.
UniGenei Mm.57149.

3D structure databases

ProteinModelPortali O88854.
SMRi O88854. Positions 23-305.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000054062.

Chemistry

GuidetoPHARMACOLOGYi 244.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O88854.

Proteomic databases

PRIDEi O88854.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000055872 ; ENSMUSP00000054062 ; ENSMUSG00000020793 .
GeneIDi 14428.
KEGGi mmu:14428.
UCSCi uc007mkr.2. mouse.

Organism-specific databases

CTDi 8811.
MGIi MGI:1337018. Galr2.

Phylogenomic databases

eggNOGi NOG320953.
GeneTreei ENSGT00620000087530.
HOGENOMi HOG000230487.
HOVERGENi HBG101447.
InParanoidi Q14A53.
KOi K04231.
OMAi FRKICAG.
OrthoDBi EOG7327PK.
TreeFami TF315737.

Miscellaneous databases

NextBioi 286037.
PROi O88854.
SOURCEi Search...

Gene expression databases

Bgeei O88854.
CleanExi MM_GALR2.
Genevestigatori O88854.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR003907. GAL2_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01419. GALANIN2R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/Sv.
  2. "The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization."
    Pang L., Hashemi T., Lee H.J., Maguire M., Graziano M.P., Bayne M., Hawes B., Wong G., Wang S.
    J. Neurochem. 71:2252-2259(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Sv.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGALR2_MOUSE
AccessioniPrimary (citable) accession number: O88854
Secondary accession number(s): Q14A53, Q9Z2B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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