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O88738

- BIRC6_MOUSE

UniProt

O88738 - BIRC6_MOUSE

Protein

Baculoviral IAP repeat-containing protein 6

Gene

Birc6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (21 Mar 2012)
      Previous versions | rss
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    Functioni

    Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Required for normal placenta development.3 Publications

    Enzyme regulationi

    Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei4691 – 46911Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. cysteine-type endopeptidase inhibitor activity Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. ubiquitin-protein transferase activity Source: MGI

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. labyrinthine layer development Source: MGI
    3. mitotic nuclear division Source: UniProtKB-KW
    4. negative regulation of apoptotic process Source: MGI
    5. negative regulation of endopeptidase activity Source: GOC
    6. placenta development Source: UniProtKB
    7. positive regulation of cell proliferation Source: MGI
    8. protein ubiquitination Source: MGI
    9. regulation of cell proliferation Source: MGI
    10. regulation of cytokinesis Source: UniProtKB
    11. spongiotrophoblast layer development Source: MGI

    Keywords - Molecular functioni

    Ligase, Protease inhibitor, Thiol protease inhibitor

    Keywords - Biological processi

    Apoptosis, Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

    Protein family/group databases

    MEROPSiI32.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Baculoviral IAP repeat-containing protein 6 (EC:6.3.2.-)
    Alternative name(s):
    BIR repeat-containing ubiquitin-conjugating enzyme
    Short name:
    BRUCE
    Ubiquitin-conjugating BIR domain enzyme apollon
    Short name:
    APOLLON
    Gene namesi
    Name:Birc6
    Synonyms:Kiaa1289
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1276108. Birc6.

    Subcellular locationi

    Golgi apparatustrans-Golgi network membrane By similarity. Midbody By similarity. Endosome By similarity. Cytoplasmcytoskeletonspindle pole By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
    Note: Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis.By similarity

    GO - Cellular componenti

    1. endosome Source: UniProtKB
    2. membrane Source: MGI
    3. microtubule organizing center Source: UniProtKB
    4. midbody Source: UniProtKB
    5. spindle pole Source: UniProtKB-SubCell
    6. trans-Golgi network Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Endosome, Golgi apparatus, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice exhibit perinatal lethality and growth deficiencies, which are linked to a defect in proper placental development.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 48824882Baculoviral IAP repeat-containing protein 6PRO_0000416247Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei483 – 4831PhosphoserineBy similarity

    Post-translational modificationi

    Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiO88738.
    PaxDbiO88738.
    PRIDEiO88738.

    PTM databases

    PhosphoSiteiO88738.

    Expressioni

    Tissue specificityi

    Widely expressed. Highly expressed in the brain and kidney.1 Publication

    Gene expression databases

    ArrayExpressiO88738.
    BgeeiO88738.
    GenevestigatoriO88738.

    Interactioni

    Subunit structurei

    Homodimer. Binds the activated, processed forms of CASP3, CASP6 and CASP7. Interacts with RNF41, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8 By similarity. Interacts with CASP9, DIABLO/SMAC and HTRA2.By similarity1 Publication

    Protein-protein interaction databases

    IntActiO88738. 10 interactions.
    MINTiMINT-4105645.

    Structurei

    3D structure databases

    ProteinModelPortaliO88738.
    SMRiO88738. Positions 4546-4843.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati292 – 36271BIRAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni4592 – 4720129Ubiquitin-conjugatingBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1669 – 169729Ala-richAdd
    BLAST
    Compositional biasi2203 – 22064Poly-Ala
    Compositional biasi2406 – 24105Poly-Leu
    Compositional biasi2694 – 26974Poly-Ser
    Compositional biasi2759 – 27646Poly-Ser
    Compositional biasi4445 – 44506Poly-Glu

    Domaini

    The BIR domain is essential for its antiapoptotic function and is important for binding to DIABLO/SMAC and CASP9.By similarity

    Sequence similaritiesi

    In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family.Curated
    Contains 1 BIR repeat.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    GeneTreeiENSGT00730000110680.
    HOGENOMiHOG000168828.
    HOVERGENiHBG050691.
    InParanoidiO88738.
    KOiK10586.
    OMAiGHVDFKF.
    OrthoDBiEOG7VTDM2.
    TreeFamiTF105357.

    Family and domain databases

    Gene3Di1.10.1170.10. 1 hit.
    2.130.10.10. 4 hits.
    3.10.110.10. 1 hit.
    InterProiIPR001370. BIR.
    IPR022103. BIRC6.
    IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00653. BIR. 1 hit.
    PF12356. DUF3643. 1 hit.
    PF00179. UQ_con. 1 hit.
    [Graphical view]
    SMARTiSM00238. BIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 4 hits.
    SSF54495. SSF54495. 1 hit.
    PROSITEiPS50143. BIR_REPEAT_2. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O88738-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVTGCGAAPP GTVTERLPSV IVLSAGRKMA AAAAEASGPS CSSAAAAAGA     50
    GAAGVSEWLV LRDGCMRCDA DGLHSLSYHP ALNAILAVTS RGTIKVIDGT 100
    SGATLQASAL SAKPGGQVKC QYISAVDKVI FVDDYAVGCR KDLNGILLLD 150
    TALQTPVSKQ DDVVQLELPV TEAQQLLSAC IEKIDVSSTE GYDLFITQLK 200
    DGLKNTSHET AANHKVAKWA TVTFHLPHHV LKSIASAIVN ELKKINQNVA 250
    ALPVASSVMD RLSYLLPSAR PELGVGPGRS VDRALMYSEA NRRETFTSWP 300
    HVGYRWAQPD PMAQAGFYHQ PASSGDDRAM CFTCSVCLVC WEPTDEPWSE 350
    HERHSPNCPF VKGEHTQNVP LSVTLATSPA QLPSADGADR IACFGSGSCP 400
    QFLAAATKRG KICIWDVSKL MKVHLKFEIN AYDPAIVQQL ILSGDPSSGV 450
    DSRRPTLAWL EDSSSCSDIP KLEGDSDDLL EDSDSEEHSR SDSVTGHTSQ 500
    KEAMEVSLDI TALSILQQPE KLQWEIVANV LEDTVKDLEE LGANPSLTNS 550
    KSEKTKEKHQ EQHNIPFPCL LAGGLLTYKS PATSPISSNS HRSLDGLSRT 600
    QGESISEQGS TDNESCTNSE LNSPLVRRTL PVLLLYSIKE SDEKAGKIFS 650
    QMNNIMSKSL HDDGFTVPQI IEMELDNQEQ LLLQDPPVTY IQQFADAAAS 700
    LTSPDSEKWN SVFPKPGALV QCLRLPKFAE EETLCIDSIT PCADGIHLLV 750
    GLRTCSVESL SAINQVEALN NLNKLNSALC NRRKGDLESN LAVVNGANIS 800
    VIQHESPADV PEHLLIRPEQ RNVVSGGYLV LYKMNYTTRI VTLEEEPVKI 850
    QHIKDPQDTI TSLILLPPDI LDNREDDCEE PAEEMQLASK NGIEREKKSD 900
    ISTLGHLVVT TQGGYVKVLD LSNFEILAKV EPPKKEGTEE QDTFVSVIYC 950
    SGTDRLCACT KGGELHFLQI GGTCDDIDEA DILVDGSLSK GIEPALEGSR 1000
    PLSNPSSPGI SGVELLVDQP FTLEILTSLV ELTRFETLTP RFSATVPPCW 1050
    VEVQQEQQQR RHPQHLHQQH HGDAAQHTRT WKLQTDSNSW DEHVFELVLP 1100
    KACMVGHVDF KFVLNSNITS VPQIQVTLLK NKAPGLGKAN ALNIEVEHNG 1150
    NPSLVDLNEE MHHMDVEESQ CLRLCPFLED HKEDILCGPV WLASGLDLSG 1200
    HAGMLTLTSP KLVKGMAGGK YRSFLIHVKA VSDRGAADEM CSSGLRPVVR 1250
    LPSLKQQGHK GYSLASLLAK VAAGKEKSSN VKNENAGGTR KSENLRGCDL 1300
    LQEVSVTIRR FKKTSICKER VQRCAMLQFS EFHEKLLNTL CRRSDDGQVT 1350
    EHAQSLVLDA LCWLAGVHSN GSGSSKEGNE CLLSKTRKCL SDIVRVCFFE 1400
    AGRSIAHKCA RFLALCISNG KCEPCQPGFG SVLLKALLDN MCFLPAAATG 1450
    GSVYWYFVLL NYVKDEDLAG CSTACAALLT AVSRQLQDRL TPLEALLQTR 1500
    YGLYSSPFDP VLFDLEMSGS SWKTVYSSST AVQSDEIDLS DVLSGNGRVS 1550
    SCTAAEGSFT SLTGLLEVEP LHFTCVSTSD GTRIERDDAS TFTVSSFGVP 1600
    PAVGGLSSGT VGEASTALSS AAQVALQSLS HAMASAEQQL QVLQEKQQQL 1650
    LKLQQQKAKL EAKLHQTTAA AAAAASAAAA AAAGPVHNAV PSNPVAAPGF 1700
    FIHPSDVIPP TPKTTPLFMT PPLTPPNEAV SVVINAELAQ LFPGSVIDPP 1750
    AVNLAAQNKN SSKSRMNPLG SGLALAISHA SHFLQPPPHQ SIIIERMHSG 1800
    ARRFVTLDFG RPILLTDVLI PTCGDLASLS IDIWTLGEEV DGRRLVVATD 1850
    ISTHSLILHD LIPPPVCRFM KITVIGRYGS TNARAKIPLG FYYGHSYILP 1900
    WESELKLMHD PLRGEGESAS QPEIDQHLAM MVALQEDIQC RYNLACHRLE 1950
    ALLQSIDLPP LNSANNAQYF LRKPDKAVEE DSRVFSAYQD CIQLQLQLNL 2000
    AHNAVQRLKV AIGASRKLLN ETSGPEDLIQ TSSTEQLRTI VRYLLDTLLS 2050
    LLHSSNGHSV PAVLQSTFHA QACEELFKHL CISGTPKIRL HTGLLLVQLC 2100
    GGERWWGQFL SNVLQELYNS EQLLIFPQDR VFMLLSCIGQ RSLSNSGVLE 2150
    SLLNLLDNLL SPLQPELSMH RRTEGVLDIP MISWVVMLVS RLLDYVATVE 2200
    DEAAAAKKPL NGKDRERFLT GNQWSFINNN LHTQNLNRSS KGGSSLDRLY 2250
    SRKIRKQLVH HKQQLNLLKA KQKALVEQME KEKIQSNKGS SYKLLVEQAK 2300
    LKQATSKHFK DLIRLRRTAE WSRSNLDTEV TTTKESPEIE PLPFTLAHDR 2350
    CISVVQKLVL FLLSMDFTCH ADLLLFVCKV LARIANATRP TIHLCEIVNE 2400
    PQLERLLLLL VGTDFNRGDI SWGGAWAQYS LTCMLQDILA GELLAPVAAE 2450
    AMEECTVSED VGATAGDSDD SLQQSPAQLL ETIDEPLTHE IAGTPPLSSL 2500
    EKDKEIDLEL LQDLMEVDID PLDIDLEKDP LAAKVFKPIS STWYDYWGAD 2550
    YGTYNYNPYI GGLGMPVAKP PSNTEKNGSQ TVSVSVSQAL DARLEVGLEQ 2600
    QAELMLKMMS TLEADSILQA LTNTSPTFSQ SPTGTDDSLL GNLQPANQNS 2650
    QLMIQLSSVP MLNVCFNKLF SMLQVHHVQL ESLLQLWLTL SLNSSSSGNK 2700
    ENGADIFLYN ANRIPVISLN QASIASFLTV LAWYPNTLLR TWCLVLHSLT 2750
    LMTNMQLNSG SSSSIGIQET TAHLLVSDPN LIHVLVKFLS GTSPHGTNQH 2800
    SPQVGPTATQ AMQEFLTRLQ VHLSSTCPQI FSELLLKLIH ILSTERGAFQ 2850
    TGQGPLDAQV KLLEFTLEQN FEVVSVSTIS AVIESVTFLV HHYITCSDKV 2900
    MSRSGSDSSA GARACFGGLF ANLIRPGDAK AVCGEMTRDQ LMFDLLKLVN 2950
    ILVQLPLSSN REYSARVSVT TNTTDSVSDE EKVSGGKDVN GSSASTPGSP 3000
    ACVADLVLAN QQIMSQILSA LGLCNSSAMA MIIGASGLHL TKHENFHGGL 3050
    DAISVGDGLF TILTTLSKKA STVHMMLQPI LTYMACGYMG RQGSLATCQL 3100
    SEPLLWFILR VLDTSDALKA FHDMGGVQLI CNNMVTSTRA IVNTARSMVS 3150
    TIMKFLDSGP NKAVDSTLKT RILASEPDNA EGIHNFAPLG TITSSSPTAQ 3200
    PAEVLLQATP PHRRARSAAW SYIFLPEEAW CDLTIHLPSA VLLKEIHIQP 3250
