SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O88819

- FUT9_MOUSE

UniProt

O88819 - FUT9_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Alpha-(1,3)-fucosyltransferase 9

Gene
Fut9
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides.1 Publication

Pathwayi

GO - Molecular functioni

  1. alpha-(1->3)-fucosyltransferase activity Source: MGI

GO - Biological processi

  1. fucosylation Source: GOC
  2. nervous system development Source: Ensembl
  3. protein glycosylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT10. Glycosyltransferase Family 10.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,3)-fucosyltransferase 9 (EC:2.4.1.-)
Alternative name(s):
Fucosyltransferase 9
Fucosyltransferase IX
Short name:
Fuc-TIX
Short name:
FucT-IX
Galactoside 3-L-fucosyltransferase
Gene namesi
Name:Fut9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1330859. Fut9.

Subcellular locationi

Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein By similarity
Note: Membrane-bound form in trans cisternae of Golgi By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei12 – 3221Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini33 – 359327Lumenal Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi cisterna membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Alpha-(1,3)-fucosyltransferase 9PRO_0000221119Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi101 – 1011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi153 – 1531N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO88819.
PRIDEiO88819.

PTM databases

PhosphoSiteiO88819.

Expressioni

Tissue specificityi

Mainly detected in brain and kidney.1 Publication

Gene expression databases

BgeeiO88819.
CleanExiMM_FUT9.
GenevestigatoriO88819.

Structurei

3D structure databases

ProteinModelPortaliO88819.
SMRiO88819. Positions 183-313.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG19459.
HOGENOMiHOG000045583.
HOVERGENiHBG000274.
InParanoidiO88819.
KOiK03663.
OMAiLIWVWPF.
OrthoDBiEOG7Z69C9.
PhylomeDBiO88819.
TreeFamiTF316348.

Family and domain databases

InterProiIPR001503. Glyco_trans_10.
[Graphical view]
PANTHERiPTHR11929. PTHR11929. 1 hit.
PfamiPF00852. Glyco_transf_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88819-1 [UniParc]FASTAAdd to Basket

« Hide

MTSTSKGILR PFLIVCIILG CFMACLLIYI KPTNSWVFSP MESASSVLKM    50
KNFFSTKTDY FNETTILVWV WPFGQTFDLT SCQAMFNIQG CHLTTDRSLY 100
NKSHAVLIHH RDISWDLTNL PQQARPPFQK WIWMNLESPT HTPQKSGIEH 150
LFNLTLTYRR DSDIQVPYGF LTVSTNPFVF EVPSKEKLVC WVVSNWNPEH 200
ARVKYYNELS KSIEIHTYGQ AFGEYVNDKN LIPTISTCKF YLSFENSIHK 250
DYITEKLYNA FLAGSVPVVL GPSRENYENY IPADSFIHVE DFNSPSELAK 300
YLKEVDKNNK LYLSYFNWRK DFTVNLPRFW ESHACLACDH VKRHQEYKSV 350
GNLEKWFWN 359
Length:359
Mass (Da):42,041
Last modified:November 1, 1998 - v1
Checksum:i96A2394547F2A44E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015426 mRNA. Translation: BAA33522.1.
AK032177 mRNA. Translation: BAC27746.1.
AK036183 mRNA. Translation: BAC29338.1.
AK043410 mRNA. Translation: BAC31540.1.
AK047650 mRNA. Translation: BAC33112.1.
AK049122 mRNA. Translation: BAC33555.1.
AK163871 mRNA. Translation: BAE37522.1.
CCDSiCCDS18011.1.
RefSeqiNP_034373.1. NM_010243.3.
UniGeneiMm.39101.

Genome annotation databases

EnsembliENSMUST00000084770; ENSMUSP00000081826; ENSMUSG00000055373.
ENSMUST00000108199; ENSMUSP00000103834; ENSMUSG00000055373.
GeneIDi14348.
KEGGimmu:14348.
UCSCiuc008sei.1. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

Fucosyltransferase 9

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB015426 mRNA. Translation: BAA33522.1 .
AK032177 mRNA. Translation: BAC27746.1 .
AK036183 mRNA. Translation: BAC29338.1 .
AK043410 mRNA. Translation: BAC31540.1 .
AK047650 mRNA. Translation: BAC33112.1 .
AK049122 mRNA. Translation: BAC33555.1 .
AK163871 mRNA. Translation: BAE37522.1 .
CCDSi CCDS18011.1.
RefSeqi NP_034373.1. NM_010243.3.
UniGenei Mm.39101.

3D structure databases

ProteinModelPortali O88819.
SMRi O88819. Positions 183-313.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT10. Glycosyltransferase Family 10.

PTM databases

PhosphoSitei O88819.

Proteomic databases

PaxDbi O88819.
PRIDEi O88819.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000084770 ; ENSMUSP00000081826 ; ENSMUSG00000055373 .
ENSMUST00000108199 ; ENSMUSP00000103834 ; ENSMUSG00000055373 .
GeneIDi 14348.
KEGGi mmu:14348.
UCSCi uc008sei.1. mouse.

Organism-specific databases

CTDi 10690.
MGIi MGI:1330859. Fut9.

Phylogenomic databases

eggNOGi NOG19459.
HOGENOMi HOG000045583.
HOVERGENi HBG000274.
InParanoidi O88819.
KOi K03663.
OMAi LIWVWPF.
OrthoDBi EOG7Z69C9.
PhylomeDBi O88819.
TreeFami TF316348.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Miscellaneous databases

NextBioi 285799.
PROi O88819.
SOURCEi Search...

Gene expression databases

Bgeei O88819.
CleanExi MM_FUT9.
Genevestigatori O88819.

Family and domain databases

InterProi IPR001503. Glyco_trans_10.
[Graphical view ]
PANTHERi PTHR11929. PTHR11929. 1 hit.
Pfami PF00852. Glyco_transf_10. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression cloning and characterization of a novel murine alpha1, 3-fucosyltransferase, mFuc-TIX, that synthesizes the Lewis x (CD15) epitope in brain and kidney."
    Kudo T., Ikehara Y., Togayachi A., Kaneko M., Hiraga T., Sasaki K., Narimatsu H.
    J. Biol. Chem. 273:26729-26738(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum, Corpus striatum and Olfactory bulb.

Entry informationi

Entry nameiFUT9_MOUSE
AccessioniPrimary (citable) accession number: O88819
Secondary accession number(s): Q3TQ63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi