O88796 (RPP30_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P protein subunit p30
Short name=RNaseP protein p30
EC=3.1.26.5

Alternative name(s):
RNase P subunit 2

Gene names

Name:	Rpp30
Synonyms:	Rnasep2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.
Subcellular location	Nucleus › nucleolus Potential.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Nucleus
Molecular function	Hydrolase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ribonuclease P activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 268	267	Ribonuclease P protein subunit p30		PRO_0000140032
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	251	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O88796 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 068028B3FA99428E	FASTA	268	29,473
	10 20 30 40 50 60 MAAFADLDLR AGSDLKALRG LVETAAHLGY SVVAINHIVD FKEKKREIEK PIAVSELFTT 70 80 90 100 110 120 LPIVQGKSRP IKILTRLTII VTDPAHCNVL RATSSRVRLY DIVAVFPKTE KLFHVACTHL 130 140 150 160 170 180 DVDLVCITVT EKLPFYFKRP PVNVAIERGL GFELVYGPAI RDATMRRYTI SNALNLMQIC 190 200 210 220 230 240 KGKNVILSSA AERPLEIRGP YDVANLGLLF GLSENDGKAA VSTNCRAVFL HGETRKTAFG 250 260 IISTVKKPRP SEADDESLPV CKKAKCEG

References

[1]	"Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P." Jarrous N., Eder P.S., Guerrier-Takada C., Hoog C., Altman S. RNA 4:407-417(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U95123 mRNA. Translation: AAC24115.1.
IPI	IPI00134346.
RefSeq	NP_062301.3. NM_019428.3.
UniGene	Mm.277891.
3D structure databases
ProteinModelPortal	O88796.
ModBase	Search...
PTM databases
PhosphoSite	O88796.
Proteomic databases
PaxDb	O88796.
PRIDE	O88796.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000025714; ENSMUSP00000025714; ENSMUSG00000024800.
GeneID	54364.
KEGG	mmu:54364.
UCSC	uc008hhg.2. mouse.
Organism-specific databases
CTD	10556.
MGI	MGI:1859683. Rpp30.
Phylogenomic databases
eggNOG	COG1603.
GeneTree	ENSGT00390000000883.
HOGENOM	HOG000157793.
HOVERGEN	HBG010226.
InParanoid	O88796.
KO	K03539.
OMA	TAFGIIS.
OrthoDB	EOG4D52Z9.
Gene expression databases
ArrayExpress	O88796.
Bgee	O88796.
CleanEx	MM_RPP30.
Genevestigator	O88796.
GermOnline	ENSMUSG00000024800. Mus musculus.
Family and domain databases
InterPro	IPR016195. Pol/histidinol_Pase-like. IPR002738. RNase_P_p30. [Graphical view]
PANTHER	PTHR13031. PTHR13031. 1 hit.
Pfam	PF01876. RNase_P_p30. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
ProtoNet	Search...
Other
NextBio	311154.
SOURCE	Search...

Entry information

Entry name

RPP30_MOUSE

Accession

Primary (citable) accession number: O88796

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	November 1, 1998
Last modified:	April 3, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program