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O88758 (KCNS1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium voltage-gated channel subfamily S member 1
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 1
Voltage-gated potassium channel subunit Kv9.1
Gene names
Name:Kcns1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potassium channel subunit. Modulates channel activity and reduces the ion flow By similarity.

Subunit structure

Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 By similarity.

Tissue specificity

Highly expressed in brain, but not in the other tissues tested.

Domain

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities

Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Potassium voltage-gated channel subfamily S member 1
PRO_0000054083

Regions

Topological domain1 – 189189Cytoplasmic Potential
Transmembrane190 – 21021Helical; Name=Segment S1; Potential
Topological domain211 – 24333Extracellular Potential
Transmembrane244 – 26421Helical; Name=Segment S2; Potential
Topological domain265 – 27511Cytoplasmic Potential
Transmembrane276 – 29621Helical; Name=Segment S3; Potential
Topological domain297 – 31115Extracellular Potential
Transmembrane312 – 33221Helical; Name=Segment S4; Potential
Topological domain333 – 34715Cytoplasmic Potential
Transmembrane348 – 36821Helical; Name=Segment S5; Potential
Topological domain369 – 37911Extracellular Potential
Intramembrane380 – 40021Pore-forming; Name=Segment H5; Potential
Topological domain401 – 4077Extracellular Potential
Transmembrane408 – 42821Helical; Name=Segment S6; Potential
Topological domain429 – 49769Cytoplasmic Potential
Motif392 – 3976Selectivity filter By similarity
Compositional bias219 – 22810Poly-Ala

Sequences

Sequence LengthMass (Da)Tools
O88758 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 268AE4D56051F7A0

FASTA49754,915
        10         20         30         40         50         60 
MVSEFPGPGS RVPWRPRDEA LRVNVGGVRR LLSARALARF PGTRLGRLQA AVSEEQARRL 

        70         80         90        100        110        120 
CDDYDAAARE FYFDRHPGFF LGLLHFYRTG HLHVLDELCV FAFGQEADYW GLGENALATC 

       130        140        150        160        170        180 
CRARYLERRV TRPRAWDEDS DAPSSVDPCP DEISDVQREL ARYGAARCGR LRRRLWLTME 

       190        200        210        220        230        240 
NPGYSLPSKL FSCVSIGVVL ASIAAMCIHS LPEYQAREAA AAVAAVAAGR SAEDVRDDPV 

       250        260        270        280        290        300 
LRRLEYFCIA WFSFEVSSRL LLAPSTRNFF CHPLNLIDIV SVLPFYLTLL AGAALGDRRG 

       310        320        330        340        350        360 
ASGEELGDLG KVVQVFRLMR IFRVLKLARH STGLRSLGAT LKHSYREVGI LLLYLAVGVS 

       370        380        390        400        410        420 
VFSGVAYTAE EKNVGFDTIP ACWWWGTVSM TTVGYGDVVP ETVAGKLAAS GCILGGILVV 

       430        440        450        460        470        480 
ALPITIIFNK FSHFYRRQKA LEAAVRSSGQ REFEDLLSSV DGVSDVSLET SRETSQEGRS 

       490 
TDLETQAPSE PAKSHSY

« Hide

References

[1]"Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain."
Stocker M., Kerschensteiner D.
Biochem. Biophys. Res. Commun. 248:927-934(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Y17606 mRNA. Translation: CAA76804.1.
IPIIPI00212488.
PIRJE0275.
RefSeqNP_446406.1. NM_053954.1.
UniGeneRn.30012.

3D structure databases

ProteinModelPortalO88758.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000018364.

PTM databases

PhosphoSiteO88758.

Proteomic databases

PRIDEO88758.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000018364; ENSRNOP00000018364; ENSRNOG00000013681.
GeneID117023.
KEGGrno:117023.
UCSCRGD:621524. rat.

Organism-specific databases

CTD3787.
RGD621524. Kcns1.

Phylogenomic databases

eggNOGCOG1226.
GeneTreeENSGT00690000102122.
HOGENOMHOG000231016.
HOVERGENHBG052230.
InParanoidO88758.
KOK04931.
OMAFSCVSIS.
OrthoDBEOG4NS3B8.

Gene expression databases

GenevestigatorO88758.
GermOnlineENSRNOG00000013681. Rattus norvegicus.

Family and domain databases

Gene3D3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
[Graphical view]
PANTHERPTHR11537. PTHR11537. 1 hit.
PfamPF00520. Ion_trans. 1 hit.
PF02214. K_tetra. 1 hit.
[Graphical view]
PRINTSPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. BTB/POZ_fold. 1 hit.
ProtoNetSearch...

Other

NextBio619783.

Entry information

Entry nameKCNS1_RAT
AccessionPrimary (citable) accession number: O88758
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: November 1, 1998
Last modified: April 3, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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