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Protein
Submitted name:

Mutant fibrillin-1

Gene

Fbn1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Mutant fibrillin-1Imported
Gene namesi
Name:Fbn1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95489. Fbn1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 38573830Sequence analysisPRO_5004160535Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiO88840.
PRIDEiO88840.

Structurei

3D structure databases

ProteinModelPortaliO88840.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini146 – 17833EGF-likeInterPro annotationAdd
BLAST
Domaini184 – 22744TB (TGF-beta binding)InterPro annotationAdd
BLAST
Domaini246 – 28742EGF-likeInterPro annotationAdd
BLAST
Domaini288 – 32942EGF-likeInterPro annotationAdd
BLAST
Domaini334 – 38956TB (TGF-beta binding)InterPro annotationAdd
BLAST
Domaini451 – 49141EGF-likeInterPro annotationAdd
BLAST
Domaini492 – 52736EGF-likeInterPro annotationAdd
BLAST
Domaini532 – 57342EGF-likeInterPro annotationAdd
BLAST
Domaini574 – 61441EGF-likeInterPro annotationAdd
BLAST
Domaini615 – 65541EGF-likeInterPro annotationAdd
BLAST
Domaini661 – 71353TB (TGF-beta binding)InterPro annotationAdd
BLAST
Domaini725 – 76642EGF-likeInterPro annotationAdd
BLAST
Domaini767 – 80842EGF-likeInterPro annotationAdd
BLAST
Domaini809 – 84840EGF-likeInterPro annotationAdd
BLAST
Domaini853 – 89240TB (TGF-beta binding)InterPro annotationAdd
BLAST
Domaini912 – 95342EGF-likeInterPro annotationAdd
BLAST
Domaini958 – 101053TB (TGF-beta binding)InterPro annotationAdd
BLAST
Domaini1030 – 107142EGF-likeInterPro annotationAdd
BLAST
Domaini1072 – 111443EGF-likeInterPro annotationAdd
BLAST
Domaini1115 – 115642EGF-likeInterPro annotationAdd
BLAST
Domaini1157 – 119842EGF-likeInterPro annotationAdd
BLAST
Domaini1199 – 123941EGF-likeInterPro annotationAdd
BLAST
Domaini1240 – 128142EGF-likeInterPro annotationAdd
BLAST
Domaini1282 – 131938EGF-likeInterPro annotationAdd
BLAST
Domaini1324 – 136441EGF-likeInterPro annotationAdd
BLAST
Domaini1365 – 140339EGF-likeInterPro annotationAdd
BLAST
Domaini1406 – 144742EGF-likeInterPro annotationAdd
BLAST
Domaini1448 – 148437EGF-likeInterPro annotationAdd
BLAST
Domaini1489 – 152941EGF-likeInterPro annotationAdd
BLAST
Domaini1534 – 159158TB (TGF-beta binding)InterPro annotationAdd
BLAST
Domaini1588 – 165669Chitin-binding type-2InterPro annotationAdd
BLAST
Domaini1608 – 164942EGF-likeInterPro annotationAdd
BLAST
Domaini1650 – 168637EGF-likeInterPro annotationAdd
BLAST
Domaini1709 – 175042EGF-likeInterPro annotationAdd
BLAST
Domaini1751 – 179242EGF-likeInterPro annotationAdd
BLAST
Domaini1793 – 183240EGF-likeInterPro annotationAdd
BLAST
Domaini1837 – 187640TB (TGF-beta binding)InterPro annotationAdd
BLAST
Domaini1896 – 193742EGF-likeInterPro annotationAdd
BLAST
Domaini1942 – 199453TB (TGF-beta binding)InterPro annotationAdd
BLAST
Domaini2014 – 205542EGF-likeInterPro annotationAdd
BLAST
Domaini2056 – 209843EGF-likeInterPro annotationAdd
BLAST
Domaini2099 – 214042EGF-likeInterPro annotationAdd
BLAST
Domaini2141 – 218242EGF-likeInterPro annotationAdd
BLAST
Domaini2183 – 222341EGF-likeInterPro annotationAdd
BLAST
Domaini2224 – 226542EGF-likeInterPro annotationAdd
BLAST
Domaini2266 – 230338EGF-likeInterPro annotationAdd
BLAST
Domaini2308 – 234841EGF-likeInterPro annotationAdd
BLAST
Domaini2349 – 238739EGF-likeInterPro annotationAdd
BLAST
Domaini2390 – 243142EGF-likeInterPro annotationAdd
BLAST
Domaini2432 – 246837EGF-likeInterPro annotationAdd
BLAST
Domaini2473 – 251341EGF-likeInterPro annotationAdd
BLAST
Domaini2518 – 257558TB (TGF-beta binding)InterPro annotationAdd
BLAST
Domaini2572 – 264069Chitin-binding type-2InterPro annotationAdd
BLAST
Domaini2592 – 263342EGF-likeInterPro annotationAdd
BLAST
Domaini2634 – 267037EGF-likeInterPro annotationAdd
BLAST
Domaini2655 – 270551Chitin-binding type-2InterPro annotationAdd
BLAST
Domaini2679 – 273456TB (TGF-beta binding)InterPro annotationAdd
BLAST
Domaini2752 – 279342EGF-likeInterPro annotationAdd
BLAST
Domaini2794 – 283441EGF-likeInterPro annotationAdd
BLAST
Domaini2835 – 287642EGF-likeInterPro annotationAdd
BLAST
Domaini2877 – 291236EGF-likeInterPro annotationAdd
BLAST
Domaini2916 – 295843EGF-likeInterPro annotationAdd
BLAST
Domaini2959 – 299840EGF-likeInterPro annotationAdd
BLAST
Domaini2999 – 304042EGF-likeInterPro annotationAdd
BLAST
Domaini3045 – 309753TB (TGF-beta binding)InterPro annotationAdd
BLAST
Domaini3113 – 315139EGF-likeInterPro annotationAdd
BLAST
Domaini3152 – 319140EGF-likeInterPro annotationAdd
BLAST
Domaini3192 – 323241EGF-likeInterPro annotationAdd
BLAST
Domaini3233 – 327341EGF-likeInterPro annotationAdd
BLAST
Domaini3277 – 331842EGF-likeInterPro annotationAdd
BLAST
Domaini3323 – 337654TB (TGF-beta binding)InterPro annotationAdd
BLAST
Domaini3388 – 342538EGF-likeInterPro annotationAdd
BLAST
Domaini3430 – 347041EGF-likeInterPro annotationAdd
BLAST
Domaini3471 – 350737EGF-likeInterPro annotationAdd
BLAST
Domaini3510 – 354839EGF-likeInterPro annotationAdd
BLAST
Domaini3553 – 359240EGF-likeInterPro annotationAdd
BLAST
Domaini3593 – 362937EGF-likeInterPro annotationAdd
BLAST
Domaini3634 – 367340EGF-likeInterPro annotationAdd
BLAST

