Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Galanin receptor type 3

Gene

Galr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for the hormone galanin and spexin-1.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 3
Short name:
GAL3-R
Short name:
GALR-3
Gene namesi
Name:Galr3
Synonyms:Galnr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1329003 Galr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20ExtracellularSequence analysisAdd BLAST20
Transmembranei21 – 41Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini42 – 57CytoplasmicSequence analysisAdd BLAST16
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 96ExtracellularSequence analysisAdd BLAST18
Transmembranei97 – 118Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini119 – 138CytoplasmicSequence analysisAdd BLAST20
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 184ExtracellularSequence analysisAdd BLAST25
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 236CytoplasmicSequence analysisAdd BLAST31
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 259ExtracellularSequence analysis2
Transmembranei260 – 280Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini281 – 370CytoplasmicSequence analysisAdd BLAST90

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694701 – 370Galanin receptor type 3Add BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
Lipidationi308S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiO88853

PTM databases

iPTMnetiO88853
PhosphoSitePlusiO88853

Expressioni

Gene expression databases

BgeeiENSMUSG00000006378
CleanExiMM_GALR3
GenevisibleiO88853 MM

Structurei

3D structure databases

ProteinModelPortaliO88853
SMRiO88853
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi218 – 225Poly-Ala8
Compositional biasi313 – 318Poly-His6

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00860000133695
HOGENOMiHOG000230487
HOVERGENiHBG101447
KOiK04232
OMAiLWPCGRR

Family and domain databases

InterProiView protein in InterPro
IPR000405 Galanin_rcpt
IPR003908 Galnin_3_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01420 GALANIN3R
PR00663 GALANINR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O88853-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADIQNISLD SPGSVGAVAV PVVFALIFLL GMVGNGLVLA VLLQPGPSAW
60 70 80 90 100
QEPGSTTDLF ILNLAVADLC FILCCVPFQA AIYTLDAWLF GAFVCKTVHL
110 120 130 140 150
LIYLTMYASS FTLAAVSVDR YLAVRHPLRS RALRTPRNAR AAVGLVWLLA
160 170 180 190 200
ALFSAPYLSY YGTVRYGALE LCVPAWEDAR RRALDVATFA AGYLLPVTVV
210 220 230 240 250
SLAYGRTLCF LWAAVGPAGA AAAEARRRAT GRAGRAMLTV AALYALCWGP
260 270 280 290 300
HHALILCFWY GRFAFSPATY ACRLASHCLA YANSCLNPLV YSLASRHFRA
310 320 330 340 350
RFRRLWPCGH RRHRHHHHRL HRALRRVQPA SSGPAGYPGD ARPRGWSMEP
360 370
RGDALRGGET RLTLSARGPQ
Length:370
Mass (Da):40,420
Last modified:July 27, 2011 - v2
Checksum:iD397A3F0C7CEFB18
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239T → A in AAC36588 (Ref. 1) Curated1
Sequence conflicti239T → A in AAI31951 (PubMed:15489334).Curated1
Sequence conflicti239T → A in AAI31953 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042783 Genomic DNA Translation: AAC36588.1
AL589670 Genomic DNA No translation available.
BC131950 mRNA Translation: AAI31951.1
BC131952 mRNA Translation: AAI31953.1
CCDSiCCDS27631.1
RefSeqiNP_056553.2, NM_015738.2
UniGeneiMm.390805

Genome annotation databases

EnsembliENSMUST00000058004; ENSMUSP00000060517; ENSMUSG00000114755
GeneIDi14429
KEGGimmu:14429
UCSCiuc007wsg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGALR3_MOUSE
AccessioniPrimary (citable) accession number: O88853
Secondary accession number(s): A2RS28, E9QPX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health