Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O88819

- FUT9_MOUSE

UniProt

O88819 - FUT9_MOUSE

Protein

Alpha-(1,3)-fucosyltransferase 9

Gene

Fut9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides.1 Publication

    Pathwayi

    GO - Molecular functioni

    1. alpha-(1->3)-fucosyltransferase activity Source: MGI

    GO - Biological processi

    1. fucosylation Source: GOC
    2. nervous system development Source: Ensembl
    3. protein glycosylation Source: MGI

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT10. Glycosyltransferase Family 10.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 9 (EC:2.4.1.-)
    Alternative name(s):
    Fucosyltransferase 9
    Fucosyltransferase IX
    Short name:
    Fuc-TIX
    Short name:
    FucT-IX
    Galactoside 3-L-fucosyltransferase
    Gene namesi
    Name:Fut9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1330859. Fut9.

    Subcellular locationi

    Golgi apparatusGolgi stack membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Membrane-bound form in trans cisternae of Golgi.By similarity

    GO - Cellular componenti

    1. Golgi cisterna membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Alpha-(1,3)-fucosyltransferase 9PRO_0000221119Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO88819.
    PRIDEiO88819.

    PTM databases

    PhosphoSiteiO88819.

    Expressioni

    Tissue specificityi

    Mainly detected in brain and kidney.1 Publication

    Gene expression databases

    BgeeiO88819.
    CleanExiMM_FUT9.
    GenevestigatoriO88819.

    Structurei

    3D structure databases

    ProteinModelPortaliO88819.
    SMRiO88819. Positions 183-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini33 – 359327LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 10 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG19459.
    HOGENOMiHOG000045583.
    HOVERGENiHBG000274.
    InParanoidiO88819.
    KOiK03663.
    OMAiLIWVWPF.
    OrthoDBiEOG7Z69C9.
    PhylomeDBiO88819.
    TreeFamiTF316348.

    Family and domain databases

    InterProiIPR001503. Glyco_trans_10.
    [Graphical view]
    PANTHERiPTHR11929. PTHR11929. 1 hit.
    PfamiPF00852. Glyco_transf_10. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O88819-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSTSKGILR PFLIVCIILG CFMACLLIYI KPTNSWVFSP MESASSVLKM    50
    KNFFSTKTDY FNETTILVWV WPFGQTFDLT SCQAMFNIQG CHLTTDRSLY 100
    NKSHAVLIHH RDISWDLTNL PQQARPPFQK WIWMNLESPT HTPQKSGIEH 150
    LFNLTLTYRR DSDIQVPYGF LTVSTNPFVF EVPSKEKLVC WVVSNWNPEH 200
    ARVKYYNELS KSIEIHTYGQ AFGEYVNDKN LIPTISTCKF YLSFENSIHK 250
    DYITEKLYNA FLAGSVPVVL GPSRENYENY IPADSFIHVE DFNSPSELAK 300
    YLKEVDKNNK LYLSYFNWRK DFTVNLPRFW ESHACLACDH VKRHQEYKSV 350
    GNLEKWFWN 359
    Length:359
    Mass (Da):42,041
    Last modified:November 1, 1998 - v1
    Checksum:i96A2394547F2A44E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015426 mRNA. Translation: BAA33522.1.
    AK032177 mRNA. Translation: BAC27746.1.
    AK036183 mRNA. Translation: BAC29338.1.
    AK043410 mRNA. Translation: BAC31540.1.
    AK047650 mRNA. Translation: BAC33112.1.
    AK049122 mRNA. Translation: BAC33555.1.
    AK163871 mRNA. Translation: BAE37522.1.
    CCDSiCCDS18011.1.
    RefSeqiNP_034373.1. NM_010243.3.
    UniGeneiMm.39101.

    Genome annotation databases

    EnsembliENSMUST00000084770; ENSMUSP00000081826; ENSMUSG00000055373.
    ENSMUST00000108199; ENSMUSP00000103834; ENSMUSG00000055373.
    GeneIDi14348.
    KEGGimmu:14348.
    UCSCiuc008sei.1. mouse.

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - GTase

    Fucosyltransferase 9

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB015426 mRNA. Translation: BAA33522.1 .
    AK032177 mRNA. Translation: BAC27746.1 .
    AK036183 mRNA. Translation: BAC29338.1 .
    AK043410 mRNA. Translation: BAC31540.1 .
    AK047650 mRNA. Translation: BAC33112.1 .
    AK049122 mRNA. Translation: BAC33555.1 .
    AK163871 mRNA. Translation: BAE37522.1 .
    CCDSi CCDS18011.1.
    RefSeqi NP_034373.1. NM_010243.3.
    UniGenei Mm.39101.

    3D structure databases

    ProteinModelPortali O88819.
    SMRi O88819. Positions 183-313.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT10. Glycosyltransferase Family 10.

    PTM databases

    PhosphoSitei O88819.

    Proteomic databases

    PaxDbi O88819.
    PRIDEi O88819.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000084770 ; ENSMUSP00000081826 ; ENSMUSG00000055373 .
    ENSMUST00000108199 ; ENSMUSP00000103834 ; ENSMUSG00000055373 .
    GeneIDi 14348.
    KEGGi mmu:14348.
    UCSCi uc008sei.1. mouse.

    Organism-specific databases

    CTDi 10690.
    MGIi MGI:1330859. Fut9.

    Phylogenomic databases

    eggNOGi NOG19459.
    HOGENOMi HOG000045583.
    HOVERGENi HBG000274.
    InParanoidi O88819.
    KOi K03663.
    OMAi LIWVWPF.
    OrthoDBi EOG7Z69C9.
    PhylomeDBi O88819.
    TreeFami TF316348.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Miscellaneous databases

    NextBioi 285799.
    PROi O88819.
    SOURCEi Search...

    Gene expression databases

    Bgeei O88819.
    CleanExi MM_FUT9.
    Genevestigatori O88819.

    Family and domain databases

    InterProi IPR001503. Glyco_trans_10.
    [Graphical view ]
    PANTHERi PTHR11929. PTHR11929. 1 hit.
    Pfami PF00852. Glyco_transf_10. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression cloning and characterization of a novel murine alpha1, 3-fucosyltransferase, mFuc-TIX, that synthesizes the Lewis x (CD15) epitope in brain and kidney."
      Kudo T., Ikehara Y., Togayachi A., Kaneko M., Hiraga T., Sasaki K., Narimatsu H.
      J. Biol. Chem. 273:26729-26738(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum, Corpus striatum and Olfactory bulb.

    Entry informationi

    Entry nameiFUT9_MOUSE
    AccessioniPrimary (citable) accession number: O88819
    Secondary accession number(s): Q3TQ63
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 9, 2004
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3