Galanin receptor type 2 - Mus musculus (Mouse)

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O88854 (GALR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 99. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Galanin receptor type 2
Short name=GAL2-R
Short name=GALR-2

Gene names

Name:	Galr2
Synonyms:	Galnr2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for the hormone galanin and for GALP. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neuron projection development Inferred from direct assay PubMed 12533601. Source: MGI
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	galanin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 371

371

Galanin receptor type 2

PRO_0000069467

Regions

Topological domain

1 – 27

Extracellular Potential

Transmembrane

28 – 48

Helical; Name=1; Potential

Topological domain

49 – 59

Cytoplasmic Potential

Transmembrane

60 – 80

Helical; Name=2; Potential

Topological domain

81 – 98

Extracellular Potential

Transmembrane

99 – 120

Helical; Name=3; Potential

Topological domain

121 – 140

Cytoplasmic Potential

Transmembrane

141 – 161

Helical; Name=4; Potential

Topological domain

162 – 186

Extracellular Potential

Transmembrane

187 – 207

Helical; Name=5; Potential

Topological domain

208 – 236

Cytoplasmic Potential

Transmembrane

237 – 257

Helical; Name=6; Potential

Topological domain

258 – 259

Extracellular Potential

Transmembrane

260 – 280

Helical; Name=7; Potential

Topological domain

281 – 371

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

97 ↔ 174

By similarity

Experimental info

Sequence conflict

130

L → M in AAC36589. Ref.1

Sequence conflict

184 – 188

RAMDL → PWNS Ref.2

Sequence conflict

192 – 193

VF → CL in AAC95468. Ref.2

Sequence conflict

221

A → V in AAC95468. Ref.2

Sequence conflict

345 – 360

SEAAG…ALPNC → KRGSRAPRPRTRTSQT Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

O88854 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: C59F6560AF2EFD34
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FASTA

371

40,516

        10         20         30         40         50         60 
MNGSDSQGAE DSSQEGGGGW QPEAVLVPLF FALIFLVGAV GNALVLAVLL RGGQAVSTTN 

        70         80         90        100        110        120 
LFILNLGVAD LCFILCCVPF QATIYTLDDW VFGSLLCKAV HFLIFLTMHA SSFTLAAVSL 

       130        140        150        160        170        180 
DRYLAIRYPL HSRELRTPRN ALAAIGLIWG LALLFSGPYL SYYSQSQLAN LTVCHPAWSA 

       190        200        210        220        230        240 
PRRRAMDLCT FVFSYLLPVL VLSLTYARTL HYLWRTVDPV AAGSGSQRAK RKVTRMIVIV 

       250        260        270        280        290        300 
AVLFCLCWMP HHALILCVWF GRFPLTRATY ALRILSHLVS YANSCVNPIV YALVSKHFRK 

       310        320        330        340        350        360 
GFRKICAGLL RRAPRRASGR VCILAPGNHS GGMLEPESTD LTQVSEAAGP LVPAPALPNC 

       370 
TTLSRTLDPA C

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3." Kolakowski L.F. Jr., O'Neill G.P., Howard A.D., Broussard S.R., Sullivan K.A., Feighner S.D., Sawzdargo M., Nguyen T., Kargman S., Shiao L.-L., Hreniuk D.L., Tan C.P., Evans J., Abramovitz M., Chateauneuf A., Coulombe N., Ng G., Johnson M.P. O'Dowd B.F. J. Neurochem. 71:2239-2251(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 129/Sv.
[2]	"The mouse GalR2 galanin receptor: genomic organization, cDNA cloning, and functional characterization." Pang L., Hashemi T., Lee H.J., Maguire M., Graziano M.P., Bayne M., Hawes B., Wong G., Wang S. J. Neurochem. 71:2252-2259(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 129/Sv.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF042784 Genomic DNA. Translation: AAC36589.1. AF077375 mRNA. Translation: AAC95468.1. AL645861 Genomic DNA. Translation: CAM16797.1. CH466558 Genomic DNA. Translation: EDL34569.1. BC116980 mRNA. Translation: AAI16981.1. BC116982 mRNA. Translation: AAI16983.1.
IPI	IPI00135283.
RefSeq	NP_034384.3. NM_010254.4.
UniGene	Mm.57149.
3D structure databases
ProteinModelPortal	O88854.
SMR	O88854. Positions 23-305.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000054062.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O88854.
Proteomic databases
PRIDE	O88854.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000055872; ENSMUSP00000054062; ENSMUSG00000020793.
GeneID	14428.
KEGG	mmu:14428.
UCSC	uc007mkr.2. mouse.
Organism-specific databases
CTD	8811.
MGI	MGI:1337018. Galr2.
Phylogenomic databases
eggNOG	NOG320953.
GeneTree	ENSGT00620000087530.
HOGENOM	HOG000230487.
HOVERGEN	HBG101447.
InParanoid	Q14A53.
KO	K04231.
OMA	FRKICAG.
OrthoDB	EOG4K9BCJ.
Gene expression databases
Bgee	O88854.
CleanEx	MM_GALR2.
Genevestigator	O88854.
GermOnline	ENSMUSG00000020793. Mus musculus.
Family and domain databases
InterPro	IPR000405. Galanin_rcpt. IPR003907. Galnin_2_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01419. GALANIN2R. PR00663. GALANINR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	286037.
SOURCE	Search...

Entry information

Entry name

GALR2_MOUSE

Accession

Primary (citable) accession number: O88854
Secondary accession number(s): Q14A53, Q9Z2B0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	July 27, 2011
Last modified:	May 29, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents