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Protein

Protein JTB

Gene

Jtb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity (By similarity). Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.By similarity1 Publication

GO - Molecular functioni

  1. protein kinase binding Source: UniProtKB

GO - Biological processi

  1. apoptotic mitochondrial changes Source: MGI
  2. cytokinesis Source: UniProtKB
  3. mitotic nuclear division Source: UniProtKB
  4. positive regulation of protein kinase activity Source: UniProtKB
  5. regulation of cell proliferation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein JTB
Gene namesi
Name:Jtb
Synonyms:Gm622
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1346082. Jtb.

Subcellular locationi

Membrane Curated; Single-pass type I membrane protein Curated. Mitochondrion 1 Publication. Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytoskeletonspindle By similarity
Note: Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase (By similarity).By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 10575ExtracellularSequence AnalysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence AnalysisAdd
BLAST
Topological domaini127 – 14620CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. cytoplasm Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. midbody Source: UniProtKB
  5. mitochondrion Source: UniProtKB
  6. spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi13 – 142AG → DD: Abolishes N-terminal proteolytic processing. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 146116Protein JTBPRO_0000021536Add
BLAST

Post-translational modificationi

Undergoes N-terminal proteolytic processing, removing a peptide of about 1 kDa from the N-terminus of the protein.1 Publication

Proteomic databases

MaxQBiO88824.
PRIDEiO88824.

PTM databases

PhosphoSiteiO88824.

Expressioni

Inductioni

Up-regulated by TGFB1 in mammary epithelial cells.1 Publication

Gene expression databases

BgeeiO88824.
CleanExiMM_JTB.
ExpressionAtlasiO88824. baseline and differential.
GenevestigatoriO88824.

Interactioni

Subunit structurei

Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliO88824.
SMRiO88824. Positions 47-103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the JTB family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG296098.
HOGENOMiHOG000294204.
HOVERGENiHBG000952.
InParanoidiO88824.
OMAiTPECGST.
OrthoDBiEOG7SR4Q2.
PhylomeDBiO88824.
TreeFamiTF316934.

Family and domain databases

InterProiIPR008657. JTB.
[Graphical view]
PfamiPF05439. JTB. 1 hit.
[Graphical view]
ProDomiPD151382. JTB. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAGAGRRGL PRAGHLCWLL CAFTLKLCEA EAPVREEKLS VSTSTSPCWL
60 70 80 90 100
AEEFVVTEEC TPCSNFQIKT TPECGSTGYV EKITCSSSKR NEFKSCRSAL
110 120 130 140
LEQHLFWKFE GVVVAVALVF ACLVIVRQRQ LDRKALEKVR KQIESI
Length:146
Mass (Da):16,329
Last modified:November 1, 1998 - v1
Checksum:i9E4DAF394B2A2107
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016490 mRNA. Translation: BAA33733.1.
BC008139 mRNA. Translation: AAH08139.1.
CCDSiCCDS17523.1.
RefSeqiNP_996807.1. NM_206924.2.
UniGeneiMm.13912.

Genome annotation databases

EnsembliENSMUST00000029546; ENSMUSP00000029546; ENSMUSG00000027937.
GeneIDi23922.
KEGGimmu:23922.
UCSCiuc008qbo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016490 mRNA. Translation: BAA33733.1.
BC008139 mRNA. Translation: AAH08139.1.
CCDSiCCDS17523.1.
RefSeqiNP_996807.1. NM_206924.2.
UniGeneiMm.13912.

3D structure databases

ProteinModelPortaliO88824.
SMRiO88824. Positions 47-103.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiO88824.

Proteomic databases

MaxQBiO88824.
PRIDEiO88824.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029546; ENSMUSP00000029546; ENSMUSG00000027937.
GeneIDi23922.
KEGGimmu:23922.
UCSCiuc008qbo.1. mouse.

Organism-specific databases

CTDi10899.
MGIiMGI:1346082. Jtb.

Phylogenomic databases

eggNOGiNOG296098.
HOGENOMiHOG000294204.
HOVERGENiHBG000952.
InParanoidiO88824.
OMAiTPECGST.
OrthoDBiEOG7SR4Q2.
PhylomeDBiO88824.
TreeFamiTF316934.

Miscellaneous databases

NextBioi303705.
PROiO88824.
SOURCEiSearch...

Gene expression databases

BgeeiO88824.
CleanExiMM_JTB.
ExpressionAtlasiO88824. baseline and differential.
GenevestigatoriO88824.

Family and domain databases

InterProiIPR008657. JTB.
[Graphical view]
PfamiPF05439. JTB. 1 hit.
[Graphical view]
ProDomiPD151382. JTB. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation."
    Hatakeyama S., Osawa M., Omine M., Ishikawa F.
    Oncogene 18:2085-2090(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  3. "Characterization of Jumping translocation breakpoint (JTB) gene product isolated as a TGF-beta1-inducible clone involved in regulation of mitochondrial function, cell growth and cell death."
    Kanome T., Itoh N., Ishikawa F., Mori K., Kim-Kaneyama J.R., Nose K., Shibanuma M.
    Oncogene 26:5991-6001(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PROTEOLYTIC PROCESSING OF N-TERMINUS, MUTAGENESIS OF 13-ALA-GLY-14, INDUCTION.

Entry informationi

Entry nameiJTB_MOUSE
AccessioniPrimary (citable) accession number: O88824
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: January 7, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.