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O88848

- ARL6_MOUSE

UniProt

O88848 - ARL6_MOUSE

Protein

ADP-ribosylation factor-like protein 6

Gene

Arl6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi50 – 501MagnesiumBy similarity
    Binding sitei50 – 501GTPBy similarity
    Binding sitei72 – 721GTP; via amide nitrogenBy similarity
    Binding sitei164 – 1641GTP; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi24 – 318GTPBy similarity
    Nucleotide bindingi69 – 735GTPBy similarity
    Nucleotide bindingi130 – 1334GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: MGI
    2. metal ion binding Source: UniProtKB-KW
    3. phospholipid binding Source: UniProtKB
    4. protein binding Source: MGI

    GO - Biological processi

    1. cilium assembly Source: UniProtKB
    2. fat cell differentiation Source: BHF-UCL
    3. protein ADP-ribosylation Source: MGI
    4. protein polymerization Source: UniProtKB
    5. protein targeting to membrane Source: UniProtKB
    6. Ras protein signal transduction Source: MGI
    7. Wnt signaling pathway Source: Ensembl

    Keywords - Biological processi

    Cilium biogenesis/degradation, Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP-ribosylation factor-like protein 6
    Gene namesi
    Name:Arl6
    Synonyms:Bbs3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1927136. Arl6.

    Subcellular locationi

    Cell projectioncilium membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmcytoskeletoncilium axoneme By similarity. Cytoplasmcytoskeletoncilium basal body By similarity
    Note: Appears in a pattern of punctae flanking the microtubule axoneme that likely correspond to small membrane-associated patches. Localizes to the so-called ciliary gate where vesicles carrying ciliary cargo fuse with the membrane By similarity.By similarity

    GO - Cellular componenti

    1. axonemal microtubule Source: UniProtKB
    2. axoneme Source: UniProtKB
    3. ciliary membrane Source: UniProtKB-SubCell
    4. cytoplasm Source: MGI
    5. membrane Source: MGI
    6. membrane coat Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Isoform 2 deficient mice present a disruption of the normal photoreceptor architecture.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedSequence Analysis
    Chaini2 – 186185ADP-ribosylation factor-like protein 6PRO_0000207473Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineSequence Analysis

    Keywords - PTMi

    Lipoprotein, Myristate

    Proteomic databases

    MaxQBiO88848.
    PaxDbiO88848.
    PRIDEiO88848.

    PTM databases

    PhosphoSiteiO88848.

    Expressioni

    Tissue specificityi

    Most abundant in brain and kidney. Expressed in heart and eye. Isoform 2 is expressed only in the retina.1 Publication

    Gene expression databases

    ArrayExpressiO88848.
    BgeeiO88848.
    CleanExiMM_ARL6.
    GenevestigatoriO88848.

    Interactioni

    Subunit structurei

    Interacts with SEC61B, ARL6IP1, ARL6IP2, ARL6IP3, ARL6IP4 ARL6IP5 and ARL6IP6. Interacts (GTP-bound form) with the BBSome a complex that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10 By similarity.By similarity

    Protein-protein interaction databases

    IntActiO88848. 10 interactions.
    STRINGi10090.ENSMUSP00000123287.

    Structurei

    3D structure databases

    ProteinModelPortaliO88848.
    SMRiO88848. Positions 16-182.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Arf family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00750000117531.
    HOGENOMiHOG000163691.
    HOVERGENiHBG002073.
    InParanoidiQ3TY77.
    KOiK07951.
    OMAiDIKHRRL.
    OrthoDBiEOG78WKTS.
    PhylomeDBiO88848.
    TreeFamiTF105466.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR024156. Small_GTPase_ARF.
    IPR006689. Small_GTPase_ARF/SAR.
    [Graphical view]
    PfamiPF00025. Arf. 1 hit.
    [Graphical view]
    PRINTSiPR00328. SAR1GTPBP.
    SMARTiSM00177. ARF. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51417. ARF. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O88848-1) [UniParc]FASTAAdd to Basket

    Also known as: Bbs3

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGLLDRLSGL LGLKKKEVHV LCLGLDNSGK TTIINKLKPS NAQSQDIVPT    50
    IGFSIEKFKS SSLSFTVFDM SGQGRYRNLW EHYYKDGQAI IFVIDSSDKL 100
    RMVVAKEELD TLLNHPDIKH RRIPILFFAN KMDLRDSVTS VKVSQLLCLE 150
    SIKDKPWHIC ASDAIKGEGL QEGVDWLQDQ IQAVKT 186
    Length:186
    Mass (Da):20,959
    Last modified:November 1, 1998 - v1
    Checksum:i4F26947318977386
    GO
    Isoform 2 (identifier: O88848-2) [UniParc]FASTAAdd to Basket