    HLASLATCPS SVSVEVSADG VNMLPLSTPV VTSGLTYIKI QLVKAEVASA 3300
    VCLRLHRPRD ASTLGLSQIK LLGLTAFGTT SSATVNNPFL PSEDQVSKTS 3350
    IGWLRLLHHC LTHISDLEGM MASAAAPTAN LLQTCAALLM SPYCGMHSPN 3400
    IEVVLVKIGL QSTRIGLKLI DILLRNCAAS GSDPTDLNSP LLFGRLNGLS 3450
    SDSTIDILYQ LGTTQDPGTK DRIQALLKWV SDSAKMAALK RSGRMNYMCP 3500
    SSSAVEYGLL MPSPSHLHCV AAILWHSYEL LVEYDLPALL DRELFELLFN 3550
    WSMSLPCNVV LKKAVDSLLC SMCHIHPNYF SLLMGWMGII PPPVQCHHRL 3600
    SMTDDSKKQD LSSSLTDDSK NAQAPLSLTE SHLATLASSS QSPEAIKQLL 3650
    DSGLPSLLVR SLASFCFSHI SYSESIAQSV DNSQDKLRRH HVPQHCNKMP 3700
    ITADLVAPIL RFLTEVGNSH IMKDWLGGSE VNPLWTALLF LLCHSGSTAG 3750
    GHNLGAQQSS TRSASHSSAT TTVLTTQQRT AIENATVAFF LQCISCHPNN 3800
    QKLMAQVLCE LFQTAPQRGS LPTSGNISGF VRRLFLQLML EDEKVTMFLQ 3850
    SPCPLYKGRI NATSHVIQHP MFGAGHKFRT LHLPVSTTLS DVLDRVSDTP 3900
    SITAKLISEQ KDDKEKKNHE EKEKVKAENG FQDNYSVVVA SGLKSQSKRA 3950
    MASTPPRPPS RRGRTIPDKI GSASSSADAA SKIITVPVFH LFHRLLAGQP 4000
    LPAEMTLAQL LTLLYDRKLP QGYRSIDLTV KLGSKVITDP SLSKTDSFKR 4050
    LHPEKDHGDL VGSCPEDEAL TPSDECMDGV LDESLLETCP IQSPLQVFAG 4100
    MGGLALIAER LPMLYPEVIQ QVSAPVIAST TQEKPKDSDQ FEWVTIEQSG 4150
    ELVYEAPETI AAEPPPVKSA VQATSPIPAH SLAAFGLFLR LPGYAEVLLK 4200
    ERKHAQCLLR LVLGVTDDGE GSHILQSPSA NVLPTLPFHV LRSLFSATPL 4250
    TTDDGVLLRR MALEIGALHL ILVCLSALSH HAPRVPNSSL SQTEPQVSNS 4300
    HNPTSAEEQQ LYWAKGTGFG TGSTASGWDV EQALTKQRLE EEHVTCLLQV 4350
    LASYINPMSG AVNGEAQASP ESRAQNSSAL PSVLLELLSQ SCLIPAMSSY 4400
    LRNDSVLDMA RHVPLYRALL ELLRAIASCT SMVPLLLPLS TENGEEEEDE 4450
    QSECQTSVGT LLAKMKTCVD TYTNRLRSKR ENVKAGVKPD APDQEPEGLA 4500
    LLVPDIQRTA EIVHAATANL RQANQEKKLG EYSKKVVMKP KPLSVLKSLE 4550
    EKYVAVMKKL QFDTFEMVSE DDDGKLGFKV NYHYMSQVKN ANDANSAARA 4600
    RRLAQEAVTL STSLPLSSSS SVFVRCDEER LDIMKVLITG PADTPYANGC 4650
    FEFDVYFPQD YPSSPPLVNL ETTGGHSVRF NPNLYNDGKV CLSILNTWHG 4700
    RPEEKWNPQT SSFLQVLVSV QSLILVAEPY FNEPGYERSR GTPSGTQSSR 4750
    EYDGNIRQAT VKWAMLEQIR NPSPCFKEVI HKHFYLKRIE LMAQCEEWIA 4800
    DIQQYSSDKR VGRTMSHHAA ALKRHTAQLR EELLKLPCPE GLDPDIEDAS 4850
    PVCRATAGAE DTLTHDHVNP SSSKDLPSDF QL 4882
    Length:4,882
    Mass (Da):532,170
    Last modified:March 21, 2012 - v2
    Checksum:i6F804ACFA3AFA211
    GO
    Isoform 2 (identifier: O88738-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2212-2220: Missing.

    Show »
    Length:4,873
    Mass (Da):531,067
    Checksum:i58562C9F94576EF2
    GO
    Isoform 3 (identifier: O88738-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2057-2062: Missing.
         2212-2220: Missing.

    Show »
    Length:4,867
    Mass (Da):530,518
    Checksum:iA6386423866153B0
    GO

    Sequence cautioni

    The sequence BAC32373.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC37801.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAA76720.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti206 – 2061T → I in CAA76720. (PubMed:9628897)Curated
    Sequence conflicti552 – 5521S → R in BAC37801. (PubMed:16141072)Curated
    Sequence conflicti718 – 7181A → T in CAA76720. (PubMed:9628897)Curated
    Sequence conflicti2107 – 21071G → R in CAA76720. (PubMed:9628897)Curated
    Sequence conflicti2455 – 24551C → G in CAA76720. (PubMed:9628897)Curated
    Sequence conflicti2996 – 29961T → I in CAA76720. (PubMed:9628897)Curated
    Sequence conflicti3214 – 32141R → K in BAC35061. (PubMed:16141072)Curated
    Sequence conflicti3263 – 32631S → T in CAA76720. (PubMed:9628897)Curated
    Sequence conflicti3951 – 39511M → V in CAA76720. (PubMed:9628897)Curated
    Sequence conflicti3966 – 39661I → V in CAA76720. (PubMed:9628897)Curated
    Sequence conflicti4383 – 43831V → M in CAA76720. (PubMed:9628897)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei2057 – 20626Missing in isoform 3. 1 PublicationVSP_042536
    Alternative sequencei2212 – 22209Missing in isoform 2 and isoform 3. 2 PublicationsVSP_042537

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y17267 mRNA. Translation: CAA76720.1. Different initiation.
    AC098726 Genomic DNA. No translation available.
    AC154442 Genomic DNA. No translation available.
    AK041241 mRNA. Translation: BAC30874.1.
    AK045446 mRNA. Translation: BAC32373.1. Different initiation.
    AK052612 mRNA. Translation: BAC35061.1.
    AK079995 mRNA. Translation: BAC37801.1. Different initiation.
    AK173143 Transcribed RNA. Translation: BAD32421.1.
    CCDSiCCDS37693.2. [O88738-2]
    PIRiT31067.
    RefSeqiNP_031592.3. NM_007566.3. [O88738-2]
    UniGeneiMm.442564.
    Mm.447926.

    Genome annotation databases

    EnsembliENSMUST00000180037; ENSMUSP00000136329; ENSMUSG00000024073. [O88738-2]
    ENSMUST00000182133; ENSMUSP00000138693; ENSMUSG00000024073. [O88738-3]
    ENSMUST00000182597; ENSMUSP00000138333; ENSMUSG00000024073. [O88738-1]
    GeneIDi12211.
    KEGGimmu:12211.
    UCSCiuc008doe.1. mouse. [O88738-1]
    uc008dof.1. mouse. [O88738-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y17267 mRNA. Translation: CAA76720.1 . Different initiation.
    AC098726 Genomic DNA. No translation available.
    AC154442 Genomic DNA. No translation available.
    AK041241 mRNA. Translation: BAC30874.1 .
    AK045446 mRNA. Translation: BAC32373.1 . Different initiation.
    AK052612 mRNA. Translation: BAC35061.1 .
    AK079995 mRNA. Translation: BAC37801.1 . Different initiation.
    AK173143 Transcribed RNA. Translation: BAD32421.1 .
    CCDSi CCDS37693.2. [O88738-2 ]
    PIRi T31067.
    RefSeqi NP_031592.3. NM_007566.3. [O88738-2 ]
    UniGenei Mm.442564.
    Mm.447926.

    3D structure databases

    ProteinModelPortali O88738.
    SMRi O88738. Positions 4546-4843.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O88738. 10 interactions.
    MINTi MINT-4105645.

    Protein family/group databases

    MEROPSi I32.006.

    PTM databases

    PhosphoSitei O88738.

    Proteomic databases

    MaxQBi O88738.
    PaxDbi O88738.
    PRIDEi O88738.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000180037 ; ENSMUSP00000136329 ; ENSMUSG00000024073 . [O88738-2 ]
    ENSMUST00000182133 ; ENSMUSP00000138693 ; ENSMUSG00000024073 . [O88738-3 ]
    ENSMUST00000182597 ; ENSMUSP00000138333 ; ENSMUSG00000024073 . [O88738-1 ]
    GeneIDi 12211.
    KEGGi mmu:12211.
    UCSCi uc008doe.1. mouse. [O88738-1 ]
    uc008dof.1. mouse. [O88738-2 ]

    Organism-specific databases

    CTDi 57448.
    MGIi MGI:1276108. Birc6.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG5078.
    GeneTreei ENSGT00730000110680.
    HOGENOMi HOG000168828.
    HOVERGENi HBG050691.
    InParanoidi O88738.
    KOi K10586.
    OMAi GHVDFKF.
    OrthoDBi EOG7VTDM2.
    TreeFami TF105357.

    Miscellaneous databases

    ChiTaRSi BIRC6. mouse.
    NextBioi 280605.
    PROi O88738.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O88738.
    Bgeei O88738.
    Genevestigatori O88738.

    Family and domain databases

    Gene3Di 1.10.1170.10. 1 hit.
    2.130.10.10. 4 hits.
    3.10.110.10. 1 hit.
    InterProi IPR001370. BIR.
    IPR022103. BIRC6.
    IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00653. BIR. 1 hit.
    PF12356. DUF3643. 1 hit.
    PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SMARTi SM00238. BIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 4 hits.
    SSF54495. SSF54495. 1 hit.
    PROSITEi PS50143. BIR_REPEAT_2. 1 hit.
    PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors."
      Hauser H.P., Bardroff M., Pyrowolakis G., Jentsch S.
      J. Cell Biol. 141:1415-1422(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY.
      Strain: C57BL/6J.
      Tissue: Aorta and Vein.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-893; 3091-3912 AND 4121-4523.
      Strain: C57BL/6J.
      Tissue: Aorta, Corpora quadrigemina, Kidney and Vein.
    4. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1905-3034 (ISOFORM 3).
      Tissue: Brain.
    5. "BRUCE, a giant E2/E3 ubiquitin ligase and inhibitor of apoptosis protein of the trans-Golgi network, is required for normal placenta development and mouse survival."
      Lotz K., Pyrowolakis G., Jentsch S.
      Mol. Cell. Biol. 24:9339-9350(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    6. "Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function."
      Hao Y., Sekine K., Kawabata A., Nakamura H., Ishioka T., Ohata H., Katayama R., Hashimoto C., Zhang X., Noda T., Tsuruo T., Naito M.
      Nat. Cell Biol. 6:849-860(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, INTERACTION WITH HTRA2; CASP9 AND DIABLO/SMAC.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiBIRC6_MOUSE
    AccessioniPrimary (citable) accession number: O88738
    Secondary accession number(s): E9PYU6
    , Q69ZM5, Q8BNX0, Q8BR72, Q8BRV7, Q8C737
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2012
    Last sequence update: March 21, 2012
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3