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O88759

- KCNS3_RAT

UniProt

O88759 - KCNS3_RAT

Protein

Potassium voltage-gated channel subfamily S member 3

Gene

Kcns3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Potassium channel subunit. Modulates channel activity and shifts the activation threshold of KCNB1 to more negative values.

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: RefGenome

    GO - Biological processi

    1. protein homooligomerization Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199159. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily S member 3
    Alternative name(s):
    Delayed-rectifier K(+) channel alpha subunit 3
    Voltage-gated potassium channel subunit Kv9.3
    Gene namesi
    Name:Kcns3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 6

    Organism-specific databases

    RGDi621527. Kcns3.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: Ensembl
    2. voltage-gated potassium channel complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Potassium voltage-gated channel subfamily S member 3PRO_0000054089Add
    BLAST

    Proteomic databases

    PRIDEiO88759.

    Expressioni

    Tissue specificityi

    Detected in lung, spleen, brain and heart.

    Gene expression databases

    GenevestigatoriO88759.

    Interactioni

    Subunit structurei

    Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO88759.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 185185CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini207 – 22317ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini245 – 2539CytoplasmicSequence Analysis
    Topological domaini275 – 28713ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini309 – 32315CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini345 – 35713ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini379 – 3846ExtracellularSequence Analysis
    Topological domaini406 – 49186CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei358 – 37821Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei186 – 20621Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei224 – 24421Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei254 – 27421Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821Helical; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei324 – 34421Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei385 – 40521Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi370 – 3756Selectivity filterBy similarity

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    GeneTreeiENSGT00740000115408.
    HOGENOMiHOG000231016.
    HOVERGENiHBG052230.
    InParanoidiO88759.
    KOiK04933.
    OMAiWDQKSND.
    OrthoDBiEOG7CRTPP.
    PhylomeDBiO88759.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O88759-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVFGEFFHRP GQDEELVNLN VGGFKQSVDQ STLLRFPHTR LGKLLTCHSE    50
    EAILELCDDY SVADKEYYFD RNPSLFRYVL NFYYTGKLHV MEELCVFSFC 100
    QEIEYWGINE LFIDSCCSSR YQERKEESHE KDWDQKSNDV STDSSFEESS 150
    LFEKELEKFD ELRFGQLRKK IWIRMENPAY CLSAKLIAIS SLSVVLASIV 200
    AMCVHSMSEF QNEDGEVDDP VLEGVEIACI AWFTGELAIR LVAAPSQKKF 250
    WKNPLNIIDF VSIIPFYATL AVDTKEEESE DIENMGKVVQ ILRLMRIFRI 300
    LKLARHSVGL RSLGATLRHS YHEVGLLLLF LSVGISIFSV LIYSVEKDEL 350
    ASSLTSIPIC WWWATISMTT VGYGDTHPVT LAGKIIASTC IICGILVVAL 400
    PITIIFNKFS KYYQKQKDMD VDQCSEDPPE KCHELPYFNI RDVYAQQVHA 450
    FITSLSSIGI VVSDPDSTDA SSVEDNEDAY NTASLENCTA K 491
    Length:491
    Mass (Da):55,866
    Last modified:November 1, 1998 - v1
    Checksum:i6157BC7EFE94CC2B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti113 – 1131I → F in AAB94882. (PubMed:9362476)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF029056 mRNA. Translation: AAB94882.1.
    Y17607 mRNA. Translation: CAA76805.1.
    PIRiJE0276.
    RefSeqiNP_113966.2. NM_031778.2.
    UniGeneiRn.10878.

    Genome annotation databases

    EnsembliENSRNOT00000006499; ENSRNOP00000006499; ENSRNOG00000004899.
    GeneIDi83588.
    KEGGirno:83588.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF029056 mRNA. Translation: AAB94882.1 .
    Y17607 mRNA. Translation: CAA76805.1 .
    PIRi JE0276.
    RefSeqi NP_113966.2. NM_031778.2.
    UniGenei Rn.10878.

    3D structure databases

    ProteinModelPortali O88759.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi O88759.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000006499 ; ENSRNOP00000006499 ; ENSRNOG00000004899 .
    GeneIDi 83588.
    KEGGi rno:83588.

    Organism-specific databases

    CTDi 3790.
    RGDi 621527. Kcns3.

    Phylogenomic databases

    eggNOGi COG1226.
    GeneTreei ENSGT00740000115408.
    HOGENOMi HOG000231016.
    HOVERGENi HBG052230.
    InParanoidi O88759.
    KOi K04933.
    OMAi WDQKSND.
    OrthoDBi EOG7CRTPP.
    PhylomeDBi O88759.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_199159. Voltage gated Potassium channels.

    Miscellaneous databases

    NextBioi 616135.
    PROi O88759.

    Gene expression databases

    Genevestigatori O88759.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes."
      Patel A.J., Lazdunski M., Honore E.
      EMBO J. 16:6615-6625(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain and Kidney.
    2. "Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain."
      Stocker M., Kerschensteiner D.
      Biochem. Biophys. Res. Commun. 248:927-934(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiKCNS3_RAT
    AccessioniPrimary (citable) accession number: O88759
    Secondary accession number(s): O54900
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Inhibited by 4-aminopyridine (4-AP). Channel activity is reversibly inhibited by hypoxia and down-regulated in the absence of intracellular ATP.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3