    Also known as: Bbs3l

    The sequence of this isoform differs from the canonical sequence as follows:
         179-186: DQIQAVKT → EKTVQSDPSCEDVKR

    Show »
    Length:193
    Mass (Da):21,778
    Checksum:iFF91E45A2D785B7C
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei179 – 1868DQIQAVKT → EKTVQSDPSCEDVKR in isoform 2. 1 PublicationVSP_040512

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031903 mRNA. Translation: AAC62194.1.
    AK158832 mRNA. Translation: BAE34686.1.
    AK003778 mRNA. Translation: BAB22990.1.
    CCDSiCCDS28259.1. [O88848-1]
    RefSeqiNP_062639.3. NM_019665.3. [O88848-1]
    XP_006522461.1. XM_006522398.1. [O88848-2]
    UniGeneiMm.392505.

    Genome annotation databases

    EnsembliENSMUST00000023405; ENSMUSP00000023405; ENSMUSG00000022722. [O88848-1]
    ENSMUST00000099646; ENSMUSP00000097238; ENSMUSG00000022722. [O88848-2]
    ENSMUST00000118438; ENSMUSP00000113127; ENSMUSG00000022722. [O88848-2]
    GeneIDi56297.
    KEGGimmu:56297.
    UCSCiuc007zpl.2. mouse. [O88848-1]
    uc007zpm.2. mouse. [O88848-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF031903 mRNA. Translation: AAC62194.1 .
    AK158832 mRNA. Translation: BAE34686.1 .
    AK003778 mRNA. Translation: BAB22990.1 .
    CCDSi CCDS28259.1. [O88848-1 ]
    RefSeqi NP_062639.3. NM_019665.3. [O88848-1 ]
    XP_006522461.1. XM_006522398.1. [O88848-2 ]
    UniGenei Mm.392505.

    3D structure databases

    ProteinModelPortali O88848.
    SMRi O88848. Positions 16-182.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O88848. 10 interactions.
    STRINGi 10090.ENSMUSP00000123287.

    PTM databases

    PhosphoSitei O88848.

    Proteomic databases

    MaxQBi O88848.
    PaxDbi O88848.
    PRIDEi O88848.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023405 ; ENSMUSP00000023405 ; ENSMUSG00000022722 . [O88848-1 ]
    ENSMUST00000099646 ; ENSMUSP00000097238 ; ENSMUSG00000022722 . [O88848-2 ]
    ENSMUST00000118438 ; ENSMUSP00000113127 ; ENSMUSG00000022722 . [O88848-2 ]
    GeneIDi 56297.
    KEGGi mmu:56297.
    UCSCi uc007zpl.2. mouse. [O88848-1 ]
    uc007zpm.2. mouse. [O88848-2 ]

    Organism-specific databases

    CTDi 84100.
    MGIi MGI:1927136. Arl6.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00750000117531.
    HOGENOMi HOG000163691.
    HOVERGENi HBG002073.
    InParanoidi Q3TY77.
    KOi K07951.
    OMAi DIKHRRL.
    OrthoDBi EOG78WKTS.
    PhylomeDBi O88848.
    TreeFami TF105466.

    Miscellaneous databases

    NextBioi 312222.
    PROi O88848.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O88848.
    Bgeei O88848.
    CleanExi MM_ARL6.
    Genevestigatori O88848.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR024156. Small_GTPase_ARF.
    IPR006689. Small_GTPase_ARF/SAR.
    [Graphical view ]
    Pfami PF00025. Arf. 1 hit.
    [Graphical view ]
    PRINTSi PR00328. SAR1GTPBP.
    SMARTi SM00177. ARF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51417. ARF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit."
      Ingley E., Williams J.H., Walker C.E., Tsai S., Colley S., Sayer M.S., Tilbrook P.A., Sarna M., Beaumont J.G., Klinken S.P.
      FEBS Lett. 459:69-74(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Embryo and Visual cortex.
    3. "Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform."
      Pretorius P.R., Baye L.M., Nishimura D.Y., Searby C.C., Bugge K., Yang B., Mullins R.F., Stone E.M., Sheffield V.C., Slusarski D.C.
      PLoS Genet. 6:E1000884-E1000884(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiARL6_MOUSE
    AccessioniPrimary (citable) accession number: O88848
    Secondary accession number(s): Q3TY77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3