Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O88824

- JTB_MOUSE

UniProt

O88824 - JTB_MOUSE

Protein

Protein JTB

Gene

Jtb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity By similarity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.By similarity1 Publication

    GO - Molecular functioni

    1. protein kinase binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic mitochondrial changes Source: MGI
    2. cytokinesis Source: UniProtKB
    3. mitotic nuclear division Source: UniProtKB
    4. positive regulation of protein kinase activity Source: UniProtKB
    5. regulation of cell proliferation Source: UniProtKB

    Keywords - Biological processi

    Apoptosis, Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein JTB
    Gene namesi
    Name:Jtb
    Synonyms:Gm622
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1346082. Jtb.

    Subcellular locationi

    Membrane Curated; Single-pass type I membrane protein Curated. Mitochondrion 1 Publication. Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytoskeletonspindle By similarity
    Note: Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase By similarity.By similarity

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. cytoplasm Source: UniProtKB
    3. integral component of membrane Source: UniProtKB-KW
    4. midbody Source: UniProtKB
    5. mitochondrion Source: UniProtKB
    6. spindle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Membrane, Mitochondrion

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi13 – 142AG → DD: Abolishes N-terminal proteolytic processing. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 146116Protein JTBPRO_0000021536Add
    BLAST

    Post-translational modificationi

    Undergoes N-terminal proteolytic processing, removing a peptide of about 1 kDa from the N-terminus of the protein.1 Publication

    Proteomic databases

    PRIDEiO88824.

    PTM databases

    PhosphoSiteiO88824.

    Expressioni

    Inductioni

    Up-regulated by TGFB1 in mammary epithelial cells.1 Publication

    Gene expression databases

    ArrayExpressiO88824.
    BgeeiO88824.
    CleanExiMM_JTB.
    GenevestigatoriO88824.

    Interactioni

    Subunit structurei

    Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO88824.
    SMRiO88824. Positions 47-103.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini31 – 10575ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini127 – 14620CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei106 – 12621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the JTB family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG296098.
    HOGENOMiHOG000294204.
    HOVERGENiHBG000952.
    InParanoidiO88824.
    OMAiTPECGST.
    OrthoDBiEOG7SR4Q2.
    PhylomeDBiO88824.
    TreeFamiTF316934.

    Family and domain databases

    InterProiIPR008657. JTB.
    [Graphical view]
    PfamiPF05439. JTB. 1 hit.
    [Graphical view]
    ProDomiPD151382. JTB. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O88824-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLAGAGRRGL PRAGHLCWLL CAFTLKLCEA EAPVREEKLS VSTSTSPCWL    50
    AEEFVVTEEC TPCSNFQIKT TPECGSTGYV EKITCSSSKR NEFKSCRSAL 100
    LEQHLFWKFE GVVVAVALVF ACLVIVRQRQ LDRKALEKVR KQIESI 146
    Length:146
    Mass (Da):16,329
    Last modified:November 1, 1998 - v1
    Checksum:i9E4DAF394B2A2107
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016490 mRNA. Translation: BAA33733.1.
    BC008139 mRNA. Translation: AAH08139.1.
    CCDSiCCDS17523.1.
    RefSeqiNP_996807.1. NM_206924.2.
    UniGeneiMm.13912.

    Genome annotation databases

    EnsembliENSMUST00000029546; ENSMUSP00000029546; ENSMUSG00000027937.
    GeneIDi23922.
    KEGGimmu:23922.
    UCSCiuc008qbo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB016490 mRNA. Translation: BAA33733.1 .
    BC008139 mRNA. Translation: AAH08139.1 .
    CCDSi CCDS17523.1.
    RefSeqi NP_996807.1. NM_206924.2.
    UniGenei Mm.13912.

    3D structure databases

    ProteinModelPortali O88824.
    SMRi O88824. Positions 47-103.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O88824.

    Proteomic databases

    PRIDEi O88824.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029546 ; ENSMUSP00000029546 ; ENSMUSG00000027937 .
    GeneIDi 23922.
    KEGGi mmu:23922.
    UCSCi uc008qbo.1. mouse.

    Organism-specific databases

    CTDi 10899.
    MGIi MGI:1346082. Jtb.

    Phylogenomic databases

    eggNOGi NOG296098.
    HOGENOMi HOG000294204.
    HOVERGENi HBG000952.
    InParanoidi O88824.
    OMAi TPECGST.
    OrthoDBi EOG7SR4Q2.
    PhylomeDBi O88824.
    TreeFami TF316934.

    Miscellaneous databases

    NextBioi 303705.
    PROi O88824.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O88824.
    Bgeei O88824.
    CleanExi MM_JTB.
    Genevestigatori O88824.

    Family and domain databases

    InterProi IPR008657. JTB.
    [Graphical view ]
    Pfami PF05439. JTB. 1 hit.
    [Graphical view ]
    ProDomi PD151382. JTB. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation."
      Hatakeyama S., Osawa M., Omine M., Ishikawa F.
      Oncogene 18:2085-2090(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.
    3. "Characterization of Jumping translocation breakpoint (JTB) gene product isolated as a TGF-beta1-inducible clone involved in regulation of mitochondrial function, cell growth and cell death."
      Kanome T., Itoh N., Ishikawa F., Mori K., Kim-Kaneyama J.R., Nose K., Shibanuma M.
      Oncogene 26:5991-6001(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, PROTEOLYTIC PROCESSING OF N-TERMINUS, MUTAGENESIS OF 13-ALA-GLY-14, INDUCTION.

    Entry informationi

    Entry nameiJTB_MOUSE
    AccessioniPrimary (citable) accession number: O88824
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3