Reviewed, UniProtKB/Swiss-Prot O88741 (GDAP1_MOUSE)

Names and origin

Protein names

Recommended name:
    Ganglioside-induced differentiation-associated protein 1
      Short name=GDAP1

Gene names

Name:

Gdap1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May function in a signal transduction pathway responsible for ganglioside-induced neurite differentiation. May also have a role in protecting myelin membranes against free radical-mediated damage.
Subcellular location	Cytoplasm.
Tissue specificity	Expressed exclusively in brain.
Developmental stage	First expressed at embryonic stage E13. Levels then increase gradually to reach maximum levels at adulthood.
Induction	Increased expression during neural differentiation.
Sequence similarities	Belongs to the GST superfamily. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	response to retinoic acid Ref.1 Inferred from direct assay. Source: MGI
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O88741-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O88741-2)

The sequence of this isoform differs from the canonical sequence as follows:
     163-163: Q → M
     164-358: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Ganglioside-induced differentiation-associated protein 1		PRO_0000186039
Regions
	Domain	24 – 105	82	GST N-terminal
	Domain	153 – 309	157	GST C-terminal
Natural variations
	Alternative sequence	163	1	Q → M in isoform 2.		VSP_008791
	Alternative sequence	164 – 358	195	Missing in isoform 2.		VSP_008792

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 7B533CB34138891F	FASTA	358	41,311
	10 20 30 40 50 60 MARRQDEARA GVPLRVEGPP DKEVHLILYH WTHSFSSQKV RLVIAEKALK CEEHDVSLPL 70 80 90 100 110 120 SEHNEPWFMR LNSAGEVPVL VHGENIICEA TQIIDYLEQT FLDERTPRLM PDEGSMYYPR 130 140 150 160 170 180 VQHYRELLDS LPMDAYTHGC ILHPELTVDS MIPAYATTRI RSQIGNTESE LKKLAEENPD 190 200 210 220 230 240 LQEAYIAKQK RLKSKLLDHD NVKYLKKILD ELEKVLDQVE TELQRRNEET PEEGNQPWLC 250 260 270 280 290 300 GESFTLADVS LAVTLHRLKF LGFARRNWGH GKRPNLETYY ERVLKRKTFN KVLGHVNNIL 310 320 330 340 350 ISAVLPTAFR VAKKRAPKVL GSTLVVGLLV GMGYFAFMLF RRRLGSMILA LRPRPNYF
	Isoform 2. Checksum: 9EB6A9DF30B75DC3	FASTA	163	18,839
	10 20 30 40 50 60 MARRQDEARA GVPLRVEGPP DKEVHLILYH WTHSFSSQKV RLVIAEKALK CEEHDVSLPL 70 80 90 100 110 120 SEHNEPWFMR LNSAGEVPVL VHGENIICEA TQIIDYLEQT FLDERTPRLM PDEGSMYYPR 130 140 150 160 VQHYRELLDS LPMDAYTHGC ILHPELTVDS MIPAYATTRI RSM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of 10 differentially expressed cDNAs in differentiated Neuro2a cells induced through controlled expression of the GD3 synthase gene." Liu H., Nakagawa T., Kanematsu T., Uchida T., Tsuji S. J. Neurochem. 72:1781-1790(1999) [PubMed: 10217254] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: ICR. Tissue: Brain.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6J. Tissue: Brain, Spinal cord and Spinal ganglion.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6. Tissue: Brain.
[4]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 162-172; 215-225 AND 292-310, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y17850 mRNA. Translation: CAA76893.1. AK020988 mRNA. Translation: BAB32270.1. AK045460 mRNA. Translation: BAC32380.1. AK049655 mRNA. Translation: BAC33861.1. AK083814 mRNA. Translation: BAC39027.1. BC048177 mRNA. Translation: AAH48177.1. BC051135 mRNA. Translation: AAH51135.1.
IPI	IPI00134137. IPI00387592.
RefSeq	NP_034397.1.
UniGene	Mm.18218
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	O88741.
Proteomic databases
PRIDE	O88741.
Genome annotation databases
Ensembl	ENSMUSG00000025777. Mus musculus. [Contig view]
GeneID	14545.
KEGG	mmu:14545.
Organism-specific databases
MGI	MGI:1338002. Gdap1.
Phylogenomic databases
HOGENOM	O88741.
HOVERGEN	O88741.
OMA	O88741. GYFAFML.
Gene expression databases
ArrayExpress	O88741.
Bgee	O88741.
GermOnline	ENSMUSG00000025777. Mus musculus.
Family and domain databases
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:1.20.1050.10. GST_C_like. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	286220.
SOURCE	Search...

Entry information

Entry name

GDAP1_MOUSE

Accession

Primary (citable) accession number: O88741
Secondary accession number(s): Q8C7Q5, Q9CTN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	November 1, 1998
Last modified:	June 16, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)