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Protein

Protein-arginine deiminase type-1

Gene

Padi1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the deimination of arginine residues of proteins.

Catalytic activityi

Protein L-arginine + H2O = protein L-citrulline + NH3.

Cofactori

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • protein-arginine deiminase activity Source: UniProtKB

GO - Biological processi

  • histone citrullination Source: GO_Central
  • protein citrullination Source: UniProtKB

Keywordsi

Molecular functionHydrolase
LigandCalcium

Enzyme and pathway databases

BRENDAi3.5.3.15 5301

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-arginine deiminase type-1 (EC:3.5.3.15)
Alternative name(s):
PAD-R11
Peptidylarginine deiminase I
Protein-arginine deiminase type I
Gene namesi
Name:Padi1
Synonyms:Pad1, Pdi1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3287 Padi1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002200251 – 662Protein-arginine deiminase type-1Add BLAST662

Proteomic databases

PaxDbiO88806
PRIDEiO88806

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009921

Structurei

3D structure databases

ProteinModelPortaliO88806
SMRiO88806
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

eggNOGiENOG410IF3F Eukaryota
ENOG410ZKF3 LUCA
HOGENOMiHOG000220908
HOVERGENiHBG053016
InParanoidiO88806
KOiK01481
PhylomeDBiO88806

Family and domain databases

Gene3Di2.60.40.1700, 1 hit
2.60.40.1860, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR004303 PAD
IPR013530 PAD_C
IPR036556 PAD_central_sf
IPR013732 PAD_N
IPR038685 PAD_N_sf
IPR013733 Prot_Arg_deaminase_cen_dom
PANTHERiPTHR10837 PTHR10837, 1 hit
PfamiView protein in Pfam
PF03068 PAD, 1 hit
PF08527 PAD_M, 1 hit
PF08526 PAD_N, 1 hit
PIRSFiPIRSF001247 Protein-arginine_deiminase, 1 hit
SUPFAMiSSF110083 SSF110083, 1 hit
SSF49503 SSF49503, 1 hit

Sequencei

Sequence statusi: Complete.

O88806-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQRAVQLS LRKPAHAVCV IGVGTLVDVY SDVPKGAKTF EVSGSSEVKI
60 70 80 90 100
YMVYDPSRVA EPAGPAHWPL DANVDVVVVA DTVSKNLHDL KVKVSYFKSQ
110 120 130 140 150
DTAALAHSLL YLTAVDVSLD VDTGRTGKVK KGSGDKKNWR WGSGGSGAIL
160 170 180 190 200
LVNCDRDVHG SREDLHDSHL RSLEDLQDMS PMVLSCDGPD DLFKSHKPVL
210 220 230 240 250
KASLPDSRRL GVFCARGGTS LSNYKQVLGP RHNSYEVERH PGERDIQFYV
260 270 280 290 300
EGLAFPDASF SGLLSLSVSL VDTRPLSEVL VFTDSVTFRV APWIMTPNTQ
310 320 330 340 350
PPLELYVCSV TDMHGSNDKF LEDMSHLATK ANCKLVVCPR LENRNDRWIQ
360 370 380 390 400
DEMEFGYIDA PHKSFPVVFD SPRNRGLRDF ALKKILGPDF GYVTREIQFA
410 420 430 440 450
GASGLDSFGN LDVSPPVRVG NTEYPLGRIL IGGNFPKSSG RRMARVVRDF
460 470 480 490 500
LHAQQVQAPV ELYSDWLSVG HVDEFLSFVP TSDQKGFRLL LASPSACLQL
510 520 530 540 550
FQEKKEEGYG EAKQFDGLKH KTKRSINDIL ADRHLRRDSA HVQKCIDWNR
560 570 580 590 600
EVLKQELGLS ESDIVDIPQL FFLKGAYAEA FFPDMVNMVV LGKYLGIPKP
610 620 630 640 650
FGPIINGRCC LEEKVRSLLE PLGLRCVFID DFLFYHQLLG EIHCGTNVRR
660
KPFAFRWWNS VP
Length:662
Mass (Da):73,857
Last modified:November 1, 1998 - v1
Checksum:i3A51464C7089D2DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010998 mRNA Translation: BAA32099.1
RefSeqiNP_062205.1, NM_019332.1
UniGeneiRn.30030

Genome annotation databases

GeneIDi54282
KEGGirno:54282
UCSCiRGD:3287 rat

Similar proteinsi

Entry informationi

Entry nameiPADI1_RAT
AccessioniPrimary (citable) accession number: O88806
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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