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O88738

- BIRC6_MOUSE

UniProt

O88738 - BIRC6_MOUSE

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Protein

Baculoviral IAP repeat-containing protein 6

Gene

Birc6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Required for normal placenta development.3 Publications

Enzyme regulationi

Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei4691 – 46911Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. cysteine-type endopeptidase inhibitor activity Source: UniProtKB
  3. ubiquitin-protein transferase activity Source: MGI

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. labyrinthine layer development Source: MGI
  3. mitotic nuclear division Source: UniProtKB-KW
  4. negative regulation of apoptotic process Source: MGI
  5. negative regulation of endopeptidase activity Source: GOC
  6. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  7. placenta development Source: UniProtKB
  8. positive regulation of cell proliferation Source: MGI
  9. protein ubiquitination Source: MGI
  10. regulation of cell proliferation Source: MGI
  11. regulation of cytokinesis Source: UniProtKB
  12. spongiotrophoblast layer development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Protease inhibitor, Thiol protease inhibitor

Keywords - Biological processi

Apoptosis, Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Baculoviral IAP repeat-containing protein 6 (EC:6.3.2.-)
Alternative name(s):
BIR repeat-containing ubiquitin-conjugating enzyme
Short name:
BRUCE
Ubiquitin-conjugating BIR domain enzyme apollon
Short name:
APOLLON
Gene namesi
Name:Birc6
Synonyms:Kiaa1289
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1276108. Birc6.

Subcellular locationi

Golgi apparatustrans-Golgi network membrane By similarity. Midbody By similarity. Endosome By similarity. Cytoplasmcytoskeletonspindle pole By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
Note: Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis.By similarity

GO - Cellular componenti

  1. endosome Source: UniProtKB
  2. membrane Source: MGI
  3. microtubule organizing center Source: UniProtKB
  4. midbody Source: UniProtKB
  5. spindle pole Source: Ensembl
  6. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice exhibit perinatal lethality and growth deficiencies, which are linked to a defect in proper placental development.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 48824882Baculoviral IAP repeat-containing protein 6PRO_0000416247Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei483 – 4831PhosphoserineBy similarity

Post-translational modificationi

Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO88738.
PaxDbiO88738.
PRIDEiO88738.

PTM databases

PhosphoSiteiO88738.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in the brain and kidney.1 Publication

Gene expression databases

BgeeiO88738.
ExpressionAtlasiO88738. baseline and differential.
GenevestigatoriO88738.

Interactioni

Subunit structurei

Homodimer. Binds the activated, processed forms of CASP3, CASP6 and CASP7. Interacts with RNF41, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8 (By similarity). Interacts with CASP9, DIABLO/SMAC and HTRA2.By similarity1 Publication

Protein-protein interaction databases

IntActiO88738. 10 interactions.
MINTiMINT-4105645.

Structurei

3D structure databases

ProteinModelPortaliO88738.
SMRiO88738. Positions 4546-4843.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati292 – 36271BIRAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni4592 – 4720129Ubiquitin-conjugatingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1669 – 169729Ala-richAdd
BLAST
Compositional biasi2203 – 22064Poly-Ala
Compositional biasi2406 – 24105Poly-Leu
Compositional biasi2694 – 26974Poly-Ser
Compositional biasi2759 – 27646Poly-Ser
Compositional biasi4445 – 44506Poly-Glu

Domaini

The BIR domain is essential for its antiapoptotic function and is important for binding to DIABLO/SMAC and CASP9.By similarity

Sequence similaritiesi

In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family.Curated
Contains 1 BIR repeat.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00730000110680.
HOGENOMiHOG000168828.
HOVERGENiHBG050691.
InParanoidiO88738.
KOiK10586.
OMAiGHVDFKF.
OrthoDBiEOG7VTDM2.
TreeFamiTF105357.

Family and domain databases

Gene3Di1.10.1170.10. 1 hit.
2.130.10.10. 4 hits.
3.10.110.10. 1 hit.
InterProiIPR001370. BIR.
IPR022103. BIRC6.
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00653. BIR. 1 hit.
PF12356. DUF3643. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view]
SMARTiSM00238. BIR. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 4 hits.
SSF54495. SSF54495. 1 hit.
PROSITEiPS50143. BIR_REPEAT_2. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O88738-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVTGCGAAPP GTVTERLPSV IVLSAGRKMA AAAAEASGPS CSSAAAAAGA
60 70 80 90 100
GAAGVSEWLV LRDGCMRCDA DGLHSLSYHP ALNAILAVTS RGTIKVIDGT
110 120 130 140 150
SGATLQASAL SAKPGGQVKC QYISAVDKVI FVDDYAVGCR KDLNGILLLD
160 170 180 190 200
TALQTPVSKQ DDVVQLELPV TEAQQLLSAC IEKIDVSSTE GYDLFITQLK
210 220 230 240 250
DGLKNTSHET AANHKVAKWA TVTFHLPHHV LKSIASAIVN ELKKINQNVA
260 270 280 290 300
ALPVASSVMD RLSYLLPSAR PELGVGPGRS VDRALMYSEA NRRETFTSWP
310 320 330 340 350
HVGYRWAQPD PMAQAGFYHQ PASSGDDRAM CFTCSVCLVC WEPTDEPWSE
360 370 380 390 400
HERHSPNCPF VKGEHTQNVP LSVTLATSPA QLPSADGADR IACFGSGSCP
410 420 430 440 450
QFLAAATKRG KICIWDVSKL MKVHLKFEIN AYDPAIVQQL ILSGDPSSGV
460 470 480 490 500
DSRRPTLAWL EDSSSCSDIP KLEGDSDDLL EDSDSEEHSR SDSVTGHTSQ
510 520 530 540 550
KEAMEVSLDI TALSILQQPE KLQWEIVANV LEDTVKDLEE LGANPSLTNS
560 570 580 590 600
KSEKTKEKHQ EQHNIPFPCL LAGGLLTYKS PATSPISSNS HRSLDGLSRT
610 620 630 640 650
QGESISEQGS TDNESCTNSE LNSPLVRRTL PVLLLYSIKE SDEKAGKIFS
660 670 680 690 700
QMNNIMSKSL HDDGFTVPQI IEMELDNQEQ LLLQDPPVTY IQQFADAAAS
710 720 730 740 750
LTSPDSEKWN SVFPKPGALV QCLRLPKFAE EETLCIDSIT PCADGIHLLV
760 770 780 790 800
GLRTCSVESL SAINQVEALN NLNKLNSALC NRRKGDLESN LAVVNGANIS
810 820 830 840 850
VIQHESPADV PEHLLIRPEQ RNVVSGGYLV LYKMNYTTRI VTLEEEPVKI
860 870 880 890 900
QHIKDPQDTI TSLILLPPDI LDNREDDCEE PAEEMQLASK NGIEREKKSD
910 920 930 940 950
ISTLGHLVVT TQGGYVKVLD LSNFEILAKV EPPKKEGTEE QDTFVSVIYC
960 970 980 990 1000
SGTDRLCACT KGGELHFLQI GGTCDDIDEA DILVDGSLSK GIEPALEGSR
1010 1020 1030 1040 1050
PLSNPSSPGI SGVELLVDQP FTLEILTSLV ELTRFETLTP RFSATVPPCW
1060 1070 1080 1090 1100
VEVQQEQQQR RHPQHLHQQH HGDAAQHTRT WKLQTDSNSW DEHVFELVLP
1110 1120 1130 1140 1150
KACMVGHVDF KFVLNSNITS VPQIQVTLLK NKAPGLGKAN ALNIEVEHNG
1160 1170 1180 1190 1200
NPSLVDLNEE MHHMDVEESQ CLRLCPFLED HKEDILCGPV WLASGLDLSG
1210 1220 1230 1240 1250
HAGMLTLTSP KLVKGMAGGK YRSFLIHVKA VSDRGAADEM CSSGLRPVVR
1260 1270 1280 1290 1300
LPSLKQQGHK GYSLASLLAK VAAGKEKSSN VKNENAGGTR KSENLRGCDL
1310 1320 1330 1340 1350
LQEVSVTIRR FKKTSICKER VQRCAMLQFS EFHEKLLNTL CRRSDDGQVT
1360 1370 1380 1390 1400
EHAQSLVLDA LCWLAGVHSN GSGSSKEGNE CLLSKTRKCL SDIVRVCFFE
1410 1420 1430 1440 1450
AGRSIAHKCA RFLALCISNG KCEPCQPGFG SVLLKALLDN MCFLPAAATG
1460 1470 1480 1490 1500
GSVYWYFVLL NYVKDEDLAG CSTACAALLT AVSRQLQDRL TPLEALLQTR
