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O88758

- KCNS1_RAT

UniProt

O88758 - KCNS1_RAT

Protein

Potassium voltage-gated channel subfamily S member 1

Gene

Kcns1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Potassium channel subunit. Modulates channel activity and reduces the ion flow By similarity.By similarity

    GO - Molecular functioni

    1. delayed rectifier potassium channel activity Source: UniProtKB
    2. potassium channel regulator activity Source: UniProtKB

    GO - Biological processi

    1. protein homooligomerization Source: InterPro

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_199159. Voltage gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium voltage-gated channel subfamily S member 1
    Alternative name(s):
    Delayed-rectifier K(+) channel alpha subunit 1
    Voltage-gated potassium channel subunit Kv9.1
    Gene namesi
    Name:Kcns1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi621524. Kcns1.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.By similarity

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB
    2. voltage-gated potassium channel complex Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Potassium voltage-gated channel subfamily S member 1PRO_0000054083Add
    BLAST

    Proteomic databases

    PRIDEiO88758.

    PTM databases

    PhosphoSiteiO88758.

    Expressioni

    Tissue specificityi

    Highly expressed in brain, but not in the other tissues tested.

    Gene expression databases

    GenevestigatoriO88758.

    Interactioni

    Subunit structurei

    Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000018364.

    Structurei

    3D structure databases

    ProteinModelPortaliO88758.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 189189CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini211 – 24333ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini265 – 27511CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini297 – 31115ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini333 – 34715CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini369 – 37911ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini401 – 4077ExtracellularSequence Analysis
    Topological domaini429 – 49769CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei380 – 40021Pore-forming; Name=Segment H5Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei190 – 21021Helical; Name=Segment S1Sequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421Helical; Name=Segment S2Sequence AnalysisAdd
    BLAST
    Transmembranei276 – 29621Helical; Name=Segment S3Sequence AnalysisAdd
    BLAST
    Transmembranei312 – 33221Helical; Name=Segment S4Sequence AnalysisAdd
    BLAST
    Transmembranei348 – 36821Helical; Name=Segment S5Sequence AnalysisAdd
    BLAST
    Transmembranei408 – 42821Helical; Name=Segment S6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi392 – 3976Selectivity filterBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi219 – 22810Poly-Ala

    Domaini

    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    GeneTreeiENSGT00740000115408.
    HOGENOMiHOG000231016.
    HOVERGENiHBG052230.
    InParanoidiO88758.
    KOiK04931.
    OMAiMVSESPG.
    OrthoDBiEOG7CRTPP.
    PhylomeDBiO88758.
    TreeFamiTF313103.

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view]
    PANTHERiPTHR11537. PTHR11537. 1 hit.
    PfamiPF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O88758-1 [UniParc]FASTAAdd to Basket

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    MVSEFPGPGS RVPWRPRDEA LRVNVGGVRR LLSARALARF PGTRLGRLQA    50
    AVSEEQARRL CDDYDAAARE FYFDRHPGFF LGLLHFYRTG HLHVLDELCV 100
    FAFGQEADYW GLGENALATC CRARYLERRV TRPRAWDEDS DAPSSVDPCP 150
    DEISDVQREL ARYGAARCGR LRRRLWLTME NPGYSLPSKL FSCVSIGVVL 200
    ASIAAMCIHS LPEYQAREAA AAVAAVAAGR SAEDVRDDPV LRRLEYFCIA 250
    WFSFEVSSRL LLAPSTRNFF CHPLNLIDIV SVLPFYLTLL AGAALGDRRG 300
    ASGEELGDLG KVVQVFRLMR IFRVLKLARH STGLRSLGAT LKHSYREVGI 350
    LLLYLAVGVS VFSGVAYTAE EKNVGFDTIP ACWWWGTVSM TTVGYGDVVP 400
    ETVAGKLAAS GCILGGILVV ALPITIIFNK FSHFYRRQKA LEAAVRSSGQ 450
    REFEDLLSSV DGVSDVSLET SRETSQEGRS TDLETQAPSE PAKSHSY 497
    Length:497
    Mass (Da):54,915
    Last modified:November 1, 1998 - v1
    Checksum:i268AE4D56051F7A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y17606 mRNA. Translation: CAA76804.1.
    PIRiJE0275.
    RefSeqiNP_446406.1. NM_053954.1.
    XP_006235570.1. XM_006235508.1.
    XP_006235571.1. XM_006235509.1.
    UniGeneiRn.30012.

    Genome annotation databases

    EnsembliENSRNOT00000018364; ENSRNOP00000018364; ENSRNOG00000013681.
    GeneIDi117023.
    KEGGirno:117023.
    UCSCiRGD:621524. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y17606 mRNA. Translation: CAA76804.1 .
    PIRi JE0275.
    RefSeqi NP_446406.1. NM_053954.1.
    XP_006235570.1. XM_006235508.1.
    XP_006235571.1. XM_006235509.1.
    UniGenei Rn.30012.

    3D structure databases

    ProteinModelPortali O88758.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000018364.

    PTM databases

    PhosphoSitei O88758.

    Proteomic databases

    PRIDEi O88758.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000018364 ; ENSRNOP00000018364 ; ENSRNOG00000013681 .
    GeneIDi 117023.
    KEGGi rno:117023.
    UCSCi RGD:621524. rat.

    Organism-specific databases

    CTDi 3787.
    RGDi 621524. Kcns1.

    Phylogenomic databases

    eggNOGi COG1226.
    GeneTreei ENSGT00740000115408.
    HOGENOMi HOG000231016.
    HOVERGENi HBG052230.
    InParanoidi O88758.
    KOi K04931.
    OMAi MVSESPG.
    OrthoDBi EOG7CRTPP.
    PhylomeDBi O88758.
    TreeFami TF313103.

    Enzyme and pathway databases

    Reactomei REACT_199159. Voltage gated Potassium channels.

    Miscellaneous databases

    NextBioi 619783.
    PROi O88758.

    Gene expression databases

    Genevestigatori O88758.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR003091. K_chnl.
    IPR003968. K_chnl_volt-dep_Kv.
    IPR003971. K_chnl_volt-dep_Kv9.
    IPR003131. T1-type_BTB.
    IPR028325. VG_K_chnl.
    [Graphical view ]
    PANTHERi PTHR11537. PTHR11537. 1 hit.
    Pfami PF02214. BTB_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR00169. KCHANNEL.
    PR01494. KV9CHANNEL.
    PR01491. KVCHANNEL.
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain."
      Stocker M., Kerschensteiner D.
      Biochem. Biophys. Res. Commun. 248:927-934(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiKCNS1_RAT
    AccessioniPrimary (citable) accession number: O88758
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3