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O88819

- FUT9_MOUSE

UniProt

O88819 - FUT9_MOUSE

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Protein

Alpha-(1,3)-fucosyltransferase 9

Gene

Fut9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides.1 Publication

Pathwayi

GO - Molecular functioni

  1. alpha-(1->3)-fucosyltransferase activity Source: MGI

GO - Biological processi

  1. fucosylation Source: GOC
  2. nervous system development Source: Ensembl
  3. protein glycosylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT10. Glycosyltransferase Family 10.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 9 (EC:2.4.1.-)
Alternative name(s):
Fucosyltransferase 9
Fucosyltransferase IX
Short name:
Fuc-TIX
Short name:
FucT-IX
Galactoside 3-L-fucosyltransferase
Gene namesi
Name:Fut9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1330859. Fut9.

Subcellular locationi

Golgi apparatusGolgi stack membrane By similarity; Single-pass type II membrane protein By similarity
Note: Membrane-bound form in trans cisternae of Golgi.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei12 – 3221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini33 – 359327LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Alpha-(1,3)-fucosyltransferase 9PRO_0000221119Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO88819.
PaxDbiO88819.
PRIDEiO88819.

PTM databases

PhosphoSiteiO88819.

Expressioni

Tissue specificityi

Mainly detected in brain and kidney.1 Publication

Gene expression databases

BgeeiO88819.
CleanExiMM_FUT9.
ExpressionAtlasiO88819. baseline and differential.
GenevestigatoriO88819.

Structurei

3D structure databases

ProteinModelPortaliO88819.
SMRiO88819. Positions 183-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 10 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG19459.
HOGENOMiHOG000045583.
HOVERGENiHBG000274.
InParanoidiO88819.
KOiK03663.
OMAiLIWVWPF.
OrthoDBiEOG7Z69C9.
PhylomeDBiO88819.
TreeFamiTF316348.

Family and domain databases

InterProiIPR001503. Glyco_trans_10.
[Graphical view]
PANTHERiPTHR11929. PTHR11929. 1 hit.
PfamiPF00852. Glyco_transf_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88819-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSTSKGILR PFLIVCIILG CFMACLLIYI KPTNSWVFSP MESASSVLKM
60 70 80 90 100
KNFFSTKTDY FNETTILVWV WPFGQTFDLT SCQAMFNIQG CHLTTDRSLY
110 120 130 140 150
NKSHAVLIHH RDISWDLTNL PQQARPPFQK WIWMNLESPT HTPQKSGIEH
160 170 180 190 200
LFNLTLTYRR DSDIQVPYGF LTVSTNPFVF EVPSKEKLVC WVVSNWNPEH
210 220 230 240 250
ARVKYYNELS KSIEIHTYGQ AFGEYVNDKN LIPTISTCKF YLSFENSIHK
260 270 280 290 300
DYITEKLYNA FLAGSVPVVL GPSRENYENY IPADSFIHVE DFNSPSELAK
310 320 330 340 350
YLKEVDKNNK LYLSYFNWRK DFTVNLPRFW ESHACLACDH VKRHQEYKSV

GNLEKWFWN
Length:359
Mass (Da):42,041
Last modified:November 1, 1998 - v1
Checksum:i96A2394547F2A44E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015426 mRNA. Translation: BAA33522.1.
AK032177 mRNA. Translation: BAC27746.1.
AK036183 mRNA. Translation: BAC29338.1.
AK043410 mRNA. Translation: BAC31540.1.
AK047650 mRNA. Translation: BAC33112.1.
AK049122 mRNA. Translation: BAC33555.1.
AK163871 mRNA. Translation: BAE37522.1.
CCDSiCCDS18011.1.
RefSeqiNP_034373.1. NM_010243.3.
UniGeneiMm.39101.

Genome annotation databases

EnsembliENSMUST00000084770; ENSMUSP00000081826; ENSMUSG00000055373.
ENSMUST00000108199; ENSMUSP00000103834; ENSMUSG00000055373.
GeneIDi14348.
KEGGimmu:14348.
UCSCiuc008sei.1. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

Fucosyltransferase 9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015426 mRNA. Translation: BAA33522.1 .
AK032177 mRNA. Translation: BAC27746.1 .
AK036183 mRNA. Translation: BAC29338.1 .
AK043410 mRNA. Translation: BAC31540.1 .
AK047650 mRNA. Translation: BAC33112.1 .
AK049122 mRNA. Translation: BAC33555.1 .
AK163871 mRNA. Translation: BAE37522.1 .
CCDSi CCDS18011.1.
RefSeqi NP_034373.1. NM_010243.3.
UniGenei Mm.39101.

3D structure databases

ProteinModelPortali O88819.
SMRi O88819. Positions 183-313.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT10. Glycosyltransferase Family 10.

PTM databases

PhosphoSitei O88819.

Proteomic databases

MaxQBi O88819.
PaxDbi O88819.
PRIDEi O88819.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000084770 ; ENSMUSP00000081826 ; ENSMUSG00000055373 .
ENSMUST00000108199 ; ENSMUSP00000103834 ; ENSMUSG00000055373 .
GeneIDi 14348.
KEGGi mmu:14348.
UCSCi uc008sei.1. mouse.

Organism-specific databases

CTDi 10690.
MGIi MGI:1330859. Fut9.

Phylogenomic databases

eggNOGi NOG19459.
HOGENOMi HOG000045583.
HOVERGENi HBG000274.
InParanoidi O88819.
KOi K03663.
OMAi LIWVWPF.
OrthoDBi EOG7Z69C9.
PhylomeDBi O88819.
TreeFami TF316348.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Miscellaneous databases

NextBioi 285799.
PROi O88819.
SOURCEi Search...

Gene expression databases

Bgeei O88819.
CleanExi MM_FUT9.
ExpressionAtlasi O88819. baseline and differential.
Genevestigatori O88819.

Family and domain databases

InterProi IPR001503. Glyco_trans_10.
[Graphical view ]
PANTHERi PTHR11929. PTHR11929. 1 hit.
Pfami PF00852. Glyco_transf_10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression cloning and characterization of a novel murine alpha1, 3-fucosyltransferase, mFuc-TIX, that synthesizes the Lewis x (CD15) epitope in brain and kidney."
    Kudo T., Ikehara Y., Togayachi A., Kaneko M., Hiraga T., Sasaki K., Narimatsu H.
    J. Biol. Chem. 273:26729-26738(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum, Corpus striatum and Olfactory bulb.

Entry informationi

Entry nameiFUT9_MOUSE
AccessioniPrimary (citable) accession number: O88819
Secondary accession number(s): Q3TQ63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3