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O88824 (JTB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein JTB
Gene names
Name:Jtb
Synonyms:Gm622
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length146 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity By similarity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential. Ref.3

Subunit structure

Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential. Mitochondrion. Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytoskeletonspindle By similarity. Note: Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase By similarity. Ref.3

Induction

Up-regulated by TGFB1 in mammary epithelial cells. Ref.3

Post-translational modification

Undergoes N-terminal proteolytic processing, removing a peptide of about 1 kDa from the N-terminus of the protein.

Sequence similarities

Belongs to the JTB family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 146116Protein JTB
PRO_0000021536

Regions

Topological domain31 – 10575Extracellular Potential
Transmembrane106 – 12621Helical; Potential
Topological domain127 – 14620Cytoplasmic Potential

Experimental info

Mutagenesis13 – 142AG → DD: Abolishes N-terminal proteolytic processing. Ref.3

Sequences

Sequence LengthMass (Da)Tools
O88824 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 9E4DAF394B2A2107

FASTA14616,329
        10         20         30         40         50         60 
MLAGAGRRGL PRAGHLCWLL CAFTLKLCEA EAPVREEKLS VSTSTSPCWL AEEFVVTEEC 

        70         80         90        100        110        120 
TPCSNFQIKT TPECGSTGYV EKITCSSSKR NEFKSCRSAL LEQHLFWKFE GVVVAVALVF 

       130        140 
ACLVIVRQRQ LDRKALEKVR KQIESI 

« Hide

References

« Hide 'large scale' references
[1]"JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation."
Hatakeyama S., Osawa M., Omine M., Ishikawa F.
Oncogene 18:2085-2090(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary gland.
[3]"Characterization of Jumping translocation breakpoint (JTB) gene product isolated as a TGF-beta1-inducible clone involved in regulation of mitochondrial function, cell growth and cell death."
Kanome T., Itoh N., Ishikawa F., Mori K., Kim-Kaneyama J.R., Nose K., Shibanuma M.
Oncogene 26:5991-6001(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, PROTEOLYTIC PROCESSING OF N-TERMINUS, MUTAGENESIS OF 13-ALA-GLY-14, INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB016490 mRNA. Translation: BAA33733.1.
BC008139 mRNA. Translation: AAH08139.1.
CCDSCCDS17523.1.
RefSeqNP_996807.1. NM_206924.2.
UniGeneMm.13912.

3D structure databases

ProteinModelPortalO88824.
SMRO88824. Positions 47-103.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteO88824.

Proteomic databases

PRIDEO88824.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029546; ENSMUSP00000029546; ENSMUSG00000027937.
GeneID23922.
KEGGmmu:23922.
UCSCuc008qbo.1. mouse.

Organism-specific databases

CTD10899.
MGIMGI:1346082. Jtb.

Phylogenomic databases

eggNOGNOG296098.
HOGENOMHOG000294204.
HOVERGENHBG000952.
InParanoidO88824.
OMATPECGST.
OrthoDBEOG7SR4Q2.
PhylomeDBO88824.
TreeFamTF316934.

Gene expression databases

ArrayExpressO88824.
BgeeO88824.
CleanExMM_JTB.
GenevestigatorO88824.

Family and domain databases

InterProIPR008657. JTB.
[Graphical view]
PfamPF05439. JTB. 1 hit.
[Graphical view]
ProDomPD151382. JTB. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

NextBio303705.
PROO88824.
SOURCESearch...

Entry information

Entry nameJTB_MOUSE
AccessionPrimary (citable) accession number: O88824
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot