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Protein

Cytochrome P450 4A10

Gene

Cyp4a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.Curated

Catalytic activityi

A long-chain fatty acid + NADPH + O2 = an omega-hydroxy-long-chain fatty acid + NADP+ + H2O.By similarity
Octane + 2 reduced rubredoxin + O2 + 2 H+ = 1-octanol + 2 oxidized rubredoxin + H2O.By similarity

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei320 – 3201Heme (covalent; via 1 link)By similarity
Metal bindingi456 – 4561Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

  • fatty acid metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

ReactomeiR-MMU-211935. Fatty acids.
R-MMU-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

Chemistry

SwissLipidsiSLP:000000399.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4A10
Alternative name(s):
CYPIVA10
Cytochrome P450-LA-omega 1
Cytochrome P452
Lauric acid omega-hydroxylase
Long-chain fatty acid omega-monooxygenase (EC:1.14.13.205)
Gene namesi
Name:Cyp4a10Imported
Synonyms:Cyp4a-10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:88611. Cyp4a10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 509508Cytochrome P450 4A10PRO_0000051815Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei439 – 4391PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO88833.
MaxQBiO88833.
PaxDbiO88833.
PRIDEiO88833.

PTM databases

iPTMnetiO88833.
PhosphoSiteiO88833.

Expressioni

Gene expression databases

BgeeiO88833.
ExpressionAtlasiO88833. baseline and differential.
GenevisibleiO88833. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061126.

Structurei

3D structure databases

ProteinModelPortaliO88833.
SMRiO88833. Positions 53-503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiO88833.
KOiK07425.
OMAiYAMATHP.
OrthoDBiEOG7CNZFK.
TreeFamiTF105088.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88833-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSALSPTR FADSLSGFLQ VASVLGLLLL LVKAVQFYLH RQWLLKAFQQ
60 70 80 90 100
FPSPPFHWFF GHEKFKGDQE LQEIVSCIEN FPSAFPRWFW GSKAYLTVYD
110 120 130 140 150
PDYMKVILGR SDPKANGAYR LLAPWIGYGL LLLNGQPWFQ HRRMLTPAFH
160 170 180 190 200
YDILKPYVKN MADSIRLMLD KWERLADQDS SIEIFQHISL MTLDTVMKCA
210 220 230 240 250
FSHKGSVQVD GNYRTYLQAI GDLNNLFHSR VRNIFHQNDT IYKLSSNGRL
260 270 280 290 300
AKQACQLAHD HTDGVIKLRK DQLQDEGELE KIKKKRRLDF LDILLFARME
310 320 330 340 350
NGDSMSDKDL RAEVDTFMFE GHDTTASGVS WIFYALATHP DHQQRCREEV
360 370 380 390 400
QSLLGDGSSI TWDHLDQIPY TTMCIKEALR LYPPVPGIVR ELSTSVTFPD
410 420 430 440 450
GRSLPKGVQV TLSIYGLHHN PKVWPNPEVF DPSRFAPDSP RHSHSFLPFS
460 470 480 490 500
GGARNCIGKQ FAMSELKVIV ALTLLRFELL PDPTRVPMPL ARLVLKSKNG

IYLHLKKLH
Length:509
Mass (Da):58,330
Last modified:July 27, 2011 - v2
Checksum:i94F22CE77BD3EDC0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621H → L in X69296 (PubMed:8031839).Curated
Sequence conflicti64 – 641K → Q in BAA33804 (Ref. 2) Curated
Sequence conflicti64 – 641K → Q in AAH10747 (PubMed:15489334).Curated
Sequence conflicti64 – 641K → Q in AAH51049 (PubMed:15489334).Curated
Sequence conflicti69 – 691Q → H in BAA33804 (Ref. 2) Curated
Sequence conflicti69 – 691Q → H in AAH10747 (PubMed:15489334).Curated
Sequence conflicti69 – 691Q → H in AAH51049 (PubMed:15489334).Curated
Sequence conflicti234 – 2341I → N in X69296 (PubMed:8031839).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69296 mRNA. No translation available.
AB018421 mRNA. Translation: BAA33804.1.
AK002528 mRNA. Translation: BAB22165.1.
AL627182 Genomic DNA. Translation: CAM21090.1.
BC010747 mRNA. Translation: AAH10747.1.
BC051049 mRNA. Translation: AAH51049.1.
CCDSiCCDS18492.1.
PIRiS47553.
RefSeqiNP_034141.3. NM_010011.3.
UniGeneiMm.10742.

Genome annotation databases

EnsembliENSMUST00000058785; ENSMUSP00000061126; ENSMUSG00000066072.
GeneIDi13117.
KEGGimmu:13117.
UCSCiuc008uex.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69296 mRNA. No translation available.
AB018421 mRNA. Translation: BAA33804.1.
AK002528 mRNA. Translation: BAB22165.1.
AL627182 Genomic DNA. Translation: CAM21090.1.
BC010747 mRNA. Translation: AAH10747.1.
BC051049 mRNA. Translation: AAH51049.1.
CCDSiCCDS18492.1.
PIRiS47553.
RefSeqiNP_034141.3. NM_010011.3.
UniGeneiMm.10742.

3D structure databases

ProteinModelPortaliO88833.
SMRiO88833. Positions 53-503.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061126.

Chemistry

SwissLipidsiSLP:000000399.

PTM databases

iPTMnetiO88833.
PhosphoSiteiO88833.

Proteomic databases

EPDiO88833.
MaxQBiO88833.
PaxDbiO88833.
PRIDEiO88833.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058785; ENSMUSP00000061126; ENSMUSG00000066072.
GeneIDi13117.
KEGGimmu:13117.
UCSCiuc008uex.2. mouse.

Organism-specific databases

CTDi13117.
MGIiMGI:88611. Cyp4a10.

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiO88833.
KOiK07425.
OMAiYAMATHP.
OrthoDBiEOG7CNZFK.
TreeFamiTF105088.

Enzyme and pathway databases

ReactomeiR-MMU-211935. Fatty acids.
R-MMU-2142816. Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).

Miscellaneous databases

ChiTaRSiCyp4a10. mouse.
PROiO88833.
SOURCEiSearch...

Gene expression databases

BgeeiO88833.
ExpressionAtlasiO88833. baseline and differential.
GenevisibleiO88833. MM.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a protein: developmental and hormonal regulation in liver and kidney."
    Henderson C.J., Bammler T., Wolf C.R.
    Biochim. Biophys. Acta 1200:182-190(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J1 Publication.
    Tissue: Liver1 Publication.
  2. "Polymorphism of cyp 4A10 sequence between C57BL/6 and ddY mouse."
    Yasumura N., Ikeda T.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ddYImported.
    Tissue: LiverImported.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: KidneyImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: KidneyImported.

Entry informationi

Entry nameiCP4AA_MOUSE
AccessioniPrimary (citable) accession number: O88833
Secondary accession number(s): A2A976, Q9DCS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.