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O88854

- GALR2_MOUSE

UniProt

O88854 - GALR2_MOUSE

Protein

Galanin receptor type 2

Gene

Galr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor for the hormone galanin, GALP and spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).

    GO - Molecular functioni

    1. galanin receptor activity Source: UniProtKB
    2. peptide hormone binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of adenylate cyclase activity Source: InterPro
    2. neuron projection development Source: MGI
    3. neuropeptide signaling pathway Source: GOC
    4. positive regulation of cytosolic calcium ion concentration Source: InterPro
    5. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galanin receptor type 2
    Short name:
    GAL2-R
    Short name:
    GALR-2
    Gene namesi
    Name:Galr2
    Synonyms:Galnr2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1337018. Galr2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 371371Galanin receptor type 2PRO_0000069467Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 174PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiO88854.

    PTM databases

    PhosphoSiteiO88854.

    Expressioni

    Gene expression databases

    BgeeiO88854.
    CleanExiMM_GALR2.
    GenevestigatoriO88854.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000054062.

    Structurei

    3D structure databases

    ProteinModelPortaliO88854.
    SMRiO88854. Positions 23-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 5911CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini81 – 9818ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 14020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini162 – 18625ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini208 – 23629CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 2592ExtracellularSequence Analysis
    Topological domaini281 – 37191CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 12022Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 16121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320953.
    GeneTreeiENSGT00620000087530.
    HOGENOMiHOG000230487.
    HOVERGENiHBG101447.
    InParanoidiQ14A53.
    KOiK04231.
    OMAiFRKICAG.
    OrthoDBiEOG7327PK.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR003907. GAL2_rcpt.
    IPR000405. Galanin_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01419. GALANIN2R.
    PR00663. GALANINR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O88854-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNGSDSQGAE DSSQEGGGGW QPEAVLVPLF FALIFLVGAV GNALVLAVLL    50
    RGGQAVSTTN LFILNLGVAD LCFILCCVPF QATIYTLDDW VFGSLLCKAV 100
    HFLIFLTMHA SSFTLAAVSL DRYLAIRYPL HSRELRTPRN ALAAIGLIWG 150
    LALLFSGPYL SYYSQSQLAN LTVCHPAWSA PRRRAMDLCT FVFSYLLPVL 200
    VLSLTYARTL HYLWRTVDPV AAGSGSQRAK RKVTRMIVIV AVLFCLCWMP 250
    HHALILCVWF GRFPLTRATY ALRILSHLVS YANSCVNPIV YALVSKHFRK 300
    GFRKICAGLL RRAPRRASGR VCILAPGNHS GGMLEPESTD LTQVSEAAGP 350
    LVPAPALPNC TTLSRTLDPA C 371
    Length:371
    Mass (Da):40,516
    Last modified:July 27, 2011 - v2
    Checksum:iC59F6560AF2EFD34
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti130 – 1301L → M in AAC36589. (PubMed:9832121)Curated
    Sequence conflicti184 – 1885RAMDL → PWNS(PubMed:9832122)Curated
    Sequence conflicti192 – 1932VF → CL in AAC95468. (PubMed:9832122)Curated
    Sequence conflicti221 – 2211A → V in AAC95468. (PubMed:9832122)Curated
    Sequence conflicti345 – 36016SEAAG…ALPNC → KRGSRAPRPRTRTSQT(PubMed:9832122)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF042784 Genomic DNA. Translation: AAC36589.1.
    AF077375 mRNA. Translation: AAC95468.1.
    AL645861 Genomic DNA. Translation: CAM16797.1.
    CH466558 Genomic DNA. Translation: EDL34569.1.
    BC116980 mRNA. Translation: AAI16981.1.
    BC116982 mRNA. Translation: AAI16983.1.
    CCDSiCCDS25663.1.
    RefSeqiNP_034384.3. NM_010254.4.
    UniGeneiMm.57149.

    Genome annotation databases

    EnsembliENSMUST00000055872; ENSMUSP00000054062; ENSMUSG00000020793.
    GeneIDi14428.
    KEGGimmu:14428.
    UCSCiuc007mkr.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF042784 Genomic DNA. Translation: AAC36589.1 .
    AF077375 mRNA. Translation: AAC95468.1 .
    AL645861 Genomic DNA. Translation: CAM16797.1 .
    CH466558 Genomic DNA. Translation: EDL34569.1 .
    BC116980 mRNA. Translation: AAI16981.1 .
    BC116982 mRNA. Translation: AAI16983.1 .
    CCDSi CCDS25663.1.
    RefSeqi NP_034384.3. NM_010254.4.
    UniGenei Mm.57149.

    3D structure databases

    ProteinModelPortali O88854.
    SMRi O88854. Positions 23-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000054062.

    Chemistry

    GuidetoPHARMACOLOGYi 244.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O88854.

    Proteomic databases

    PRIDEi O88854.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055872 ; ENSMUSP00000054062 ; ENSMUSG00000020793 .
    GeneIDi 14428.
    KEGGi mmu:14428.
    UCSCi uc007mkr.2. mouse.

    Organism-specific databases

    CTDi 8811.
    MGIi MGI:1337018. Galr2.

    Phylogenomic databases

    eggNOGi NOG320953.
    GeneTreei ENSGT00620000087530.
    HOGENOMi HOG000230487.
    HOVERGENi HBG101447.
    InParanoidi Q14A53.
    KOi K04231.
    OMAi FRKICAG.
    OrthoDBi EOG7327PK.
    TreeFami TF315737.

    Miscellaneous databases

    NextBioi 286037.
    PROi O88854.
    SOURCEi Search...

    Gene expression databases

    Bgeei O88854.
    CleanExi MM_GALR2.
    Genevestigatori O88854.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR003907. GAL2_rcpt.
    IPR000405. Galanin_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01419. GALANIN2R.
    PR00663. GALANINR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/Sv.
    2. "The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization."
      Pang L., Hashemi T., Lee H.J., Maguire M., Graziano M.P., Bayne M., Hawes B., Wong G., Wang S.
      J. Neurochem. 71:2252-2259(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/Sv.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiGALR2_MOUSE
    AccessioniPrimary (citable) accession number: O88854
    Secondary accession number(s): Q14A53, Q9Z2B0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3