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O88799

- ZAN_MOUSE

UniProt

O88799 - ZAN_MOUSE

Protein

Zonadhesin

Gene

Zan

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling.

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. regulation of binding of sperm to zona pellucida Source: MGI

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zonadhesin
    Gene namesi
    Name:Zan
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:106656. Zan.

    Subcellular locationi

    Cell membrane; Single-pass type I membrane protein
    Note: Exclusively on the apical region of the sperm head.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 53765359ZonadhesinPRO_0000007784Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi339 – 3391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi499 – 4991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1216 – 12161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1239 – 12391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1314 – 13141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1814 – 18141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1908 – 19081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1933 – 19331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2028 – 20281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2111 – 21111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2142 – 21421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2332 – 23321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2533 – 25331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2575 – 25751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2692 – 26921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi2812 – 28121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3052 – 30521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3065 – 30651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3144 – 31441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3172 – 31721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3288 – 32881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3292 – 32921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi3782 – 37821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4005 – 40051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4136 – 41361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4243 – 42431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4254 – 42541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4335 – 43351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4376 – 43761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi4586 – 45861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi5136 – 51361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi5252 – 52521N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi5263 ↔ 5274By similarity
    Disulfide bondi5268 ↔ 5283By similarity
    Disulfide bondi5285 ↔ 5294By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO88799.
    PRIDEiO88799.

    PTM databases

    PhosphoSiteiO88799.

    Expressioni

    Tissue specificityi

    In testis, primarily in haploid spermatids.

    Gene expression databases

    CleanExiMM_ZAN.
    GenevestigatoriO88799.

    Interactioni

    Subunit structurei

    Probably forms covalent oligomers.

    Structurei

    3D structure databases

    ProteinModelPortaliO88799.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 53105293ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini5338 – 537639CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5311 – 533727HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini45 – 210166MAM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini215 – 374160MAM 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini377 – 542166MAM 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini1171 – 122050TIL 1Add
    BLAST
    Domaini1227 – 127549VWFC 1Add
    BLAST
    Domaini1281 – 1500220VWFD 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1555 – 160854TIL 2Add
    BLAST
    Domaini1609 – 166456VWFC 2Add
    BLAST
    Domaini1670 – 1887218VWFD 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1941 – 199555TIL 3Add
    BLAST
    Domaini1996 – 205257VWFC 3Add
    BLAST
    Domaini2057 – 2273217VWFD 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini2340 – 239859TIL 4Add
    BLAST
    Domaini2399 – 245456VWFC 4Add
    BLAST
    Domaini2460 – 251859TIL 5Add
    BLAST
    Domaini2519 – 257456VWFC 5Add
    BLAST
    Domaini2580 – 263859TIL 6Add
    BLAST
    Domaini2639 – 269456VWFC 6Add
    BLAST
    Domaini2700 – 275859TIL 7Add
    BLAST
    Domaini2759 – 281456VWFC 7Add
    BLAST
    Domaini2820 – 287859TIL 8Add
    BLAST
    Domaini2879 – 293456VWFC 8Add
    BLAST
    Domaini2940 – 299859TIL 9Add
    BLAST
    Domaini2999 – 305456VWFC 9Add
    BLAST
    Domaini3060 – 311859TIL 10Add
    BLAST
    Domaini3119 – 317456VWFC 10Add
    BLAST
    Domaini3180 – 323859TIL 11Add
    BLAST
    Domaini3239 – 329456VWFC 11Add
    BLAST
    Domaini3300 – 335556TIL 12Add
    BLAST
    Domaini3356 – 341156VWFC 12Add
    BLAST
    Domaini3417 – 347559TIL 13Add
    BLAST
    Domaini3476 – 353156VWFC 13Add
    BLAST
    Domaini3537 – 359559TIL 14Add
    BLAST
    Domaini3596 – 365156VWFC 14Add
    BLAST
    Domaini3657 – 371559TIL 15Add
    BLAST
    Domaini3716 – 377156VWFC 15Add
    BLAST
    Domaini3777 – 383559TIL 16Add
    BLAST
    Domaini3836 – 389156VWFC 16Add
    BLAST
    Domaini3893 – 395159TIL 17Add
    BLAST
    Domaini3952 – 400756VWFC 17Add
    BLAST
    Domaini4029 – 408759TIL 18Add
    BLAST
    Domaini4088 – 414356VWFC 18Add
    BLAST
    Domaini4149 – 420759TIL 19Add
    BLAST
    Domaini4208 – 426255VWFC 19Add
    BLAST
    Domaini4264 – 432259TIL 20Add
    BLAST
    Domaini4323 – 437856VWFC 20Add
    BLAST
    Domaini4384 – 444259TIL 21Add
    BLAST
    Domaini4443 – 449856VWFC 21Add
    BLAST
    Domaini4504 – 456259TIL 22Add
    BLAST
    Domaini4563 – 461856VWFC 22Add
    BLAST
    Domaini4624 – 468259TIL 23Add
    BLAST
    Domaini4683 – 473856VWFC 23Add
    BLAST
    Domaini4744 – 480259TIL 24Add
    BLAST
    Domaini4803 – 485856VWFC 24Add
    BLAST
    Domaini4864 – 5065202VWFD 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini5150 – 520354TIL 25Add
    BLAST
    Domaini5204 – 525855VWFC 25Add
    BLAST
    Domaini5259 – 529537EGF-likePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni547 – 117062480 X heptapeptide repeats (approximate) (mucin-like domain)Add
    BLAST

    Domaini

    The MAM domains probably mediates sperm adhesion to the zona pellucida.
    During sperm migration through the reproductive tracts, the mucin-like domain might inhibit inappropriate trapping of spermatozoa or promoting adhesion to the oviductal isthmus.
    The VWFD domain 2 may mediate covalent oligomerization.By similarity

    Sequence similaritiesi

    Contains 1 EGF-like domain.PROSITE-ProRule annotation
    Contains 3 MAM domains.PROSITE-ProRule annotation
    Contains 25 VWFC domains.Curated
    Contains 4 VWFD domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG12793.
    HOVERGENiHBG003977.
    PhylomeDBiO88799.

    Family and domain databases

    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR003645. Fol_N.
    IPR000998. MAM_dom.
    IPR002919. TIL_dom.
    IPR025615. TILa_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view]
    PfamiPF00629. MAM. 3 hits.
    PF01826. TIL. 25 hits.
    PF12714. TILa. 25 hits.
    PF00094. VWD. 4 hits.
    [Graphical view]
    SMARTiSM00832. C8. 4 hits.
    SM00181. EGF. 2 hits.
    SM00274. FOLN. 20 hits.
    SM00137. MAM. 3 hits.
    SM00214. VWC. 17 hits.
    SM00216. VWD. 4 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 3 hits.
    SSF57567. SSF57567. 25 hits.
    PROSITEiPS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 18 hits.
    PS50026. EGF_3. 1 hit.
    PS00740. MAM_1. 1 hit.
    PS50060. MAM_2. 3 hits.
    PS51233. VWFD. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O88799-1 [UniParc]FASTAAdd to Basket

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    MALPVWTLML LVGAAWGQEQ VPAWRPNSPD LGPMVHTSRE DSILSKCDFE     50
    DNSRPFCDWS QMSADDGDWI RTTGPSLTGT SGPPGGYPNG EGYYLHMDPK 100
    TFPQGGVARL RSPDIWEQGP LCVHFAFHMF GLSWGAQLRL LLLRGRKHLR 150
    PYVLWKHVNT QSPSWMPTTV TVPADHDIPS WLMFEGMRGN TAYLDISLDG 200
    LSIQRGTCNQ VCMSQMCTFD TLNDLCGWSW VPTATGAKWT QKKGPTGKQG 250
    VGPAEDFSNP GNGYYMLLDS TNARPGQKAV LLSPLSHSRG CMTLSFHYIM 300
    HGQGHEEGLF VYATFLGNIR KYTLFSGHPG PDWQAVSVNY TGQGQIQFMV 350
    VGMFGNIPEP AIAVDAISIA PCGESFPQCD FEDRVHPFCD WNQVYGDMGH 400
    WSWGSKSVPT LIAGSPREFP YGGEHYIFFD SVKLSQEGQS ARLVSPPFCA 450
    PGGICVEFAY HMYGLGKGTT LKLLLGSPAG SSPIPLWNRV GSQSSGWMNS 500
    SVTIPKGYQQ PMQLFIEATR GTSTAFVVAL NFILISHGPC RVLLQTEIPS 550
    SPLLPPTGPS ESTVPTLPME QPTSPTKATT VTIEIPTTPT EEATIPTETT 600
    TVPTEVINVS PKETSIPPEV TIPTEVITVS PEEIISPTEV TPVPTDVTAA 650
    YVEATNASPE ETSVPPEVTI LTEVTTVSPE ETTVPTEVPI VLIEATAFPT 700
    GETTLYTEVP TVPTEVTGVH TEVTNVSPEE TSVPTEETIS TEVTTVSPEE 750
    TTVPTEVPIV LIEATASPTG EITLYTEVPT VPTEVTGVHT EVTNVSPEET 800
    SVPTEETIST EVTTVSPEET TLPTEVPTVS TEVTNVSPEE TSVPPEETIL 850
    TTLYTEVPTV PTEVTGVHTE VTNVSPEETS VPTEETISTE VTTVSPEETT 900
    LPTEVPTVST EVTNVSPEET SVPPEETILT EITTVSPEET VFPIEGTTLP 950
    TEVLTVPIEV TTFPTGETTV PTEVPTVSTE MTGVHTEVTT VFPEETSIPT 1000
    EVATVLPASI PPEETTTPTE VTTTPPEETT IPAEVTTVPP ASIPPEETAS 1050
    LTEVTTTPPE ETTTPTEVTT VPPEKTTIPT EVTTVPPASI FPEETTVPPE 1100
    ETTIASEETT VSTQETTLLT EQSAVTQTSI ACRPPCPSPP LMPIGPLLSK 1150
    PPGVSMFSLA PTTGVSTTES CPPNAHIELC ACPASCESPK PSCQPPCIPG 1200
    CVCNPGFLFS NNQCINESSC NCPYNNKHYK PGEEWFTPNC TERCRCLPGS 1250
    LMECQISQCG THTVCQLKSD QYQCEPYGKA TCLVYGDLHF VTFDERHIGF 1300
    TGTCTYILTQ TCSNSTDHFF RITANTEERG VEGVSCLDKV VISLPETTVT 1350
    MISGRHTLIG DQEVTLPAIL SDDTYVGLSG RFVELRTTFG LRVRWDGDQQ 1400
    LFVTVSSTFS GKLCGFCGNY DGDSSNDNLK SDGMMTHDEE ELRLSWQVEE 1450
    DEDKDWVSSR CQKKKNPPSC DAALGSTMSG PKLCGQLVNP SGPFEACLLH 1500
    LKASSFLDNC VTDMCSFQGL QQKLCARMSA MTATCQDAGY PVKPWREPQF 1550
    CPLVCPKNSR YSLCAKPCPE TCHPISTTQH CSDKCVEGCE CDPGFILSGS 1600
    ECVPSSQCGC TSFQGRYFKL QEQWFNPDCK EICTCESHNH ILCKPWKCKA 1650
    QEACSYKNGV LGCHAQGAAT CMVSGDPHYL TFDGALHHFM GTCTYVLTQP 1700
    CWSKSQENNF VVSATNEIHD GNLEVSYVKA VHVQVFDLKI SMFKGQKVVL 1750
    NNQRVVLPVW PSQGRVTIRL SGIFVLLYTN FGLQVRYDGR HLVEVTVPSS 1800
    YTGSLCGLCG NYNNNSMDDN LRADMKPAGN SLLLGAAWKI LEASDPGCFL 1850
    AGGKPSRCAD SDMDDVWTKK CAILMNPLGP FSNCHEAVPP QASFSSCVYG 1900
    QCETNGDNLT FCHSLQAYAS LCAQAGQVTT WRNSTFCPMR CPPRSSYNPC 1950
    ANSCPATCLT LSTPRDCPTL PCVEGCECQS GHILSGTTCV PLRQCGCSDQ 2000
    DGSYHLLGES WYTEKTCTTL CTCSAHSNIT CSPTACKANH VCLRQEGLLR 2050
    CAAEMGECRI SEDSQIVSFD DHSHPIQDTC TYILVKVCHP NTNMPFFMIS 2100
    AKTDINTNGK NKTFGVYQLY IDIFNFHITL QKDHLVLISL INDSIVTLPT 2150
    TTHIPGVSVM TEDVYTIVTI KDEIQVKFES NNFLDVKIPA SSNGKVCGVC 2200
    GNFNGEEEDE LMTPSGELAE DEQEFMNSWK DKSMDPNCQK IEGQNLQVEQ 2250
    QEIMNGKCRP IDFEKAQANC QTALQGPAWA HCSSRVPIKP FLLKCMNSFC 2300
    EFRELFRALC DSLQSFEDAC QNQGLKPPIW RNSSFCPLEC PAHSHYTNCL 2350
    PSCPPSCLDP DSRCEGSGHK VPATCREGCI CQPDYVLLND KCVLRSHCGC 2400
    KDAQGVFIPA GKTWISEDCT QSCTCMKGSM RCWDFQCPPG TYCKNSNDGS 2450
    SNCVKISLQC PAHSKFTDCL PPCHPSCSDP DGHCEGISTN AHSNCKEGCV 2500
    CQPGYVLRND KCVLRIECGC QHTQGGFIPA GKNWTSRGCS QSCDCMEGVI 2550
    RCQNFQCPSG TYCQDIEDGT SNCANITLQC PAHSSFTNCL PPCQPSCSDP 2600
    EGHCGGSTTK APSACQEGCV CEPDYVVLNN KCVPRIECGC KDAQGVLIPA 2650
    DKIWINKGCT QTCACVTGTI HCRDFQCPSG TYCKDIKDDA SNCTEIILQC 2700
    PDHSLYTHCL PSCLLSCSDP DGLCRGTSPE APSTCKEGCV CDPDYVLSND 2750
    KCVLRIECGC KDAQGVLIPA GKTWINRGCT QSCSCMGGAI QCQNFKCPSE 2800
    AYCQDMEDGN SNCTSIPLQC PAHSHYTNCL PTCQPSCSDP DGHCEGSSTK 2850
    APSACKEGCV CEPDYVMLNN KCVPRIECGC KDTQGVLIPA DKTWINRGCT 2900
    QSCTCRGGAI QCQKYHCSSG TYCKDMEDDS SSCATITLQC PAHSHFTNCL 2950
    PPCQPSCLDS EGHCEGSTTK APSACQEGCV CEPDYVVLNN KCVPRIECGC 3000
    KDAQGVLIPA DKTWINRGCT QSCTCKGGAI QCQKFQCPSE TYCKDIEDGN 3050
    SNCTRISLQC PANSNFTSCL PSCQPSCSNT DVHCEGSSPN TLSSCREGCV 3100
    CQSGYVLHND KCILRNQCGC KDAQGALIPE GKTWITSGCT QSCNCTGGAI 3150
    QCQNFQCPLK TYCKDLKDGS SNCTNIPLQC PAHSRYTNCL PSCPPLCLDP 3200
    EGLCEGTSPK VPSTCREGCI CQPGYLMHKN KCVLRIFCGC KNTQGAFISA 3250
    DKTWISRGCT QSCTCPAGAI HCRNFKCPSG TYCKNGDNGS SNCTEITLQC 3300
    PTNSQFTDCL PSCVPSCSNR CEVTSPSVPS SCREGCLCNH GFVFSEDKCV 3350
    PRTQCGCKDA RGAIIPAGKT WTSKGCTQSC ACVEGNIQCQ NFQCPPETYC 3400
    KDNSEGSSTC TKITLQCPAH TQYTSCLPSC LPSCLDPEGL CKDISPKVPS 3450
    TCKEGCVCQS GYVLNSDKCV LRAECDCKDA QGALIPAGKT WTSPGCTQSC 3500
    ACMGGAVQCQ SSQCPPGTYC KDNEDGNSNC AKITLQCPAH SLFTNCLPPC 3550
    LPSCLDPDGL CKGASPKVPS TCKEGCICQS GYVLSNNKCL LRNRCGCKDA 3600
    HGALIPEDKT WVSRGCTQSC VCTGGSIQCL SSQCPPGAYC KDNEDGSSNC 3650
    ARIPPQCPAN SHYTDCFPPC PPSCSDPEGH CEASGPRVLS TCREGCLCNP 3700
    GFVLDRDKCV PRVECGCKDA QGALIPSGKT WTSPGCTQSC ACMGGVVQCQ 3750
    SSQCPPGTYC KDNEDGNSNC AKITLQCPTH SNYTDCLPFC LPSCLDPSAL 3800
    CGGTSPKGPS TCKEGCVCQP GYVLDKDKCI LKIECGCRDT QGAVIPAGKT 3850
    WLSTGCIQSC ACVEGTIQCQ NFQCPPGTYC NHNNNCAKIP LQCPAHSHFT 3900
    SCLPSCPPSC ANLDGSCEQT SPKVPSTCKE GCLCQPGYFL NNGKCVLQTH 3950
    CDCKDAEGGL VPAGKTWTSK DCTQSCACTG GAVQCQNFQC PLGTYCKDSG 4000
    DGSSNCTKIH KGAMGDGVLM AGGIRALQCP AHSHFTSCLP SCPPSCSNLD 4050
    GSCVESNFKA PSVCKKGCIC QPGYLLNNDK CVLRIQCGCK DTQGGLIPAG 4100
    RTWISSDCTK SCSCMGGIIQ CRDFQCPPGT YCKESNDSSR TCAKIPLQCP 4150
    AHSHYTNCLP ACSRSCTDLD GHCEGTSPKV PSPCKEGCLC QPGYVVHNHK 4200
    CVLQIHCGCK DAQGGFVPAG KTWISRGCTQ SCACVGGAVQ CHNFTCPTGT 4250
    QCQNSSCSKI TVQCPAHSQY TTCLPSCLPS CFDPEGLCGG ASPRAPSTCR 4300
    EGCVCEADYV LREDKCVLRT QCGCKDAQGD LIPANKTWLT RGCAQKCTCK 4350
    GGNIHCWNFK CPLGTECKDS VDGGSNCTKI ALQCPAHSHH TYCLPSCIPS 4400
    CSNVNDRCES TSLQRPSTCI EGCLCHSGFV FSKDKCVPRT QCGCKDSQGT 4450
    LIPAGKNWIT TGCSQRCTCT GGLVQCHDFQ CPSGAECQDI EDGNSNCVEI 4500
    TVQCPAHSHY SKCLPPCQPS CSDPDGHCEG TSPEAPSTCE EGCVCEPDYV 4550
    LSNDKCVPSS ECGCKDAHGV LIPESKTWVS RGCTKNCTCK GGTVQCHDFS 4600
    CPTGSRCLDN NEGNSNCVTY ALKCPAHSLY TNCLPSCLPS CSDPEGLCGG 4650
    TSPEVPSTCK EGCICQSGYV LHKNKCMLRI HCDCKDFQGS LIKTGQTWIS 4700
    SGCSKICTCK GGFFQCQSYK CPSGTQCEES EDGSSNCVSS TMKCPANSLY 4750
    THCLPTCLPS CSNPDGRCEG TSHKAPSTCR EGCVCQPGYL LNKDTCVHKN 4800
    QCGCKDIRGN IIPAGNTWIS SDCTQSCACT DGVIQCQNFV CPSGSHCQYN 4850
    EDGSSDCAAN KLERCTIFGD PYYLTFDGFT YHFLGRMNYY LIKTVDKLPR 4900
    GIEPLIMEGR NKISPKGSST LHEVTTIVYG YKIQLQEELV VLVNDEKVAV 4950
    PYNPNEHLRV MLRAQRLLLV TDFEMVLDFD GKHSAVISLP TTYRGLTRGL 5000
    CGNYDRDQSN ELMLPSGVLT SNVHVFGNSW EVKAQHAFFR FPRALPEDEE 5050
    RDEEPDLLQS ECSQEQTALI SSTQACRVLV DPQGPFAACH QIIAPEPFEQ 5100
    RCMLDMCTGW KTKEEEELRC RVLSGYAIIC QEAGANMTGW RDHTHCAMTC 5150
    PANTVYQRCM TPCPASCAKF VTPKVCEGPC VEGCASLPGY IYSDTQSLPV 5200
    THCGCTADGI YYKLGDSFVT NDCSQHCTCA SQGILLCEPY GCRAGESCMV 5250
    ANFTRGCFQD SPCLQNPCHN DGRCEEQGAT FICHCDFGYG GEFCTEPQDI 5300
    TTRKKIEASS LVAILPGVLV MVLVPVLLPR VYVYMATRTT MGRRRMKRKE 5350
    KKLLRQSRLR LEDADVPEPT FKATEF 5376
    Length:5,376
    Mass (Da):579,913
    Last modified:November 1, 1998 - v1
    Checksum:i0E44DB77DF2A2620
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U97068 mRNA. Translation: AAC26680.1.
    U83190 mRNA. Translation: AAC53125.1.
    PIRiT42215.
    UniGeneiMm.7984.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U97068 mRNA. Translation: AAC26680.1 .
    U83190 mRNA. Translation: AAC53125.1 .
    PIRi T42215.
    UniGenei Mm.7984.

    3D structure databases

    ProteinModelPortali O88799.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O88799.

    Proteomic databases

    PaxDbi O88799.
    PRIDEi O88799.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:106656. Zan.

    Phylogenomic databases

    eggNOGi NOG12793.
    HOVERGENi HBG003977.
    PhylomeDBi O88799.

    Miscellaneous databases

    PROi O88799.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_ZAN.
    Genevestigatori O88799.

    Family and domain databases

    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR003645. Fol_N.
    IPR000998. MAM_dom.
    IPR002919. TIL_dom.
    IPR025615. TILa_dom.
    IPR014853. Unchr_dom_Cys-rich.
    IPR001007. VWF_C.
    IPR001846. VWF_type-D.
    [Graphical view ]
    Pfami PF00629. MAM. 3 hits.
    PF01826. TIL. 25 hits.
    PF12714. TILa. 25 hits.
    PF00094. VWD. 4 hits.
    [Graphical view ]
    SMARTi SM00832. C8. 4 hits.
    SM00181. EGF. 2 hits.
    SM00274. FOLN. 20 hits.
    SM00137. MAM. 3 hits.
    SM00214. VWC. 17 hits.
    SM00216. VWD. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 3 hits.
    SSF57567. SSF57567. 25 hits.
    PROSITEi PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 18 hits.
    PS50026. EGF_3. 1 hit.
    PS00740. MAM_1. 1 hit.
    PS50060. MAM_2. 3 hits.
    PS51233. VWFD. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Species diversity in the structure of zonadhesin, a sperm-specific membrane protein containing multiple cell adhesion molecule-like domains."
      Gao Z., Garbers D.L.
      J. Biol. Chem. 273:3415-3421(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "Chromosome localization of the mouse zonadhesin gene and the human zonadhesin gene (ZAN)."
      Gao Z., Harumi T., Garbers D.L.
      Genomics 41:119-122(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4864-5376.
      Tissue: Testis.

    Entry informationi

    Entry nameiZAN_MOUSE
    AccessioniPrimary (citable) accession number: O88799
    Secondary accession number(s): O08647
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3