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Protein

SH2 domain-containing adapter protein D

Gene

Shd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May function as an adapter protein.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
SH2 domain-containing adapter protein D
Gene namesi
Name:Shd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1099461. Shd.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343SH2 domain-containing adapter protein DPRO_0000246774Add
BLAST

Post-translational modificationi

Tyrosine phosphorylated by ABL.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO88834.
PaxDbiO88834.
PRIDEiO88834.

PTM databases

PhosphoSiteiO88834.

Expressioni

Tissue specificityi

Specifically expressed in brain.1 Publication

Gene expression databases

BgeeiO88834.
GenevisibleiO88834. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047656.

Structurei

3D structure databases

ProteinModelPortaliO88834.
SMRiO88834. Positions 219-302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini225 – 32096SH2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiENOG410IGWI. Eukaryota.
ENOG410XQJ2. LUCA.
GeneTreeiENSGT00390000015203.
HOGENOMiHOG000038038.
HOVERGENiHBG066172.
InParanoidiO88834.
OMAiFYTTHKL.
OrthoDBiEOG793B9C.
PhylomeDBiO88834.
TreeFamiTF325799.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O88834-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKWLRDYLN LGSRRPPPQP PTPDYTESDI LRAYREQKDL DFEDPYEDSN
60 70 80 90 100
GRAEPEVTGS GDPKYNSPRH RLIKVEAADM ARAKALLGSP GEEPEAETEY
110 120 130 140 150
SDPFDAQPQP PAPNSGYMEP YDARSVSSEQ PSRAVQLYDT PYEEQATKPE
160 170 180 190 200
DGGSSGQSRR PLEDERPADE YDQPWEWKKD HISRAFAVQF DGPDWERTPC
210 220 230 240 250
STKEPWRPQP AERVDTALAL EKQPWFHGPL SRAEAENLLS LCKEGSYLVR
260 270 280 290 300
LSETRAQDCI LSLRSNQGSM HLKFARTREN QVVLGQHSGP FPSIPELVLH
310 320 330 340
YSARPLPVQG AEHLALLYPV TSSQSSQGPC TLAAKPERGQ GDP
Length:343
Mass (Da):38,481
Last modified:November 1, 1998 - v1
Checksum:iC55412EEA5AC40EC
GO
Isoform 2 (identifier: O88834-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-93: E → EQ

Show »
Length:344
Mass (Da):38,610
Checksum:iD31DD059FB0D48B4
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei93 – 931E → EQ in isoform 2. 1 PublicationVSP_019860

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018423 mRNA. Translation: BAA33805.1.
AK142491 mRNA. Translation: BAE25084.1.
AK164639 mRNA. Translation: BAE37855.1.
BC103798 mRNA. Translation: AAI03799.1.
CCDSiCCDS50149.1. [O88834-2]
RefSeqiNP_001152995.1. NM_001159523.1. [O88834-2]
NP_033194.1. NM_009168.2. [O88834-1]
XP_011244636.1. XM_011246334.1. [O88834-2]
UniGeneiMm.20908.

Genome annotation databases

EnsembliENSMUST00000044216; ENSMUSP00000047656; ENSMUSG00000039154. [O88834-2]
GeneIDi20420.
KEGGimmu:20420.
UCSCiuc008dal.2. mouse. [O88834-1]
uc008dam.2. mouse. [O88834-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018423 mRNA. Translation: BAA33805.1.
AK142491 mRNA. Translation: BAE25084.1.
AK164639 mRNA. Translation: BAE37855.1.
BC103798 mRNA. Translation: AAI03799.1.
CCDSiCCDS50149.1. [O88834-2]
RefSeqiNP_001152995.1. NM_001159523.1. [O88834-2]
NP_033194.1. NM_009168.2. [O88834-1]
XP_011244636.1. XM_011246334.1. [O88834-2]
UniGeneiMm.20908.

3D structure databases

ProteinModelPortaliO88834.
SMRiO88834. Positions 219-302.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047656.

PTM databases

PhosphoSiteiO88834.

Proteomic databases

MaxQBiO88834.
PaxDbiO88834.
PRIDEiO88834.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044216; ENSMUSP00000047656; ENSMUSG00000039154. [O88834-2]
GeneIDi20420.
KEGGimmu:20420.
UCSCiuc008dal.2. mouse. [O88834-1]
uc008dam.2. mouse. [O88834-2]

Organism-specific databases

CTDi56961.
MGIiMGI:1099461. Shd.

Phylogenomic databases

eggNOGiENOG410IGWI. Eukaryota.
ENOG410XQJ2. LUCA.
GeneTreeiENSGT00390000015203.
HOGENOMiHOG000038038.
HOVERGENiHBG066172.
InParanoidiO88834.
OMAiFYTTHKL.
OrthoDBiEOG793B9C.
PhylomeDBiO88834.
TreeFamiTF325799.

Miscellaneous databases

NextBioi298424.
PROiO88834.
SOURCEiSearch...

Gene expression databases

BgeeiO88834.
GenevisibleiO88834. MM.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00252. SH2. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase."
    Oda T., Kujovich J., Reis M., Newman B., Druker B.J.
    Oncogene 15:1255-1262(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION BY ABL.
    Tissue: Embryo.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Stomach.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Jaw and Limb.

Entry informationi

Entry nameiSHD_MOUSE
AccessioniPrimary (citable) accession number: O88834
Secondary accession number(s): Q3SYI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 1, 1998
Last modified: January 20, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.