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Protein

Protein JTB

Gene

Jtb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein JTB
Gene namesi
Name:Jtb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2942. Jtb.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 10575ExtracellularSequence analysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Topological domaini127 – 14620CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 146116Protein JTBPRO_0000021537Add
BLAST

Proteomic databases

PaxDbiO88823.
PRIDEiO88823.

Expressioni

Gene expression databases

GenevisibleiO88823. RN.

Interactioni

Subunit structurei

Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060227.

Family & Domainsi

Sequence similaritiesi

Belongs to the JTB family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4084. Eukaryota.
ENOG4111VSR. LUCA.
GeneTreeiENSGT00390000016136.
HOGENOMiHOG000294204.
HOVERGENiHBG000952.
InParanoidiO88823.
OMAiTPECGST.
OrthoDBiEOG7SR4Q2.
PhylomeDBiO88823.
TreeFamiTF316934.

Family and domain databases

InterProiIPR008657. JTB.
[Graphical view]
PfamiPF05439. JTB. 1 hit.
[Graphical view]
ProDomiPD151382. JTB. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVGAGRRGL PRGGHLCWLL CAFTLKLCEA EAPVREEKLS VSTSTSPCWL
60 70 80 90 100
VEEFVVTEEC TPCSNFQIKT TPECGSTGYV EKITCSSSKR NEFKSCRSAL
110 120 130 140
LEQHLFWKFE GIVVGVALVF ACLVIIRQRQ LDRKALEKVR KQIESI
Length:146
Mass (Da):16,385
Last modified:November 1, 1998 - v1
Checksum:i52334B38F6326848
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016489 mRNA. Translation: BAA33732.1.
BC062090 mRNA. Translation: AAH62090.1.
RefSeqiNP_062086.1. NM_019213.2.
UniGeneiRn.91803.

Genome annotation databases

EnsembliENSRNOT00000064752; ENSRNOP00000060227; ENSRNOG00000016379.
GeneIDi29439.
KEGGirno:29439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016489 mRNA. Translation: BAA33732.1.
BC062090 mRNA. Translation: AAH62090.1.
RefSeqiNP_062086.1. NM_019213.2.
UniGeneiRn.91803.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060227.

Proteomic databases

PaxDbiO88823.
PRIDEiO88823.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000064752; ENSRNOP00000060227; ENSRNOG00000016379.
GeneIDi29439.
KEGGirno:29439.

Organism-specific databases

CTDi10899.
RGDi2942. Jtb.

Phylogenomic databases

eggNOGiKOG4084. Eukaryota.
ENOG4111VSR. LUCA.
GeneTreeiENSGT00390000016136.
HOGENOMiHOG000294204.
HOVERGENiHBG000952.
InParanoidiO88823.
OMAiTPECGST.
OrthoDBiEOG7SR4Q2.
PhylomeDBiO88823.
TreeFamiTF316934.

Miscellaneous databases

NextBioi609185.
PROiO88823.

Gene expression databases

GenevisibleiO88823. RN.

Family and domain databases

InterProiIPR008657. JTB.
[Graphical view]
PfamiPF05439. JTB. 1 hit.
[Graphical view]
ProDomiPD151382. JTB. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation."
    Hatakeyama S., Osawa M., Omine M., Ishikawa F.
    Oncogene 18:2085-2090(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiJTB_RAT
AccessioniPrimary (citable) accession number: O88823
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: November 11, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.