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O88824

- JTB_MOUSE

UniProt

O88824 - JTB_MOUSE

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Protein

Protein JTB

Gene
Jtb, Gm622
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity By similarity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.1 Publication

GO - Molecular functioni

  1. protein kinase binding Source: UniProtKB

GO - Biological processi

  1. apoptotic mitochondrial changes Source: MGI
  2. cytokinesis Source: UniProtKB
  3. mitotic nuclear division Source: UniProtKB
  4. positive regulation of protein kinase activity Source: UniProtKB
  5. regulation of cell proliferation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein JTB
Gene namesi
Name:Jtb
Synonyms:Gm622
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1346082. Jtb.

Subcellular locationi

Membrane; Single-pass type I membrane protein Reviewed prediction. Mitochondrion. Cytoplasm By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytoskeletonspindle By similarity
Note: Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase By similarity.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 10575Extracellular Reviewed predictionAdd
BLAST
Transmembranei106 – 12621Helical; Reviewed predictionAdd
BLAST
Topological domaini127 – 14620Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. cytoplasm Source: UniProtKB
  3. integral component of membrane Source: UniProtKB-KW
  4. midbody Source: UniProtKB
  5. mitochondrion Source: UniProtKB
  6. spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi13 – 142AG → DD: Abolishes N-terminal proteolytic processing. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed predictionAdd
BLAST
Chaini31 – 146116Protein JTBPRO_0000021536Add
BLAST

Post-translational modificationi

Undergoes N-terminal proteolytic processing, removing a peptide of about 1 kDa from the N-terminus of the protein.

Proteomic databases

PRIDEiO88824.

PTM databases

PhosphoSiteiO88824.

Expressioni

Inductioni

Up-regulated by TGFB1 in mammary epithelial cells.1 Publication

Gene expression databases

ArrayExpressiO88824.
BgeeiO88824.
CleanExiMM_JTB.
GenevestigatoriO88824.

Interactioni

Subunit structurei

Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B By similarity.

Structurei

3D structure databases

ProteinModelPortaliO88824.
SMRiO88824. Positions 47-103.

Family & Domainsi

Sequence similaritiesi

Belongs to the JTB family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG296098.
HOGENOMiHOG000294204.
HOVERGENiHBG000952.
InParanoidiO88824.
OMAiTPECGST.
OrthoDBiEOG7SR4Q2.
PhylomeDBiO88824.
TreeFamiTF316934.

Family and domain databases

InterProiIPR008657. JTB.
[Graphical view]
PfamiPF05439. JTB. 1 hit.
[Graphical view]
ProDomiPD151382. JTB. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88824-1 [UniParc]FASTAAdd to Basket

« Hide

MLAGAGRRGL PRAGHLCWLL CAFTLKLCEA EAPVREEKLS VSTSTSPCWL    50
AEEFVVTEEC TPCSNFQIKT TPECGSTGYV EKITCSSSKR NEFKSCRSAL 100
LEQHLFWKFE GVVVAVALVF ACLVIVRQRQ LDRKALEKVR KQIESI 146
Length:146
Mass (Da):16,329
Last modified:November 1, 1998 - v1
Checksum:i9E4DAF394B2A2107
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB016490 mRNA. Translation: BAA33733.1.
BC008139 mRNA. Translation: AAH08139.1.
CCDSiCCDS17523.1.
RefSeqiNP_996807.1. NM_206924.2.
UniGeneiMm.13912.

Genome annotation databases

EnsembliENSMUST00000029546; ENSMUSP00000029546; ENSMUSG00000027937.
GeneIDi23922.
KEGGimmu:23922.
UCSCiuc008qbo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB016490 mRNA. Translation: BAA33733.1 .
BC008139 mRNA. Translation: AAH08139.1 .
CCDSi CCDS17523.1.
RefSeqi NP_996807.1. NM_206924.2.
UniGenei Mm.13912.

3D structure databases

ProteinModelPortali O88824.
SMRi O88824. Positions 47-103.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O88824.

Proteomic databases

PRIDEi O88824.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029546 ; ENSMUSP00000029546 ; ENSMUSG00000027937 .
GeneIDi 23922.
KEGGi mmu:23922.
UCSCi uc008qbo.1. mouse.

Organism-specific databases

CTDi 10899.
MGIi MGI:1346082. Jtb.

Phylogenomic databases

eggNOGi NOG296098.
HOGENOMi HOG000294204.
HOVERGENi HBG000952.
InParanoidi O88824.
OMAi TPECGST.
OrthoDBi EOG7SR4Q2.
PhylomeDBi O88824.
TreeFami TF316934.

Miscellaneous databases

NextBioi 303705.
PROi O88824.
SOURCEi Search...

Gene expression databases

ArrayExpressi O88824.
Bgeei O88824.
CleanExi MM_JTB.
Genevestigatori O88824.

Family and domain databases

InterProi IPR008657. JTB.
[Graphical view ]
Pfami PF05439. JTB. 1 hit.
[Graphical view ]
ProDomi PD151382. JTB. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation."
    Hatakeyama S., Osawa M., Omine M., Ishikawa F.
    Oncogene 18:2085-2090(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  3. "Characterization of Jumping translocation breakpoint (JTB) gene product isolated as a TGF-beta1-inducible clone involved in regulation of mitochondrial function, cell growth and cell death."
    Kanome T., Itoh N., Ishikawa F., Mori K., Kim-Kaneyama J.R., Nose K., Shibanuma M.
    Oncogene 26:5991-6001(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PROTEOLYTIC PROCESSING OF N-TERMINUS, MUTAGENESIS OF 13-ALA-GLY-14, INDUCTION.

Entry informationi

Entry nameiJTB_MOUSE
AccessioniPrimary (citable) accession number: O88824
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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