O88738 (BIRC6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Baculoviral IAP repeat-containing protein 6
EC=6.3.2.-

Alternative name(s):
BIR repeat-containing ubiquitin-conjugating enzyme
Short name=BRUCE
Ubiquitin-conjugating BIR domain enzyme apollon
Short name=APOLLON

Gene names

Name:	Birc6
Synonyms:	Kiaa1289

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	4882 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Required for normal placenta development. Ref.1 Ref.5 Ref.6
Enzyme regulation	Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9 By similarity.
Subunit structure	Homodimer. Binds the activated, processed forms of CASP3, CASP6 and CASP7. Interacts with RNF41, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8 By similarity. Interacts with CASP9, DIABLO/SMAC and HTRA2. Ref.6
Subcellular location	Golgi apparatus › trans-Golgi network membrane By similarity. Midbody By similarity. Endosome By similarity. Cytoplasm › cytoskeleton › spindle pole By similarity. Cytoplasm › cytoskeleton › centrosome By similarity. Note: Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis By similarity.
Tissue specificity	Widely expressed. Highly expressed in the brain and kidney. Ref.1
Domain	The BIR domain is essential for its antiapoptotic function and is important for binding to DIABLO/SMAC and CASP9 By similarity.
Post-translational modification	Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY By similarity.
Disruption phenotype	Mice exhibit perinatal lethality and growth deficiencies, which are linked to a defect in proper placental development. Ref.5
Sequence similarities	In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family. Contains 1 BIR repeat.
Sequence caution	The sequence BAC32373.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC37801.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAA76720.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Apoptosis Cell cycle Cell division Mitosis Ubl conjugation pathway
Cellular component	Cytoplasm Cytoskeleton Endosome Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing
Molecular function	Ligase Protease inhibitor Thiol protease inhibitor
PTM	Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW labyrinthine layer development Inferred from mutant phenotype Ref.5. Source: MGI mitosis Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of apoptotic process Inferred from mutant phenotype Ref.6. Source: MGI positive regulation of cell proliferation Inferred from mutant phenotype PubMed 15887267. Source: MGI regulation of cytokinesis Inferred from sequence or structural similarity. Source: UniProtKB spongiotrophoblast layer development Inferred from mutant phenotype Ref.5. Source: MGI
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell endosome Inferred from sequence or structural similarity. Source: UniProtKB membrane Inferred from direct assay Ref.1. Source: MGI microtubule organizing center Inferred from sequence or structural similarity. Source: UniProtKB midbody Inferred from sequence or structural similarity. Source: UniProtKB spindle pole Inferred from electronic annotation. Source: UniProtKB-SubCell trans-Golgi network Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	cysteine-type endopeptidase inhibitor activity Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin-protein ligase activity Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O88738-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O88738-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2212-2220: Missing.

Isoform 3 (identifier: O88738-3)

The sequence of this isoform differs from the canonical sequence as follows:
     2057-2062: Missing.
     2212-2220: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 4882	4882	Baculoviral IAP repeat-containing protein 6		PRO_0000416247
Regions
	Repeat	292 – 362	71	BIR
	Region	4592 – 4720	129	Ubiquitin-conjugating By similarity
	Compositional bias	1669 – 1697	29	Ala-rich
	Compositional bias	2203 – 2206	4	Poly-Ala
	Compositional bias	2406 – 2410	5	Poly-Leu
	Compositional bias	2694 – 2697	4	Poly-Ser
	Compositional bias	2759 – 2764	6	Poly-Ser
	Compositional bias	4445 – 4450	6	Poly-Glu
Sites
	Active site	4691	1	Glycyl thioester intermediate By similarity
Amino acid modifications
	Modified residue	476	1	Phosphoserine Ref.7
	Modified residue	483	1	Phosphoserine Ref.8
	Modified residue	489	1	Phosphoserine Ref.7
	Modified residue	2976	1	Phosphoserine Ref.7
Natural variations
	Alternative sequence	2057 – 2062	6	Missing in isoform 3.		VSP_042536
	Alternative sequence	2212 – 2220	9	Missing in isoform 2 and isoform 3.		VSP_042537
Experimental info
	Sequence conflict	206	1	T → I in CAA76720. Ref.1
	Sequence conflict	552	1	S → R in BAC37801. Ref.3
	Sequence conflict	718	1	A → T in CAA76720. Ref.1
	Sequence conflict	2107	1	G → R in CAA76720. Ref.1
	Sequence conflict	2455	1	C → G in CAA76720. Ref.1
	Sequence conflict	2996	1	T → I in CAA76720. Ref.1
	Sequence conflict	3214	1	R → K in BAC35061. Ref.3
	Sequence conflict	3263	1	S → T in CAA76720. Ref.1
	Sequence conflict	3951	1	M → V in CAA76720. Ref.1
	Sequence conflict	3966	1	I → V in CAA76720. Ref.1
	Sequence conflict	4383	1	V → M in CAA76720. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 21, 2012. Version 2. Checksum: 6F804ACFA3AFA211	FASTA	4,882	532,170
	10 20 30 40 50 60 MVTGCGAAPP GTVTERLPSV IVLSAGRKMA AAAAEASGPS CSSAAAAAGA GAAGVSEWLV 70 80 90 100 110 120 LRDGCMRCDA DGLHSLSYHP ALNAILAVTS RGTIKVIDGT SGATLQASAL SAKPGGQVKC 130 140 150 160 170 180 QYISAVDKVI FVDDYAVGCR KDLNGILLLD TALQTPVSKQ DDVVQLELPV TEAQQLLSAC 190 200 210 220 230 240 IEKIDVSSTE GYDLFITQLK DGLKNTSHET AANHKVAKWA TVTFHLPHHV LKSIASAIVN 250 260 270 280 290 300 ELKKINQNVA ALPVASSVMD RLSYLLPSAR PELGVGPGRS VDRALMYSEA NRRETFTSWP 310 320 330 340 350 360 HVGYRWAQPD PMAQAGFYHQ PASSGDDRAM CFTCSVCLVC WEPTDEPWSE HERHSPNCPF 370 380 390 400 410 420 VKGEHTQNVP LSVTLATSPA QLPSADGADR IACFGSGSCP QFLAAATKRG KICIWDVSKL 430 440 450 460 470 480 MKVHLKFEIN AYDPAIVQQL ILSGDPSSGV DSRRPTLAWL EDSSSCSDIP KLEGDSDDLL 490 500 510 520 530 540 EDSDSEEHSR SDSVTGHTSQ KEAMEVSLDI TALSILQQPE KLQWEIVANV LEDTVKDLEE 550 560 570 580 590 600 LGANPSLTNS KSEKTKEKHQ EQHNIPFPCL LAGGLLTYKS PATSPISSNS HRSLDGLSRT 610 620 630 640 650 660 QGESISEQGS TDNESCTNSE LNSPLVRRTL PVLLLYSIKE SDEKAGKIFS QMNNIMSKSL 670 680 690 700 710 720 HDDGFTVPQI IEMELDNQEQ LLLQDPPVTY IQQFADAAAS LTSPDSEKWN SVFPKPGALV 730 740 750 760 770 780 QCLRLPKFAE EETLCIDSIT PCADGIHLLV GLRTCSVESL SAINQVEALN NLNKLNSALC 790 800 810 820 830 840 NRRKGDLESN LAVVNGANIS VIQHESPADV PEHLLIRPEQ RNVVSGGYLV LYKMNYTTRI 850 860 870 880 890 900 VTLEEEPVKI QHIKDPQDTI TSLILLPPDI LDNREDDCEE PAEEMQLASK NGIEREKKSD 910 920 930 940 950 960 ISTLGHLVVT TQGGYVKVLD LSNFEILAKV EPPKKEGTEE QDTFVSVIYC SGTDRLCACT 970 980 990 1000 1010 1020 KGGELHFLQI GGTCDDIDEA DILVDGSLSK GIEPALEGSR PLSNPSSPGI SGVELLVDQP 1030 1040 1050 1060 1070 1080 FTLEILTSLV ELTRFETLTP RFSATVPPCW VEVQQEQQQR RHPQHLHQQH HGDAAQHTRT 1090 1100 1110 1120 1130 1140 WKLQTDSNSW DEHVFELVLP KACMVGHVDF KFVLNSNITS VPQIQVTLLK NKAPGLGKAN 1150 1160 1170 1180 1190 1200 ALNIEVEHNG NPSLVDLNEE MHHMDVEESQ CLRLCPFLED HKEDILCGPV WLASGLDLSG 1210 1220 1230 1240 1250 1260 HAGMLTLTSP KLVKGMAGGK YRSFLIHVKA VSDRGAADEM CSSGLRPVVR LPSLKQQGHK 1270 1280 1290 1300 1310 1320 GYSLASLLAK VAAGKEKSSN VKNENAGGTR KSENLRGCDL LQEVSVTIRR FKKTSICKER 1330 1340 1350 1360 1370 1380 VQRCAMLQFS EFHEKLLNTL CRRSDDGQVT EHAQSLVLDA LCWLAGVHSN GSGSSKEGNE 1390 1400 1410 1420 1430 1440 CLLSKTRKCL SDIVRVCFFE AGRSIAHKCA RFLALCISNG KCEPCQPGFG SVLLKALLDN 1450 1460 1470 1480 1490 1500 MCFLPAAATG GSVYWYFVLL NYVKDEDLAG CSTACAALLT AVSRQLQDRL TPLEALLQTR 1510 1520 1530 1540 1550 1560 YGLYSSPFDP VLFDLEMSGS SWKTVYSSST AVQSDEIDLS DVLSGNGRVS SCTAAEGSFT 1570 1580 1590 1600 1610 1620 SLTGLLEVEP LHFTCVSTSD GTRIERDDAS TFTVSSFGVP PAVGGLSSGT VGEASTALSS 1630 1640 1650 1660 1670 1680 AAQVALQSLS HAMASAEQQL QVLQEKQQQL LKLQQQKAKL EAKLHQTTAA AAAAASAAAA 1690 1700 1710 1720 1730 1740 AAAGPVHNAV PSNPVAAPGF FIHPSDVIPP TPKTTPLFMT PPLTPPNEAV SVVINAELAQ 1750 1760 1770 1780 1790 1800 LFPGSVIDPP AVNLAAQNKN SSKSRMNPLG SGLALAISHA SHFLQPPPHQ SIIIERMHSG 1810 1820 1830 1840 