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Protein

Potassium voltage-gated channel subfamily S member 1

Gene

Kcns1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity).By similarity

GO - Molecular functioni

  1. delayed rectifier potassium channel activity Source: UniProtKB
  2. potassium channel regulator activity Source: UniProtKB

GO - Biological processi

  1. potassium ion transmembrane transport Source: GO_Central
  2. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199159. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily S member 1
Alternative name(s):
Delayed-rectifier K(+) channel alpha subunit 1
Voltage-gated potassium channel subunit Kv9.1
Gene namesi
Name:Kcns1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 3

Organism-specific databases

RGDi621524. Kcns1.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity
Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 189189CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei190 – 21021Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Topological domaini211 – 24333ExtracellularSequence AnalysisAdd
BLAST
Transmembranei244 – 26421Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Topological domaini265 – 27511CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Topological domaini297 – 31115ExtracellularSequence AnalysisAdd
BLAST
Transmembranei312 – 33221Helical; Name=Segment S4Sequence AnalysisAdd
BLAST
Topological domaini333 – 34715CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei348 – 36821Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Topological domaini369 – 37911ExtracellularSequence AnalysisAdd
BLAST
Intramembranei380 – 40021Pore-forming; Name=Segment H5Sequence AnalysisAdd
BLAST
Topological domaini401 – 4077ExtracellularSequence Analysis
Transmembranei408 – 42821Helical; Name=Segment S6Sequence AnalysisAdd
BLAST
Topological domaini429 – 49769CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
  2. plasma membrane Source: UniProtKB
  3. voltage-gated potassium channel complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Potassium voltage-gated channel subfamily S member 1PRO_0000054083Add
BLAST

Proteomic databases

PRIDEiO88758.

PTM databases

PhosphoSiteiO88758.

Expressioni

Tissue specificityi

Highly expressed in brain, but not in the other tissues tested.

Gene expression databases

GenevestigatoriO88758.

Interactioni

Subunit structurei

Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018364.

Structurei

3D structure databases

ProteinModelPortaliO88758.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi392 – 3976Selectivity filterBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi219 – 22810Poly-Ala

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiO88758.
KOiK04931.
OMAiWLTLENP.
OrthoDBiEOG7CRTPP.
PhylomeDBiO88758.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

O88758-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSEFPGPGS RVPWRPRDEA LRVNVGGVRR LLSARALARF PGTRLGRLQA
60 70 80 90 100
AVSEEQARRL CDDYDAAARE FYFDRHPGFF LGLLHFYRTG HLHVLDELCV
110 120 130 140 150
FAFGQEADYW GLGENALATC CRARYLERRV TRPRAWDEDS DAPSSVDPCP
160 170 180 190 200
DEISDVQREL ARYGAARCGR LRRRLWLTME NPGYSLPSKL FSCVSIGVVL
210 220 230 240 250
ASIAAMCIHS LPEYQAREAA AAVAAVAAGR SAEDVRDDPV LRRLEYFCIA
260 270 280 290 300
WFSFEVSSRL LLAPSTRNFF CHPLNLIDIV SVLPFYLTLL AGAALGDRRG
310 320 330 340 350
ASGEELGDLG KVVQVFRLMR IFRVLKLARH STGLRSLGAT LKHSYREVGI
360 370 380 390 400
LLLYLAVGVS VFSGVAYTAE EKNVGFDTIP ACWWWGTVSM TTVGYGDVVP
410 420 430 440 450
ETVAGKLAAS GCILGGILVV ALPITIIFNK FSHFYRRQKA LEAAVRSSGQ
460 470 480 490
REFEDLLSSV DGVSDVSLET SRETSQEGRS TDLETQAPSE PAKSHSY
Length:497
Mass (Da):54,915
Last modified:November 1, 1998 - v1
Checksum:i268AE4D56051F7A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17606 mRNA. Translation: CAA76804.1.
PIRiJE0275.
RefSeqiNP_446406.1. NM_053954.1.
XP_006235571.1. XM_006235509.2.
UniGeneiRn.30012.

Genome annotation databases

EnsembliENSRNOT00000018364; ENSRNOP00000018364; ENSRNOG00000013681.
GeneIDi117023.
KEGGirno:117023.
UCSCiRGD:621524. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17606 mRNA. Translation: CAA76804.1.
PIRiJE0275.
RefSeqiNP_446406.1. NM_053954.1.
XP_006235571.1. XM_006235509.2.
UniGeneiRn.30012.

3D structure databases

ProteinModelPortaliO88758.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018364.

PTM databases

PhosphoSiteiO88758.

Proteomic databases

PRIDEiO88758.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018364; ENSRNOP00000018364; ENSRNOG00000013681.
GeneIDi117023.
KEGGirno:117023.
UCSCiRGD:621524. rat.

Organism-specific databases

CTDi3787.
RGDi621524. Kcns1.

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118981.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiO88758.
KOiK04931.
OMAiWLTLENP.
OrthoDBiEOG7CRTPP.
PhylomeDBiO88758.
TreeFamiTF313103.

Enzyme and pathway databases

ReactomeiREACT_199159. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi619783.
PROiO88758.

Gene expression databases

GenevestigatoriO88758.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain."
    Stocker M., Kerschensteiner D.
    Biochem. Biophys. Res. Commun. 248:927-934(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiKCNS1_RAT
AccessioniPrimary (citable) accession number: O88758
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: November 1, 1998
Last modified: February 4, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.