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Protein

Interleukin-13 receptor subunit alpha-2

Gene

Il13ra2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds as a monomer with high affinity to interleukin-13 (IL13).1 Publication

GO - Molecular functioni

GO - Biological processi

  • immunoglobulin mediated immune response Source: MGI
  • negative regulation of immunoglobulin production Source: MGI
  • negative regulation of mast cell degranulation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-13 receptor subunit alpha-2
Short name:
IL-13 receptor subunit alpha-2
Short name:
IL-13R subunit alpha-2
Short name:
IL-13R-alpha-2
Short name:
IL-13RA2
Alternative name(s):
CD_antigen: CD213a2
Gene namesi
Name:Il13ra2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1277954. Il13ra2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 334ExtracellularSequence analysisAdd BLAST313
Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
Topological domaini356 – 383CytoplasmicSequence analysisAdd BLAST28

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000037845222 – 383Interleukin-13 receptor subunit alpha-2Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 107By similarity
Glycosylationi109N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi139 ↔ 149By similarity
Glycosylationi162N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi178 ↔ 191By similarity
Glycosylationi209N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi263 ↔ 310By similarity
Glycosylationi293N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO88786.
PRIDEiO88786.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031289.
GenevisibleiO88786. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033646.

Structurei

3D structure databases

ProteinModelPortaliO88786.
SMRiO88786.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 128Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST101
Domaini131 – 219Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST89
Domaini234 – 332Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST99

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi316 – 320WSXWS motif5

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.By similarity

Sequence similaritiesi

Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUDW. Eukaryota.
ENOG4111JMU. LUCA.
GeneTreeiENSGT00530000063295.
HOGENOMiHOG000004823.
InParanoidiO88786.
KOiK05077.
OMAiLFYWYEG.
OrthoDBiEOG091G0FOF.
PhylomeDBiO88786.
TreeFamiTF331549.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003532. Short_hematopoietin_rcpt_2_CS.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O88786-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFVHIRCLC FILLCTITGY SLEIKVNPPQ DFEILDPGLL GYLYLQWKPP
60 70 80 90 100
VVIEKFKGCT LEYELKYRNV DSDSWKTIIT RNLIYKDGFD LNKGIEGKIR
110 120 130 140 150
THLSEHCTNG SEVQSPWIEA SYGISDEGSL ETKIQDMKCI YYNWQYLVCS
160 170 180 190 200
WKPGKTVYSD TNYTMFFWYE GLDHALQCAD YLQHDEKNVG CKLSNLDSSD
210 220 230 240 250
YKDFFICVNG SSKLEPIRSS YTVFQLQNIV KPLPPEFLHI SVENSIDIRM
260 270 280 290 300
KWSTPGGPIP PRCYTYEIVI REDDISWESA TDKNDMKLKR RANESEDLCF
310 320 330 340 350
FVRCKVNIYC ADDGIWSEWS EEECWEGYTG PDSKIIFIVP VCLFFIFLLL
360 370 380
LLCLIVEKEE PEPTLSLHVD LNKEVCAYED TLC
Length:383
Mass (Da):44,483
Last modified:November 1, 1998 - v1
Checksum:iC25212325C47E35B
GO
Isoform 2 (identifier: O88786-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-339: GYTGPDSKIIFIV → EPPCGSEQRSVCL
     340-383: Missing.

Show »
Length:339
Mass (Da):39,429
Checksum:i63C0896950A07627
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti330G → W in BAE43400 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037588327 – 339GYTGP…IIFIV → EPPCGSEQRSVCL in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_037589340 – 383Missing in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65747 mRNA. Translation: AAC33240.1.
EF219410 mRNA. Translation: ABN11267.1.
AK089687 mRNA. Translation: BAE43400.1.
AL662932, AL807780, BX005200 Genomic DNA. Translation: CAM15764.1.
BX005200, AL662932, AL807780 Genomic DNA. Translation: CAM20758.1.
AL807780, AL662932, BX005200 Genomic DNA. Translation: CAM24879.1.
CH466610 Genomic DNA. Translation: EDL14709.1.
BC003723 mRNA. Translation: AAH03723.1.
CCDSiCCDS30460.1. [O88786-1]
RefSeqiNP_001292988.1. NM_001306059.1. [O88786-2]
NP_032382.1. NM_008356.4. [O88786-1]
XP_006528770.1. XM_006528707.3. [O88786-1]
XP_006528771.1. XM_006528708.3. [O88786-1]
XP_017173884.1. XM_017318395.1. [O88786-2]
UniGeneiMm.368330.

Genome annotation databases

EnsembliENSMUST00000033646; ENSMUSP00000033646; ENSMUSG00000031289. [O88786-1]
ENSMUST00000112827; ENSMUSP00000108446; ENSMUSG00000031289. [O88786-1]
GeneIDi16165.
KEGGimmu:16165.
UCSCiuc009unf.1. mouse. [O88786-1]
uc012hqe.1. mouse. [O88786-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65747 mRNA. Translation: AAC33240.1.
EF219410 mRNA. Translation: ABN11267.1.
AK089687 mRNA. Translation: BAE43400.1.
AL662932, AL807780, BX005200 Genomic DNA. Translation: CAM15764.1.
BX005200, AL662932, AL807780 Genomic DNA. Translation: CAM20758.1.
AL807780, AL662932, BX005200 Genomic DNA. Translation: CAM24879.1.
CH466610 Genomic DNA. Translation: EDL14709.1.
BC003723 mRNA. Translation: AAH03723.1.
CCDSiCCDS30460.1. [O88786-1]
RefSeqiNP_001292988.1. NM_001306059.1. [O88786-2]
NP_032382.1. NM_008356.4. [O88786-1]
XP_006528770.1. XM_006528707.3. [O88786-1]
XP_006528771.1. XM_006528708.3. [O88786-1]
XP_017173884.1. XM_017318395.1. [O88786-2]
UniGeneiMm.368330.

3D structure databases

ProteinModelPortaliO88786.
SMRiO88786.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033646.

Proteomic databases

PaxDbiO88786.
PRIDEiO88786.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033646; ENSMUSP00000033646; ENSMUSG00000031289. [O88786-1]
ENSMUST00000112827; ENSMUSP00000108446; ENSMUSG00000031289. [O88786-1]
GeneIDi16165.
KEGGimmu:16165.
UCSCiuc009unf.1. mouse. [O88786-1]
uc012hqe.1. mouse. [O88786-2]

Organism-specific databases

CTDi3598.
MGIiMGI:1277954. Il13ra2.

Phylogenomic databases

eggNOGiENOG410IUDW. Eukaryota.
ENOG4111JMU. LUCA.
GeneTreeiENSGT00530000063295.
HOGENOMiHOG000004823.
InParanoidiO88786.
KOiK05077.
OMAiLFYWYEG.
OrthoDBiEOG091G0FOF.
PhylomeDBiO88786.
TreeFamiTF331549.

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Miscellaneous databases

PROiO88786.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031289.
GenevisibleiO88786. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR003532. Short_hematopoietin_rcpt_2_CS.
IPR015321. TypeI_recpt_CBD.
[Graphical view]
PfamiPF09240. IL6Ra-bind. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01356. HEMATOPO_REC_S_F2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI13R2_MOUSE
AccessioniPrimary (citable) accession number: O88786
Secondary accession number(s): A3F812, Q3V2V5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.