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O88799

- ZAN_MOUSE

UniProt

O88799 - ZAN_MOUSE

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Protein

Zonadhesin

Gene

Zan

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. regulation of binding of sperm to zona pellucida Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Zonadhesin
Gene namesi
Name:Zan
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:106656. Zan.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein
Note: Exclusively on the apical region of the sperm head.

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 53765359ZonadhesinPRO_0000007784Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi339 – 3391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi499 – 4991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1216 – 12161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1239 – 12391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1314 – 13141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1814 – 18141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1908 – 19081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1933 – 19331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2028 – 20281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2111 – 21111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2142 – 21421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2332 – 23321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2533 – 25331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2575 – 25751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2692 – 26921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2812 – 28121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3052 – 30521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3065 – 30651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3144 – 31441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3172 – 31721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3288 – 32881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3292 – 32921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3782 – 37821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4005 – 40051N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4136 – 41361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4243 – 42431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4254 – 42541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4335 – 43351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4376 – 43761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4586 – 45861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi5136 – 51361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi5252 – 52521N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi5263 ↔ 5274By similarity
Disulfide bondi5268 ↔ 5283By similarity
Disulfide bondi5285 ↔ 5294By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88799.
PRIDEiO88799.

PTM databases

PhosphoSiteiO88799.

Expressioni

Tissue specificityi

In testis, primarily in haploid spermatids.

Gene expression databases

CleanExiMM_ZAN.
GenevestigatoriO88799.

Interactioni

Subunit structurei

Probably forms covalent oligomers.

Structurei

3D structure databases

ProteinModelPortaliO88799.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 53105293ExtracellularSequence AnalysisAdd
BLAST
Topological domaini5338 – 537639CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5311 – 533727HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 210166MAM 1PROSITE-ProRule annotationAdd
BLAST
Domaini215 – 374160MAM 2PROSITE-ProRule annotationAdd
BLAST
Domaini377 – 542166MAM 3PROSITE-ProRule annotationAdd
BLAST
Domaini1171 – 122050TIL 1Add
BLAST
Domaini1227 – 127549VWFC 1Add
BLAST
Domaini1281 – 1500220VWFD 1PROSITE-ProRule annotationAdd
BLAST
Domaini1555 – 160854TIL 2Add
BLAST
Domaini1609 – 166456VWFC 2Add
BLAST
Domaini1670 – 1887218VWFD 2PROSITE-ProRule annotationAdd
BLAST
Domaini1941 – 199555TIL 3Add
BLAST
Domaini1996 – 205257VWFC 3Add
BLAST
Domaini2057 – 2273217VWFD 3PROSITE-ProRule annotationAdd
BLAST
Domaini2340 – 239859TIL 4Add
BLAST
Domaini2399 – 245456VWFC 4Add
BLAST
Domaini2460 – 251859TIL 5Add
BLAST
Domaini2519 – 257456VWFC 5Add
BLAST
Domaini2580 – 263859TIL 6Add
BLAST
Domaini2639 – 269456VWFC 6Add
BLAST
Domaini2700 – 275859TIL 7Add
BLAST
Domaini2759 – 281456VWFC 7Add
BLAST
Domaini2820 – 287859TIL 8Add
BLAST
Domaini2879 – 293456VWFC 8Add
BLAST
Domaini2940 – 299859TIL 9Add
BLAST
Domaini2999 – 305456VWFC 9Add
BLAST
Domaini3060 – 311859TIL 10Add
BLAST
Domaini3119 – 317456VWFC 10Add
BLAST
Domaini3180 – 323859TIL 11Add
BLAST
Domaini3239 – 329456VWFC 11Add
BLAST
Domaini3300 – 335556TIL 12Add
BLAST
Domaini3356 – 341156VWFC 12Add
BLAST
Domaini3417 – 347559TIL 13Add
BLAST
Domaini3476 – 353156VWFC 13Add
BLAST
Domaini3537 – 359559TIL 14Add
BLAST
Domaini3596 – 365156VWFC 14Add
BLAST
Domaini3657 – 371559TIL 15Add
BLAST
Domaini3716 – 377156VWFC 15Add
BLAST
Domaini3777 – 383559TIL 16Add
BLAST
Domaini3836 – 389156VWFC 16Add
BLAST
Domaini3893 – 395159TIL 17Add
BLAST
Domaini3952 – 400756VWFC 17Add
BLAST
Domaini4029 – 408759TIL 18Add
BLAST
Domaini4088 – 414356VWFC 18Add
BLAST
Domaini4149 – 420759TIL 19Add
BLAST
Domaini4208 – 426255VWFC 19Add
BLAST
Domaini4264 – 432259TIL 20Add
BLAST
Domaini4323 – 437856VWFC 20Add
BLAST
Domaini4384 – 444259TIL 21Add
BLAST
Domaini4443 – 449856VWFC 21Add
BLAST
Domaini4504 – 456259TIL 22Add
BLAST
Domaini4563 – 461856VWFC 22Add
BLAST
Domaini4624 – 468259TIL 23Add
BLAST
Domaini4683 – 473856VWFC 23Add
BLAST
Domaini4744 – 480259TIL 24Add
BLAST
Domaini4803 – 485856VWFC 24Add
BLAST
Domaini4864 – 5065202VWFD 4PROSITE-ProRule annotationAdd
BLAST
Domaini5150 – 520354TIL 25Add
BLAST
Domaini5204 – 525855VWFC 25Add
BLAST
Domaini5259 – 529537EGF-likePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni547 – 117062480 X heptapeptide repeats (approximate) (mucin-like domain)Add
BLAST

Domaini

The MAM domains probably mediates sperm adhesion to the zona pellucida.
During sperm migration through the reproductive tracts, the mucin-like domain might inhibit inappropriate trapping of spermatozoa or promoting adhesion to the oviductal isthmus.
The VWFD domain 2 may mediate covalent oligomerization.By similarity

Sequence similaritiesi

Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 3 MAM domains.PROSITE-ProRule annotation
Contains 25 VWFC domains.Curated
Contains 4 VWFD domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG12793.
HOVERGENiHBG003977.
InParanoidiO88799.
PhylomeDBiO88799.

Family and domain databases

InterProiIPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR003645. Fol_N.
IPR000998. MAM_dom.
IPR002919. TIL_dom.
IPR025615. TILa_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF00629. MAM. 3 hits.
PF01826. TIL. 25 hits.
PF12714. TILa. 25 hits.
PF00094. VWD. 4 hits.
[Graphical view]
SMARTiSM00832. C8. 4 hits.
SM00181. EGF. 2 hits.
SM00274. FOLN. 20 hits.
SM00137. MAM. 3 hits.
SM00214. VWC. 17 hits.
SM00216. VWD. 4 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 3 hits.
SSF57567. SSF57567. 25 hits.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 18 hits.
PS50026. EGF_3. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 3 hits.
PS51233. VWFD. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88799-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MALPVWTLML LVGAAWGQEQ VPAWRPNSPD LGPMVHTSRE DSILSKCDFE
60 70 80 90 100
DNSRPFCDWS QMSADDGDWI RTTGPSLTGT SGPPGGYPNG EGYYLHMDPK
110 120 130 140 150
TFPQGGVARL RSPDIWEQGP LCVHFAFHMF GLSWGAQLRL LLLRGRKHLR
160 170 180 190 200
PYVLWKHVNT QSPSWMPTTV TVPADHDIPS WLMFEGMRGN TAYLDISLDG
210 220 230 240 250
LSIQRGTCNQ VCMSQMCTFD TLNDLCGWSW VPTATGAKWT QKKGPTGKQG
260 270 280 290 300
VGPAEDFSNP GNGYYMLLDS TNARPGQKAV LLSPLSHSRG CMTLSFHYIM
310 320 330 340 350
HGQGHEEGLF VYATFLGNIR KYTLFSGHPG PDWQAVSVNY TGQGQIQFMV
360 370 380 390 400
VGMFGNIPEP AIAVDAISIA PCGESFPQCD FEDRVHPFCD WNQVYGDMGH
410 420 430 440 450
WSWGSKSVPT LIAGSPREFP YGGEHYIFFD SVKLSQEGQS ARLVSPPFCA
460 470 480 490 500
PGGICVEFAY HMYGLGKGTT LKLLLGSPAG SSPIPLWNRV GSQSSGWMNS
510 520 530 540 550
SVTIPKGYQQ PMQLFIEATR GTSTAFVVAL NFILISHGPC RVLLQTEIPS
560 570 580 590 600
SPLLPPTGPS ESTVPTLPME QPTSPTKATT VTIEIPTTPT EEATIPTETT
610 620 630 640 650
TVPTEVINVS PKETSIPPEV TIPTEVITVS PEEIISPTEV TPVPTDVTAA
660 670 680 690 700
YVEATNASPE ETSVPPEVTI LTEVTTVSPE ETTVPTEVPI VLIEATAFPT
710 720 730 740 750
GETTLYTEVP TVPTEVTGVH TEVTNVSPEE TSVPTEETIS TEVTTVSPEE
760 770 780 790 800