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

HOVERGENiHBG005643.

Family and domain databases

Gene3Di3.90.290.10. 13 hits.
InterProiIPR026823. cEGF.
IPR002557. Chitin-bd_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR011398. FBN.
IPR009030. Growth_fac_rcpt_.
IPR017878. TB_dom.
[Graphical view]
PANTHERiPTHR24039. PTHR24039. 2 hits.
PfamiPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 58 hits.
PF00683. TB. 12 hits.
[Graphical view]
SMARTiSM00494. ChtBD2. 5 hits.
SM00181. EGF. 64 hits.
SM00179. EGF_CA. 62 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 16 hits.
SSF57581. SSF57581. 12 hits.
PROSITEiPS00010. ASX_HYDROXYL. 61 hits.
PS50940. CHIT_BIND_II. 3 hits.
PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 50 hits.
PS50026. EGF_3. 63 hits.
PS01187. EGF_CA. 61 hits.
PS51364. TB. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88840-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRGGLLEVA LAFALLLESY TSHGADANLE AGSLKETRAN RAKRRGGGGH
60 70 80 90 100
DALKGPNVCG SRYNAYCCPG WKTLPGGNQC IVPICRHSCG DGFCSRPNMC
110 120 130 140 150
TCPSGQISPS CGSRSIQHCS IRCMNGGSCS DDHCLCQKGY IGTHCGQPVC
160 170 180 190 200
ESGCLNGGRC VAPNRCACTY GFTGPQCERD YRTGPCFTVV SNQMCQGQLS
210 220 230 240 250
GIVCTKTLCC ATVGRAWGHP CEMCPAQPHP CRRGFIPNIR TGACQDVDEC
260 270 280 290 300
QAIPGMCQGG NCINTVGSFE CKCPAGHKFN EVSQKCEDID ECSTIPGVCD
310 320 330 340 350
GGECTNTVSS YFCKCPPGFY TSPDGTRCVD VRPGYCYTAL ANGRCSNQLP
360 370 380 390 400
QSITKMQCCC DLGRCWSPGV TVAPEMCPIR STEDFNKLCS VPLVIPGRPE
410 420 430 440 450
YPPPPIGPLP PVQPVPPGYP PGPVIPAPRP PPEYPYPSPS REPPRVLPFN
460 470 480 490 500
VTDYCQLVRY LCQNGRCIPT PGSYRCECNK GFQLDIRGEC IDVDECEKNP
510 520 530 540 550
CTGGECINNQ GSYTCHCRAG YQSTLTRTEC RDIDECLQNG RICNNGRCIN
560 570 580 590 600
TDGSFHCVCN AGFHVTRDGK NCEDMDECSI RNMCLNGMCI NEDGSFKCIC
610 620 630 640 650
KPGFQLASDG RYCKDINECE TPGICMNGRC VNTDGSYRCE CFPGLAVGLD
660 670 680 690 700
GRVCVDTHMR STCYGGYRRG QCVKPLFGAV TKSECCCAST EYAFGEPCQP
710 720 730 740 750
CPAQNSAEYQ ALCSSGPGMT SAGTDINECA LDPDICPNGI CENLRGTYKC
760 770 780 790 800
ICNSGYEVDI TGKNCVDINE CVLNSLLCDN GQCRNTPGSF VCTCPKGFVY
810 820 830 840 850
KPDLKTCEDI DECESSPCIN GVCKNSPGSF ICECSPESTL DPTKTICIET
860 870 880 890 900
IKGTCWQTVI DGRCEINING ATLKSECCSS LGAAWGSPCT ICQLDPICGK
910 920 930 940 950
GFSRIKGTQC EDINECEVFP GVCKNGLCVN SRGSFKCECP NGTTLDATGR
