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Protein

Kallikrein-8

Gene

Klk8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury (By similarity).By similarity

Catalytic activityi

Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73Charge relay systemBy similarity1
Active sitei120Charge relay systemBy similarity1
Active sitei212Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.118 5301

Protein family/group databases

MEROPSiS01.244

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-8 (EC:3.4.21.118)
Alternative name(s):
Brain serine protease 1
Neuropsin
Short name:
NP
Serine protease 19
Gene namesi
Name:Klk8
Synonyms:Bsp1, Nrpn, Prss19
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1305998 Klk8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
PropeptideiPRO_000002795029 – 32By similarity4
ChainiPRO_000002795133 – 260Kallikrein-8Add BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 173PROSITE-ProRule annotation
Disulfide bondi58 ↔ 74PROSITE-ProRule annotation
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi145 ↔ 246PROSITE-ProRule annotation
Disulfide bondi152 ↔ 218PROSITE-ProRule annotation
Disulfide bondi184 ↔ 198PROSITE-ProRule annotation
Disulfide bondi208 ↔ 233PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiO88780
PRIDEiO88780

PTM databases

CarbonylDBiO88780

Expressioni

Tissue specificityi

Restricted to hippocampus.

Interactioni

Subunit structurei

Interacts with SPINK9.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025174

Structurei

3D structure databases

ProteinModelPortaliO88780
SMRiO88780
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 257Peptidase S1PROSITE-ProRule annotationAdd BLAST225

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiO88780
PhylomeDBiO88780

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O88780-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRPPPCAIQ TWILLFLLMG AWAGLTRAQG SKILEGQECK PHSQPWQTAL
60 70 80 90 100
FQGERLVCGG VLVGDRWVLT AAHCKKDKYS VRLGDHSLQK RDEPEQEIQV
110 120 130 140 150
ARSIQHPCFN SSNPEDHSHD IMLIRLQNSA NLGDKVKPIE LANLCPKVGQ
160 170 180 190 200
KCIISGWGTV TSPQENFPNT LNCAEVKIYS QNKCERAYPG KITEGMVCAG
210 220 230 240 250
SSNGADTCQG DSGGPLVCNG VLQGITTWGS DPCGKPEKPG VYTKICRYTN
260
WIKKTMGKRD
Length:260
Mass (Da):28,510
Last modified:November 1, 1998 - v1
Checksum:i58DF4F0602A0B7F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005641 mRNA Translation: CAA06643.1
UniGeneiRn.77746

Genome annotation databases

UCSCiRGD:1305998 rat

Similar proteinsi

Entry informationi

Entry nameiKLK8_RAT
AccessioniPrimary (citable) accession number: O88780
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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