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O88780

- KLK8_RAT

UniProt

O88780 - KLK8_RAT

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Protein

Kallikrein-8

Gene

Klk8

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury (By similarity).By similarity

Catalytic activityi

Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731Charge relay systemBy similarity
Active sitei120 – 1201Charge relay systemBy similarity
Active sitei212 – 2121Charge relay systemBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: UniProtKB

GO - Biological processi

  1. cell death Source: UniProtKB
  2. keratinocyte proliferation Source: UniProtKB
  3. memory Source: UniProtKB
  4. negative regulation of axon regeneration Source: UniProtKB
  5. negative regulation of myelination Source: UniProtKB
  6. neuron projection morphogenesis Source: UniProtKB
  7. regulation of synapse organization Source: UniProtKB
  8. response to wounding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.118. 5301.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-8 (EC:3.4.21.118)
Alternative name(s):
Brain serine protease 1
Neuropsin
Short name:
NP
Serine protease 19
Gene namesi
Name:Klk8
Synonyms:Bsp1, Nrpn, Prss19
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi1305998. Klk8.

Subcellular locationi

Secreted By similarity. Cytoplasm By similarity
Note: Shows a cytoplasmic distribution in the keratinocytes.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Propeptidei29 – 324By similarityPRO_0000027950
Chaini33 – 260228Kallikrein-8PRO_0000027951Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi39 ↔ 173PROSITE-ProRule annotation
Disulfide bondi58 ↔ 74PROSITE-ProRule annotation
Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi145 ↔ 246PROSITE-ProRule annotation
Disulfide bondi152 ↔ 218PROSITE-ProRule annotation
Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
Disulfide bondi208 ↔ 233PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiO88780.

Expressioni

Tissue specificityi

Restricted to hippocampus.

Gene expression databases

GenevestigatoriO88780.

Interactioni

Subunit structurei

Interacts with SPINK9.By similarity

Structurei

3D structure databases

ProteinModelPortaliO88780.
SMRiO88780. Positions 33-256.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 257225Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiO88780.
PhylomeDBiO88780.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88780 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRPPPCAIQ TWILLFLLMG AWAGLTRAQG SKILEGQECK PHSQPWQTAL
60 70 80 90 100
FQGERLVCGG VLVGDRWVLT AAHCKKDKYS VRLGDHSLQK RDEPEQEIQV
110 120 130 140 150
ARSIQHPCFN SSNPEDHSHD IMLIRLQNSA NLGDKVKPIE LANLCPKVGQ
160 170 180 190 200
KCIISGWGTV TSPQENFPNT LNCAEVKIYS QNKCERAYPG KITEGMVCAG
210 220 230 240 250
SSNGADTCQG DSGGPLVCNG VLQGITTWGS DPCGKPEKPG VYTKICRYTN
260
WIKKTMGKRD
Length:260
Mass (Da):28,510
Last modified:November 1, 1998 - v1
Checksum:i58DF4F0602A0B7F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ005641 mRNA. Translation: CAA06643.1.
UniGeneiRn.77746.

Genome annotation databases

UCSCiRGD:1305998. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ005641 mRNA. Translation: CAA06643.1 .
UniGenei Rn.77746.

3D structure databases

ProteinModelPortali O88780.
SMRi O88780. Positions 33-256.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O88780.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:1305998. rat.

Organism-specific databases

RGDi 1305998. Klk8.

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi O88780.
PhylomeDBi O88780.

Enzyme and pathway databases

BRENDAi 3.4.21.118. 5301.

Miscellaneous databases

PROi O88780.

Gene expression databases

Genevestigatori O88780.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fischer.
    Tissue: Brain.

Entry informationi

Entry nameiKLK8_RAT
AccessioniPrimary (citable) accession number: O88780
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3