960 970 980 990 1000
ICLDIRLETC FLKYDDEECT LPIAGRHRMD ACCCSVGAAW GTEECEECPL
1010 1020 1030 1040 1050
RNSREYEELC PRGPGFATKD ITNGKPFFKD INECKMIPSL CTHGKCRNTI
1060 1070 1080 1090 1100
GSFKCRCDSG FALDSEERNC TDIDECRISP DLCGRGQCVN TPGDFECKCD
1110 1120 1130 1140 1150
EGYESGFMMM KNCMDIDECQ RDPLLCRGGI CHNTEGSYRC ECPPGHQLSP
1160 1170 1180 1190 1200
NISACIDINE CELSANLCPH GRCVNLIGKY QCACNPGYHP THDRLFCVDI
1210 1220 1230 1240 1250
DECSIMNGGC ETFCTNSDGS YECSCQPGFA LMPDQRSCTD IDECEDNPNI
1260 1270 1280 1290 1300
CDGGQCTNIP GEYRCLCYDG FMASEDMKTC VDVNECDLNP NICLSGTCEN
1310 1320 1330 1340 1350
TKGSFICHCD MGYSGKKGKT GCTDINECEI GAHNCGRHAV CTNTAGSFKC
1360 1370 1380 1390 1400
SCSPGWIGDG IKCTDLDECS NGTHMCSQHA DCKNTMGSYR CLCKDGYTGD
1410 1420 1430 1440 1450
GFTCTDLDEC SENLNLCGNG QCLNAPGGYR CECDMGFVPS ADGKACEDID
1460 1470 1480 1490 1500
ECSLPNICVF GTCHNLPGLF RCECEIGYEL DRSGGNCTDV NECLDPTTCI
1510 1520 1530 1540 1550
SGNCVNTPGS YTCDCPPDFE LNPTRVGCVD TCSGNCYLDI RPRGDNGDTA
1560 1570 1580 1590 1600
CSNEIGVGVS KASCCCSLGK AWGTPCELCP SVNTSEYKIL CPGGEGFRPN
1610 1620 1630 1640 1650
PITVILEDID ECQELPGLCQ GGKCINTFGS FQCRCPTGYY LNEDTRVCDD
1660 1670 1680 1690 1700
VNECETPGIC GPGTCYNTVG NYTCICPPDY MQVNGGNNCM AEYQALCSSG
1710 1720 1730 1740 1750
PGMTSAGTDI NECALDPDIC PNGICENLRG TYKCICNSGY EVDITGKNCV
1760 1770 1780 1790 1800
DINECVLNSL LCDNGQCRNT PGSFVCTCPK GFVYKPDLKT CEDIDECESS
1810 1820 1830 1840 1850
PCINGVCKNS PGSFICECSP ESTLDPTKTI CIETIKGTCW QTVIDGRCEI
1860 1870 1880 1890 1900
NINGATLKSE CCSSLGAAWG SPCTICQLDP ICGKGFSRIK GTQCEDINEC
1910 1920 1930 1940 1950
EVFPGVCKNG LCVNSRGSFK CECPNGMTLD ATGRICLDIR LETCFLKYDD
1960 1970 1980 1990 2000
EECTLPIAGR HRMDACCCSV GAAWGTEECE ECPLRNSREY EELCPRGPGF
2010 2020 2030 2040 2050
ATKDITNGKP FFKDINECKM IPSLCTHGKC RNTIGSFKCR CDSGFALDSE
2060 2070 2080 2090 2100
ERNCTDIDEC RISPDLCGRG QCVNTPGDFE CKCDEGYESG FMMMKNCMDI
2110 2120 2130 2140 2150
DECQRDPLLC RGGICHNTEG SYRCECPPGH QLSPNISACI DINECELSAN
2160 2170 2180 2190 2200
LCPHGRCVNL IGKYQCACNP GYHPTHDRLF CVDIDECSIM NGGCETFCTN
2210 2220 2230 2240 2250
SDGSYECSCQ PGFALMPDQR SCTDIDECED NPNICDGGQC TNIPGEYRCL
2260 2270 2280 2290 2300
CYDGFMASED MKTCVDVNEC DLNPNICLSG TCENTKGSFI CHCDMGYSGK
2310 2320 2330 2340 2350
KGKTGCTDIN ECEIGAHNCD RHAVCTNTAG SFKCSCSPGW IGDGIKCTDL
2360 2370 2380 2390 2400
DECSSGTHMC SQHADCKNTM GSYRCLCKDG YTGDGFTCTD LDECSENLNL
