Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Galanin receptor type 3

Gene

Galr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the hormone galanin and spexin-1.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 3
Short name:
GAL3-R
Short name:
GALR-3
Gene namesi
Name:Galr3
Synonyms:Galnr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1329003. Galr3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020ExtracellularSequence analysisAdd
BLAST
Transmembranei21 – 4121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini42 – 5716CytoplasmicSequence analysisAdd
BLAST
Transmembranei58 – 7821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini79 – 9618ExtracellularSequence analysisAdd
BLAST
Transmembranei97 – 11822Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini119 – 13820CytoplasmicSequence analysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini160 – 18425ExtracellularSequence analysisAdd
BLAST
Transmembranei185 – 20521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini206 – 23631CytoplasmicSequence analysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini258 – 2592ExtracellularSequence analysis
Transmembranei260 – 28021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini281 – 37090CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • nonmotile primary cilium Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Galanin receptor type 3PRO_0000069470Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
Lipidationi308 – 3081S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

EPDiO88853.
PRIDEiO88853.

PTM databases

iPTMnetiO88853.
PhosphoSiteiO88853.

Expressioni

Gene expression databases

BgeeiO88853.
CleanExiMM_GALR3.
ExpressionAtlasiO88853. baseline and differential.
GenevisibleiO88853. MM.

Structurei

3D structure databases

ProteinModelPortaliO88853.
SMRiO88853. Positions 18-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi218 – 2258Poly-Ala
Compositional biasi313 – 3186Poly-His

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000063111.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
KOiK04232.
OMAiPGGWNAS.

Family and domain databases

InterProiIPR000405. Galanin_rcpt.
IPR003908. Galnin_3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01420. GALANIN3R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88853-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADIQNISLD SPGSVGAVAV PVVFALIFLL GMVGNGLVLA VLLQPGPSAW
60 70 80 90 100
QEPGSTTDLF ILNLAVADLC FILCCVPFQA AIYTLDAWLF GAFVCKTVHL
110 120 130 140 150
LIYLTMYASS FTLAAVSVDR YLAVRHPLRS RALRTPRNAR AAVGLVWLLA
160 170 180 190 200
ALFSAPYLSY YGTVRYGALE LCVPAWEDAR RRALDVATFA AGYLLPVTVV
210 220 230 240 250
SLAYGRTLCF LWAAVGPAGA AAAEARRRAT GRAGRAMLTV AALYALCWGP
260 270 280 290 300
HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YSLASRHFRA
310 320 330 340 350
RFRRLWPCGH RRHRHHHHRL HRALRRVQPA SSGPAGYPGD ARPRGWSMEP
360 370
RGDALRGGET RLTLSARGPQ
Length:370
Mass (Da):40,420
Last modified:July 27, 2011 - v2
Checksum:iD397A3F0C7CEFB18
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti239 – 2391T → A in AAC36588 (Ref. 1) Curated
Sequence conflicti239 – 2391T → A in AAI31951 (PubMed:15489334).Curated
Sequence conflicti239 – 2391T → A in AAI31953 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042783 Genomic DNA. Translation: AAC36588.1.
AL589670 Genomic DNA. No translation available.
BC131950 mRNA. Translation: AAI31951.1.
BC131952 mRNA. Translation: AAI31953.1.
CCDSiCCDS27631.1.
RefSeqiNP_056553.2. NM_015738.2.
UniGeneiMm.390805.

Genome annotation databases

EnsembliENSMUST00000058004; ENSMUSP00000060517; ENSMUSG00000006378.
GeneIDi14429.
KEGGimmu:14429.
UCSCiuc007wsg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042783 Genomic DNA. Translation: AAC36588.1.
AL589670 Genomic DNA. No translation available.
BC131950 mRNA. Translation: AAI31951.1.
BC131952 mRNA. Translation: AAI31953.1.
CCDSiCCDS27631.1.
RefSeqiNP_056553.2. NM_015738.2.
UniGeneiMm.390805.

3D structure databases

ProteinModelPortaliO88853.
SMRiO88853. Positions 18-308.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO88853.
PhosphoSiteiO88853.

Proteomic databases

EPDiO88853.
PRIDEiO88853.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058004; ENSMUSP00000060517; ENSMUSG00000006378.
GeneIDi14429.
KEGGimmu:14429.
UCSCiuc007wsg.2. mouse.

Organism-specific databases

CTDi8484.
MGIiMGI:1329003. Galr3.

Phylogenomic databases

GeneTreeiENSGT00530000063111.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
KOiK04232.
OMAiPGGWNAS.

Miscellaneous databases

PROiO88853.
SOURCEiSearch...

Gene expression databases

BgeeiO88853.
CleanExiMM_GALR3.
ExpressionAtlasiO88853. baseline and differential.
GenevisibleiO88853. MM.

Family and domain databases

InterProiIPR000405. Galanin_rcpt.
IPR003908. Galnin_3_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01420. GALANIN3R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGALR3_MOUSE
AccessioniPrimary (citable) accession number: O88853
Secondary accession number(s): A2RS28, E9QPX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: June 8, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.