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O88796

- RPP30_MOUSE

UniProt

O88796 - RPP30_MOUSE

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Protein
Ribonuclease P protein subunit p30
Gene
Rpp30, Rnasep2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

Catalytic activityi

Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

GO - Molecular functioni

  1. ribonuclease P activity Source: UniProtKB-EC

GO - Biological processi

  1. tRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

tRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease P protein subunit p30 (EC:3.1.26.5)
Short name:
RNaseP protein p30
Alternative name(s):
RNase P subunit 2
Gene namesi
Name:Rpp30
Synonyms:Rnasep2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1859683. Rpp30.

Subcellular locationi

Nucleusnucleolus Reviewed prediction

GO - Cellular componenti

  1. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 268267Ribonuclease P protein subunit p30
PRO_0000140032Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei251 – 2511Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO88796.
PaxDbiO88796.
PRIDEiO88796.

PTM databases

PhosphoSiteiO88796.

Expressioni

Gene expression databases

ArrayExpressiO88796.
BgeeiO88796.
CleanExiMM_RPP30.
GenevestigatoriO88796.

Interactioni

Protein-protein interaction databases

IntActiO88796. 1 interaction.
MINTiMINT-4132955.

Structurei

3D structure databases

ProteinModelPortaliO88796.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1603.
GeneTreeiENSGT00390000000883.
HOGENOMiHOG000157793.
HOVERGENiHBG010226.
InParanoidiO88796.
KOiK03539.
OMAiGVCFELV.
OrthoDBiEOG73FQNP.
PhylomeDBiO88796.
TreeFamiTF106113.

Family and domain databases

InterProiIPR016195. Pol/histidinol_Pase-like.
IPR002738. RNase_P_p30.
[Graphical view]
PANTHERiPTHR13031. PTHR13031. 1 hit.
PfamiPF01876. RNase_P_p30. 1 hit.
[Graphical view]
SUPFAMiSSF89550. SSF89550. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88796-1 [UniParc]FASTAAdd to Basket

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MAAFADLDLR AGSDLKALRG LVETAAHLGY SVVAINHIVD FKEKKREIEK    50
PIAVSELFTT LPIVQGKSRP IKILTRLTII VTDPAHCNVL RATSSRVRLY 100
DIVAVFPKTE KLFHVACTHL DVDLVCITVT EKLPFYFKRP PVNVAIERGL 150
GFELVYGPAI RDATMRRYTI SNALNLMQIC KGKNVILSSA AERPLEIRGP 200
YDVANLGLLF GLSENDGKAA VSTNCRAVFL HGETRKTAFG IISTVKKPRP 250
SEADDESLPV CKKAKCEG 268
Length:268
Mass (Da):29,473
Last modified:November 1, 1998 - v1
Checksum:i068028B3FA99428E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U95123 mRNA. Translation: AAC24115.1.
CCDSiCCDS29770.1.
RefSeqiNP_062301.3. NM_019428.3.
UniGeneiMm.277891.

Genome annotation databases

EnsembliENSMUST00000025714; ENSMUSP00000025714; ENSMUSG00000024800.
GeneIDi54364.
KEGGimmu:54364.
UCSCiuc008hhg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U95123 mRNA. Translation: AAC24115.1 .
CCDSi CCDS29770.1.
RefSeqi NP_062301.3. NM_019428.3.
UniGenei Mm.277891.

3D structure databases

ProteinModelPortali O88796.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O88796. 1 interaction.
MINTi MINT-4132955.

PTM databases

PhosphoSitei O88796.

Proteomic databases

MaxQBi O88796.
PaxDbi O88796.
PRIDEi O88796.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025714 ; ENSMUSP00000025714 ; ENSMUSG00000024800 .
GeneIDi 54364.
KEGGi mmu:54364.
UCSCi uc008hhg.2. mouse.

Organism-specific databases

CTDi 10556.
MGIi MGI:1859683. Rpp30.

Phylogenomic databases

eggNOGi COG1603.
GeneTreei ENSGT00390000000883.
HOGENOMi HOG000157793.
HOVERGENi HBG010226.
InParanoidi O88796.
KOi K03539.
OMAi GVCFELV.
OrthoDBi EOG73FQNP.
PhylomeDBi O88796.
TreeFami TF106113.

Miscellaneous databases

NextBioi 311154.
PROi O88796.
SOURCEi Search...

Gene expression databases

ArrayExpressi O88796.
Bgeei O88796.
CleanExi MM_RPP30.
Genevestigatori O88796.

Family and domain databases

InterProi IPR016195. Pol/histidinol_Pase-like.
IPR002738. RNase_P_p30.
[Graphical view ]
PANTHERi PTHR13031. PTHR13031. 1 hit.
Pfami PF01876. RNase_P_p30. 1 hit.
[Graphical view ]
SUPFAMi SSF89550. SSF89550. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P."
    Jarrous N., Eder P.S., Guerrier-Takada C., Hoog C., Altman S.
    RNA 4:407-417(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiRPP30_MOUSE
AccessioniPrimary (citable) accession number: O88796
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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