2410 2420 2430 2440 2450
CGNGQCLNAP GGYRCECDMG FVPSADGKAC EDIDECSLPN ICVFGTCHNL
2460 2470 2480 2490 2500
PGLFRCECEI GYELDRSGGN CTDVNECLDP TTCISGNCVN TPGSYTCDCP
2510 2520 2530 2540 2550
PDFELNPTRV GCVDTRSGNC YLDIRPRGDN GDTACSNEIG VGVSKASCCC
2560 2570 2580 2590 2600
SLGKAWGTPC ELCPSVNTSE YKILCPGGEG FRPNPITVIL EDIDECQELP
2610 2620 2630 2640 2650
GLCQGGKCIN TFGSFQCRCP TGYYLNEDTR VCDDVNECET PGICGPGTCY
2660 2670 2680 2690 2700
NTVGNYTCIC PPDYMQVNGG NNCMDMRRSL CYRNYYADNQ TCDGELLFNM
2710 2720 2730 2740 2750
TKKMCCCSYN IGRAWNKPCE QCPIPSTDEF ATLCGSQRPG FVIDIYTGLP
2760 2770 2780 2790 2800
VDIDECREIP GVCENGVCIN MVGSFRCGCP VGFFYNDKLL VCEDIDECQN
2810 2820 2830 2840 2850
GPVCQRNAEC INTAGSYRCD CKPGYRLTST GQCNDRNECQ EIPNICSHGQ
2860 2870 2880 2890 2900
CIDTVGSFYC LCHTGFKTNV DQTMCLDINE CERDACGNGT CRNTIGSFNC
2910 2920 2930 2940 2950
RCNHGFILSH NNDCIDVDEC ATGNGNLCRN GQCVNTVGSF QCRCNEGYEV
2960 2970 2980 2990 3000
APDGRTCVDI NECVLDPGKC APGTCQNLDG SYRCICPPGY SLQNDKCEDI
3010 3020 3030 3040 3050
DECVEEPEIC ALGTCSNTEG SFKCLCPEGF SLSSTGRRCQ DLRMSYCYAK
3060 3070 3080 3090 3100
FEGGKCSSPK SRNHSKQECC CALKGEGWGD PCELCPTEPD EAFRQICPFG
3110 3120 3130 3140 3150
SGIIVGPDDS AVDMDECKEP DVCRHGQCIN TDGSYRCECP FGYILEGNEC
3160 3170 3180 3190 3200
VDTDECSVGN PCGNGTCKNV IGGFECTCEE GFEPGPMMTC EDINECAQNP
3210 3220 3230 3240 3250
LLCAFRCVNT YGSYECKCPV GYVLREDRRM CKDEDECAEG KHDCTEKQME
3260 3270 3280 3290 3300
CKNLIGTYMC ICGPGYQRRP DGEGCIDENE CQTKPGICEN GRCLNTLGSY
3310 3320 3330 3340 3350
TCECNDGFTA SPTQDECLDN REGYCFSEVL QNMCQIGSSN RNPVTKSECC
3360 3370 3380 3390 3400
CDGGRGWGPH CEICPFEGTV AYKKLCPHGR GFMTNGADID ECKVIHDVCR
3410 3420 3430 3440 3450
NGECVNDRGS YHCICKTGYT PDITGTACVD LNECNQAPKP CNFICKNTEG
3460 3470 3480 3490 3500
SYQCSCPKGY ILQEDGRSCK DLDECATKQH NCQFLCVNTI GGFTCKCPPG
3510 3520 3530 3540 3550
FTQHHTACID NNECTSDINL CGSKGVCQNT PGSFTCECQR GFSLDQSGAS
3560 3570 3580 3590 3600
CEDVDECEGN HRCQHGCQNI IGGYRCSCPQ GYLQHYQWNQ CVDENECLSA
3610 3620 3630 3640 3650
HVCGGASCHN TLGSYKCMCP TGFQYEQFSG GCQDINECGS SQAPCSYGCS
3660 3670 3680 3690 3700
NTEGGYLCGC PPGYFRIGQG HCVSGMGMGR GGPEPPASSE MDDNSLSPEA
3710 3720 3730 3740 3750
CYECKINGYP KRGRKRRSTN ETDASDIQDG SEMEANVSLA SWDVEKPASF
3760 3770 3780 3790 3800
AFNISHVNNK VRILELLPAL TTLMNHNRYL IESGNEDGFF KINQKEGVSY
3810 3820 3830 3840 3850
LHFTKKKPVA GTYSLQISST PLYKKKELNQ LEDRYDKDYL SGELGDNLKM