1850 1860 ARRFVTLDFG RPILLTDVLI PTCGDLASLS IDIWTLGEEV DGRRLVVATD ISTHSLILHD 1870 1880 1890 1900 1910 1920 LIPPPVCRFM KITVIGRYGS TNARAKIPLG FYYGHSYILP WESELKLMHD PLRGEGESAS 1930 1940 1950 1960 1970 1980 QPEIDQHLAM MVALQEDIQC RYNLACHRLE ALLQSIDLPP LNSANNAQYF LRKPDKAVEE 1990 2000 2010 2020 2030 2040 DSRVFSAYQD CIQLQLQLNL AHNAVQRLKV AIGASRKLLN ETSGPEDLIQ TSSTEQLRTI 2050 2060 2070 2080 2090 2100 VRYLLDTLLS LLHSSNGHSV PAVLQSTFHA QACEELFKHL CISGTPKIRL HTGLLLVQLC 2110 2120 2130 2140 2150 2160 GGERWWGQFL SNVLQELYNS EQLLIFPQDR VFMLLSCIGQ RSLSNSGVLE SLLNLLDNLL 2170 2180 2190 2200 2210 2220 SPLQPELSMH RRTEGVLDIP MISWVVMLVS RLLDYVATVE DEAAAAKKPL NGKDRERFLT 2230 2240 2250 2260 2270 2280 GNQWSFINNN LHTQNLNRSS KGGSSLDRLY SRKIRKQLVH HKQQLNLLKA KQKALVEQME 2290 2300 2310 2320 2330 2340 KEKIQSNKGS SYKLLVEQAK LKQATSKHFK DLIRLRRTAE WSRSNLDTEV TTTKESPEIE 2350 2360 2370 2380 2390 2400 PLPFTLAHDR CISVVQKLVL FLLSMDFTCH ADLLLFVCKV LARIANATRP TIHLCEIVNE 2410 2420 2430 2440 2450 2460 PQLERLLLLL VGTDFNRGDI SWGGAWAQYS LTCMLQDILA GELLAPVAAE AMEECTVSED 2470 2480 2490 2500 2510 2520 VGATAGDSDD SLQQSPAQLL ETIDEPLTHE IAGTPPLSSL EKDKEIDLEL LQDLMEVDID 2530 2540 2550 2560 2570 2580 PLDIDLEKDP LAAKVFKPIS STWYDYWGAD YGTYNYNPYI GGLGMPVAKP PSNTEKNGSQ 2590 2600 2610 2620 2630 2640 TVSVSVSQAL DARLEVGLEQ QAELMLKMMS TLEADSILQA LTNTSPTFSQ SPTGTDDSLL 2650 2660 2670 2680 2690 2700 GNLQPANQNS QLMIQLSSVP MLNVCFNKLF SMLQVHHVQL ESLLQLWLTL SLNSSSSGNK 2710 2720 2730 2740 2750 2760 ENGADIFLYN ANRIPVISLN QASIASFLTV LAWYPNTLLR TWCLVLHSLT LMTNMQLNSG 2770 2780 2790 2800 2810 2820 SSSSIGIQET TAHLLVSDPN LIHVLVKFLS GTSPHGTNQH SPQVGPTATQ AMQEFLTRLQ 2830 2840 2850 2860 2870 2880 VHLSSTCPQI FSELLLKLIH ILSTERGAFQ TGQGPLDAQV KLLEFTLEQN FEVVSVSTIS 2890 2900 2910 2920 2930 2940 AVIESVTFLV HHYITCSDKV MSRSGSDSSA GARACFGGLF ANLIRPGDAK AVCGEMTRDQ 2950 2960 2970 2980 2990 3000 LMFDLLKLVN ILVQLPLSSN REYSARVSVT TNTTDSVSDE EKVSGGKDVN GSSASTPGSP 3010 3020 3030 3040 3050 3060 ACVADLVLAN QQIMSQILSA LGLCNSSAMA MIIGASGLHL TKHENFHGGL DAISVGDGLF 3070 3080 3090 3100 3110 3120 TILTTLSKKA STVHMMLQPI LTYMACGYMG RQGSLATCQL SEPLLWFILR VLDTSDALKA 3130 3140 3150 3160 3170 3180 FHDMGGVQLI CNNMVTSTRA IVNTARSMVS TIMKFLDSGP NKAVDSTLKT RILASEPDNA 3190 3200 3210 3220 3230 3240 EGIHNFAPLG TITSSSPTAQ PAEVLLQATP PHRRARSAAW SYIFLPEEAW CDLTIHLPSA 3250 3260 3270 3280 3290 3300 VLLKEIHIQP HLASLATCPS SVSVEVSADG VNMLPLSTPV VTSGLTYIKI QLVKAEVASA 3310 3320 3330 3340 3350 3360 VCLRLHRPRD ASTLGLSQIK LLGLTAFGTT SSATVNNPFL PSEDQVSKTS IGWLRLLHHC 3370 3380 3390 3400 3410 3420 LTHISDLEGM MASAAAPTAN LLQTCAALLM SPYCGMHSPN IEVVLVKIGL QSTRIGLKLI 3430 3440 3450 3460 3470 3480 DILLRNCAAS GSDPTDLNSP LLFGRLNGLS SDSTIDILYQ LGTTQDPGTK DRIQALLKWV 3490 3500 3510 3520 3530 3540 SDSAKMAALK RSGRMNYMCP SSSAVEYGLL MPSPSHLHCV AAILWHSYEL LVEYDLPALL 3550 3560 3570 3580 3590 3600 DRELFELLFN WSMSLPCNVV LKKAVDSLLC SMCHIHPNYF SLLMGWMGII PPPVQCHHRL 3610 3620 3630 3640 3650 3660 SMTDDSKKQD LSSSLTDDSK NAQAPLSLTE SHLATLASSS QSPEAIKQLL DSGLPSLLVR 3670 3680 3690 3700 3710 3720 SLASFCFSHI SYSESIAQSV DNSQDKLRRH HVPQHCNKMP ITADLVAPIL RFLTEVGNSH 3730 3740 3750 3760 3770 3780 IMKDWLGGSE VNPLWTALLF LLCHSGSTAG GHNLGAQQSS TRSASHSSAT TTVLTTQQRT 3790 3800 3810 3820 3830 3840 AIENATVAFF LQCISCHPNN QKLMAQVLCE LFQTAPQRGS LPTSGNISGF VRRLFLQLML 3850 3860 3870 3880 3890 3900 EDEKVTMFLQ SPCPLYKGRI NATSHVIQHP MFGAGHKFRT LHLPVSTTLS DVLDRVSDTP 3910 3920 3930 3940 3950 3960 SITAKLISEQ KDDKEKKNHE EKEKVKAENG FQDNYSVVVA SGLKSQSKRA MASTPPRPPS 3970 3980 3990 4000 4010 4020 RRGRTIPDKI GSASSSADAA SKIITVPVFH LFHRLLAGQP LPAEMTLAQL LTLLYDRKLP 4030 4040 4050 4060 4070 4080 QGYRSIDLTV KLGSKVITDP SLSKTDSFKR LHPEKDHGDL VGSCPEDEAL TPSDECMDGV 4090 4100 4110 4120 4130 4140 LDESLLETCP IQSPLQVFAG MGGLALIAER LPMLYPEVIQ QVSAPVIAST TQEKPKDSDQ 4150 4160 4170 4180 4190 4200 FEWVTIEQSG ELVYEAPETI AAEPPPVKSA VQATSPIPAH SLAAFGLFLR LPGYAEVLLK 4210 4220 4230 4240 4250 4260 ERKHAQCLLR LVLGVTDDGE GSHILQSPSA NVLPTLPFHV LRSLFSATPL TTDDGVLLRR 4270 4280 4290 4300 4310 4320 MALEIGALHL ILVCLSALSH HAPRVPNSSL SQTEPQVSNS HNPTSAEEQQ LYWAKGTGFG 4330 4340 4350 4360 4370 4380 TGSTASGWDV