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Protein

Death domain-containing protein CRADD

Gene

Cradd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-MMU-6803207. TP53 Regulates Transcription of Caspase Activators and Caspases.

Names & Taxonomyi

Protein namesi
Recommended name:
Death domain-containing protein CRADD
Alternative name(s):
Caspase and RIP adapter with death domain
RIP-associated protein with a death domain
Gene namesi
Name:Cradd
Synonyms:Raidd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1336168. Cradd.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi128G → R: Impairs the interaction with PIDD. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000793271 – 199Death domain-containing protein CRADDAdd BLAST199

Proteomic databases

EPDiO88843.
PaxDbiO88843.
PeptideAtlasiO88843.
PRIDEiO88843.

PTM databases

PhosphoSitePlusiO88843.

Expressioni

Gene expression databases

BgeeiENSMUSG00000045867.
ExpressionAtlasiO88843. baseline and differential.
GenevisibleiO88843. MM.

Interactioni

Subunit structurei

Interacts with PIDD.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiO88843. 1 interactor.
MINTiMINT-4092002.
STRINGi10090.ENSMUSP00000050295.

Structurei

3D structure databases

ProteinModelPortaliO88843.
SMRiO88843.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 92CARDPROSITE-ProRule annotationAdd BLAST92
Domaini116 – 188DeathPROSITE-ProRule annotationAdd BLAST73

Domaini

Contains a death domain involved in the binding of RIP protein.
The CARD domain mediates the interaction with caspase-2.

Sequence similaritiesi

Contains 1 CARD domain.PROSITE-ProRule annotation
Contains 1 death domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJAM. Eukaryota.
ENOG4111SYE. LUCA.
GeneTreeiENSGT00390000014448.
HOGENOMiHOG000111965.
HOVERGENiHBG051112.
InParanoidiO88843.
KOiK02832.
OMAiPRAFHAF.
OrthoDBiEOG091G0M3P.
PhylomeDBiO88843.
TreeFamiTF333055.

Family and domain databases

Gene3Di1.10.533.10. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00531. Death. 1 hit.
[Graphical view]
SMARTiSM00114. CARD. 1 hit.
SM00005. DEATH. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
PROSITEiPS50209. CARD. 1 hit.
PS50017. DEATH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEARDKQVLR SLRLELGAEV LVEGLVLQYL YQEGILTENH IQEIKAQTTG
60 70 80 90 100
LRKTMLLLDI LPSRGPKAFD TFLDSLQEFP WVREKLEKAR EEVTAELPTG
110 120 130 140 150
DWMAGIPSHI LSSSPSDQQI NQLAQRLGPE WEPVVLSLGL SQTDIYRCKA
160 170 180 190
NHPHNVHSQV VEAFVRWRQR FGKQATFLSL HKGLQAVEAD PSLLQHMLE
Length:199
Mass (Da):22,656
Last modified:December 1, 2000 - v2
Checksum:i6C2F987B1ED47229
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti185Q → H in AAC35882 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017992 mRNA. Translation: AAC35882.1.
AJ224738 mRNA. Translation: CAA12107.1.
AJ224740 mRNA. Translation: CAA12109.1.
BC005608 mRNA. Translation: AAH05608.1.
CCDSiCCDS24135.1.
RefSeqiNP_001317067.1. NM_001330138.1.
NP_001317070.1. NM_001330141.1.
NP_001317104.1. NM_001330175.1.
NP_034080.1. NM_009950.3.
XP_006513243.1. XM_006513180.2.
XP_006513244.1. XM_006513181.3.
UniGeneiMm.473739.

Genome annotation databases

EnsembliENSMUST00000053594; ENSMUSP00000050295; ENSMUSG00000045867.
GeneIDi12905.
KEGGimmu:12905.
UCSCiuc007gwa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017992 mRNA. Translation: AAC35882.1.
AJ224738 mRNA. Translation: CAA12107.1.
AJ224740 mRNA. Translation: CAA12109.1.
BC005608 mRNA. Translation: AAH05608.1.
CCDSiCCDS24135.1.
RefSeqiNP_001317067.1. NM_001330138.1.
NP_001317070.1. NM_001330141.1.
NP_001317104.1. NM_001330175.1.
NP_034080.1. NM_009950.3.
XP_006513243.1. XM_006513180.2.
XP_006513244.1. XM_006513181.3.
UniGeneiMm.473739.

3D structure databases

ProteinModelPortaliO88843.
SMRiO88843.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO88843. 1 interactor.
MINTiMINT-4092002.
STRINGi10090.ENSMUSP00000050295.

PTM databases

PhosphoSitePlusiO88843.

Proteomic databases

EPDiO88843.
PaxDbiO88843.
PeptideAtlasiO88843.
PRIDEiO88843.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053594; ENSMUSP00000050295; ENSMUSG00000045867.
GeneIDi12905.
KEGGimmu:12905.
UCSCiuc007gwa.1. mouse.

Organism-specific databases

CTDi8738.
MGIiMGI:1336168. Cradd.

Phylogenomic databases

eggNOGiENOG410IJAM. Eukaryota.
ENOG4111SYE. LUCA.
GeneTreeiENSGT00390000014448.
HOGENOMiHOG000111965.
HOVERGENiHBG051112.
InParanoidiO88843.
KOiK02832.
OMAiPRAFHAF.
OrthoDBiEOG091G0M3P.
PhylomeDBiO88843.
TreeFamiTF333055.

Enzyme and pathway databases

ReactomeiR-MMU-6803207. TP53 Regulates Transcription of Caspase Activators and Caspases.

Miscellaneous databases

PROiO88843.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045867.
ExpressionAtlasiO88843. baseline and differential.
GenevisibleiO88843. MM.

Family and domain databases

Gene3Di1.10.533.10. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00531. Death. 1 hit.
[Graphical view]
SMARTiSM00114. CARD. 1 hit.
SM00005. DEATH. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
PROSITEiPS50209. CARD. 1 hit.
PS50017. DEATH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRADD_MOUSE
AccessioniPrimary (citable) accession number: O88843
Secondary accession number(s): Q9QUN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.