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Protein

26S proteasome non-ATPase regulatory subunit 1

Gene

Psmd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 1
Alternative name(s):
26S proteasome regulatory subunit RPN2
26S proteasome regulatory subunit S1
26S proteasome subunit p112
Gene namesi
Name:Psmd1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621669. Psmd1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Proteasome

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2176782.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 95395326S proteasome non-ATPase regulatory subunit 1PRO_0000173802Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei273 – 2731PhosphothreonineCombined sources
Modified residuei310 – 3101N6-acetyllysineBy similarity
Modified residuei311 – 3111PhosphothreonineCombined sources
Modified residuei315 – 3151PhosphoserineCombined sources
Modified residuei720 – 7201N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO88761.
PRIDEiO88761.

PTM databases

iPTMnetiO88761.
PhosphoSiteiO88761.

Interactioni

Subunit structurei

Interacts with ADRM1.By similarity

Protein-protein interaction databases

BioGridi249841. 2 interactions.
IntActiO88761. 2 interactions.
STRINGi10116.ENSRNOP00000024306.

Structurei

3D structure databases

ProteinModelPortaliO88761.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati403 – 43634PC 1Add
BLAST
Repeati441 – 47434PC 2Add
BLAST
Repeati476 – 51035PC 3Add
BLAST
Repeati511 – 54535PC 4Add
BLAST
Repeati547 – 58034PC 5Add
BLAST
Repeati581 – 61636PC 6Add
BLAST
Repeati617 – 64933PC 7Add
BLAST
Repeati651 – 68535PC 8Add
BLAST
Repeati686 – 72641PC 9Add
BLAST
Repeati729 – 76133PC 10Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi936 – 9438Poly-Glu

Sequence similaritiesi

Belongs to the proteasome subunit S1 family.Curated
Contains 10 PC repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2062. Eukaryota.
COG5116. LUCA.
HOGENOMiHOG000189403.
HOVERGENiHBG007543.
InParanoidiO88761.
KOiK03032.
PhylomeDBiO88761.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR016642. 26S_Psome_Rpn2.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002015. Proteasome/cyclosome_rpt.
[Graphical view]
PfamiPF01851. PC_rep. 3 hits.
[Graphical view]
PIRSFiPIRSF015947. 26S_Psome_Rpn2. 1 hit.
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

O88761-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITSAAGIIS LLDEEEPQLK EFALHKLNAV VNDFWAEISE SVDKIEVLYE
60 70 80 90 100
DEGFRSRQFA ALVASKVFYH LGAFEESLNY ALGAGDLFNV NDNSEYVETI
110 120 130 140 150
IAKCIDHYTK QCVENADLPE GEKKPIDQRL EGIVNKMFQR CLDDHKYKQA
160 170 180 190 200
IGIALETRRL DVFEKTILES NDVPGMLAYS LKLCMSLMQN KQFRNKVLRV
210 220 230 240 250
LVKIYMNLEK PDFINVCQCL IFLDDTQAVS DILEKLVKED NLLMAYQICF
260 270 280 290 300
DLYESASQQF LSSVIQNLRT VGTPIASVPG STNTGTVPGP EKDSDSMETE
310 320 330 340 350
EKTAGAVAGK TPDASPEPKD QTLKMIKILS GEMAIELHLQ FLIRNNNTDL
360 370 380 390 400
MILKNTKDAV RNSVCHTATV IANSFMHCGT TSDQFLRDNL EWLARATNWA
410 420 430 440 450
KFTATASLGV IHKGHEKEAL QLMATYLPKD TSPGSAYQEG GGLYALGLIH
460 470 480 490 500
ANHGGDIIDY LLNQLKNASN DIVRHGGSLG LGLAAMGTAR QDVYDLLKTN
510 520 530 540 550
LYQDDAVTGE AAGLALGLVM LGSKNTQAIE DMVGYAQETQ HEKILRGLAV
560 570 580 590 600
GIALVMYGRM EEADALIESL CRDKDPILRR SGMYTVAMAY CGSGNNKAIR
610 620 630 640 650
RLLHVAVSDV NDDVRRAAVE SLGFILFRTP EQCPSVVSLL SESYNPHVRY
660 670 680 690 700
GAAMALGVCC AGTGNKEAIN LLEPMTNDPV NYVRQGALIA SALIMIQQTE
710 720 730 740 750
ITCPKVNQFR QLYSKVINDK HDDVMAKFGA ILAQGILDAG GHNVTISLQS
760 770 780 790 800
RTGHTHMPSV VGVLVFTQFW FWFPLSHFLS LAYTPTCIIG LNKDLKMPKV
810 820 830 840 850
QYKSNCKPST FAYPAPLEVP KEKEKEKVST AVLSITAKAK KKEKEKEKKE
860 870 880 890 900
EEKMEVDEAE KKEEKEKKKE PEPNFQLLDN PARVMPAQLK VLSMTETCRY
910 920 930 940 950
QPFKPLSIGG IIILKDTSED IEELVEPVAA HGPKIEEEEQ EPEPPEPFEY

IDD
Length:953
Mass (Da):105,748
Last modified:November 1, 1998 - v1
Checksum:i55B698EFCE692106
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006340 mRNA. Translation: CAA06983.1.
RefSeqiNP_114184.1. NM_031978.1.
UniGeneiRn.2891.

Genome annotation databases

GeneIDi83806.
KEGGirno:83806.
UCSCiRGD:621669. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006340 mRNA. Translation: CAA06983.1.
RefSeqiNP_114184.1. NM_031978.1.
UniGeneiRn.2891.

3D structure databases

ProteinModelPortaliO88761.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249841. 2 interactions.
IntActiO88761. 2 interactions.
STRINGi10116.ENSRNOP00000024306.

Chemistry

ChEMBLiCHEMBL2176782.

PTM databases

iPTMnetiO88761.
PhosphoSiteiO88761.

Proteomic databases

PaxDbiO88761.
PRIDEiO88761.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi83806.
KEGGirno:83806.
UCSCiRGD:621669. rat.

Organism-specific databases

CTDi5707.
RGDi621669. Psmd1.

Phylogenomic databases

eggNOGiKOG2062. Eukaryota.
COG5116. LUCA.
HOGENOMiHOG000189403.
HOVERGENiHBG007543.
InParanoidiO88761.
KOiK03032.
PhylomeDBiO88761.

Miscellaneous databases

NextBioi616403.
PROiO88761.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR016642. 26S_Psome_Rpn2.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002015. Proteasome/cyclosome_rpt.
[Graphical view]
PfamiPF01851. PC_rep. 3 hits.
[Graphical view]
PIRSFiPIRSF015947. 26S_Psome_Rpn2. 1 hit.
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Proteasome involvement in quinolinic acid generated excitotoxicity: Evidence from differential RNA display."
    Seidel B., Jiang L., Reinheckel T., Keilhoff G., Schneider-Stock R., Wolf G.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-273; THR-311 AND SER-315, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPSMD1_RAT
AccessioniPrimary (citable) accession number: O88761
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.