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Protein

Interleukin-13 receptor subunit alpha-2

Gene

Il13ra2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Binds as a monomer with high affinity to interleukin-13 (IL13).1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to mechanical stimulus Source: Ensembl
  • immunoglobulin mediated immune response Source: MGI
  • negative regulation of immunoglobulin production Source: MGI
  • negative regulation of mast cell degranulation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13 receptor subunit alpha-2
Short name:
IL-13 receptor subunit alpha-2
Short name:
IL-13R subunit alpha-2
Short name:
IL-13R-alpha-2
Short name:
IL-13RA2
Alternative name(s):
CD_antigen: CD213a2
Gene namesi
Name:Il13ra2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1277954. Il13ra2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 334313ExtracellularSequence analysisAdd
BLAST
Transmembranei335 – 35521HelicalSequence analysisAdd
BLAST
Topological domaini356 – 38328CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 383362Interleukin-13 receptor subunit alpha-2PRO_0000378452Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi59 ↔ 107By similarity
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence analysis
Disulfide bondi139 ↔ 149By similarity
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence analysis
Disulfide bondi178 ↔ 191By similarity
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence analysis
Disulfide bondi263 ↔ 310By similarity
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88786.
PRIDEiO88786.

Expressioni

Gene expression databases

BgeeiO88786.
GenevisibleiO88786. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033646.

Structurei

3D structure databases

ProteinModelPortaliO88786.
SMRiO88786. Positions 23-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 128101Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini131 – 21989Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini234 – 33299Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi316 – 3205WSXWS motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.By similarity

Sequence similaritiesi

Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUDW. Eukaryota.
ENOG4111JMU. LUCA.
GeneTreeiENSGT00530000063295.
HOGENOMiHOG000004823.
InParanoidiO88786.
KOiK05077.
OMAiLFYWYEG.
OrthoDBiEOG71P2B1.
PhylomeDBiO88786.
TreeFamiTF331549.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003532. Short_hematopoietin_rcpt_2_CS.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O88786-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFVHIRCLC FILLCTITGY SLEIKVNPPQ DFEILDPGLL GYLYLQWKPP
60 70 80 90 100
VVIEKFKGCT LEYELKYRNV DSDSWKTIIT RNLIYKDGFD LNKGIEGKIR
110 120 130 140 150
THLSEHCTNG SEVQSPWIEA SYGISDEGSL ETKIQDMKCI YYNWQYLVCS
160 170 180 190 200
WKPGKTVYSD TNYTMFFWYE GLDHALQCAD YLQHDEKNVG CKLSNLDSSD
210 220 230 240 250
YKDFFICVNG SSKLEPIRSS YTVFQLQNIV KPLPPEFLHI SVENSIDIRM
260 270 280 290 300
KWSTPGGPIP PRCYTYEIVI REDDISWESA TDKNDMKLKR RANESEDLCF
310 320 330 340 350
FVRCKVNIYC ADDGIWSEWS EEECWEGYTG PDSKIIFIVP VCLFFIFLLL
360 370 380
LLCLIVEKEE PEPTLSLHVD LNKEVCAYED TLC
Length:383
Mass (Da):44,483
Last modified:November 1, 1998 - v1
Checksum:iC25212325C47E35B
GO
Isoform 2 (identifier: O88786-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-339: GYTGPDSKIIFIV → EPPCGSEQRSVCL
     340-383: Missing.

Show »
Length:339
Mass (Da):39,429
Checksum:i63C0896950A07627
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti330 – 3301G → W in BAE43400 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei327 – 33913GYTGP…IIFIV → EPPCGSEQRSVCL in isoform 2. 1 PublicationVSP_037588Add
BLAST
Alternative sequencei340 – 38344Missing in isoform 2. 1 PublicationVSP_037589Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65747 mRNA. Translation: AAC33240.1.
EF219410 mRNA. Translation: ABN11267.1.
AK089687 mRNA. Translation: BAE43400.1.
AL662932, AL807780, BX005200 Genomic DNA. Translation: CAM15764.1.
BX005200, AL662932, AL807780 Genomic DNA. Translation: CAM20758.1.
AL807780, AL662932, BX005200 Genomic DNA. Translation: CAM24879.1.
CH466610 Genomic DNA. Translation: EDL14709.1.
BC003723 mRNA. Translation: AAH03723.1.
CCDSiCCDS30460.1. [O88786-1]
RefSeqiNP_001292988.1. NM_001306059.1. [O88786-2]
NP_032382.1. NM_008356.4. [O88786-1]
XP_006528770.1. XM_006528707.2. [O88786-1]
XP_006528771.1. XM_006528708.2. [O88786-1]
XP_006528773.1. XM_006528710.2. [O88786-2]
UniGeneiMm.368330.

Genome annotation databases

EnsembliENSMUST00000033646; ENSMUSP00000033646; ENSMUSG00000031289. [O88786-1]
ENSMUST00000112827; ENSMUSP00000108446; ENSMUSG00000031289. [O88786-1]
GeneIDi16165.
KEGGimmu:16165.
UCSCiuc009unf.1. mouse. [O88786-1]
uc012hqe.1. mouse. [O88786-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65747 mRNA. Translation: AAC33240.1.
EF219410 mRNA. Translation: ABN11267.1.
AK089687 mRNA. Translation: BAE43400.1.
AL662932, AL807780, BX005200 Genomic DNA. Translation: CAM15764.1.
BX005200, AL662932, AL807780 Genomic DNA. Translation: CAM20758.1.
AL807780, AL662932, BX005200 Genomic DNA. Translation: CAM24879.1.
CH466610 Genomic DNA. Translation: EDL14709.1.
BC003723 mRNA. Translation: AAH03723.1.
CCDSiCCDS30460.1. [O88786-1]
RefSeqiNP_001292988.1. NM_001306059.1. [O88786-2]
NP_032382.1. NM_008356.4. [O88786-1]
XP_006528770.1. XM_006528707.2. [O88786-1]
XP_006528771.1. XM_006528708.2. [O88786-1]
XP_006528773.1. XM_006528710.2. [O88786-2]
UniGeneiMm.368330.

3D structure databases

ProteinModelPortaliO88786.
SMRiO88786. Positions 23-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033646.

Proteomic databases

PaxDbiO88786.
PRIDEiO88786.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033646; ENSMUSP00000033646; ENSMUSG00000031289. [O88786-1]
ENSMUST00000112827; ENSMUSP00000108446; ENSMUSG00000031289. [O88786-1]
GeneIDi16165.
KEGGimmu:16165.
UCSCiuc009unf.1. mouse. [O88786-1]
uc012hqe.1. mouse. [O88786-2]

Organism-specific databases

CTDi3598.
MGIiMGI:1277954. Il13ra2.

Phylogenomic databases

eggNOGiENOG410IUDW. Eukaryota.
ENOG4111JMU. LUCA.
GeneTreeiENSGT00530000063295.
HOGENOMiHOG000004823.
InParanoidiO88786.
KOiK05077.
OMAiLFYWYEG.
OrthoDBiEOG71P2B1.
PhylomeDBiO88786.
TreeFamiTF331549.

Miscellaneous databases

NextBioi288999.
PROiO88786.
SOURCEiSearch...

Gene expression databases

BgeeiO88786.
GenevisibleiO88786. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003532. Short_hematopoietin_rcpt_2_CS.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1."
    Donaldson D.D., Whitters M.J., Fitz L., Neben T.Y., Finnerty H., Henderson S.L., O'Hara R.M. Jr., Beier D.R., Turner K.J., Wood C.R., Collins M.
    J. Immunol. 161:2317-2324(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION.
    Strain: C3H/HeJ.
    Tissue: Thymus.
  2. "Allergy-driven alternative splicing of IL-13 receptor alpha2 yields distinct membrane and soluble forms."
    Tabata Y., Chen W., Warrier M.R., Gibson A.M., Daines M.O., Hershey G.K.
    J. Immunol. 177:7905-7912(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, ALTERNATIVE SPLICING.
    Strain: BALB/cJ.
    Tissue: Spleen.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: NOD.
    Tissue: Spleen.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiI13R2_MOUSE
AccessioniPrimary (citable) accession number: O88786
Secondary accession number(s): A3F812, Q3V2V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: November 1, 1998
Last modified: February 17, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.