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O88851

- RBBP9_MOUSE

UniProt

O88851 - RBBP9_MOUSE

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Protein

Putative hydrolase RBBP9

Gene

Rbbp9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblastoma and the subsequent displacement of E2F-1.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei75 – 751Charge relay systemSequence Analysis
Active sitei138 – 1381Charge relay systemSequence Analysis
Active sitei165 – 1651Charge relay systemSequence Analysis

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of cell proliferation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative hydrolase RBBP9 (EC:3.-.-.-)
Alternative name(s):
B5T-overexpressed gene protein
Short name:
Protein BOG
Retinoblastoma-binding protein 9
Short name:
RBBP-9
Gene namesi
Name:Rbbp9
Synonyms:Bog
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1347074. Rbbp9.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
  3. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186Putative hydrolase RBBP9PRO_0000097181Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491Phosphothreonine; by CK2Sequence Analysis
Modified residuei135 – 1351Phosphoserine; by CK2Sequence Analysis

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO88851.
PaxDbiO88851.
PRIDEiO88851.

2D gel databases

REPRODUCTION-2DPAGEO88851.

PTM databases

PhosphoSiteiO88851.

Expressioni

Gene expression databases

BgeeiO88851.
CleanExiMM_RBBP9.
ExpressionAtlasiO88851. baseline and differential.
GenevestigatoriO88851.

Interactioni

Protein-protein interaction databases

IntActiO88851. 4 interactions.
MINTiMINT-4131919.

Structurei

3D structure databases

ProteinModelPortaliO88851.
SMRiO88851. Positions 3-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni56 – 7015Retinoblastoma protein bindingSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the RBBP9 family.Curated

Phylogenomic databases

eggNOGiNOG79530.
GeneTreeiENSGT00390000014861.
HOGENOMiHOG000231689.
HOVERGENiHBG056175.
InParanoidiO88851.
KOiK07002.
OMAiHCDERTI.
OrthoDBiEOG7XWPPP.
PhylomeDBiO88851.
TreeFamiTF106470.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR010662. Hydrolase_RBBP9/YdeN.
[Graphical view]
PfamiPF06821. Ser_hydrolase. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

O88851 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASPNKAVIV PGNGGGDVAT HGWYGWVKKG LEQIPGFQCL AKNMPDPITA
60 70 80 90 100
RESIWLPFME TELHCDEKTI IIGHSSGAIA AMRYAETHQV YALVLVSAYT
110 120 130 140 150
SDLGDENERA SGYFSRPWQW EKIKANCPHI VQFGSTDDPF LPWKEQQEVA
160 170 180
DRLDAKLYKF TDRGHFQNTE FHELISVVKS MLKGPE
Length:186
Mass (Da):20,912
Last modified:September 26, 2001 - v2
Checksum:iA2351381F228FCCC
GO

Sequence cautioni

The sequence AAC63497.1 differs from that shown. Reason: Frameshift at position 152.
The sequence AK017606 differs from that shown. Reason: Frameshift at position 20.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti131 – 1311V → I in AAC63497. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF039563 mRNA. Translation: AAC63497.1. Frameshift.
AK017606 mRNA. No translation available.
BC011107 mRNA. Translation: AAH11107.1.
CCDSiCCDS16821.1.
RefSeqiNP_056569.2. NM_015754.2.
UniGeneiMm.440564.

Genome annotation databases

EnsembliENSMUST00000028915; ENSMUSP00000028915; ENSMUSG00000027428.
GeneIDi26450.
KEGGimmu:26450.
UCSCiuc008mri.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF039563 mRNA. Translation: AAC63497.1 . Frameshift.
AK017606 mRNA. No translation available.
BC011107 mRNA. Translation: AAH11107.1 .
CCDSi CCDS16821.1.
RefSeqi NP_056569.2. NM_015754.2.
UniGenei Mm.440564.

3D structure databases

ProteinModelPortali O88851.
SMRi O88851. Positions 3-185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O88851. 4 interactions.
MINTi MINT-4131919.

PTM databases

PhosphoSitei O88851.

2D gel databases

REPRODUCTION-2DPAGE O88851.

Proteomic databases

MaxQBi O88851.
PaxDbi O88851.
PRIDEi O88851.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028915 ; ENSMUSP00000028915 ; ENSMUSG00000027428 .
GeneIDi 26450.
KEGGi mmu:26450.
UCSCi uc008mri.1. mouse.

Organism-specific databases

CTDi 10741.
MGIi MGI:1347074. Rbbp9.

Phylogenomic databases

eggNOGi NOG79530.
GeneTreei ENSGT00390000014861.
HOGENOMi HOG000231689.
HOVERGENi HBG056175.
InParanoidi O88851.
KOi K07002.
OMAi HCDERTI.
OrthoDBi EOG7XWPPP.
PhylomeDBi O88851.
TreeFami TF106470.

Miscellaneous databases

NextBioi 304553.
PROi O88851.
SOURCEi Search...

Gene expression databases

Bgeei O88851.
CleanExi MM_RBBP9.
ExpressionAtlasi O88851. baseline and differential.
Genevestigatori O88851.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR010662. Hydrolase_RBBP9/YdeN.
[Graphical view ]
Pfami PF06821. Ser_hydrolase. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary gland.
  3. Woitach J.T.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-174.
  4. Lubec G., Klug S.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 164-179, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.

Entry informationi

Entry nameiRBBP9_MOUSE
AccessioniPrimary (citable) accession number: O88851
Secondary accession number(s): Q9CYJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: September 26, 2001
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3