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Protein

Homer protein homolog 2

Gene

Homer2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Required for normal hearing (By similarity).By similarity

GO - Molecular functioni

  • actin binding Source: Ensembl
  • GKAP/Homer scaffold activity Source: Ensembl
  • glutamate receptor binding Source: RGD
  • G-protein coupled glutamate receptor binding Source: UniProtKB
  • protein domain specific binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

GO - Biological processi

Keywordsi

Biological processHearing

Enzyme and pathway databases

ReactomeiR-RNO-6794361. Neurexins and neuroligins.

Names & Taxonomyi

Protein namesi
Recommended name:
Homer protein homolog 2
Short name:
Homer-2
Alternative name(s):
Cupidin
VASP/Ena-related gene up-regulated during seizure and LTP 2
Short name:
Vesl-2
Gene namesi
Name:Homer2
Synonyms:Vesl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620705. Homer2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910101 – 354Homer protein homolog 2Add BLAST354

Proteomic databases

PaxDbiO88801.
PRIDEiO88801.

PTM databases

iPTMnetiO88801.
PhosphoSitePlusiO88801.

Expressioni

Tissue specificityi

Constitutively expressed in the adult hippocampus.

Developmental stagei

In the developing hippocampus, expression is high at P8, then decreased along with hippocampal development.

Gene expression databases

BgeeiENSRNOG00000061450.
GenevisibleiO88801. RN.

Interactioni

Subunit structurei

Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.

GO - Molecular functioni

  • actin binding Source: Ensembl
  • GKAP/Homer scaffold activity Source: Ensembl
  • glutamate receptor binding Source: RGD
  • G-protein coupled glutamate receptor binding Source: UniProtKB
  • protein domain specific binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

BioGridi248181. 3 interactors.
IntActiO88801. 2 interactors.
STRINGi10116.ENSRNOP00000026158.

Structurei

3D structure databases

ProteinModelPortaliO88801.
SMRiO88801.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 110WH1PROSITE-ProRule annotationAdd BLAST110

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili92 – 120Sequence analysisAdd BLAST29
Coiled coili160 – 329Sequence analysisAdd BLAST170

Domaini

The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.

Sequence similaritiesi

Belongs to the Homer family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGRQ. Eukaryota.
ENOG410XQWT. LUCA.
GeneTreeiENSGT00390000017850.
HOGENOMiHOG000006979.
HOVERGENiHBG051918.
InParanoidiO88801.
KOiK15010.
OMAiREKCNDQ.
OrthoDBiEOG091G0CQ0.
PhylomeDBiO88801.
TreeFamiTF325627.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR011993. PH_dom-like.
IPR000697. WH1/EVH1_dom.
PfamiView protein in Pfam
PF00568. WH1. 1 hit.
SMARTiView protein in SMART
SM00461. WH1. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS50229. WH1. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O88801-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEQPIFTTR AHVFQIDPST KKNWVPASKQ AVTVSYFYDV TRNSYRIISV
60 70 80 90 100
DGAKVIINST ITPNMTFTKT SQKFGQWADS RANTVFGLGF SSEQQLTKFA
110 120 130 140 150
EKFQEVREAA RLARDKSQEK IETSSNHSQE SGCETPSSTQ ASSVNGTDDE
160 170 180 190 200
KASHASPADT HLKSENDKLK IALTQSAANV KKWEIELQTL RESNARLTTA
210 220 230 240 250
LQESAASVEQ WKRQFSICRD ENDRLRSKIE ELEEQCGEIN REKEKNTQLK
260 270 280 290 300
RRIEELESEV REKEMELKDL RKQSEIIPQL MSECEYVSEK LEAAERDNQN
310 320 330 340 350
LEDKVRSLKT DIEESKYRQR HLKGELKSFL EVLDGKIDDL HDFRRGLSKL

GTDN
Length:354
Mass (Da):40,563
Last modified:November 1, 1998 - v1
Checksum:i205FA6358F9D198E
GO
Isoform 2 (identifier: O88801-2) [UniParc]FASTAAdd to basket
Also known as: Vesl-2(delta 11)

The sequence of this isoform differs from the canonical sequence as follows:
     130-140: Missing.

Show »
Length:343
Mass (Da):39,456
Checksum:i4A96526D4BECBFCB
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009072130 – 140Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007689 mRNA. Translation: BAA32478.1.
AB007690 mRNA. Translation: BAA32479.1.
RefSeqiNP_445761.1. NM_053309.1. [O88801-1]
UniGeneiRn.30014.

Genome annotation databases

EnsembliENSRNOT00000087785; ENSRNOP00000070858; ENSRNOG00000061450. [O88801-1]
GeneIDi29547.
KEGGirno:29547.
UCSCiRGD:620705. rat. [O88801-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHOME2_RAT
AccessioniPrimary (citable) accession number: O88801
Secondary accession number(s): O88802
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: November 1, 1998
Last modified: October 25, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families