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O88759 (KCNS3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily S member 3
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 3
Voltage-gated potassium channel subunit Kv9.3
Gene names
Name:Kcns3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potassium channel subunit. Modulates channel activity and shifts the activation threshold of KCNB1 to more negative values.

Subunit structure

Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 By similarity.

Tissue specificity

Detected in lung, spleen, brain and heart.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Miscellaneous

Inhibited by 4-aminopyridine (4-AP). Channel activity is reversibly inhibited by hypoxia and down-regulated in the absence of intracellular ATP.

Sequence similarities

Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Potassium voltage-gated channel subfamily S member 3
PRO_0000054089

Regions

Topological domain1 – 185185Cytoplasmic Potential
Transmembrane186 – 20621Helical; Name=Segment S1; Potential
Topological domain207 – 22317Extracellular Potential
Transmembrane224 – 24421Helical; Name=Segment S2; Potential
Topological domain245 – 2539Cytoplasmic Potential
Transmembrane254 – 27421Helical; Name=Segment S3; Potential
Topological domain275 – 28713Extracellular Potential
Transmembrane288 – 30821Helical; Name=Segment S4; Potential
Topological domain309 – 32315Cytoplasmic Potential
Transmembrane324 – 34421Helical; Name=Segment S5; Potential
Topological domain345 – 35713Extracellular Potential
Intramembrane358 – 37821Pore-forming; Name=Segment H5; Potential
Topological domain379 – 3846Extracellular Potential
Transmembrane385 – 40521Helical; Name=Segment S6; Potential
Topological domain406 – 49186Cytoplasmic Potential
Motif370 – 3756Selectivity filter By similarity

Experimental info

Sequence conflict1131I → F in AAB94882. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O88759 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 6157BC7EFE94CC2B

FASTA49155,866
        10         20         30         40         50         60 
MVFGEFFHRP GQDEELVNLN VGGFKQSVDQ STLLRFPHTR LGKLLTCHSE EAILELCDDY 

        70         80         90        100        110        120 
SVADKEYYFD RNPSLFRYVL NFYYTGKLHV MEELCVFSFC QEIEYWGINE LFIDSCCSSR 

       130        140        150        160        170        180 
YQERKEESHE KDWDQKSNDV STDSSFEESS LFEKELEKFD ELRFGQLRKK IWIRMENPAY 

       190        200        210        220        230        240 
CLSAKLIAIS SLSVVLASIV AMCVHSMSEF QNEDGEVDDP VLEGVEIACI AWFTGELAIR 

       250        260        270        280        290        300 
LVAAPSQKKF WKNPLNIIDF VSIIPFYATL AVDTKEEESE DIENMGKVVQ ILRLMRIFRI 

       310        320        330        340        350        360 
LKLARHSVGL RSLGATLRHS YHEVGLLLLF LSVGISIFSV LIYSVEKDEL ASSLTSIPIC 

       370        380        390        400        410        420 
WWWATISMTT VGYGDTHPVT LAGKIIASTC IICGILVVAL PITIIFNKFS KYYQKQKDMD 

       430        440        450        460        470        480 
VDQCSEDPPE KCHELPYFNI RDVYAQQVHA FITSLSSIGI VVSDPDSTDA SSVEDNEDAY 

       490 
NTASLENCTA K

« Hide

References

[1]"Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes."
Patel A.J., Lazdunski M., Honore E.
EMBO J. 16:6615-6625(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain and Kidney.
[2]"Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain."
Stocker M., Kerschensteiner D.
Biochem. Biophys. Res. Commun. 248:927-934(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF029056 mRNA. Translation: AAB94882.1.
Y17607 mRNA. Translation: CAA76805.1.
IPIIPI00327668.
PIRJE0276.
RefSeqNP_113966.2. NM_031778.2.
UniGeneRn.10878.

3D structure databases

ProteinModelPortalO88759.
ModBaseSearch...

Proteomic databases

PRIDEO88759.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000006499; ENSRNOP00000006499; ENSRNOG00000004899.
GeneID83588.
KEGGrno:83588.

Organism-specific databases

CTD3790.
RGD621527. Kcns3.

Phylogenomic databases

eggNOGCOG1226.
GeneTreeENSGT00690000102122.
HOGENOMHOG000231016.
HOVERGENHBG052230.
InParanoidO88759.
KOK04933.
OMAPSQKKFW.
OrthoDBEOG4PVNZS.

Gene expression databases

GenevestigatorO88759.
GermOnlineENSRNOG00000004899. Rattus norvegicus.

Family and domain databases

Gene3D3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF00520. Ion_trans. 1 hit.
PF02214. K_tetra. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. BTB/POZ_fold. 1 hit.
ProtoNetSearch...

Other

NextBio616135.

Entry information

Entry nameKCNS3_RAT
AccessionPrimary (citable) accession number: O88759
Secondary accession number(s): O54900
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: November 1, 1998
Last modified: April 3, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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