1510 1520 1530 1540 1550
YGLYSSPFDP VLFDLEMSGS SWKTVYSSST AVQSDEIDLS DVLSGNGRVS
1560 1570 1580 1590 1600
SCTAAEGSFT SLTGLLEVEP LHFTCVSTSD GTRIERDDAS TFTVSSFGVP
1610 1620 1630 1640 1650
PAVGGLSSGT VGEASTALSS AAQVALQSLS HAMASAEQQL QVLQEKQQQL
1660 1670 1680 1690 1700
LKLQQQKAKL EAKLHQTTAA AAAAASAAAA AAAGPVHNAV PSNPVAAPGF
1710 1720 1730 1740 1750
FIHPSDVIPP TPKTTPLFMT PPLTPPNEAV SVVINAELAQ LFPGSVIDPP
1760 1770 1780 1790 1800
AVNLAAQNKN SSKSRMNPLG SGLALAISHA SHFLQPPPHQ SIIIERMHSG
1810 1820 1830 1840 1850
ARRFVTLDFG RPILLTDVLI PTCGDLASLS IDIWTLGEEV DGRRLVVATD
1860 1870 1880 1890 1900
ISTHSLILHD LIPPPVCRFM KITVIGRYGS TNARAKIPLG FYYGHSYILP
1910 1920 1930 1940 1950
WESELKLMHD PLRGEGESAS QPEIDQHLAM MVALQEDIQC RYNLACHRLE
1960 1970 1980 1990 2000
ALLQSIDLPP LNSANNAQYF LRKPDKAVEE DSRVFSAYQD CIQLQLQLNL
2010 2020 2030 2040 2050
AHNAVQRLKV AIGASRKLLN ETSGPEDLIQ TSSTEQLRTI VRYLLDTLLS
2060 2070 2080 2090 2100
LLHSSNGHSV PAVLQSTFHA QACEELFKHL CISGTPKIRL HTGLLLVQLC
2110 2120 2130 2140 2150
GGERWWGQFL SNVLQELYNS EQLLIFPQDR VFMLLSCIGQ RSLSNSGVLE
2160 2170 2180 2190 2200
SLLNLLDNLL SPLQPELSMH RRTEGVLDIP MISWVVMLVS RLLDYVATVE
2210 2220 2230 2240 2250
DEAAAAKKPL NGKDRERFLT GNQWSFINNN LHTQNLNRSS KGGSSLDRLY
2260 2270 2280 2290 2300
SRKIRKQLVH HKQQLNLLKA KQKALVEQME KEKIQSNKGS SYKLLVEQAK
2310 2320 2330 2340 2350
LKQATSKHFK DLIRLRRTAE WSRSNLDTEV TTTKESPEIE PLPFTLAHDR
2360 2370 2380 2390 2400
CISVVQKLVL FLLSMDFTCH ADLLLFVCKV LARIANATRP TIHLCEIVNE
2410 2420 2430 2440 2450
PQLERLLLLL VGTDFNRGDI SWGGAWAQYS LTCMLQDILA GELLAPVAAE
2460 2470 2480 2490 2500
AMEECTVSED VGATAGDSDD SLQQSPAQLL ETIDEPLTHE IAGTPPLSSL
2510 2520 2530 2540 2550
EKDKEIDLEL LQDLMEVDID PLDIDLEKDP LAAKVFKPIS STWYDYWGAD
2560 2570 2580 2590 2600
YGTYNYNPYI GGLGMPVAKP PSNTEKNGSQ TVSVSVSQAL DARLEVGLEQ
2610 2620 2630 2640 2650
QAELMLKMMS TLEADSILQA LTNTSPTFSQ SPTGTDDSLL GNLQPANQNS
2660 2670 2680 2690 2700
QLMIQLSSVP MLNVCFNKLF SMLQVHHVQL ESLLQLWLTL SLNSSSSGNK
2710 2720 2730 2740 2750
ENGADIFLYN ANRIPVISLN QASIASFLTV LAWYPNTLLR TWCLVLHSLT
2760 2770 2780 2790 2800
LMTNMQLNSG SSSSIGIQET TAHLLVSDPN LIHVLVKFLS GTSPHGTNQH
2810 2820 2830 2840 2850
SPQVGPTATQ AMQEFLTRLQ VHLSSTCPQI FSELLLKLIH ILSTERGAFQ
2860 2870 2880 2890 2900
TGQGPLDAQV KLLEFTLEQN FEVVSVSTIS AVIESVTFLV HHYITCSDKV
2910 2920 2930 2940 2950
MSRSGSDSSA GARACFGGLF ANLIRPGDAK AVCGEMTRDQ LMFDLLKLVN
2960 2970 2980 2990 3000
ILVQLPLSSN REYSARVSVT TNTTDSVSDE EKVSGGKDVN GSSASTPGSP
3010 3020 3030 3040 3050
ACVADLVLAN QQIMSQILSA LGLCNSSAMA MIIGASGLHL TKHENFHGGL
3060 3070 3080 3090 3100
DAISVGDGLF TILTTLSKKA STVHMMLQPI LTYMACGYMG RQGSLATCQL
3110 3120 3130 3140 3150
SEPLLWFILR VLDTSDALKA FHDMGGVQLI CNNMVTSTRA IVNTARSMVS
3160 3170 3180 3190 3200
TIMKFLDSGP NKAVDSTLKT RILASEPDNA EGIHNFAPLG TITSSSPTAQ
3210 3220 3230 3240 3250
PAEVLLQATP PHRRARSAAW SYIFLPEEAW CDLTIHLPSA VLLKEIHIQP
3260 3270 3280 3290 3300
HLASLATCPS SVSVEVSADG VNMLPLSTPV VTSGLTYIKI QLVKAEVASA
3310 3320 3330 3340 3350
VCLRLHRPRD ASTLGLSQIK LLGLTAFGTT SSATVNNPFL PSEDQVSKTS
3360 3370 3380 3390 3400
IGWLRLLHHC LTHISDLEGM MASAAAPTAN LLQTCAALLM SPYCGMHSPN
3410 3420 3430 3440 3450
IEVVLVKIGL QSTRIGLKLI DILLRNCAAS GSDPTDLNSP LLFGRLNGLS
3460 3470 3480 3490 3500
SDSTIDILYQ LGTTQDPGTK DRIQALLKWV SDSAKMAALK RSGRMNYMCP
3510 3520 3530 3540 3550
SSSAVEYGLL MPSPSHLHCV AAILWHSYEL LVEYDLPALL DRELFELLFN
3560 3570 3580 3590 3600
WSMSLPCNVV LKKAVDSLLC SMCHIHPNYF SLLMGWMGII PPPVQCHHRL
3610 3620 3630 3640 3650
SMTDDSKKQD LSSSLTDDSK NAQAPLSLTE SHLATLASSS QSPEAIKQLL
3660 3670 3680 3690 3700
DSGLPSLLVR SLASFCFSHI SYSESIAQSV DNSQDKLRRH HVPQHCNKMP
3710 3720 3730 3740 3750
ITADLVAPIL RFLTEVGNSH IMKDWLGGSE VNPLWTALLF LLCHSGSTAG
3760 3770 3780 3790 3800
GHNLGAQQSS TRSASHSSAT TTVLTTQQRT AIENATVAFF LQCISCHPNN
3810 3820 3830 3840 3850
QKLMAQVLCE LFQTAPQRGS LPTSGNISGF VRRLFLQLML EDEKVTMFLQ
3860 3870 3880 3890 3900
SPCPLYKGRI NATSHVIQHP MFGAGHKFRT LHLPVSTTLS DVLDRVSDTP
3910 3920 3930 3940 3950
SITAKLISEQ KDDKEKKNHE EKEKVKAENG FQDNYSVVVA SGLKSQSKRA
3960 3970 3980 3990 4000
MASTPPRPPS RRGRTIPDKI GSASSSADAA SKIITVPVFH LFHRLLAGQP
4010 4020 4030 4040 4050
LPAEMTLAQL LTLLYDRKLP QGYRSIDLTV KLGSKVITDP SLSKTDSFKR
4060 4070 4080 4090 4100
LHPEKDHGDL VGSCPEDEAL TPSDECMDGV LDESLLETCP IQSPLQVFAG
4110 4120 4130 4140 4150
MGGLALIAER LPMLYPEVIQ QVSAPVIAST TQEKPKDSDQ FEWVTIEQSG
4160 4170 4180 4190 4200
ELVYEAPETI AAEPPPVKSA VQATSPIPAH SLAAFGLFLR LPGYAEVLLK
4210 4220 4230 4240 4250
ERKHAQCLLR LVLGVTDDGE GSHILQSPSA NVLPTLPFHV LRSLFSATPL
4260 4270 4280 4290 4300
TTDDGVLLRR MALEIGALHL ILVCLSALSH HAPRVPNSSL SQTEPQVSNS
4310 4320 4330 4340 4350
HNPTSAEEQQ LYWAKGTGFG TGSTASGWDV EQALTKQRLE EEHVTCLLQV
4360 4370 4380 4390 4400
LASYINPMSG AVNGEAQASP ESRAQNSSAL PSVLLELLSQ SCLIPAMSSY
4410 4420 4430 4440 4450
LRNDSVLDMA RHVPLYRALL ELLRAIASCT SMVPLLLPLS TENGEEEEDE
4460 4470 4480 4490 4500
QSECQTSVGT LLAKMKTCVD TYTNRLRSKR ENVKAGVKPD APDQEPEGLA
4510 4520 4530 4540 4550
LLVPDIQRTA EIVHAATANL RQANQEKKLG EYSKKVVMKP KPLSVLKSLE
4560 4570 4580 4590 4600
EKYVAVMKKL QFDTFEMVSE DDDGKLGFKV NYHYMSQVKN ANDANSAARA
4610 4620 4630 4640 4650
RRLAQEAVTL STSLPLSSSS SVFVRCDEER LDIMKVLITG PADTPYANGC
4660 4670 4680 4690 4700
FEFDVYFPQD YPSSPPLVNL ETTGGHSVRF NPNLYNDGKV CLSILNTWHG
4710 4720 4730 4740 4750
RPEEKWNPQT SSFLQVLVSV QSLILVAEPY FNEPGYERSR GTPSGTQSSR
4760 4770 4780 4790 4800
EYDGNIRQAT VKWAMLEQIR NPSPCFKEVI HKHFYLKRIE LMAQCEEWIA
4810 4820 4830 4840 4850
DIQQYSSDKR VGRTMSHHAA ALKRHTAQLR EELLKLPCPE GLDPDIEDAS
4860 4870 4880
PVCRATAGAE DTLTHDHVNP SSSKDLPSDF QL
Length:4,882
Mass (Da):532,170
Last modified:March 21, 2012 - v2
Checksum:i6F804ACFA3AFA211
GO
Isoform 2 (identifier: O88738-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2212-2220: Missing.

Show »
Length:4,873
Mass (Da):531,067
Checksum:i58562C9F94576EF2
GO
Isoform 3 (identifier: O88738-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2057-2062: Missing.
     2212-2220: Missing.

Show »
Length:4,867
Mass (Da):530,518
Checksum:iA6386423866153B0
GO

Sequence cautioni

The sequence BAC32373.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC37801.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAA76720.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti206 – 2061T → I in CAA76720. (PubMed:9628897)Curated
Sequence conflicti552 – 5521S → R in BAC37801. (PubMed:16141072)Curated
Sequence conflicti718 – 7181A → T in CAA76720. (PubMed:9628897)Curated
Sequence conflicti2107 – 21071G → R in CAA76720. (PubMed:9628897)Curated
Sequence conflicti2455 – 24551C → G in CAA76720. (PubMed:9628897)Curated
Sequence conflicti2996 – 29961T → I in CAA76720. (PubMed:9628897)Curated
Sequence conflicti3214 – 32141R → K in BAC35061. (PubMed:16141072)Curated
Sequence conflicti3263 – 32631S → T in CAA76720. (PubMed:9628897)Curated
Sequence conflicti3951 – 39511M → V in CAA76720. (PubMed:9628897)Curated
Sequence conflicti3966 – 39661I → V in CAA76720. (PubMed:9628897)Curated
Sequence conflicti4383 – 43831V → M in CAA76720. (PubMed:9628897)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2057 – 20626Missing in isoform 3. 1 PublicationVSP_042536
Alternative sequencei2212 – 22209Missing in isoform 2 and isoform 3. 2 PublicationsVSP_042537

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y17267 mRNA. Translation: CAA76720.1. Different initiation.
AC098726 Genomic DNA. No translation available.
AC154442 Genomic DNA. No translation available.
AK041241 mRNA. Translation: BAC30874.1.
AK045446 mRNA. Translation: BAC32373.1. Different initiation.
AK052612 mRNA. Translation: BAC35061.1.
AK079995 mRNA. Translation: BAC37801.1. Different initiation.
AK173143 Transcribed RNA. Translation: BAD32421.1.
CCDSiCCDS37693.2. [O88738-2]
PIRiT31067.
RefSeqiNP_031592.3. NM_007566.3. [O88738-2]
UniGeneiMm.442564.
Mm.447926.

Genome annotation databases

EnsembliENSMUST00000180037; ENSMUSP00000136329; ENSMUSG00000024073. [O88738-2]
ENSMUST00000182133; ENSMUSP00000138693; ENSMUSG00000024073. [O88738-3]
ENSMUST00000182597; ENSMUSP00000138333; ENSMUSG00000024073. [O88738-1]
GeneIDi12211.
KEGGimmu:12211.
UCSCiuc008doe.1. mouse. [O88738-1]
uc008dof.1. mouse. [O88738-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y17267 mRNA. Translation: CAA76720.1 . Different initiation.
AC098726 Genomic DNA. No translation available.
AC154442 Genomic DNA. No translation available.
AK041241 mRNA. Translation: BAC30874.1 .
AK045446 mRNA. Translation: BAC32373.1 . Different initiation.
AK052612 mRNA. Translation: BAC35061.1 .
AK079995 mRNA. Translation: BAC37801.1 . Different initiation.
AK173143 Transcribed RNA. Translation: BAD32421.1 .
CCDSi CCDS37693.2. [O88738-2 ]
PIRi T31067.
RefSeqi NP_031592.3. NM_007566.3. [O88738-2 ]
UniGenei Mm.442564.
Mm.447926.

3D structure databases

ProteinModelPortali O88738.
SMRi O88738. Positions 4546-4843.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O88738. 10 interactions.
MINTi MINT-4105645.

PTM databases

PhosphoSitei O88738.

Proteomic databases

MaxQBi O88738.
PaxDbi O88738.
PRIDEi O88738.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000180037 ; ENSMUSP00000136329 ; ENSMUSG00000024073 . [O88738-2 ]
ENSMUST00000182133 ; ENSMUSP00000138693 ; ENSMUSG00000024073 . [O88738-3 ]
ENSMUST00000182597 ; ENSMUSP00000138333 ; ENSMUSG00000024073 . [O88738-1 ]
GeneIDi 12211.
KEGGi mmu:12211.
UCSCi uc008doe.1. mouse. [O88738-1 ]
uc008dof.1. mouse. [O88738-2 ]

Organism-specific databases

CTDi 57448.
MGIi MGI:1276108. Birc6.
Rougei Search...

Phylogenomic databases

eggNOGi COG5078.
GeneTreei ENSGT00730000110680.
HOGENOMi HOG000168828.
HOVERGENi HBG050691.
InParanoidi O88738.
KOi K10586.
OMAi GHVDFKF.
OrthoDBi EOG7VTDM2.
TreeFami TF105357.

Miscellaneous databases

ChiTaRSi BIRC6. mouse.
NextBioi 280605.
PROi O88738.
SOURCEi Search...

Gene expression databases

Bgeei O88738.
ExpressionAtlasi O88738. baseline and differential.
Genevestigatori O88738.

Family and domain databases

Gene3Di 1.10.1170.10. 1 hit.
2.130.10.10. 4 hits.
3.10.110.10. 1 hit.
InterProi IPR001370. BIR.
IPR022103. BIRC6.
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00653. BIR. 1 hit.
PF12356. DUF3643. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view ]
SMARTi SM00238. BIR. 1 hit.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 4 hits.
SSF54495. SSF54495. 1 hit.
PROSITEi PS50143. BIR_REPEAT_2. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors."
    Hauser H.P., Bardroff M., Pyrowolakis G., Jentsch S.
    J. Cell Biol. 141:1415-1422(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Aorta and Vein.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-893; 3091-3912 AND 4121-4523.
    Strain: C57BL/6J.
    Tissue: Aorta, Corpora quadrigemina, Kidney and Vein.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1905-3034 (ISOFORM 3).
    Tissue: Brain.
  5. "BRUCE, a giant E2/E3 ubiquitin ligase and inhibitor of apoptosis protein of the trans-Golgi network, is required for normal placenta development and mouse survival."
    Lotz K., Pyrowolakis G., Jentsch S.
    Mol. Cell. Biol. 24:9339-9350(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  6. "Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function."
    Hao Y., Sekine K., Kawabata A., Nakamura H., Ishioka T., Ohata H., Katayama R., Hashimoto C., Zhang X., Noda T., Tsuruo T., Naito M.
    Nat. Cell Biol. 6:849-860(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INTERACTION WITH HTRA2; CASP9 AND DIABLO/SMAC.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiBIRC6_MOUSE
AccessioniPrimary (citable) accession number: O88738
Secondary accession number(s): E9PYU6
, Q69ZM5, Q8BNX0, Q8BR72, Q8BRV7, Q8C737
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: March 21, 2012
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3