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Protein
Submitted name:

ArfGAP with dual PH domains 1

Gene

Adap1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • GTPase activator activity Source: InterPro
  • phosphatidylinositol-3,4,5-trisphosphate binding Source: RGD

GO - Biological processi

  • inositol phosphate-mediated signaling Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
ArfGAP with dual PH domains 1Imported
Submitted name:
IP4/PIP3 binding proteinImported
Submitted name:
Protein Adap1Imported
Gene namesi
Name:Adap1Imported
Synonyms:Centa1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi621418. Adap1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSRNOG00000001291.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001736.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 230PHInterPro annotationAdd BLAST102
Domaini252 – 356PHInterPro annotationAdd BLAST105

Sequence similaritiesi

Contains 2 PH domains.UniRule annotation

Phylogenomic databases

eggNOGiKOG0703. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00860000133778.
HOVERGENiHBG050888.
TreeFamiTF324540.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR001164. ArfGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
PF00169. PH. 2 hits.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88768-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGERRRALL ELLTRPGNSR CADCGAPDPD WASYTLGVFI CLSCSGIHRN
60 70 80 90 100
IPQVSKVKSV RLDAWDETQV EFMTSHGNEA ARATFESKVP PFYYRPTFSD
110 120 130 140 150
CQLLREQWIR AKYERQEFLH VEKQEPYSTG YREGLLWKRG RDNGQFLSRK
160 170 180 190 200
FVLTEREGAL KYFNKNDAKE PKAVMKIEHL NATFQPAKIG HPHGLQVTYL
210 220 230 240 250
KDNSTRNIFI YHEDGKEIVD WFNALRAARF HYLQVAFPGA SDADLVPKLS
260 270 280 290 300
RNYLKEGYME KTGPKQTEGF RKRWFTMDDR RLMYFKDPLD AFARGEVFIG
310 320 330 340 350
SKESGYTVLE GLPPSTQSHH WPHGITIVTP DRKFLFTCET ESDQREWIAA
360 370
FQKVVDRPML PQEYAVEAHF KHKP
Length:374
Mass (Da):43,426
Last modified:November 1, 1998 - v1
Checksum:i8EA0A0300BC3078E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127903 Genomic DNA. No translation available.
BC099775 mRNA. Translation: AAH99775.1.
AJ007422 mRNA. Translation: CAA07496.1.
RefSeqiNP_598251.1. NM_133567.2.
UniGeneiRn.10539.

Genome annotation databases

EnsembliENSRNOT00000089590; ENSRNOP00000075236; ENSRNOG00000054033.
GeneIDi171097.
KEGGirno:171097.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127903 Genomic DNA. No translation available.
BC099775 mRNA. Translation: AAH99775.1.
AJ007422 mRNA. Translation: CAA07496.1.
RefSeqiNP_598251.1. NM_133567.2.
UniGeneiRn.10539.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001736.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000089590; ENSRNOP00000075236; ENSRNOG00000054033.
GeneIDi171097.
KEGGirno:171097.

Organism-specific databases

CTDi11033.
RGDi621418. Adap1.

Phylogenomic databases

eggNOGiKOG0703. Eukaryota.
COG5347. LUCA.
GeneTreeiENSGT00860000133778.
HOVERGENiHBG050888.
TreeFamiTF324540.

Gene expression databases

BgeeiENSRNOG00000001291.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR001164. ArfGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF01412. ArfGap. 1 hit.
PF00169. PH. 2 hits.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00105. ArfGap. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS50115. ARFGAP. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO88768_RAT
AccessioniPrimary (citable) accession number: O88768
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.