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O88759

- KCNS3_RAT

UniProt

O88759 - KCNS3_RAT

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Protein

Potassium voltage-gated channel subfamily S member 3

Gene

Kcns3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Potassium channel subunit. Modulates channel activity and shifts the activation threshold of KCNB1 to more negative values.

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: RefGenome

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199159. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily S member 3
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 3
Voltage-gated potassium channel subunit Kv9.3
Gene namesi
Name:Kcns3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi621527. Kcns3.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity
Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.By similarity

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Potassium voltage-gated channel subfamily S member 3PRO_0000054089Add
BLAST

Proteomic databases

PRIDEiO88759.

Expressioni

Tissue specificityi

Detected in lung, spleen, brain and heart.

Gene expression databases

GenevestigatoriO88759.

Interactioni

Subunit structurei

Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliO88759.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 185185CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini207 – 22317ExtracellularSequence AnalysisAdd
BLAST
Topological domaini245 – 2539CytoplasmicSequence Analysis
Topological domaini275 – 28713ExtracellularSequence AnalysisAdd
BLAST
Topological domaini309 – 32315CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini345 – 35713ExtracellularSequence AnalysisAdd
BLAST
Topological domaini379 – 3846ExtracellularSequence Analysis
Topological domaini406 – 49186CytoplasmicSequence AnalysisAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei358 – 37821Pore-forming; Name=Segment H5Sequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei186 – 20621Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei224 – 24421Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei254 – 27421Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei288 – 30821Helical; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei324 – 34421Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei385 – 40521Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi370 – 3756Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiO88759.
KOiK04933.
OMAiWDQKSND.
OrthoDBiEOG7CRTPP.
PhylomeDBiO88759.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

O88759-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVFGEFFHRP GQDEELVNLN VGGFKQSVDQ STLLRFPHTR LGKLLTCHSE
60 70 80 90 100
EAILELCDDY SVADKEYYFD RNPSLFRYVL NFYYTGKLHV MEELCVFSFC
110 120 130 140 150
QEIEYWGINE LFIDSCCSSR YQERKEESHE KDWDQKSNDV STDSSFEESS
160 170 180 190 200
LFEKELEKFD ELRFGQLRKK IWIRMENPAY CLSAKLIAIS SLSVVLASIV
210 220 230 240 250
AMCVHSMSEF QNEDGEVDDP VLEGVEIACI AWFTGELAIR LVAAPSQKKF
260 270 280 290 300
WKNPLNIIDF VSIIPFYATL AVDTKEEESE DIENMGKVVQ ILRLMRIFRI
310 320 330 340 350
LKLARHSVGL RSLGATLRHS YHEVGLLLLF LSVGISIFSV LIYSVEKDEL
360 370 380 390 400
ASSLTSIPIC WWWATISMTT VGYGDTHPVT LAGKIIASTC IICGILVVAL
410 420 430 440 450
PITIIFNKFS KYYQKQKDMD VDQCSEDPPE KCHELPYFNI RDVYAQQVHA
460 470 480 490
FITSLSSIGI VVSDPDSTDA SSVEDNEDAY NTASLENCTA K
Length:491
Mass (Da):55,866
Last modified:November 1, 1998 - v1
Checksum:i6157BC7EFE94CC2B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131I → F in AAB94882. (PubMed:9362476)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF029056 mRNA. Translation: AAB94882.1.
Y17607 mRNA. Translation: CAA76805.1.
PIRiJE0276.
RefSeqiNP_113966.2. NM_031778.2.
UniGeneiRn.10878.

Genome annotation databases

EnsembliENSRNOT00000006499; ENSRNOP00000006499; ENSRNOG00000004899.
GeneIDi83588.
KEGGirno:83588.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF029056 mRNA. Translation: AAB94882.1 .
Y17607 mRNA. Translation: CAA76805.1 .
PIRi JE0276.
RefSeqi NP_113966.2. NM_031778.2.
UniGenei Rn.10878.

3D structure databases

ProteinModelPortali O88759.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O88759.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000006499 ; ENSRNOP00000006499 ; ENSRNOG00000004899 .
GeneIDi 83588.
KEGGi rno:83588.

Organism-specific databases

CTDi 3790.
RGDi 621527. Kcns3.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00760000118981.
HOGENOMi HOG000231016.
HOVERGENi HBG052230.
InParanoidi O88759.
KOi K04933.
OMAi WDQKSND.
OrthoDBi EOG7CRTPP.
PhylomeDBi O88759.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_199159. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 616135.
PROi O88759.

Gene expression databases

Genevestigatori O88759.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes."
    Patel A.J., Lazdunski M., Honore E.
    EMBO J. 16:6615-6625(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain and Kidney.
  2. "Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain."
    Stocker M., Kerschensteiner D.
    Biochem. Biophys. Res. Commun. 248:927-934(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiKCNS3_RAT
AccessioniPrimary (citable) accession number: O88759
Secondary accession number(s): O54900
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: November 1, 1998
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Inhibited by 4-aminopyridine (4-AP). Channel activity is reversibly inhibited by hypoxia and down-regulated in the absence of intracellular ATP.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3