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O88746

- TOM1_MOUSE

UniProt

O88746 - TOM1_MOUSE

Protein

Target of Myb protein 1

Gene

Tom1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    May be involved in intracellular trafficking. Probable association with membranes.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. intracellular protein transport Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Target of Myb protein 1
    Gene namesi
    Name:Tom1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6, UP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1338026. Tom1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. early endosome Source: UniProtKB
    3. membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 492492Target of Myb protein 1PRO_0000072629Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei11 – 111PhosphoserineBy similarity
    Modified residuei160 – 1601PhosphoserineBy similarity
    Modified residuei164 – 1641PhosphothreonineBy similarity
    Modified residuei176 – 1761Phosphoserine1 Publication
    Modified residuei355 – 3551PhosphoserineBy similarity
    Modified residuei462 – 4621PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiO88746.
    PaxDbiO88746.
    PRIDEiO88746.

    PTM databases

    PhosphoSiteiO88746.

    Miscellaneous databases

    PMAP-CutDBO88746.

    Expressioni

    Tissue specificityi

    Ubiquitous. In adult brain, it is highly expressed at the mesencephalic level, in the hippocampal formation and medial lemniscus. In cerebellum, it is highly expressed in Purkinje cells and granular layers.

    Developmental stagei

    Ubiquitously expressed in the embryo, with a higher expression in the intestines.

    Gene expression databases

    BgeeiO88746.
    CleanExiMM_TOM1.
    GenevestigatoriO88746.

    Interactioni

    Subunit structurei

    Interacts with ZFYVE16; interaction is required to target it to endosomes.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TollipQ9QZ062EBI-74264,EBI-74272

    Protein-protein interaction databases

    BioGridi204274. 1 interaction.
    IntActiO88746. 4 interactions.
    MINTiMINT-4138215.
    STRINGi10090.ENSMUSP00000036849.

    Structurei

    3D structure databases

    ProteinModelPortaliO88746.
    SMRiO88746. Positions 2-153, 215-307.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 152133VHSPROSITE-ProRule annotationAdd
    BLAST
    Domaini215 – 30389GATPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TOM1 family.Curated
    Contains 1 GAT domain.PROSITE-ProRule annotation
    Contains 1 VHS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG118960.
    HOGENOMiHOG000285970.
    HOVERGENiHBG025068.
    InParanoidiO88746.
    OMAiEEPKGVT.
    OrthoDBiEOG75B859.
    PhylomeDBiO88746.
    TreeFamiTF314105.

    Family and domain databases

    Gene3Di1.25.40.90. 1 hit.
    InterProiIPR008942. ENTH_VHS.
    IPR004152. GAT.
    IPR014645. TOM1.
    IPR002014. VHS.
    IPR018205. VHS_subgr.
    [Graphical view]
    PfamiPF03127. GAT. 1 hit.
    PF00790. VHS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036948. TOM1. 1 hit.
    SMARTiSM00288. VHS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48464. SSF48464. 1 hit.
    PROSITEiPS50909. GAT. 1 hit.
    PS50179. VHS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O88746-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDFLLGNPFS SPVGQRIEKA TDGSLQSEDW ALNMEICDII NETEEGPKDA    50
    FRAVKKRIMG NKNFHEVMLA LTVLETCVKN CGHRFHVLVA NQDFVENVLV 100
    RTILPKNNPP TIVHDKVLNL IQSWADAFRS SPDLTGVVAV YEDLRRKGLE 150
    FPMTDLDMLS PIHTPQRTVF NSETPSRQNS VSSNTSQRGD LSQHATPLPT 200
    PAVLPGDSPI TPTPEQIGKL RSELEMVSGN VRVMSEMLTE LVPTQVEPAD 250
    LELLQELNRT CRAMQQRILE LIPRISNEQL TEELLMINDN LNNVFLRHER 300
    FERFRTGQTA KASSEAELAT DLIDMGPDPA ATNNLSSQLA GMNLGSRSVR 350
    AGLQSLETSG HLEDDFDMFA LTRGSSLADQ RKGVKYEAPQ TTDGLAGALD 400
    ARQQSTGAIP ATQARIMEDI EQWLSTDVGN SAEEPSGVTS EEFDKFLEER 450
    AKAADRLPNL ASPSAEGPPR PSPGTAPRRK TQEKDDDMLF AL 492
    Length:492
    Mass (Da):54,325
    Last modified:November 1, 1998 - v1
    Checksum:iA15F24FD9B4D31C3
    GO
    Isoform 2 (identifier: O88746-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-324: Missing.
         325-343: MGPDPAATNNLSSQLAGMN → MGRANGTAGLLPGPSVSAD

    Show »
    Length:168
    Mass (Da):17,788
    Checksum:i3AA2CF5B2EBAD575
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 324324Missing in isoform 2. 1 PublicationVSP_003991Add
    BLAST
    Alternative sequencei325 – 34319MGPDP…LAGMN → MGRANGTAGLLPGPSVSAD in isoform 2. 1 PublicationVSP_003992Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ006972 mRNA. Translation: CAA07361.1.
    AK004063 mRNA. Translation: BAE43160.1.
    AK028398 mRNA. Translation: BAC25932.1.
    BC021633 mRNA. Translation: AAH21633.1.
    CCDSiCCDS52601.1. [O88746-1]
    RefSeqiNP_035752.1. NM_011622.3. [O88746-1]
    UniGeneiMm.290868.

    Genome annotation databases

    EnsembliENSMUST00000036712; ENSMUSP00000036849; ENSMUSG00000037827. [O88746-1]
    ENSMUST00000165630; ENSMUSP00000130854; ENSMUSG00000042870. [O88746-1]
    GeneIDi21968.
    KEGGimmu:21968.
    UCSCiuc009mha.2. mouse. [O88746-1]
    uc009mhb.2. mouse. [O88746-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ006972 mRNA. Translation: CAA07361.1 .
    AK004063 mRNA. Translation: BAE43160.1 .
    AK028398 mRNA. Translation: BAC25932.1 .
    BC021633 mRNA. Translation: AAH21633.1 .
    CCDSi CCDS52601.1. [O88746-1 ]
    RefSeqi NP_035752.1. NM_011622.3. [O88746-1 ]
    UniGenei Mm.290868.

    3D structure databases

    ProteinModelPortali O88746.
    SMRi O88746. Positions 2-153, 215-307.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204274. 1 interaction.
    IntActi O88746. 4 interactions.
    MINTi MINT-4138215.
    STRINGi 10090.ENSMUSP00000036849.

    PTM databases

    PhosphoSitei O88746.

    Proteomic databases

    MaxQBi O88746.
    PaxDbi O88746.
    PRIDEi O88746.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036712 ; ENSMUSP00000036849 ; ENSMUSG00000037827 . [O88746-1 ]
    ENSMUST00000165630 ; ENSMUSP00000130854 ; ENSMUSG00000042870 . [O88746-1 ]
    GeneIDi 21968.
    KEGGi mmu:21968.
    UCSCi uc009mha.2. mouse. [O88746-1 ]
    uc009mhb.2. mouse. [O88746-2 ]

    Organism-specific databases

    CTDi 10043.
    MGIi MGI:1338026. Tom1.

    Phylogenomic databases

    eggNOGi NOG118960.
    HOGENOMi HOG000285970.
    HOVERGENi HBG025068.
    InParanoidi O88746.
    OMAi EEPKGVT.
    OrthoDBi EOG75B859.
    PhylomeDBi O88746.
    TreeFami TF314105.

    Miscellaneous databases

    NextBioi 301662.
    PMAP-CutDB O88746.
    PROi O88746.
    SOURCEi Search...

    Gene expression databases

    Bgeei O88746.
    CleanExi MM_TOM1.
    Genevestigatori O88746.

    Family and domain databases

    Gene3Di 1.25.40.90. 1 hit.
    InterProi IPR008942. ENTH_VHS.
    IPR004152. GAT.
    IPR014645. TOM1.
    IPR002014. VHS.
    IPR018205. VHS_subgr.
    [Graphical view ]
    Pfami PF03127. GAT. 1 hit.
    PF00790. VHS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036948. TOM1. 1 hit.
    SMARTi SM00288. VHS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48464. SSF48464. 1 hit.
    PROSITEi PS50909. GAT. 1 hit.
    PS50179. VHS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM."
      Seroussi E., Kedra D., Kost-Alimova M., Sandberg-Nordqvist A.-C., Fransson I., Jacobs J.F.M., Fu Y., Pan H.-Q., Roe B.A., Imreh S., Dumanski J.P.
      Genomics 57:380-388(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Thymus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-176, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiTOM1_MOUSE
    AccessioniPrimary (citable) accession number: O88746
    Secondary accession number(s): Q3V4C6, Q9D120
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3