EQALTKQRLE EEHVTCLLQV LASYINPMSG AVNGEAQASP ESRAQNSSAL 4390 4400 4410 4420 4430 4440 PSVLLELLSQ SCLIPAMSSY LRNDSVLDMA RHVPLYRALL ELLRAIASCT SMVPLLLPLS 4450 4460 4470 4480 4490 4500 TENGEEEEDE QSECQTSVGT LLAKMKTCVD TYTNRLRSKR ENVKAGVKPD APDQEPEGLA 4510 4520 4530 4540 4550 4560 LLVPDIQRTA EIVHAATANL RQANQEKKLG EYSKKVVMKP KPLSVLKSLE EKYVAVMKKL 4570 4580 4590 4600 4610 4620 QFDTFEMVSE DDDGKLGFKV NYHYMSQVKN ANDANSAARA RRLAQEAVTL STSLPLSSSS 4630 4640 4650 4660 4670 4680 SVFVRCDEER LDIMKVLITG PADTPYANGC FEFDVYFPQD YPSSPPLVNL ETTGGHSVRF 4690 4700 4710 4720 4730 4740 NPNLYNDGKV CLSILNTWHG RPEEKWNPQT SSFLQVLVSV QSLILVAEPY FNEPGYERSR 4750 4760 4770 4780 4790 4800 GTPSGTQSSR EYDGNIRQAT VKWAMLEQIR NPSPCFKEVI HKHFYLKRIE LMAQCEEWIA 4810 4820 4830 4840 4850 4860 DIQQYSSDKR VGRTMSHHAA ALKRHTAQLR EELLKLPCPE GLDPDIEDAS PVCRATAGAE 4870 4880 DTLTHDHVNP SSSKDLPSDF QL
	Isoform 2 [UniParc]. Checksum: 58562C9F94576EF2	FASTA	4,873	531,067
	10 20 30 40 50 60 MVTGCGAAPP GTVTERLPSV IVLSAGRKMA AAAAEASGPS CSSAAAAAGA GAAGVSEWLV 70 80 90 100 110 120 LRDGCMRCDA DGLHSLSYHP ALNAILAVTS RGTIKVIDGT SGATLQASAL SAKPGGQVKC 130 140 150 160 170 180 QYISAVDKVI FVDDYAVGCR KDLNGILLLD TALQTPVSKQ DDVVQLELPV TEAQQLLSAC 190 200 210 220 230 240 IEKIDVSSTE GYDLFITQLK DGLKNTSHET AANHKVAKWA TVTFHLPHHV LKSIASAIVN 250 260 270 280 290 300 ELKKINQNVA ALPVASSVMD RLSYLLPSAR PELGVGPGRS VDRALMYSEA NRRETFTSWP 310 320 330 340 350 360 HVGYRWAQPD PMAQAGFYHQ PASSGDDRAM CFTCSVCLVC WEPTDEPWSE HERHSPNCPF 370 380 390 400 410 420 VKGEHTQNVP LSVTLATSPA QLPSADGADR IACFGSGSCP QFLAAATKRG KICIWDVSKL 430 440 450 460 470 480 MKVHLKFEIN AYDPAIVQQL ILSGDPSSGV DSRRPTLAWL EDSSSCSDIP KLEGDSDDLL 490 500 510 520 530 540 EDSDSEEHSR SDSVTGHTSQ KEAMEVSLDI TALSILQQPE KLQWEIVANV LEDTVKDLEE 550 560 570 580 590 600 LGANPSLTNS KSEKTKEKHQ EQHNIPFPCL LAGGLLTYKS PATSPISSNS HRSLDGLSRT 610 620 630 640 650 660 QGESISEQGS TDNESCTNSE LNSPLVRRTL PVLLLYSIKE SDEKAGKIFS QMNNIMSKSL 670 680 690 700 710 720 HDDGFTVPQI IEMELDNQEQ LLLQDPPVTY IQQFADAAAS LTSPDSEKWN SVFPKPGALV 730 740 750 760 770 780 QCLRLPKFAE EETLCIDSIT PCADGIHLLV GLRTCSVESL SAINQVEALN NLNKLNSALC 790 800 810 820 830 840 NRRKGDLESN LAVVNGANIS VIQHESPADV PEHLLIRPEQ RNVVSGGYLV LYKMNYTTRI 850 860 870 880 890 900 VTLEEEPVKI QHIKDPQDTI TSLILLPPDI LDNREDDCEE PAEEMQLASK NGIEREKKSD 910 920 930 940 950 960 ISTLGHLVVT TQGGYVKVLD LSNFEILAKV EPPKKEGTEE QDTFVSVIYC SGTDRLCACT 970 980 990 1000 1010 1020 KGGELHFLQI GGTCDDIDEA DILVDGSLSK GIEPALEGSR PLSNPSSPGI SGVELLVDQP 1030 1040 1050 1060 1070 1080 FTLEILTSLV ELTRFETLTP RFSATVPPCW VEVQQEQQQR RHPQHLHQQH HGDAAQHTRT 1090 1100 1110 1120 1130 1140 WKLQTDSNSW DEHVFELVLP KACMVGHVDF KFVLNSNITS VPQIQVTLLK NKAPGLGKAN 1150 1160 1170 1180 1190 1200 ALNIEVEHNG NPSLVDLNEE MHHMDVEESQ CLRLCPFLED HKEDILCGPV WLASGLDLSG 1210 1220 1230 1240 1250 1260 HAGMLTLTSP KLVKGMAGGK YRSFLIHVKA VSDRGAADEM CSSGLRPVVR LPSLKQQGHK 1270 1280 1290 1300 1310 1320 GYSLASLLAK VAAGKEKSSN VKNENAGGTR KSENLRGCDL LQEVSVTIRR FKKTSICKER 1330 1340 1350 1360 1370 1380 VQRCAMLQFS EFHEKLLNTL CRRSDDGQVT EHAQSLVLDA LCWLAGVHSN GSGSSKEGNE 1390 1400 1410 1420 1430 1440 CLLSKTRKCL SDIVRVCFFE AGRSIAHKCA RFLALCISNG KCEPCQPGFG SVLLKALLDN 1450 1460 1470 1480 1490 1500 MCFLPAAATG GSVYWYFVLL NYVKDEDLAG CSTACAALLT AVSRQLQDRL TPLEALLQTR 1510 1520 1530 1540 1550 1560 YGLYSSPFDP VLFDLEMSGS SWKTVYSSST AVQSDEIDLS DVLSGNGRVS SCTAAEGSFT 1570 1580 1590 1600 1610 1620 SLTGLLEVEP LHFTCVSTSD GTRIERDDAS TFTVSSFGVP PAVGGLSSGT VGEASTALSS 1630 1640 1650 1660 1670 1680 AAQVALQSLS HAMASAEQQL QVLQEKQQQL LKLQQQKAKL EAKLHQTTAA AAAAASAAAA 1690 1700 1710 1720 1730 1740 AAAGPVHNAV PSNPVAAPGF FIHPSDVIPP TPKTTPLFMT PPLTPPNEAV SVVINAELAQ 1750 1760 1770 1780 1790 1800 LFPGSVIDPP AVNLAAQNKN SSKSRMNPLG SGLALAISHA SHFLQPPPHQ SIIIERMHSG 1810 1820 1830 1840 1850 1860 ARRFVTLDFG RPILLTDVLI PTCGDLASLS IDIWTLGEEV DGRRLVVATD ISTHSLILHD 1870 1880 1890 1900 1910 1920 LIPPPVCRFM KITVIGRYGS TNARAKIPLG FYYGHSYILP WESELKLMHD PLRGEGESAS 1930 1940 1950 1960 1970 1980 QPEIDQHLAM MVALQEDIQC RYNLACHRLE ALLQSIDLPP LNSANNAQYF LRKPDKAVEE 1990 2000 2010 2020 2030 2040 DSRVFSAYQD CIQLQLQLNL AHNAVQRLKV