TTVPTEVPIV LIEATASPTG EITLYTEVPT VPTEVTGVHT EVTNVSPEET
810 820 830 840 850
SVPTEETIST EVTTVSPEET TLPTEVPTVS TEVTNVSPEE TSVPPEETIL
860 870 880 890 900
TTLYTEVPTV PTEVTGVHTE VTNVSPEETS VPTEETISTE VTTVSPEETT
910 920 930 940 950
LPTEVPTVST EVTNVSPEET SVPPEETILT EITTVSPEET VFPIEGTTLP
960 970 980 990 1000
TEVLTVPIEV TTFPTGETTV PTEVPTVSTE MTGVHTEVTT VFPEETSIPT
1010 1020 1030 1040 1050
EVATVLPASI PPEETTTPTE VTTTPPEETT IPAEVTTVPP ASIPPEETAS
1060 1070 1080 1090 1100
LTEVTTTPPE ETTTPTEVTT VPPEKTTIPT EVTTVPPASI FPEETTVPPE
1110 1120 1130 1140 1150
ETTIASEETT VSTQETTLLT EQSAVTQTSI ACRPPCPSPP LMPIGPLLSK
1160 1170 1180 1190 1200
PPGVSMFSLA PTTGVSTTES CPPNAHIELC ACPASCESPK PSCQPPCIPG
1210 1220 1230 1240 1250
CVCNPGFLFS NNQCINESSC NCPYNNKHYK PGEEWFTPNC TERCRCLPGS
1260 1270 1280 1290 1300
LMECQISQCG THTVCQLKSD QYQCEPYGKA TCLVYGDLHF VTFDERHIGF
1310 1320 1330 1340 1350
TGTCTYILTQ TCSNSTDHFF RITANTEERG VEGVSCLDKV VISLPETTVT
1360 1370 1380 1390 1400
MISGRHTLIG DQEVTLPAIL SDDTYVGLSG RFVELRTTFG LRVRWDGDQQ
1410 1420 1430 1440 1450
LFVTVSSTFS GKLCGFCGNY DGDSSNDNLK SDGMMTHDEE ELRLSWQVEE
1460 1470 1480 1490 1500
DEDKDWVSSR CQKKKNPPSC DAALGSTMSG PKLCGQLVNP SGPFEACLLH
1510 1520 1530 1540 1550
LKASSFLDNC VTDMCSFQGL QQKLCARMSA MTATCQDAGY PVKPWREPQF
1560 1570 1580 1590 1600
CPLVCPKNSR YSLCAKPCPE TCHPISTTQH CSDKCVEGCE CDPGFILSGS
1610 1620 1630 1640 1650
ECVPSSQCGC TSFQGRYFKL QEQWFNPDCK EICTCESHNH ILCKPWKCKA
1660 1670 1680 1690 1700
QEACSYKNGV LGCHAQGAAT CMVSGDPHYL TFDGALHHFM GTCTYVLTQP
1710 1720 1730 1740 1750
CWSKSQENNF VVSATNEIHD GNLEVSYVKA VHVQVFDLKI SMFKGQKVVL
1760 1770 1780 1790 1800
NNQRVVLPVW PSQGRVTIRL SGIFVLLYTN FGLQVRYDGR HLVEVTVPSS
1810 1820 1830 1840 1850
YTGSLCGLCG NYNNNSMDDN LRADMKPAGN SLLLGAAWKI LEASDPGCFL
1860 1870 1880 1890 1900
AGGKPSRCAD SDMDDVWTKK CAILMNPLGP FSNCHEAVPP QASFSSCVYG
1910 1920 1930 1940 1950
QCETNGDNLT FCHSLQAYAS LCAQAGQVTT WRNSTFCPMR CPPRSSYNPC
1960 1970 1980 1990 2000
ANSCPATCLT LSTPRDCPTL PCVEGCECQS GHILSGTTCV PLRQCGCSDQ
2010 2020 2030 2040 2050
DGSYHLLGES WYTEKTCTTL CTCSAHSNIT CSPTACKANH VCLRQEGLLR
2060 2070 2080 2090 2100
CAAEMGECRI SEDSQIVSFD DHSHPIQDTC TYILVKVCHP NTNMPFFMIS
2110 2120 2130 2140 2150
AKTDINTNGK NKTFGVYQLY IDIFNFHITL QKDHLVLISL INDSIVTLPT
2160 2170 2180 2190 2200
TTHIPGVSVM TEDVYTIVTI KDEIQVKFES NNFLDVKIPA SSNGKVCGVC
2210 2220 2230 2240 2250
GNFNGEEEDE LMTPSGELAE DEQEFMNSWK DKSMDPNCQK IEGQNLQVEQ
2260 2270 2280 2290 2300
QEIMNGKCRP IDFEKAQANC QTALQGPAWA HCSSRVPIKP FLLKCMNSFC
2310 2320 2330 2340 2350
EFRELFRALC DSLQSFEDAC QNQGLKPPIW RNSSFCPLEC PAHSHYTNCL
2360 2370 2380 2390 2400
PSCPPSCLDP DSRCEGSGHK VPATCREGCI CQPDYVLLND KCVLRSHCGC
2410 2420 2430 2440 2450
KDAQGVFIPA GKTWISEDCT QSCTCMKGSM RCWDFQCPPG TYCKNSNDGS
2460 2470 2480 2490 2500
SNCVKISLQC PAHSKFTDCL PPCHPSCSDP DGHCEGISTN AHSNCKEGCV
2510 2520 2530 2540 2550
CQPGYVLRND KCVLRIECGC QHTQGGFIPA GKNWTSRGCS QSCDCMEGVI
2560 2570 2580 2590 2600
RCQNFQCPSG TYCQDIEDGT SNCANITLQC PAHSSFTNCL PPCQPSCSDP
2610 2620 2630 2640 2650
EGHCGGSTTK APSACQEGCV CEPDYVVLNN KCVPRIECGC KDAQGVLIPA
2660 2670 2680 2690 2700
DKIWINKGCT QTCACVTGTI HCRDFQCPSG TYCKDIKDDA SNCTEIILQC
2710 2720 2730 2740 2750
PDHSLYTHCL PSCLLSCSDP DGLCRGTSPE APSTCKEGCV CDPDYVLSND
2760 2770 2780 2790 2800
KCVLRIECGC KDAQGVLIPA GKTWINRGCT QSCSCMGGAI QCQNFKCPSE
2810 2820 2830 2840 2850
AYCQDMEDGN SNCTSIPLQC PAHSHYTNCL PTCQPSCSDP DGHCEGSSTK
2860 2870 2880 2890 2900
APSACKEGCV CEPDYVMLNN KCVPRIECGC KDTQGVLIPA DKTWINRGCT
2910 2920 2930 2940 2950
QSCTCRGGAI QCQKYHCSSG TYCKDMEDDS SSCATITLQC PAHSHFTNCL
2960 2970 2980 2990 3000
PPCQPSCLDS EGHCEGSTTK APSACQEGCV CEPDYVVLNN KCVPRIECGC
3010 3020 3030 3040 3050
KDAQGVLIPA DKTWINRGCT QSCTCKGGAI QCQKFQCPSE TYCKDIEDGN
3060 3070 3080 3090 3100
SNCTRISLQC PANSNFTSCL PSCQPSCSNT DVHCEGSSPN TLSSCREGCV
3110 3120 3130 3140 3150
CQSGYVLHND KCILRNQCGC KDAQGALIPE GKTWITSGCT QSCNCTGGAI
3160 3170 3180 3190 3200
QCQNFQCPLK TYCKDLKDGS SNCTNIPLQC PAHSRYTNCL PSCPPLCLDP
3210 3220 3230 3240 3250
EGLCEGTSPK VPSTCREGCI CQPGYLMHKN KCVLRIFCGC KNTQGAFISA
3260 3270 3280 3290 3300
DKTWISRGCT QSCTCPAGAI HCRNFKCPSG TYCKNGDNGS SNCTEITLQC
3310 3320 3330 3340 3350
PTNSQFTDCL PSCVPSCSNR CEVTSPSVPS SCREGCLCNH GFVFSEDKCV
3360 3370 3380 3390 3400
PRTQCGCKDA RGAIIPAGKT WTSKGCTQSC ACVEGNIQCQ NFQCPPETYC
3410 3420 3430 3440 3450
KDNSEGSSTC TKITLQCPAH TQYTSCLPSC LPSCLDPEGL CKDISPKVPS
3460 3470 3480 3490 3500
TCKEGCVCQS GYVLNSDKCV LRAECDCKDA QGALIPAGKT WTSPGCTQSC
3510 3520 3530 3540 3550
ACMGGAVQCQ SSQCPPGTYC KDNEDGNSNC AKITLQCPAH SLFTNCLPPC
3560 3570 3580 3590 3600
LPSCLDPDGL CKGASPKVPS TCKEGCICQS GYVLSNNKCL LRNRCGCKDA
3610 3620 3630 3640 3650
HGALIPEDKT WVSRGCTQSC VCTGGSIQCL SSQCPPGAYC KDNEDGSSNC
3660 3670 3680 3690 3700
ARIPPQCPAN SHYTDCFPPC PPSCSDPEGH CEASGPRVLS TCREGCLCNP
3710 3720 3730 3740 3750
GFVLDRDKCV PRVECGCKDA QGALIPSGKT WTSPGCTQSC ACMGGVVQCQ
3760 3770 3780 3790 3800
SSQCPPGTYC KDNEDGNSNC AKITLQCPTH SNYTDCLPFC LPSCLDPSAL
3810 3820 3830 3840 3850
CGGTSPKGPS TCKEGCVCQP GYVLDKDKCI LKIECGCRDT QGAVIPAGKT
3860 3870 3880 3890 3900
WLSTGCIQSC ACVEGTIQCQ NFQCPPGTYC NHNNNCAKIP LQCPAHSHFT
3910 3920 3930 3940 3950
SCLPSCPPSC ANLDGSCEQT SPKVPSTCKE GCLCQPGYFL NNGKCVLQTH
3960 3970 3980 3990 4000
CDCKDAEGGL VPAGKTWTSK DCTQSCACTG GAVQCQNFQC PLGTYCKDSG
4010 4020 4030 4040 4050
DGSSNCTKIH KGAMGDGVLM AGGIRALQCP AHSHFTSCLP SCPPSCSNLD
4060 4070 4080 4090 4100
GSCVESNFKA PSVCKKGCIC QPGYLLNNDK CVLRIQCGCK DTQGGLIPAG
4110 4120 4130 4140 4150
RTWISSDCTK SCSCMGGIIQ CRDFQCPPGT YCKESNDSSR TCAKIPLQCP
4160 4170 4180 4190 4200
AHSHYTNCLP ACSRSCTDLD GHCEGTSPKV PSPCKEGCLC QPGYVVHNHK
4210 4220 4230 4240 4250
CVLQIHCGCK DAQGGFVPAG KTWISRGCTQ SCACVGGAVQ CHNFTCPTGT
4260 4270 4280 4290 4300
QCQNSSCSKI TVQCPAHSQY TTCLPSCLPS CFDPEGLCGG ASPRAPSTCR
4310 4320 4330 4340 4350
EGCVCEADYV LREDKCVLRT QCGCKDAQGD LIPANKTWLT RGCAQKCTCK
4360 4370 4380 4390 4400
GGNIHCWNFK CPLGTECKDS VDGGSNCTKI ALQCPAHSHH TYCLPSCIPS
4410 4420 4430 4440 4450
CSNVNDRCES TSLQRPSTCI EGCLCHSGFV FSKDKCVPRT QCGCKDSQGT
4460 4470 4480 4490 4500
LIPAGKNWIT TGCSQRCTCT GGLVQCHDFQ CPSGAECQDI EDGNSNCVEI
4510 4520 4530 4540 4550
TVQCPAHSHY SKCLPPCQPS CSDPDGHCEG TSPEAPSTCE EGCVCEPDYV
4560 4570 4580 4590 4600
LSNDKCVPSS ECGCKDAHGV LIPESKTWVS RGCTKNCTCK GGTVQCHDFS
4610 4620 4630 4640 4650
CPTGSRCLDN NEGNSNCVTY ALKCPAHSLY TNCLPSCLPS CSDPEGLCGG
4660 4670 4680 4690 4700
TSPEVPSTCK EGCICQSGYV LHKNKCMLRI HCDCKDFQGS LIKTGQTWIS
4710 4720 4730 4740 4750
SGCSKICTCK GGFFQCQSYK CPSGTQCEES EDGSSNCVSS TMKCPANSLY
4760 4770 4780 4790 4800
THCLPTCLPS CSNPDGRCEG TSHKAPSTCR EGCVCQPGYL LNKDTCVHKN
4810 4820 4830 4840 4850
QCGCKDIRGN IIPAGNTWIS SDCTQSCACT DGVIQCQNFV CPSGSHCQYN
4860 4870 4880 4890 4900
EDGSSDCAAN KLERCTIFGD PYYLTFDGFT YHFLGRMNYY LIKTVDKLPR
4910 4920 4930 4940 4950
GIEPLIMEGR NKISPKGSST LHEVTTIVYG YKIQLQEELV VLVNDEKVAV
4960 4970 4980 4990 5000
PYNPNEHLRV MLRAQRLLLV TDFEMVLDFD GKHSAVISLP TTYRGLTRGL
5010 5020 5030 5040 5050
CGNYDRDQSN ELMLPSGVLT SNVHVFGNSW EVKAQHAFFR FPRALPEDEE
5060 5070 5080 5090 5100
RDEEPDLLQS ECSQEQTALI SSTQACRVLV DPQGPFAACH QIIAPEPFEQ
5110 5120 5130 5140 5150
RCMLDMCTGW KTKEEEELRC RVLSGYAIIC QEAGANMTGW RDHTHCAMTC
5160 5170 5180 5190 5200
PANTVYQRCM TPCPASCAKF VTPKVCEGPC VEGCASLPGY IYSDTQSLPV
5210 5220 5230 5240 5250
THCGCTADGI YYKLGDSFVT NDCSQHCTCA SQGILLCEPY GCRAGESCMV
5260 5270 5280 5290 5300
ANFTRGCFQD SPCLQNPCHN DGRCEEQGAT FICHCDFGYG GEFCTEPQDI
5310 5320 5330 5340 5350
TTRKKIEASS LVAILPGVLV MVLVPVLLPR VYVYMATRTT MGRRRMKRKE
5360 5370
KKLLRQSRLR LEDADVPEPT FKATEF
Length:5,376
Mass (Da):579,913
Last modified:November 1, 1998 - v1
Checksum:i0E44DB77DF2A2620
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U97068 mRNA. Translation: AAC26680.1.
U83190 mRNA. Translation: AAC53125.1.
PIRiT42215.
UniGeneiMm.7984.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U97068 mRNA. Translation: AAC26680.1 .
U83190 mRNA. Translation: AAC53125.1 .
PIRi T42215.
UniGenei Mm.7984.

