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Protein

Target of Myb protein 1

Gene

Tom1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in intracellular trafficking. Probable association with membranes.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Target of Myb protein 1
Gene namesi
Name:Tom1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1338026. Tom1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Target of Myb protein 1PRO_0000072629Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei11 – 111PhosphoserineBy similarity
Modified residuei160 – 1601PhosphoserineCombined sources
Modified residuei164 – 1641PhosphothreonineCombined sources
Modified residuei176 – 1761PhosphoserineCombined sources
Modified residuei180 – 1801PhosphoserineCombined sources
Modified residuei208 – 2081PhosphoserineCombined sources
Modified residuei355 – 3551PhosphoserineBy similarity
Modified residuei376 – 3761PhosphoserineBy similarity
Modified residuei462 – 4621PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO88746.
PaxDbiO88746.
PeptideAtlasiO88746.
PRIDEiO88746.

PTM databases

iPTMnetiO88746.
PhosphoSiteiO88746.

Miscellaneous databases

PMAP-CutDBO88746.

Expressioni

Tissue specificityi

Ubiquitous. In adult brain, it is highly expressed at the mesencephalic level, in the hippocampal formation and medial lemniscus. In cerebellum, it is highly expressed in Purkinje cells and granular layers.

Developmental stagei

Ubiquitously expressed in the embryo, with a higher expression in the intestines.

Gene expression databases

BgeeiENSMUSG00000037827.
CleanExiMM_TOM1.
ExpressionAtlasiO88746. baseline.
GenevisibleiO88746. MM.

Interactioni

Subunit structurei

Interacts with ZFYVE16; interaction is required to target it to endosomes.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TollipQ9QZ062EBI-74264,EBI-74272

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204274. 1 interaction.
IntActiO88746. 4 interactions.
MINTiMINT-4138215.
STRINGi10090.ENSMUSP00000036849.

Structurei

3D structure databases

ProteinModelPortaliO88746.
SMRiO88746. Positions 2-153, 215-309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 152133VHSPROSITE-ProRule annotationAdd
BLAST
Domaini215 – 30389GATPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TOM1 family.Curated
Contains 1 GAT domain.PROSITE-ProRule annotation
Contains 1 VHS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1087. Eukaryota.
ENOG410Y26G. LUCA.
GeneTreeiENSGT00700000104139.
HOGENOMiHOG000285970.
HOVERGENiHBG025068.
InParanoidiO88746.
PhylomeDBiO88746.
TreeFamiTF314105.

Family and domain databases

Gene3Di1.20.58.160. 1 hit.
1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR014645. TOM1.
IPR002014. VHS_dom.
[Graphical view]
PfamiPF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PIRSFiPIRSF036948. TOM1. 1 hit.
SMARTiSM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O88746-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDFLLGNPFS SPVGQRIEKA TDGSLQSEDW ALNMEICDII NETEEGPKDA
60 70 80 90 100
FRAVKKRIMG NKNFHEVMLA LTVLETCVKN CGHRFHVLVA NQDFVENVLV
110 120 130 140 150
RTILPKNNPP TIVHDKVLNL IQSWADAFRS SPDLTGVVAV YEDLRRKGLE
160 170 180 190 200
FPMTDLDMLS PIHTPQRTVF NSETPSRQNS VSSNTSQRGD LSQHATPLPT
210 220 230 240 250
PAVLPGDSPI TPTPEQIGKL RSELEMVSGN VRVMSEMLTE LVPTQVEPAD
260 270 280 290 300
LELLQELNRT CRAMQQRILE LIPRISNEQL TEELLMINDN LNNVFLRHER
310 320 330 340 350
FERFRTGQTA KASSEAELAT DLIDMGPDPA ATNNLSSQLA GMNLGSRSVR
360 370 380 390 400
AGLQSLETSG HLEDDFDMFA LTRGSSLADQ RKGVKYEAPQ TTDGLAGALD
410 420 430 440 450
ARQQSTGAIP ATQARIMEDI EQWLSTDVGN SAEEPSGVTS EEFDKFLEER
460 470 480 490
AKAADRLPNL ASPSAEGPPR PSPGTAPRRK TQEKDDDMLF AL
Length:492
Mass (Da):54,325
Last modified:November 1, 1998 - v1
Checksum:iA15F24FD9B4D31C3
GO
Isoform 2 (identifier: O88746-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-324: Missing.
     325-343: MGPDPAATNNLSSQLAGMN → MGRANGTAGLLPGPSVSAD

