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O88796

- RPP30_MOUSE

UniProt

O88796 - RPP30_MOUSE

Protein

Ribonuclease P protein subunit p30

Gene

Rpp30

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.

    GO - Molecular functioni

    1. ribonuclease P activity Source: UniProtKB-EC

    GO - Biological processi

    1. tRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    tRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein subunit p30 (EC:3.1.26.5)
    Short name:
    RNaseP protein p30
    Alternative name(s):
    RNase P subunit 2
    Gene namesi
    Name:Rpp30
    Synonyms:Rnasep2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1859683. Rpp30.

    Subcellular locationi

    Nucleusnucleolus Curated

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 268267Ribonuclease P protein subunit p30PRO_0000140032Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei251 – 2511PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO88796.
    PaxDbiO88796.
    PRIDEiO88796.

    PTM databases

    PhosphoSiteiO88796.

    Expressioni

    Gene expression databases

    ArrayExpressiO88796.
    BgeeiO88796.
    CleanExiMM_RPP30.
    GenevestigatoriO88796.

    Interactioni

    Protein-protein interaction databases

    IntActiO88796. 1 interaction.
    MINTiMINT-4132955.

    Structurei

    3D structure databases

    ProteinModelPortaliO88796.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1603.
    GeneTreeiENSGT00390000000883.
    HOGENOMiHOG000157793.
    HOVERGENiHBG010226.
    InParanoidiO88796.
    KOiK03539.
    OMAiGVCFELV.
    OrthoDBiEOG73FQNP.
    PhylomeDBiO88796.
    TreeFamiTF106113.

    Family and domain databases

    InterProiIPR016195. Pol/histidinol_Pase-like.
    IPR002738. RNase_P_p30.
    [Graphical view]
    PANTHERiPTHR13031. PTHR13031. 1 hit.
    PfamiPF01876. RNase_P_p30. 1 hit.
    [Graphical view]
    SUPFAMiSSF89550. SSF89550. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O88796-1 [UniParc]FASTAAdd to Basket

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    MAAFADLDLR AGSDLKALRG LVETAAHLGY SVVAINHIVD FKEKKREIEK    50
    PIAVSELFTT LPIVQGKSRP IKILTRLTII VTDPAHCNVL RATSSRVRLY 100
    DIVAVFPKTE KLFHVACTHL DVDLVCITVT EKLPFYFKRP PVNVAIERGL 150
    GFELVYGPAI RDATMRRYTI SNALNLMQIC KGKNVILSSA AERPLEIRGP 200
    YDVANLGLLF GLSENDGKAA VSTNCRAVFL HGETRKTAFG IISTVKKPRP 250
    SEADDESLPV CKKAKCEG 268
    Length:268
    Mass (Da):29,473
    Last modified:November 1, 1998 - v1
    Checksum:i068028B3FA99428E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U95123 mRNA. Translation: AAC24115.1.
    CCDSiCCDS29770.1.
    RefSeqiNP_062301.3. NM_019428.3.
    UniGeneiMm.277891.

    Genome annotation databases

    EnsembliENSMUST00000025714; ENSMUSP00000025714; ENSMUSG00000024800.
    GeneIDi54364.
    KEGGimmu:54364.
    UCSCiuc008hhg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U95123 mRNA. Translation: AAC24115.1 .
    CCDSi CCDS29770.1.
    RefSeqi NP_062301.3. NM_019428.3.
    UniGenei Mm.277891.

    3D structure databases

    ProteinModelPortali O88796.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O88796. 1 interaction.
    MINTi MINT-4132955.

    PTM databases

    PhosphoSitei O88796.

    Proteomic databases

    MaxQBi O88796.
    PaxDbi O88796.
    PRIDEi O88796.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025714 ; ENSMUSP00000025714 ; ENSMUSG00000024800 .
    GeneIDi 54364.
    KEGGi mmu:54364.
    UCSCi uc008hhg.2. mouse.

    Organism-specific databases

    CTDi 10556.
    MGIi MGI:1859683. Rpp30.

    Phylogenomic databases

    eggNOGi COG1603.
    GeneTreei ENSGT00390000000883.
    HOGENOMi HOG000157793.
    HOVERGENi HBG010226.
    InParanoidi O88796.
    KOi K03539.
    OMAi GVCFELV.
    OrthoDBi EOG73FQNP.
    PhylomeDBi O88796.
    TreeFami TF106113.

    Miscellaneous databases

    NextBioi 311154.
    PROi O88796.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O88796.
    Bgeei O88796.
    CleanExi MM_RPP30.
    Genevestigatori O88796.

    Family and domain databases

    InterProi IPR016195. Pol/histidinol_Pase-like.
    IPR002738. RNase_P_p30.
    [Graphical view ]
    PANTHERi PTHR13031. PTHR13031. 1 hit.
    Pfami PF01876. RNase_P_p30. 1 hit.
    [Graphical view ]
    SUPFAMi SSF89550. SSF89550. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P."
      Jarrous N., Eder P.S., Guerrier-Takada C., Hoog C., Altman S.
      RNA 4:407-417(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiRPP30_MOUSE
    AccessioniPrimary (citable) accession number: O88796
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3