AIGASRKLLN ETSGPEDLIQ TSSTEQLRTI 2050 2060 2070 2080 2090 2100 VRYLLDTLLS LLHSSNGHSV PAVLQSTFHA QACEELFKHL CISGTPKIRL HTGLLLVQLC 2110 2120 2130 2140 2150 2160 GGERWWGQFL SNVLQELYNS EQLLIFPQDR VFMLLSCIGQ RSLSNSGVLE SLLNLLDNLL 2170 2180 2190 2200 2210 2220 SPLQPELSMH RRTEGVLDIP MISWVVMLVS RLLDYVATVE DEAAAAKKPL NGNQWSFINN 2230 2240 2250 2260 2270 2280 NLHTQNLNRS SKGGSSLDRL YSRKIRKQLV HHKQQLNLLK AKQKALVEQM EKEKIQSNKG 2290 2300 2310 2320 2330 2340 SSYKLLVEQA KLKQATSKHF KDLIRLRRTA EWSRSNLDTE VTTTKESPEI EPLPFTLAHD 2350 2360 2370 2380 2390 2400 RCISVVQKLV LFLLSMDFTC HADLLLFVCK VLARIANATR PTIHLCEIVN EPQLERLLLL 2410 2420 2430 2440 2450 2460 LVGTDFNRGD ISWGGAWAQY SLTCMLQDIL AGELLAPVAA EAMEECTVSE DVGATAGDSD 2470 2480 2490 2500 2510 2520 DSLQQSPAQL LETIDEPLTH EIAGTPPLSS LEKDKEIDLE LLQDLMEVDI DPLDIDLEKD 2530 2540 2550 2560 2570 2580 PLAAKVFKPI SSTWYDYWGA DYGTYNYNPY IGGLGMPVAK PPSNTEKNGS QTVSVSVSQA 2590 2600 2610 2620 2630 2640 LDARLEVGLE QQAELMLKMM STLEADSILQ ALTNTSPTFS QSPTGTDDSL LGNLQPANQN 2650 2660 2670 2680 2690 2700 SQLMIQLSSV PMLNVCFNKL FSMLQVHHVQ LESLLQLWLT LSLNSSSSGN KENGADIFLY 2710 2720 2730 2740 2750 2760 NANRIPVISL NQASIASFLT VLAWYPNTLL RTWCLVLHSL TLMTNMQLNS GSSSSIGIQE 2770 2780 2790 2800 2810 2820 TTAHLLVSDP NLIHVLVKFL SGTSPHGTNQ HSPQVGPTAT QAMQEFLTRL QVHLSSTCPQ 2830 2840 2850 2860 2870 2880 IFSELLLKLI HILSTERGAF QTGQGPLDAQ VKLLEFTLEQ NFEVVSVSTI SAVIESVTFL 2890 2900 2910 2920 2930 2940 VHHYITCSDK VMSRSGSDSS AGARACFGGL FANLIRPGDA KAVCGEMTRD QLMFDLLKLV 2950 2960 2970 2980 2990 3000 NILVQLPLSS NREYSARVSV TTNTTDSVSD EEKVSGGKDV NGSSASTPGS PACVADLVLA 3010 3020 3030 3040 3050 3060 NQQIMSQILS ALGLCNSSAM AMIIGASGLH LTKHENFHGG LDAISVGDGL FTILTTLSKK 3070 3080 3090 3100 3110 3120 ASTVHMMLQP ILTYMACGYM GRQGSLATCQ LSEPLLWFIL RVLDTSDALK AFHDMGGVQL 3130 3140 3150 3160 3170 3180 ICNNMVTSTR AIVNTARSMV STIMKFLDSG PNKAVDSTLK TRILASEPDN AEGIHNFAPL 3190 3200 3210 3220 3230 3240 GTITSSSPTA QPAEVLLQAT PPHRRARSAA WSYIFLPEEA WCDLTIHLPS AVLLKEIHIQ 3250 3260 3270 3280 3290 3300 PHLASLATCP SSVSVEVSAD GVNMLPLSTP VVTSGLTYIK IQLVKAEVAS AVCLRLHRPR 3310 3320 3330 3340 3350 3360 DASTLGLSQI KLLGLTAFGT TSSATVNNPF LPSEDQVSKT SIGWLRLLHH CLTHISDLEG 3370 3380 3390 3400 3410 3420 MMASAAAPTA NLLQTCAALL MSPYCGMHSP NIEVVLVKIG LQSTRIGLKL IDILLRNCAA 3430 3440 3450 3460 3470 3480 SGSDPTDLNS PLLFGRLNGL SSDSTIDILY QLGTTQDPGT KDRIQALLKW VSDSAKMAAL 3490 3500 3510 3520 3530 3540 KRSGRMNYMC PSSSAVEYGL LMPSPSHLHC VAAILWHSYE LLVEYDLPAL LDRELFELLF 3550 3560 3570 3580 3590 3600 NWSMSLPCNV VLKKAVDSLL CSMCHIHPNY FSLLMGWMGI IPPPVQCHHR LSMTDDSKKQ 3610 3620 3630 3640 3650 3660 DLSSSLTDDS KNAQAPLSLT ESHLATLASS SQSPEAIKQL LDSGLPSLLV RSLASFCFSH 3670 3680 3690 3700 3710 3720 ISYSESIAQS VDNSQDKLRR HHVPQHCNKM PITADLVAPI LRFLTEVGNS HIMKDWLGGS 3730 3740 3750 3760 3770 3780 EVNPLWTALL FLLCHSGSTA GGHNLGAQQS STRSASHSSA TTTVLTTQQR TAIENATVAF 3790 3800 3810 3820 3830 3840 FLQCISCHPN NQKLMAQVLC ELFQTAPQRG SLPTSGNISG FVRRLFLQLM LEDEKVTMFL 3850 3860 3870 3880 3890 3900 QSPCPLYKGR INATSHVIQH PMFGAGHKFR TLHLPVSTTL SDVLDRVSDT PSITAKLISE 3910 3920 3930 3940 3950 3960 QKDDKEKKNH EEKEKVKAEN GFQDNYSVVV ASGLKSQSKR AMASTPPRPP SRRGRTIPDK 3970 3980 3990 4000 4010 4020 IGSASSSADA ASKIITVPVF HLFHRLLAGQ PLPAEMTLAQ LLTLLYDRKL PQGYRSIDLT 4030 4040 4050 4060 4070 4080 VKLGSKVITD PSLSKTDSFK RLHPEKDHGD LVGSCPEDEA LTPSDECMDG VLDESLLETC 4090 4100 4110 4120 4130 4140 PIQSPLQVFA GMGGLALIAE RLPMLYPEVI QQVSAPVIAS TTQEKPKDSD QFEWVTIEQS 4150 4160 4170 4180 4190 4200 GELVYEAPET IAAEPPPVKS AVQATSPIPA HSLAAFGLFL RLPGYAEVLL KERKHAQCLL 4210 4220 4230 4240 4250 4260 RLVLGVTDDG EGSHILQSPS ANVLPTLPFH VLRSLFSATP LTTDDGVLLR RMALEIGALH 4270 4280 4290 4300 4310 4320 LILVCLSALS HHAPRVPNSS LSQTEPQVSN SHNPTSAEEQ QLYWAKGTGF GTGSTASGWD 4330 4340 4350 4360 4370 4380 VEQALTKQRL EEEHVTCLLQ VLASYINPMS GAVNGEAQAS PESRAQNSSA LPSVLLELLS 4390 4400 4410 4420 4430 4440 QSCLIPAMSS YLRNDSVLDM ARHVPLYRAL LELLRAIASC TSMVPLLLPL STENGEEEED 4450 4460 4470 4480 4490 4500 EQSECQTSVG TLLAKMKTCV DTYTNRLRSK RENVKAGVKP DAPDQEPEGL ALLVPDIQRT 4510 4520 4530 4540 4550 4560 AEIVHAATAN LRQANQEKKL GEYSKKVVMK PKPLSVLKSL EEKYVAVMKK LQFDTFEMVS 4570 4580 4590 4600 4610 4620 EDDDGKLGFK VNYHYMSQVK NANDANSAAR ARRLAQEAVT LSTSLPLSSS SSVFVRCDEE 4630 4640 4650 4660 4670 4680 RLDIMKVLIT GPADTPYANG CFEFDVYFPQ DYPSSPPLVN LETTGGHSVR FNPNLYNDGK 4690 4700 4710 4720 4730 4740 VCLSILNTWH GRPEEKWNPQ TSSFLQVLVS VQSLILVAEP YFNEPGYERS RGTPSGTQSS 4750 4760 4770 4780 4790 4800 REYDGNIRQA TVKWAMLEQI RNPSPCFKEV IHKHFYLKRI ELMAQCEEWI ADIQQYSSDK 4810 4820 4830 4840 4850 4860 RVGRTMSHHA AALKRHTAQL REELLKLPCP EGLDPDIEDA SPVCRATAGA EDTLTHDHVN 4870 PSSSKDLPSD FQL
