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Protein

Protein-arginine deiminase type-1

Gene

Padi1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the deimination of arginine residues of proteins.

Catalytic activityi

Protein L-arginine + H2O = protein L-citrulline + NH3.

Cofactori

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • protein-arginine deiminase activity Source: UniProtKB

GO - Biological processi

  • protein citrullination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BRENDAi3.5.3.15. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine deiminase type-1 (EC:3.5.3.15)
Alternative name(s):
PAD-R11
Peptidylarginine deiminase I
Protein-arginine deiminase type I
Gene namesi
Name:Padi1
Synonyms:Pad1, Pdi1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3287. Padi1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 662662Protein-arginine deiminase type-1PRO_0000220025Add
BLAST

Proteomic databases

PaxDbiO88806.
PRIDEiO88806.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009921.

Structurei

3D structure databases

ProteinModelPortaliO88806.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

eggNOGiENOG410IF3F. Eukaryota.
ENOG410ZKF3. LUCA.
HOGENOMiHOG000220908.
HOVERGENiHBG053016.
InParanoidiO88806.
KOiK01481.
PhylomeDBiO88806.

Family and domain databases

InterProiIPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
[Graphical view]
PANTHERiPTHR10837. PTHR10837. 1 hit.
PfamiPF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMiSSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.

Sequencei

Sequence statusi: Complete.

O88806-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQRAVQLS LRKPAHAVCV IGVGTLVDVY SDVPKGAKTF EVSGSSEVKI
60 70 80 90 100
YMVYDPSRVA EPAGPAHWPL DANVDVVVVA DTVSKNLHDL KVKVSYFKSQ
110 120 130 140 150
DTAALAHSLL YLTAVDVSLD VDTGRTGKVK KGSGDKKNWR WGSGGSGAIL
160 170 180 190 200
LVNCDRDVHG SREDLHDSHL RSLEDLQDMS PMVLSCDGPD DLFKSHKPVL
210 220 230 240 250
KASLPDSRRL GVFCARGGTS LSNYKQVLGP RHNSYEVERH PGERDIQFYV
260 270 280 290 300
EGLAFPDASF SGLLSLSVSL VDTRPLSEVL VFTDSVTFRV APWIMTPNTQ
310 320 330 340 350
PPLELYVCSV TDMHGSNDKF LEDMSHLATK ANCKLVVCPR LENRNDRWIQ
360 370 380 390 400
DEMEFGYIDA PHKSFPVVFD SPRNRGLRDF ALKKILGPDF GYVTREIQFA
410 420 430 440 450
GASGLDSFGN LDVSPPVRVG NTEYPLGRIL IGGNFPKSSG RRMARVVRDF
460 470 480 490 500
LHAQQVQAPV ELYSDWLSVG HVDEFLSFVP TSDQKGFRLL LASPSACLQL
510 520 530 540 550
FQEKKEEGYG EAKQFDGLKH KTKRSINDIL ADRHLRRDSA HVQKCIDWNR
560 570 580 590 600
EVLKQELGLS ESDIVDIPQL FFLKGAYAEA FFPDMVNMVV LGKYLGIPKP
610 620 630 640 650
FGPIINGRCC LEEKVRSLLE PLGLRCVFID DFLFYHQLLG EIHCGTNVRR
660
KPFAFRWWNS VP
Length:662
Mass (Da):73,857
Last modified:November 1, 1998 - v1
Checksum:i3A51464C7089D2DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010998 mRNA. Translation: BAA32099.1.
RefSeqiNP_062205.1. NM_019332.1.
UniGeneiRn.30030.

Genome annotation databases

GeneIDi54282.
KEGGirno:54282.
UCSCiRGD:3287. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010998 mRNA. Translation: BAA32099.1.
RefSeqiNP_062205.1. NM_019332.1.
UniGeneiRn.30030.

3D structure databases

ProteinModelPortaliO88806.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009921.

Proteomic databases

PaxDbiO88806.
PRIDEiO88806.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi54282.
KEGGirno:54282.
UCSCiRGD:3287. rat.

Organism-specific databases

CTDi29943.
RGDi3287. Padi1.

Phylogenomic databases

eggNOGiENOG410IF3F. Eukaryota.
ENOG410ZKF3. LUCA.
HOGENOMiHOG000220908.
HOVERGENiHBG053016.
InParanoidiO88806.
KOiK01481.
PhylomeDBiO88806.

Enzyme and pathway databases

BRENDAi3.5.3.15. 5301.

Miscellaneous databases

NextBioi610858.
PROiO88806.

Family and domain databases

InterProiIPR008972. Cupredoxin.
IPR004303. PAD.
IPR013530. PAD_C.
IPR013732. PAD_N.
IPR013733. Prot_Arg_deaminase_cen_dom.
[Graphical view]
PANTHERiPTHR10837. PTHR10837. 1 hit.
PfamiPF03068. PAD. 1 hit.
PF08527. PAD_M. 1 hit.
PF08526. PAD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001247. Protein-arginine_deiminase. 1 hit.
SUPFAMiSSF110083. SSF110083. 1 hit.
SSF49503. SSF49503. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of two novel types of peptidylarginine deiminase cDNAs from retinoic acid-treated culture of a newborn rat keratinocyte cell line."
    Ishigami A., Kuramoto M., Yamada M., Watanabe K., Senshu T.
    FEBS Lett. 433:113-118(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPADI1_RAT
AccessioniPrimary (citable) accession number: O88806
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: December 9, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.