Show »
Length:168
Mass (Da):17,788
Checksum:i3AA2CF5B2EBAD575
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 324324Missing in isoform 2. 1 PublicationVSP_003991Add
BLAST
Alternative sequencei325 – 34319MGPDP…LAGMN → MGRANGTAGLLPGPSVSAD in isoform 2. 1 PublicationVSP_003992Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006972 mRNA. Translation: CAA07361.1.
AK004063 mRNA. Translation: BAE43160.1.
AK028398 mRNA. Translation: BAC25932.1.
BC021633 mRNA. Translation: AAH21633.1.
CCDSiCCDS52601.1. [O88746-1]
RefSeqiNP_035752.1. NM_011622.3. [O88746-1]
UniGeneiMm.1967.
Mm.290868.

Genome annotation databases

EnsembliENSMUST00000165630; ENSMUSP00000130854; ENSMUSG00000042870. [O88746-1]
GeneIDi21968.
KEGGimmu:21968.
UCSCiuc009mha.2. mouse. [O88746-1]
uc009mhb.2. mouse. [O88746-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006972 mRNA. Translation: CAA07361.1.
AK004063 mRNA. Translation: BAE43160.1.
AK028398 mRNA. Translation: BAC25932.1.
BC021633 mRNA. Translation: AAH21633.1.
CCDSiCCDS52601.1. [O88746-1]
RefSeqiNP_035752.1. NM_011622.3. [O88746-1]
UniGeneiMm.1967.
Mm.290868.

3D structure databases

ProteinModelPortaliO88746.
SMRiO88746. Positions 2-153, 215-309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204274. 1 interaction.
IntActiO88746. 4 interactions.
MINTiMINT-4138215.
STRINGi10090.ENSMUSP00000036849.

PTM databases

iPTMnetiO88746.
PhosphoSiteiO88746.

Proteomic databases

EPDiO88746.
PaxDbiO88746.
PeptideAtlasiO88746.
PRIDEiO88746.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165630; ENSMUSP00000130854; ENSMUSG00000042870. [O88746-1]
GeneIDi21968.
KEGGimmu:21968.
UCSCiuc009mha.2. mouse. [O88746-1]
uc009mhb.2. mouse. [O88746-2]

Organism-specific databases

CTDi10043.
MGIiMGI:1338026. Tom1.

Phylogenomic databases

eggNOGiKOG1087. Eukaryota.
ENOG410Y26G. LUCA.
GeneTreeiENSGT00700000104139.
HOGENOMiHOG000285970.
HOVERGENiHBG025068.
InParanoidiO88746.
PhylomeDBiO88746.
TreeFamiTF314105.

Miscellaneous databases

PMAP-CutDBO88746.
PROiO88746.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037827.
CleanExiMM_TOM1.
ExpressionAtlasiO88746. baseline.
GenevisibleiO88746. MM.

Family and domain databases

Gene3Di1.20.58.160. 1 hit.
1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR004152. GAT_dom.
IPR014645. TOM1.
IPR002014. VHS_dom.
[Graphical view]
PfamiPF03127. GAT. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PIRSFiPIRSF036948. TOM1. 1 hit.
SMARTiSM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS50909. GAT. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOM1_MOUSE
AccessioniPrimary (citable) accession number: O88746
Secondary accession number(s): Q3V4C6, Q9D120
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.