	Isoform 3 [UniParc]. Checksum: A6386423866153B0	FASTA	4,867	530,518
	10 20 30 40 50 60 MVTGCGAAPP GTVTERLPSV IVLSAGRKMA AAAAEASGPS CSSAAAAAGA GAAGVSEWLV 70 80 90 100 110 120 LRDGCMRCDA DGLHSLSYHP ALNAILAVTS RGTIKVIDGT SGATLQASAL SAKPGGQVKC 130 140 150 160 170 180 QYISAVDKVI FVDDYAVGCR KDLNGILLLD TALQTPVSKQ DDVVQLELPV TEAQQLLSAC 190 200 210 220 230 240 IEKIDVSSTE GYDLFITQLK DGLKNTSHET AANHKVAKWA TVTFHLPHHV LKSIASAIVN 250 260 270 280 290 300 ELKKINQNVA ALPVASSVMD RLSYLLPSAR PELGVGPGRS VDRALMYSEA NRRETFTSWP 310 320 330 340 350 360 HVGYRWAQPD PMAQAGFYHQ PASSGDDRAM CFTCSVCLVC WEPTDEPWSE HERHSPNCPF 370 380 390 400 410 420 VKGEHTQNVP LSVTLATSPA QLPSADGADR IACFGSGSCP QFLAAATKRG KICIWDVSKL 430 440 450 460 470 480 MKVHLKFEIN AYDPAIVQQL ILSGDPSSGV DSRRPTLAWL EDSSSCSDIP KLEGDSDDLL 490 500 510 520 530 540 EDSDSEEHSR SDSVTGHTSQ KEAMEVSLDI TALSILQQPE KLQWEIVANV LEDTVKDLEE 550 560 570 580 590 600 LGANPSLTNS KSEKTKEKHQ EQHNIPFPCL LAGGLLTYKS PATSPISSNS HRSLDGLSRT 610 620 630 640 650 660 QGESISEQGS TDNESCTNSE LNSPLVRRTL PVLLLYSIKE SDEKAGKIFS QMNNIMSKSL 670 680 690 700 710 720 HDDGFTVPQI IEMELDNQEQ LLLQDPPVTY IQQFADAAAS LTSPDSEKWN SVFPKPGALV 730 740 750 760 770 780 QCLRLPKFAE EETLCIDSIT PCADGIHLLV GLRTCSVESL SAINQVEALN NLNKLNSALC 790 800 810 820 830 840 NRRKGDLESN LAVVNGANIS VIQHESPADV PEHLLIRPEQ RNVVSGGYLV LYKMNYTTRI 850 860 870 880 890 900 VTLEEEPVKI QHIKDPQDTI TSLILLPPDI LDNREDDCEE PAEEMQLASK NGIEREKKSD 910 920 930 940 950 960 ISTLGHLVVT TQGGYVKVLD LSNFEILAKV EPPKKEGTEE QDTFVSVIYC SGTDRLCACT 970 980 990 1000 1010 1020 KGGELHFLQI GGTCDDIDEA DILVDGSLSK GIEPALEGSR PLSNPSSPGI SGVELLVDQP 1030 1040 1050 1060 1070 1080 FTLEILTSLV ELTRFETLTP RFSATVPPCW VEVQQEQQQR RHPQHLHQQH HGDAAQHTRT 1090 1100 1110 1120 1130 1140 WKLQTDSNSW DEHVFELVLP KACMVGHVDF KFVLNSNITS VPQIQVTLLK NKAPGLGKAN 1150 1160 1170 1180 1190 1200 ALNIEVEHNG NPSLVDLNEE MHHMDVEESQ CLRLCPFLED HKEDILCGPV WLASGLDLSG 1210 1220 1230 1240 1250 1260 HAGMLTLTSP KLVKGMAGGK YRSFLIHVKA VSDRGAADEM CSSGLRPVVR LPSLKQQGHK 1270 1280 1290 1300 1310 1320 GYSLASLLAK VAAGKEKSSN VKNENAGGTR KSENLRGCDL LQEVSVTIRR FKKTSICKER 1330 1340 1350 1360 1370 1380 VQRCAMLQFS EFHEKLLNTL CRRSDDGQVT EHAQSLVLDA LCWLAGVHSN GSGSSKEGNE 1390 1400 1410 1420 1430 1440 CLLSKTRKCL SDIVRVCFFE AGRSIAHKCA RFLALCISNG KCEPCQPGFG SVLLKALLDN 1450 1460 1470 1480 1490 1500 MCFLPAAATG GSVYWYFVLL NYVKDEDLAG CSTACAALLT AVSRQLQDRL TPLEALLQTR 1510 1520 1530 1540 1550 1560 YGLYSSPFDP VLFDLEMSGS SWKTVYSSST AVQSDEIDLS DVLSGNGRVS SCTAAEGSFT 1570 1580 1590 1600 1610 1620 SLTGLLEVEP LHFTCVSTSD GTRIERDDAS TFTVSSFGVP PAVGGLSSGT VGEASTALSS 1630 1640 1650 1660 1670 1680 AAQVALQSLS HAMASAEQQL QVLQEKQQQL LKLQQQKAKL EAKLHQTTAA AAAAASAAAA 1690 1700 1710 1720 1730 1740 AAAGPVHNAV PSNPVAAPGF FIHPSDVIPP TPKTTPLFMT PPLTPPNEAV SVVINAELAQ 1750 1760 1770 1780 1790 1800 LFPGSVIDPP AVNLAAQNKN SSKSRMNPLG SGLALAISHA SHFLQPPPHQ SIIIERMHSG 1810 1820 1830 1840 1850 1860 ARRFVTLDFG RPILLTDVLI PTCGDLASLS IDIWTLGEEV DGRRLVVATD ISTHSLILHD 1870 1880 1890 1900 1910 1920 LIPPPVCRFM KITVIGRYGS TNARAKIPLG FYYGHSYILP WESELKLMHD PLRGEGESAS 1930 1940 1950 1960 1970 1980 QPEIDQHLAM MVALQEDIQC RYNLACHRLE ALLQSIDLPP LNSANNAQYF LRKPDKAVEE 1990 2000 2010 2020 2030 2040 DSRVFSAYQD CIQLQLQLNL AHNAVQRLKV AIGASRKLLN ETSGPEDLIQ TSSTEQLRTI 2050 2060 2070 2080 2090 2100 VRYLLDTLLS LLHSSNVLQS TFHAQACEEL FKHLCISGTP KIRLHTGLLL VQLCGGERWW 2110 2120 2130 2140 2150 2160 GQFLSNVLQE LYNSEQLLIF PQDRVFMLLS CIGQRSLSNS GVLESLLNLL DNLLSPLQPE 2170 2180 2190 2200 2210 2220 LSMHRRTEGV LDIPMISWVV MLVSRLLDYV ATVEDEAAAA KKPLNGNQWS FINNNLHTQN 2230 2240 2250 2260 2270 