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Protein

Tubby protein homolog

Gene

Tub

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Phagocytosis, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Tubby protein homolog
Gene namesi
Name:Tub
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3918. Tub.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus By similarity
  • Secreted 1 Publication
  • Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity

  • Note: Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus, Secreted

Pathology & Biotechi

Keywords - Diseasei

Obesity

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Tubby protein homologPRO_0000186465Add
BLAST

Proteomic databases

PaxDbiO88808.

Expressioni

Gene expression databases

GenevisibleiO88808. RN.

Interactioni

Subunit structurei

Interacts with GNAQ. Interacts with TULP1.By similarity

Protein-protein interaction databases

BioGridi247638. 1 interaction.
STRINGi10116.ENSRNOP00000064486.

Structurei

3D structure databases

ProteinModelPortaliO88808.
SMRiO88808. Positions 233-504.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi197 – 2048Asp/Glu-rich
Compositional biasi206 – 2105Poly-Ser

Sequence similaritiesi

Belongs to the TUB family.Curated

Phylogenomic databases

eggNOGiKOG2502. Eukaryota.
ENOG410XQFT. LUCA.
GeneTreeiENSGT00610000085970.
HOVERGENiHBG018010.
InParanoidiO88808.
OMAiATMQRKG.
OrthoDBiEOG77HDDQ.
PhylomeDBiO88808.

Family and domain databases

Gene3Di3.20.90.10. 1 hit.
InterProiIPR000007. Tubby_C.
IPR025659. Tubby_C-like.
IPR018066. Tubby_C_CS.
IPR005398. Tubby_N.
[Graphical view]
PfamiPF01167. Tub. 1 hit.
PF16322. Tub_N. 1 hit.
[Graphical view]
PRINTSiPR01573. SUPERTUBBY.
PR01574. TUBBYPROTEIN.
SUPFAMiSSF54518. SSF54518. 1 hit.
PROSITEiPS01200. TUB_1. 1 hit.
PS01201. TUB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKPHSDWI PYSVLDDEGS NLRQQKLDRQ RALLEQKQKK KRQEPLMVQA
60 70 80 90 100
NADGRPRSRR ARQSEEQAPL VESYLSSSGS TSYQVQEADS LASVQPGATR
110 120 130 140 150
PPAPASAKKT KGAAASGGQG GAPRKEKKGK HKGTSGPATL AEDKSEAQGP
160 170 180 190 200
VQILTVGQSD HAKDAGETAA GGGAQPSGQD LRATMQRKGI SSSMSFDEEE
210 220 230 240 250
DEDENSSSSS QLNSNTRPSS ATSRKSTREA ASAPSPAAPE PPVDIEVQDL
260 270 280 290 300
EEFALRPAPQ GITIKCRITR DKKGMDRGMY PTYFLHLDRE DGKKVFLLAG
310 320 330 340 350
RKRKKSKTSN YLISVDPTDL SRGGDSYIGK LRSNLMGTKF TVYDNGVNPQ
360 370 380 390 400
KASSSTLESG TLRQELAAVC YETNVLGFKG PRKMSVIVPG MNMVHERVCI
410 420 430 440 450
RPRNEHETLL ARWQNKNTES IIELQNKTPV WNDDTQSYVL NFHGRVTQAS
460 470 480 490 500
VKNFQIIHGN DPDYIVMQFG RVAEDVFTMD YNYPLCALQA FAIALSSFDS

KLACE
Length:505
Mass (Da):55,318
Last modified:November 1, 1998 - v1
Checksum:i8ECAAB751B06469F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti362 – 37918LRQEL…VLGFK → CARSWQPCAMRQMSRLQ in AAD09251 (Ref. 2) CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011544 mRNA. Translation: BAA32734.1.
U92546 mRNA. Translation: AAD09251.1.
RefSeqiNP_037209.1. NM_013077.1.
UniGeneiRn.30017.

Genome annotation databases

EnsembliENSRNOT00000074636; ENSRNOP00000064486; ENSRNOG00000046566.
GeneIDi25609.
KEGGirno:25609.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011544 mRNA. Translation: BAA32734.1.
U92546 mRNA. Translation: AAD09251.1.
RefSeqiNP_037209.1. NM_013077.1.
UniGeneiRn.30017.

3D structure databases

ProteinModelPortaliO88808.
SMRiO88808. Positions 233-504.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247638. 1 interaction.
STRINGi10116.ENSRNOP00000064486.

Proteomic databases

PaxDbiO88808.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000074636; ENSRNOP00000064486; ENSRNOG00000046566.
GeneIDi25609.
KEGGirno:25609.

Organism-specific databases

CTDi7275.
RGDi3918. Tub.

Phylogenomic databases

eggNOGiKOG2502. Eukaryota.
ENOG410XQFT. LUCA.
GeneTreeiENSGT00610000085970.
HOVERGENiHBG018010.
InParanoidiO88808.
OMAiATMQRKG.
OrthoDBiEOG77HDDQ.
PhylomeDBiO88808.

Miscellaneous databases

NextBioi607343.
PROiO88808.

Gene expression databases

GenevisibleiO88808. RN.

Family and domain databases

Gene3Di3.20.90.10. 1 hit.
InterProiIPR000007. Tubby_C.
IPR025659. Tubby_C-like.
IPR018066. Tubby_C_CS.
IPR005398. Tubby_N.
[Graphical view]
PfamiPF01167. Tub. 1 hit.
PF16322. Tub_N. 1 hit.
[Graphical view]
PRINTSiPR01573. SUPERTUBBY.
PR01574. TUBBYPROTEIN.
SUPFAMiSSF54518. SSF54518. 1 hit.
PROSITEiPS01200. TUB_1. 1 hit.
PS01201. TUB_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of rat TUBBY gene."
    Miyakita A., Okuno S., Watanabe T.K., Oga K., Tsuji A., Hishigaki H., Suto T., Nakagawa K., Nakahara Y., Higashi K.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Cloning and expression of the rat gene tubby."
    Koritschoner N.P., Alvarez-Dolado M., Zenke M.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 291-404.
    Strain: Wistar.
  3. "Unconventional secretion of tubby and tubby-like protein 1."
    Caberoy N.B., Li W.
    FEBS Lett. 583:3057-3062(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiTUB_RAT
AccessioniPrimary (citable) accession number: O88808
Secondary accession number(s): Q9Z1A2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.