KIQILLH
Length:3,857
Mass (Da):418,307
Last modified:November 1, 1998 - v1
Checksum:i5BC0618BC527E04C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007248 mRNA. Translation: AAC62317.1.
UniGeneiMm.271644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007248 mRNA. Translation: AAC62317.1.
UniGeneiMm.271644.

3D structure databases

ProteinModelPortaliO88840.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiO88840.
PRIDEiO88840.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95489. Fbn1.

Phylogenomic databases

HOVERGENiHBG005643.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di3.90.290.10. 13 hits.
InterProiIPR026823. cEGF.
IPR002557. Chitin-bd_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR011398. FBN.
IPR009030. Growth_fac_rcpt_.
IPR017878. TB_dom.
[Graphical view]
PANTHERiPTHR24039. PTHR24039. 2 hits.
PfamiPF12662. cEGF. 1 hit.
PF07645. EGF_CA. 58 hits.
PF00683. TB. 12 hits.
[Graphical view]
SMARTiSM00494. ChtBD2. 5 hits.
SM00181. EGF. 64 hits.
SM00179. EGF_CA. 62 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 16 hits.
SSF57581. SSF57581. 12 hits.
PROSITEiPS00010. ASX_HYDROXYL. 61 hits.
PS50940. CHIT_BIND_II. 3 hits.
PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 50 hits.
PS50026. EGF_3. 63 hits.
PS01187. EGF_CA. 61 hits.
PS51364. TB. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure of the mutant fibrillin-1 gene in the tight skin (TSK) mouse."
    Bona C.A., Murai C., Casares S., Kasturi K., Nishimura H., Honjo T., Matsuda F.
    DNA Res. 4:267-271(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B10.D2Imported.

Entry informationi

Entry nameiO88840_MOUSE
AccessioniPrimary (citable) accession number: O88840
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: July 6, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.