2280 LNRSSKGGSS LDRLYSRKIR KQLVHHKQQL NLLKAKQKAL VEQMEKEKIQ SNKGSSYKLL 2290 2300 2310 2320 2330 2340 VEQAKLKQAT SKHFKDLIRL RRTAEWSRSN LDTEVTTTKE SPEIEPLPFT LAHDRCISVV 2350 2360 2370 2380 2390 2400 QKLVLFLLSM DFTCHADLLL FVCKVLARIA NATRPTIHLC EIVNEPQLER LLLLLVGTDF 2410 2420 2430 2440 2450 2460 NRGDISWGGA WAQYSLTCML QDILAGELLA PVAAEAMEEC TVSEDVGATA GDSDDSLQQS 2470 2480 2490 2500 2510 2520 PAQLLETIDE PLTHEIAGTP PLSSLEKDKE IDLELLQDLM EVDIDPLDID LEKDPLAAKV 2530 2540 2550 2560 2570 2580 FKPISSTWYD YWGADYGTYN YNPYIGGLGM PVAKPPSNTE KNGSQTVSVS VSQALDARLE 2590 2600 2610 2620 2630 2640 VGLEQQAELM LKMMSTLEAD SILQALTNTS PTFSQSPTGT DDSLLGNLQP ANQNSQLMIQ 2650 2660 2670 2680 2690 2700 LSSVPMLNVC FNKLFSMLQV HHVQLESLLQ LWLTLSLNSS SSGNKENGAD IFLYNANRIP 2710 2720 2730 2740 2750 2760 VISLNQASIA SFLTVLAWYP NTLLRTWCLV LHSLTLMTNM QLNSGSSSSI GIQETTAHLL 2770 2780 2790 2800 2810 2820 VSDPNLIHVL VKFLSGTSPH GTNQHSPQVG PTATQAMQEF LTRLQVHLSS TCPQIFSELL 2830 2840 2850 2860 2870 2880 LKLIHILSTE RGAFQTGQGP LDAQVKLLEF TLEQNFEVVS VSTISAVIES VTFLVHHYIT 2890 2900 2910 2920 2930 2940 CSDKVMSRSG SDSSAGARAC FGGLFANLIR PGDAKAVCGE MTRDQLMFDL LKLVNILVQL 2950 2960 2970 2980 2990 3000 PLSSNREYSA RVSVTTNTTD SVSDEEKVSG GKDVNGSSAS TPGSPACVAD LVLANQQIMS 3010 3020 3030 3040 3050 3060 QILSALGLCN SSAMAMIIGA SGLHLTKHEN FHGGLDAISV GDGLFTILTT LSKKASTVHM 3070 3080 3090 3100 3110 3120 MLQPILTYMA CGYMGRQGSL ATCQLSEPLL WFILRVLDTS DALKAFHDMG GVQLICNNMV 3130 3140 3150 3160 3170 3180 TSTRAIVNTA RSMVSTIMKF LDSGPNKAVD STLKTRILAS EPDNAEGIHN FAPLGTITSS 3190 3200 3210 3220 3230 3240 SPTAQPAEVL LQATPPHRRA RSAAWSYIFL PEEAWCDLTI HLPSAVLLKE IHIQPHLASL 3250 3260 3270 3280 3290 3300 ATCPSSVSVE VSADGVNMLP LSTPVVTSGL TYIKIQLVKA EVASAVCLRL HRPRDASTLG 3310 3320 3330 3340 3350 3360 LSQIKLLGLT AFGTTSSATV NNPFLPSEDQ VSKTSIGWLR LLHHCLTHIS DLEGMMASAA 3370 3380 3390 3400 3410 3420 APTANLLQTC AALLMSPYCG MHSPNIEVVL VKIGLQSTRI GLKLIDILLR NCAASGSDPT 3430 3440 3450 3460 3470 3480 DLNSPLLFGR LNGLSSDSTI DILYQLGTTQ DPGTKDRIQA LLKWVSDSAK MAALKRSGRM 3490 3500 3510 3520 3530 3540 NYMCPSSSAV EYGLLMPSPS HLHCVAAILW HSYELLVEYD LPALLDRELF ELLFNWSMSL 3550 3560 3570 3580 3590 3600 PCNVVLKKAV DSLLCSMCHI HPNYFSLLMG WMGIIPPPVQ CHHRLSMTDD SKKQDLSSSL 3610 3620 3630 3640 3650 3660 TDDSKNAQAP LSLTESHLAT LASSSQSPEA IKQLLDSGLP SLLVRSLASF CFSHISYSES 3670 3680 3690 3700 3710 3720 IAQSVDNSQD KLRRHHVPQH CNKMPITADL VAPILRFLTE VGNSHIMKDW LGGSEVNPLW 3730 3740 3750 3760 3770 3780 TALLFLLCHS GSTAGGHNLG AQQSSTRSAS HSSATTTVLT TQQRTAIENA TVAFFLQCIS 3790 3800 3810 3820 3830 3840 CHPNNQKLMA QVLCELFQTA PQRGSLPTSG NISGFVRRLF LQLMLEDEKV TMFLQSPCPL 3850 3860 3870 3880 3890 3900 YKGRINATSH VIQHPMFGAG HKFRTLHLPV STTLSDVLDR VSDTPSITAK LISEQKDDKE 3910 3920 3930 3940 3950 3960 KKNHEEKEKV KAENGFQDNY SVVVASGLKS QSKRAMASTP PRPPSRRGRT IPDKIGSASS 3970 3980 3990 4000 4010 4020 SADAASKIIT VPVFHLFHRL LAGQPLPAEM TLAQLLTLLY DRKLPQGYRS IDLTVKLGSK 4030 4040 4050 4060 4070 4080 VITDPSLSKT DSFKRLHPEK DHGDLVGSCP EDEALTPSDE CMDGVLDESL LETCPIQSPL 4090 4100 4110 4120 4130 4140 QVFAGMGGLA LIAERLPMLY PEVIQQVSAP VIASTTQEKP KDSDQFEWVT IEQSGELVYE 4150 4160 4170 4180 4190 4200 APETIAAEPP PVKSAVQATS PIPAHSLAAF GLFLRLPGYA EVLLKERKHA QCLLRLVLGV 4210 4220 4230 4240 4250 4260 TDDGEGSHIL QSPSANVLPT LPFHVLRSLF SATPLTTDDG VLLRRMALEI GALHLILVCL 4270 4280 4290 4300 4310 4320 SALSHHAPRV PNSSLSQTEP QVSNSHNPTS AEEQQLYWAK GTGFGTGSTA SGWDVEQALT 4330 4340 4350 4360 4370 4380 KQRLEEEHVT CLLQVLASYI NPMSGAVNGE AQASPESRAQ NSSALPSVLL ELLSQSCLIP 4390 4400 4410 4420 4430 4440 AMSSYLRNDS VLDMARHVPL YRALLELLRA IASCTSMVPL LLPLSTENGE EEEDEQSECQ 4450 4460 4470 4480 4490 4500 TSVGTLLAKM KTCVDTYTNR LRSKRENVKA GVKPDAPDQE PEGLALLVPD IQRTAEIVHA 4510 4520 4530 4540 4550 4560 ATANLRQANQ EKKLGEYSKK VVMKPKPLSV LKSLEEKYVA VMKKLQFDTF EMVSEDDDGK 4570 4580 4590 4600 4610 4620 LGFKVNYHYM SQVKNANDAN SAARARRLAQ EAVTLSTSLP LSSSSSVFVR CDEERLDIMK 4630 4640 4650 4660 4670 4680 VLITGPADTP YANGCFEFDV YFPQDYPSSP PLVNLETTGG HSVRFNPNLY NDGKVCLSIL 4690 4700 4710 4720 4730 4740 NTWHGRPEEK WNPQTSSFLQ VLVSVQSLIL VAEPYFNEPG YERSRGTPSG TQSSREYDGN 4750 4760 4770 4780 4790 4800 IRQATVKWAM LEQIRNPSPC FKEVIHKHFY LKRIELMAQC EEWIADIQQY SSDKRVGRTM 4810 4820 4830 4840 4850 4860 SHHAAALKRH TAQLREELLK LPCPEGLDPD IEDASPVCRA TAGAEDTLTH DHVNPSSSKD LPSDFQL

