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Protein

Protein JTB

Gene

Jtb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein JTB
Gene namesi
Name:Jtb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2942. Jtb.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 105ExtracellularSequence analysisAdd BLAST75
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 146CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000002153731 – 146Protein JTBAdd BLAST116

Proteomic databases

PaxDbiO88823.
PRIDEiO88823.

Expressioni

Gene expression databases

BgeeiENSRNOG00000016379.
GenevisibleiO88823. RN.

Interactioni

Subunit structurei

Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060227.

Family & Domainsi

Sequence similaritiesi

Belongs to the JTB family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4084. Eukaryota.
ENOG4111VSR. LUCA.
GeneTreeiENSGT00390000016136.
HOGENOMiHOG000294204.
HOVERGENiHBG000952.
InParanoidiO88823.
OMAiCWMVEEF.
OrthoDBiEOG091G0PNA.
PhylomeDBiO88823.
TreeFamiTF316934.

Family and domain databases

InterProiIPR008657. JTB.
[Graphical view]
PfamiPF05439. JTB. 1 hit.
[Graphical view]
ProDomiPD151382. JTB. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88823-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVGAGRRGL PRGGHLCWLL CAFTLKLCEA EAPVREEKLS VSTSTSPCWL
60 70 80 90 100
VEEFVVTEEC TPCSNFQIKT TPECGSTGYV EKITCSSSKR NEFKSCRSAL
110 120 130 140
LEQHLFWKFE GIVVGVALVF ACLVIIRQRQ LDRKALEKVR KQIESI
Length:146
Mass (Da):16,385
Last modified:November 1, 1998 - v1
Checksum:i52334B38F6326848
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016489 mRNA. Translation: BAA33732.1.
BC062090 mRNA. Translation: AAH62090.1.
RefSeqiNP_062086.1. NM_019213.2.
UniGeneiRn.91803.

Genome annotation databases

EnsembliENSRNOT00000064752; ENSRNOP00000060227; ENSRNOG00000016379.
GeneIDi29439.
KEGGirno:29439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016489 mRNA. Translation: BAA33732.1.
BC062090 mRNA. Translation: AAH62090.1.
RefSeqiNP_062086.1. NM_019213.2.
UniGeneiRn.91803.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060227.

Proteomic databases

PaxDbiO88823.
PRIDEiO88823.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000064752; ENSRNOP00000060227; ENSRNOG00000016379.
GeneIDi29439.
KEGGirno:29439.

Organism-specific databases

CTDi10899.
RGDi2942. Jtb.

Phylogenomic databases

eggNOGiKOG4084. Eukaryota.
ENOG4111VSR. LUCA.
GeneTreeiENSGT00390000016136.
HOGENOMiHOG000294204.
HOVERGENiHBG000952.
InParanoidiO88823.
OMAiCWMVEEF.
OrthoDBiEOG091G0PNA.
PhylomeDBiO88823.
TreeFamiTF316934.

Miscellaneous databases

PROiO88823.

Gene expression databases

BgeeiENSRNOG00000016379.
GenevisibleiO88823. RN.

Family and domain databases

InterProiIPR008657. JTB.
[Graphical view]
PfamiPF05439. JTB. 1 hit.
[Graphical view]
ProDomiPD151382. JTB. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiJTB_RAT
AccessioniPrimary (citable) accession number: O88823
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.