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Protein

Death domain-containing protein CRADD

Gene

Cradd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Death domain-containing protein CRADD
Alternative name(s):
Caspase and RIP adapter with death domain
RIP-associated protein with a death domain
Gene namesi
Name:Cradd
Synonyms:Raidd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1336168. Cradd.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi128 – 1281G → R: Impairs the interaction with PIDD. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 199199Death domain-containing protein CRADDPRO_0000079327Add
BLAST

Proteomic databases

EPDiO88843.
PaxDbiO88843.
PRIDEiO88843.

Expressioni

Gene expression databases

BgeeiO88843.
ExpressionAtlasiO88843. baseline and differential.
GenevisibleiO88843. MM.

Interactioni

Subunit structurei

Interacts with PIDD.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiO88843. 1 interaction.
MINTiMINT-4092002.
STRINGi10090.ENSMUSP00000050295.

Structurei

3D structure databases

ProteinModelPortaliO88843.
SMRiO88843. Positions 1-100, 109-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9292CARDPROSITE-ProRule annotationAdd
BLAST
Domaini116 – 18873DeathPROSITE-ProRule annotationAdd
BLAST

Domaini

Contains a death domain involved in the binding of RIP protein.
The CARD domain mediates the interaction with caspase-2.

Sequence similaritiesi

Contains 1 CARD domain.PROSITE-ProRule annotation
Contains 1 death domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJAM. Eukaryota.
ENOG4111SYE. LUCA.
HOGENOMiHOG000111965.
HOVERGENiHBG051112.
InParanoidiO88843.
KOiK02832.
OMAiPRAFHAF.
OrthoDBiEOG7SV0X1.
PhylomeDBiO88843.
TreeFamiTF333055.

Family and domain databases

Gene3Di1.10.533.10. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00531. Death. 1 hit.
[Graphical view]
SMARTiSM00114. CARD. 1 hit.
SM00005. DEATH. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
PROSITEiPS50209. CARD. 1 hit.
PS50017. DEATH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEARDKQVLR SLRLELGAEV LVEGLVLQYL YQEGILTENH IQEIKAQTTG
60 70 80 90 100
LRKTMLLLDI LPSRGPKAFD TFLDSLQEFP WVREKLEKAR EEVTAELPTG
110 120 130 140 150
DWMAGIPSHI LSSSPSDQQI NQLAQRLGPE WEPVVLSLGL SQTDIYRCKA
160 170 180 190
NHPHNVHSQV VEAFVRWRQR FGKQATFLSL HKGLQAVEAD PSLLQHMLE
Length:199
Mass (Da):22,656
Last modified:December 1, 2000 - v2
Checksum:i6C2F987B1ED47229
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti185 – 1851Q → H in AAC35882 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017992 mRNA. Translation: AAC35882.1.
AJ224738 mRNA. Translation: CAA12107.1.
AJ224740 mRNA. Translation: CAA12109.1.
BC005608 mRNA. Translation: AAH05608.1.
CCDSiCCDS24135.1.
RefSeqiNP_034080.1. NM_009950.2.
XP_006513241.1. XM_006513178.2.
XP_006513242.1. XM_006513179.1.
XP_006513243.1. XM_006513180.2.
XP_006513244.1. XM_006513181.2.
XP_006513245.1. XM_006513182.2.
UniGeneiMm.473739.

Genome annotation databases

EnsembliENSMUST00000053594; ENSMUSP00000050295; ENSMUSG00000045867.
GeneIDi12905.
KEGGimmu:12905.
UCSCiuc007gwa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017992 mRNA. Translation: AAC35882.1.
AJ224738 mRNA. Translation: CAA12107.1.
AJ224740 mRNA. Translation: CAA12109.1.
BC005608 mRNA. Translation: AAH05608.1.
CCDSiCCDS24135.1.
RefSeqiNP_034080.1. NM_009950.2.
XP_006513241.1. XM_006513178.2.
XP_006513242.1. XM_006513179.1.
XP_006513243.1. XM_006513180.2.
XP_006513244.1. XM_006513181.2.
XP_006513245.1. XM_006513182.2.
UniGeneiMm.473739.

3D structure databases

ProteinModelPortaliO88843.
SMRiO88843. Positions 1-100, 109-199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88843. 1 interaction.
MINTiMINT-4092002.
STRINGi10090.ENSMUSP00000050295.

Proteomic databases

EPDiO88843.
PaxDbiO88843.
PRIDEiO88843.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053594; ENSMUSP00000050295; ENSMUSG00000045867.
GeneIDi12905.
KEGGimmu:12905.
UCSCiuc007gwa.1. mouse.

Organism-specific databases

CTDi8738.
MGIiMGI:1336168. Cradd.

Phylogenomic databases

eggNOGiENOG410IJAM. Eukaryota.
ENOG4111SYE. LUCA.
HOGENOMiHOG000111965.
HOVERGENiHBG051112.
InParanoidiO88843.
KOiK02832.
OMAiPRAFHAF.
OrthoDBiEOG7SV0X1.
PhylomeDBiO88843.
TreeFamiTF333055.

Miscellaneous databases

NextBioi282528.
PROiO88843.
SOURCEiSearch...

Gene expression databases

BgeeiO88843.
ExpressionAtlasiO88843. baseline and differential.
GenevisibleiO88843. MM.

Family and domain databases

Gene3Di1.10.533.10. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00531. Death. 1 hit.
[Graphical view]
SMARTiSM00114. CARD. 1 hit.
SM00005. DEATH. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
PROSITEiPS50209. CARD. 1 hit.
PS50017. DEATH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A mouse cell death adaptor molecule that contains a death domain and a CARD domain."
    Pan G.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A 500-kb YAC and BAC contig encompassing the high-growth deletion in mouse chromosome 10 and identification of the murine Raidd/Cradd gene in the candidate region."
    Horvat S., Medrano J.F.
    Genomics 54:159-164(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart, Kidney, Liver, Lung, Pancreas and Spleen.
  5. Cited for: SUBCELLULAR LOCATION, INTERACTION WITH PIDD, MUTAGENESIS OF GLY-128.

Entry informationi

Entry nameiCRADD_MOUSE
AccessioniPrimary (citable) accession number: O88843
Secondary accession number(s): Q9QUN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: March 16, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.