References

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[1]	"A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors." Hauser H.P., Bardroff M., Pyrowolakis G., Jentsch S. J. Cell Biol. 141:1415-1422(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY. Strain: C57BL/6J. Tissue: Aorta and Vein.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-893; 3091-3912 AND 4121-4523. Strain: C57BL/6J. Tissue: Aorta, Corpora quadrigemina, Kidney and Vein.
[4]	"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H. DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1905-3034 (ISOFORM 3). Tissue: Brain.
[5]	"BRUCE, a giant E2/E3 ubiquitin ligase and inhibitor of apoptosis protein of the trans-Golgi network, is required for normal placenta development and mouse survival." Lotz K., Pyrowolakis G., Jentsch S. Mol. Cell. Biol. 24:9339-9350(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[6]	"Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function." Hao Y., Sekine K., Kawabata A., Nakamura H., Ishioka T., Ohata H., Katayama R., Hashimoto C., Zhang X., Noda T., Tsuruo T., Naito M. Nat. Cell Biol. 6:849-860(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBUNIT, INTERACTION WITH HTRA2; CASP9 AND DIABLO/SMAC.
[7]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-476; SER-489 AND SER-2976, MASS SPECTROMETRY. Tissue: Liver.
[8]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-483, MASS SPECTROMETRY. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y17267 mRNA. Translation: CAA76720.1. Different initiation. AC098726 Genomic DNA. No translation available. AC154442 Genomic DNA. No translation available. AK041241 mRNA. Translation: BAC30874.1. AK045446 mRNA. Translation: BAC32373.1. Different initiation. AK052612 mRNA. Translation: BAC35061.1. AK079995 mRNA. Translation: BAC37801.1. Different initiation. AK173143 Transcribed RNA. Translation: BAD32421.1.
IPI	IPI00134095.
PIR	T31067.
RefSeq	NP_031592.3. NM_007566.3.
UniGene	Mm.290908. Mm.447926.
3D structure databases
HSSP	HSSP built from PDB template 1I3O based on UniProtKB P98170.
ProteinModelPortal	O88738.
SMR	O88738. Positions 4546-4843.
ModBase	Search...
Protein-protein interaction databases
IntAct	O88738. 7 interactions.
MINT	MINT-4105645.
Protein family/group databases
MEROPS	I32.006.
PTM databases
PhosphoSite	O88738.
Proteomic databases
PaxDb	O88738.
PRIDE	O88738.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000180037; ENSMUSP00000136329; ENSMUSG00000024073.
GeneID	12211.
KEGG	mmu:12211.
UCSC	uc008doe.1. mouse.
Organism-specific databases
CTD	57448.
MGI	MGI:1276108. Birc6.
Rouge	Search...
Phylogenomic databases
eggNOG	COG5078.
GeneTree	ENSGT00700000104488.
HOGENOM	HOG000168828.
HOVERGEN	HBG050691.
InParanoid	O88738.
KO	K10586.
OMA	FLIHVKA.
OrthoDB	EOG4DJJVH.
Gene expression databases
ArrayExpress	O88738.
Bgee	O88738.
Genevestigator	O88738.
Family and domain databases
Gene3D	1.10.1170.10. 1 hit. 2.130.10.10. 4 hits. 3.10.110.10. 1 hit.
InterPro	IPR001370. BIR. IPR022103. DUF3643. IPR000608. UBQ-conjugat_E2. IPR016135. UBQ-conjugating_enzyme/RWD. IPR015943. WD40/YVTN_repeat-like_dom. [Graphical view]
Pfam	PF00653. BIR. 1 hit. PF12356. DUF3643. 1 hit. PF00179. UQ_con. 1 hit. [Graphical view]
SMART	SM00238. BIR. 1 hit. [Graphical view]
SUPFAM	SSF54495. UBQ-conjugat/RWD-like. 1 hit.
PROSITE	PS01282. BIR_REPEAT_1. False negative. PS50143. BIR_REPEAT_2. 1 hit. PS00183. UBIQUITIN_CONJUGAT_1. False negative. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	BIRC6. mouse.
NextBio	280605.
SOURCE	Search...

Entry information

Entry name

BIRC6_MOUSE

Accession

Primary (citable) accession number: O88738
Secondary accession number(s): E9PYU6 , Q69ZM5, Q8BNX0, Q8BR72, Q8BRV7, Q8C737

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2012
Last sequence update:	March 21, 2012
Last modified:	May 1, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program