3D structure databases

ProteinModelPortali O88799.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei O88799.

Proteomic databases

PaxDbi O88799.
PRIDEi O88799.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:106656. Zan.

Phylogenomic databases

eggNOGi NOG12793.
HOVERGENi HBG003977.
InParanoidi O88799.
PhylomeDBi O88799.

Miscellaneous databases

PROi O88799.
SOURCEi Search...

Gene expression databases

CleanExi MM_ZAN.
Genevestigatori O88799.

Family and domain databases

InterProi IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR003645. Fol_N.
IPR000998. MAM_dom.
IPR002919. TIL_dom.
IPR025615. TILa_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
[Graphical view ]
Pfami PF00629. MAM. 3 hits.
PF01826. TIL. 25 hits.
PF12714. TILa. 25 hits.
PF00094. VWD. 4 hits.
[Graphical view ]
SMARTi SM00832. C8. 4 hits.
SM00181. EGF. 2 hits.
SM00274. FOLN. 20 hits.
SM00137. MAM. 3 hits.
SM00214. VWC. 17 hits.
SM00216. VWD. 4 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 3 hits.
SSF57567. SSF57567. 25 hits.
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 18 hits.
PS50026. EGF_3. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 3 hits.
PS51233. VWFD. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Species diversity in the structure of zonadhesin, a sperm-specific membrane protein containing multiple cell adhesion molecule-like domains."
    Gao Z., Garbers D.L.
    J. Biol. Chem. 273:3415-3421(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Chromosome localization of the mouse zonadhesin gene and the human zonadhesin gene (ZAN)."
    Gao Z., Harumi T., Garbers D.L.
    Genomics 41:119-122(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4864-5376.
    Tissue: Testis.

Entry informationi

Entry nameiZAN_MOUSE
AccessioniPrimary (citable) accession number: O88799
Secondary accession number(s): O08647
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3