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Protein

Protein JTB

Gene

Jtb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein JTB
Gene namesi
Name:Jtb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2942 Jtb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 105ExtracellularSequence analysisAdd BLAST75
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 146CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000002153731 – 146Protein JTBAdd BLAST116

Proteomic databases

PaxDbiO88823
PRIDEiO88823

Expressioni

Gene expression databases

BgeeiENSRNOG00000016379
GenevisibleiO88823 RN

Interactioni

Subunit structurei

Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060227

Structurei

3D structure databases

SMRiO88823
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the JTB family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4084 Eukaryota
ENOG4111VSR LUCA
GeneTreeiENSGT00390000016136
HOGENOMiHOG000294204
HOVERGENiHBG000952
InParanoidiO88823
OMAiTPECGST
OrthoDBiEOG091G0PNA
PhylomeDBiO88823
TreeFamiTF316934

Family and domain databases

InterProiView protein in InterPro
IPR008657 JTB
PANTHERiPTHR13041 PTHR13041, 1 hit
PfamiView protein in Pfam
PF05439 JTB, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD151382 JTB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVGAGRRGL PRGGHLCWLL CAFTLKLCEA EAPVREEKLS VSTSTSPCWL
60 70 80 90 100
VEEFVVTEEC TPCSNFQIKT TPECGSTGYV EKITCSSSKR NEFKSCRSAL
110 120 130 140
LEQHLFWKFE GIVVGVALVF ACLVIIRQRQ LDRKALEKVR KQIESI
Length:146
Mass (Da):16,385
Last modified:November 1, 1998 - v1
Checksum:i52334B38F6326848
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016489 mRNA Translation: BAA33732.1
BC062090 mRNA Translation: AAH62090.1
RefSeqiNP_062086.1, NM_019213.2
UniGeneiRn.91803

Genome annotation databases

EnsembliENSRNOT00000064752; ENSRNOP00000060227; ENSRNOG00000016379
GeneIDi29439
KEGGirno:29439

Similar proteinsi

Entry informationi

Entry nameiJTB_RAT
AccessioniPrimary (citable) accession number: O88823
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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