O88819 (FUT9_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 101.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Alpha-(1,3)-fucosyltransferase EC=2.4.1.- Alternative name(s): Fucosyltransferase 9 Fucosyltransferase IX Short name=Fuc-TIX Short name=FucT-IX Galactoside 3-L-fucosyltransferase | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) [Reference proteome] | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 359 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides. Ref.1 |
| Pathway | |
| Subcellular location | Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. Note: Membrane-bound form in trans cisternae of Golgi By similarity. |
| Tissue specificity | Mainly detected in brain and kidney. Ref.1 |
| Sequence similarities | Belongs to the glycosyltransferase 10 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Golgi apparatus Membrane |
| Domain | Signal-anchor Transmembrane Transmembrane helix |
| Molecular function | Glycosyltransferase Transferase |
| PTM | Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | nervous system development Inferred from electronic annotation. Source: Compara protein glycosylationInferred from direct assay PubMed 15364956. Source: MGI |
| Cellular_component | Golgi cisterna membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular_function | alpha-(1->3)-fucosyltransferase activity Inferred from direct assay PubMed 15364956. Source: MGI |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 359 | 359 | Alpha-(1,3)-fucosyltransferase | PRO_0000221119 | |||||
Regions | |||||||||
| Topological domain | 1 – 11 | 11 | Cytoplasmic Potential | ||||||
| Transmembrane | 12 – 32 | 21 | Helical; Signal-anchor for type II membrane protein; Potential | ||||||
| Topological domain | 33 – 359 | 327 | Lumenal Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 62 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 101 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 153 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Expression cloning and characterization of a novel murine alpha1, 3-fucosyltransferase, mFuc-TIX, that synthesizes the Lewis x (CD15) epitope in brain and kidney." Kudo T., Ikehara Y., Togayachi A., Kaneko M., Hiraga T., Sasaki K., Narimatsu H. J. Biol. Chem. 273:26729-26738(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.  Hayashizaki Y.Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Cerebellum, Corpus striatum and Olfactory bulb. |
| + | Additional computationally mapped references. |
Web resources
| Functional Glycomics Gateway - GTase Fucosyltransferase 9 |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB015426 mRNA. Translation: BAA33522.1. AK032177 mRNA. Translation: BAC27746.1. AK036183 mRNA. Translation: BAC29338.1. AK043410 mRNA. Translation: BAC31540.1. AK047650 mRNA. Translation: BAC33112.1. AK049122 mRNA. Translation: BAC33555.1. AK163871 mRNA. Translation: BAE37522.1. |
| IPI | IPI00135088. |
| RefSeq | NP_034373.1. NM_010243.3. |
| UniGene | Mm.39101. |
3D structure databases | |
| ProteinModelPortal | O88819. |
| SMR | O88819. Positions 183-313. |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GT10. Glycosyltransferase Family 10. |
PTM databases | |
| PhosphoSite | O88819. |
Proteomic databases | |
| PaxDb | O88819. |
| PRIDE | O88819. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000084770; ENSMUSP00000081826; ENSMUSG00000055373. ENSMUST00000108199; ENSMUSP00000103834; ENSMUSG00000055373. |
| GeneID | 14348. |
| KEGG | mmu:14348. |
Organism-specific databases | |
| CTD | 10690. |
| MGI | MGI:1330859. Fut9. |
Phylogenomic databases | |
| eggNOG | NOG19459. |
| HOGENOM | HOG000045583. |
| HOVERGEN | HBG000274. |
| InParanoid | O88819. |
| KO | K03663. |
| OMA | LIWVWPF. |
| OrthoDB | EOG412M5N. |
Enzyme and pathway databases | |
| UniPathway | UPA00378. |
Gene expression databases | |
| ArrayExpress | O88819. |
| Bgee | O88819. |
| CleanEx | MM_FUT9. |
| Genevestigator | O88819. |
| GermOnline | ENSMUSG00000055373. Mus musculus. |
Family and domain databases | |
| InterPro | IPR001503. Glyco_trans_10. [Graphical view] |
| PANTHER | PTHR11929. PTHR11929. 1 hit. |
| Pfam | PF00852. Glyco_transf_10. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 285799. |
| SOURCE | Search... |
Entry information
| Entry name | FUT9_MOUSE | ||||||||
| Accession | Primary (citable) accession number: O88819 Secondary accession number(s): Q3TQ63 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |