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O88796 (RPP30_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease P protein subunit p30

Short name=RNaseP protein p30
EC=3.1.26.5
Alternative name(s):
RNase P subunit 2
Gene names
Name:Rpp30
Synonyms:Rnasep2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

Catalytic activity

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

Subcellular location

Nucleusnucleolus Potential.

Sequence similarities

Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentNucleus
   Molecular functionHydrolase
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionribonuclease P activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 268267Ribonuclease P protein subunit p30
PRO_0000140032

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue2511Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
O88796 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 068028B3FA99428E

FASTA26829,473
        10         20         30         40         50         60 
MAAFADLDLR AGSDLKALRG LVETAAHLGY SVVAINHIVD FKEKKREIEK PIAVSELFTT 

        70         80         90        100        110        120 
LPIVQGKSRP IKILTRLTII VTDPAHCNVL RATSSRVRLY DIVAVFPKTE KLFHVACTHL 

       130        140        150        160        170        180 
DVDLVCITVT EKLPFYFKRP PVNVAIERGL GFELVYGPAI RDATMRRYTI SNALNLMQIC 

       190        200        210        220        230        240 
KGKNVILSSA AERPLEIRGP YDVANLGLLF GLSENDGKAA VSTNCRAVFL HGETRKTAFG 

       250        260 
IISTVKKPRP SEADDESLPV CKKAKCEG 

« Hide

References

[1]"Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P."
Jarrous N., Eder P.S., Guerrier-Takada C., Hoog C., Altman S.
RNA 4:407-417(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U95123 mRNA. Translation: AAC24115.1.
CCDSCCDS29770.1.
RefSeqNP_062301.3. NM_019428.3.
UniGeneMm.277891.

3D structure databases

ProteinModelPortalO88796.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO88796. 1 interaction.
MINTMINT-4132955.

PTM databases

PhosphoSiteO88796.

Proteomic databases

MaxQBO88796.
PaxDbO88796.
PRIDEO88796.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025714; ENSMUSP00000025714; ENSMUSG00000024800.
GeneID54364.
KEGGmmu:54364.
UCSCuc008hhg.2. mouse.

Organism-specific databases

CTD10556.
MGIMGI:1859683. Rpp30.

Phylogenomic databases

eggNOGCOG1603.
GeneTreeENSGT00390000000883.
HOGENOMHOG000157793.
HOVERGENHBG010226.
InParanoidO88796.
KOK03539.
OMAGVCFELV.
OrthoDBEOG73FQNP.
PhylomeDBO88796.
TreeFamTF106113.

Gene expression databases

ArrayExpressO88796.
BgeeO88796.
CleanExMM_RPP30.
GenevestigatorO88796.

Family and domain databases

InterProIPR016195. Pol/histidinol_Pase-like.
IPR002738. RNase_P_p30.
[Graphical view]
PANTHERPTHR13031. PTHR13031. 1 hit.
PfamPF01876. RNase_P_p30. 1 hit.
[Graphical view]
SUPFAMSSF89550. SSF89550. 1 hit.
ProtoNetSearch...

Other

NextBio311154.
PROO88796.
SOURCESearch...

Entry information

Entry nameRPP30_MOUSE
AccessionPrimary (citable) accession number: O88796
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot