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O88746

- TOM1_MOUSE

UniProt

O88746 - TOM1_MOUSE

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Protein

Target of Myb protein 1

Gene
Tom1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in intracellular trafficking. Probable association with membranes.

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. intracellular protein transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Target of Myb protein 1
Gene namesi
Name:Tom1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6, UP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1338026. Tom1.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. early endosome Source: UniProtKB
  3. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Target of Myb protein 1PRO_0000072629Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei11 – 111Phosphoserine By similarity
Modified residuei160 – 1601Phosphoserine By similarity
Modified residuei164 – 1641Phosphothreonine By similarity
Modified residuei176 – 1761Phosphoserine1 Publication
Modified residuei355 – 3551Phosphoserine By similarity
Modified residuei462 – 4621Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO88746.
PaxDbiO88746.
PRIDEiO88746.

PTM databases

PhosphoSiteiO88746.

Miscellaneous databases

PMAP-CutDBO88746.

Expressioni

Tissue specificityi

Ubiquitous. In adult brain, it is highly expressed at the mesencephalic level, in the hippocampal formation and medial lemniscus. In cerebellum, it is highly expressed in Purkinje cells and granular layers.

Developmental stagei

Ubiquitously expressed in the embryo, with a higher expression in the intestines.

Gene expression databases

BgeeiO88746.
CleanExiMM_TOM1.
GenevestigatoriO88746.

Interactioni

Subunit structurei

Interacts with ZFYVE16; interaction is required to target it to endosomes By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
TollipQ9QZ062EBI-74264,EBI-74272

Protein-protein interaction databases

BioGridi204274. 1 interaction.
IntActiO88746. 4 interactions.
MINTiMINT-4138215.
STRINGi10090.ENSMUSP00000036849.

Structurei

3D structure databases

ProteinModelPortaliO88746.
SMRiO88746. Positions 2-153, 215-307.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 152133VHSAdd
BLAST
Domaini215 – 30389GATAdd
BLAST

Sequence similaritiesi

Belongs to the TOM1 family.
Contains 1 GAT domain.
Contains 1 VHS domain.

Phylogenomic databases

eggNOGiNOG118960.
HOGENOMiHOG000285970.
HOVERGENiHBG025068.
InParanoidiO88746.
OMAiEEPKGVT.
OrthoDBiEOG75B859.
PhylomeDBiO88746.
TreeFamiTF314105.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR004152. GAT.
IPR014645. TOM1.
IPR002014. VHS.
IPR018205. VHS_subgr.
[Graphical view]
PfamiPF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PIRSFiPIRSF036948. TOM1. 1 hit.
SMARTiSM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O88746-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDFLLGNPFS SPVGQRIEKA TDGSLQSEDW ALNMEICDII NETEEGPKDA    50
FRAVKKRIMG NKNFHEVMLA LTVLETCVKN CGHRFHVLVA NQDFVENVLV 100
RTILPKNNPP TIVHDKVLNL IQSWADAFRS SPDLTGVVAV YEDLRRKGLE 150
FPMTDLDMLS PIHTPQRTVF NSETPSRQNS VSSNTSQRGD LSQHATPLPT 200
PAVLPGDSPI TPTPEQIGKL RSELEMVSGN VRVMSEMLTE LVPTQVEPAD 250
LELLQELNRT CRAMQQRILE LIPRISNEQL TEELLMINDN LNNVFLRHER 300
FERFRTGQTA KASSEAELAT DLIDMGPDPA ATNNLSSQLA GMNLGSRSVR 350
AGLQSLETSG HLEDDFDMFA LTRGSSLADQ RKGVKYEAPQ TTDGLAGALD 400
ARQQSTGAIP ATQARIMEDI EQWLSTDVGN SAEEPSGVTS EEFDKFLEER 450
AKAADRLPNL ASPSAEGPPR PSPGTAPRRK TQEKDDDMLF AL 492
Length:492
Mass (Da):54,325
Last modified:November 1, 1998 - v1
Checksum:iA15F24FD9B4D31C3
GO
Isoform 2 (identifier: O88746-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-324: Missing.
     325-343: MGPDPAATNNLSSQLAGMN → MGRANGTAGLLPGPSVSAD

Show »
Length:168
Mass (Da):17,788
Checksum:i3AA2CF5B2EBAD575
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 324324Missing in isoform 2. VSP_003991Add
BLAST
Alternative sequencei325 – 34319MGPDP…LAGMN → MGRANGTAGLLPGPSVSAD in isoform 2. VSP_003992Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ006972 mRNA. Translation: CAA07361.1.
AK004063 mRNA. Translation: BAE43160.1.
AK028398 mRNA. Translation: BAC25932.1.
BC021633 mRNA. Translation: AAH21633.1.
CCDSiCCDS52601.1. [O88746-1]
RefSeqiNP_035752.1. NM_011622.3. [O88746-1]
UniGeneiMm.290868.

Genome annotation databases

EnsembliENSMUST00000036712; ENSMUSP00000036849; ENSMUSG00000037827. [O88746-1]
ENSMUST00000165630; ENSMUSP00000130854; ENSMUSG00000042870. [O88746-1]
GeneIDi21968.
KEGGimmu:21968.
UCSCiuc009mha.2. mouse. [O88746-1]
uc009mhb.2. mouse. [O88746-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ006972 mRNA. Translation: CAA07361.1 .
AK004063 mRNA. Translation: BAE43160.1 .
AK028398 mRNA. Translation: BAC25932.1 .
BC021633 mRNA. Translation: AAH21633.1 .
CCDSi CCDS52601.1. [O88746-1 ]
RefSeqi NP_035752.1. NM_011622.3. [O88746-1 ]
UniGenei Mm.290868.

3D structure databases

ProteinModelPortali O88746.
SMRi O88746. Positions 2-153, 215-307.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204274. 1 interaction.
IntActi O88746. 4 interactions.
MINTi MINT-4138215.
STRINGi 10090.ENSMUSP00000036849.

PTM databases

PhosphoSitei O88746.

Proteomic databases

MaxQBi O88746.
PaxDbi O88746.
PRIDEi O88746.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036712 ; ENSMUSP00000036849 ; ENSMUSG00000037827 . [O88746-1 ]
ENSMUST00000165630 ; ENSMUSP00000130854 ; ENSMUSG00000042870 . [O88746-1 ]
GeneIDi 21968.
KEGGi mmu:21968.
UCSCi uc009mha.2. mouse. [O88746-1 ]
uc009mhb.2. mouse. [O88746-2 ]

Organism-specific databases

CTDi 10043.
MGIi MGI:1338026. Tom1.

Phylogenomic databases

eggNOGi NOG118960.
HOGENOMi HOG000285970.
HOVERGENi HBG025068.
InParanoidi O88746.
OMAi EEPKGVT.
OrthoDBi EOG75B859.
PhylomeDBi O88746.
TreeFami TF314105.

Miscellaneous databases

NextBioi 301662.
PMAP-CutDB O88746.
PROi O88746.
SOURCEi Search...

Gene expression databases

Bgeei O88746.
CleanExi MM_TOM1.
Genevestigatori O88746.

Family and domain databases

Gene3Di 1.25.40.90. 1 hit.
InterProi IPR008942. ENTH_VHS.
IPR004152. GAT.
IPR014645. TOM1.
IPR002014. VHS.
IPR018205. VHS_subgr.
[Graphical view ]
Pfami PF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view ]
PIRSFi PIRSF036948. TOM1. 1 hit.
SMARTi SM00288. VHS. 1 hit.
[Graphical view ]
SUPFAMi SSF48464. SSF48464. 1 hit.
PROSITEi PS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM."
    Seroussi E., Kedra D., Kost-Alimova M., Sandberg-Nordqvist A.-C., Fransson I., Jacobs J.F.M., Fu Y., Pan H.-Q., Roe B.A., Imreh S., Dumanski J.P.
    Genomics 57:380-388(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-176, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTOM1_MOUSE
AccessioniPrimary (citable) accession number: O88746
Secondary accession number(s): Q3V4C6, Q9D120
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi