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O88738

- BIRC6_MOUSE

UniProt

O88738 - BIRC6_MOUSE

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Protein

Baculoviral IAP repeat-containing protein 6

Gene
Birc6, Kiaa1289
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Required for normal placenta development.3 Publications

Enzyme regulationi

Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9 By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei4691 – 46911Glycyl thioester intermediate By similarity

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. cysteine-type endopeptidase inhibitor activity Source: UniProtKB
  3. protein binding Source: UniProtKB
  4. ubiquitin-protein transferase activity Source: MGI

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. labyrinthine layer development Source: MGI
  3. mitotic nuclear division Source: UniProtKB-KW
  4. negative regulation of apoptotic process Source: MGI
  5. negative regulation of endopeptidase activity Source: GOC
  6. placenta development Source: UniProtKB
  7. positive regulation of cell proliferation Source: MGI
  8. protein ubiquitination Source: MGI
  9. regulation of cell proliferation Source: MGI
  10. regulation of cytokinesis Source: UniProtKB
  11. spongiotrophoblast layer development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Protease inhibitor, Thiol protease inhibitor

Keywords - Biological processi

Apoptosis, Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Protein family/group databases

MEROPSiI32.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Baculoviral IAP repeat-containing protein 6 (EC:6.3.2.-)
Alternative name(s):
BIR repeat-containing ubiquitin-conjugating enzyme
Short name:
BRUCE
Ubiquitin-conjugating BIR domain enzyme apollon
Short name:
APOLLON
Gene namesi
Name:Birc6
Synonyms:Kiaa1289
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1276108. Birc6.

Subcellular locationi

Golgi apparatustrans-Golgi network membrane By similarity. Midbody By similarity. Endosome By similarity. Cytoplasmcytoskeletonspindle pole By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity
Note: Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis By similarity.

GO - Cellular componenti

  1. endosome Source: UniProtKB
  2. membrane Source: MGI
  3. microtubule organizing center Source: UniProtKB
  4. midbody Source: UniProtKB
  5. spindle pole Source: UniProtKB-SubCell
  6. trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice exhibit perinatal lethality and growth deficiencies, which are linked to a defect in proper placental development.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 48824882Baculoviral IAP repeat-containing protein 6PRO_0000416247Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei483 – 4831Phosphoserine By similarity

Post-translational modificationi

Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY By similarity.

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiO88738.
PaxDbiO88738.
PRIDEiO88738.

PTM databases

PhosphoSiteiO88738.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in the brain and kidney.1 Publication

Gene expression databases

ArrayExpressiO88738.
BgeeiO88738.
GenevestigatoriO88738.

Interactioni

Subunit structurei

Homodimer. Binds the activated, processed forms of CASP3, CASP6 and CASP7. Interacts with RNF41, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8 By similarity. Interacts with CASP9, DIABLO/SMAC and HTRA2.1 Publication

Protein-protein interaction databases

IntActiO88738. 10 interactions.
MINTiMINT-4105645.

Structurei

3D structure databases

ProteinModelPortaliO88738.
SMRiO88738. Positions 4546-4843.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati292 – 36271BIRAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni4592 – 4720129Ubiquitin-conjugating By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1669 – 169729Ala-richAdd
BLAST
Compositional biasi2203 – 22064Poly-Ala
Compositional biasi2406 – 24105Poly-Leu
Compositional biasi2694 – 26974Poly-Ser
Compositional biasi2759 – 27646Poly-Ser
Compositional biasi4445 – 44506Poly-Glu

Domaini

The BIR domain is essential for its antiapoptotic function and is important for binding to DIABLO/SMAC and CASP9 By similarity.

Sequence similaritiesi

In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family.
Contains 1 BIR repeat.

Phylogenomic databases

eggNOGiCOG5078.
GeneTreeiENSGT00730000110680.
HOGENOMiHOG000168828.
HOVERGENiHBG050691.
InParanoidiO88738.
KOiK10586.
OMAiGHVDFKF.
OrthoDBiEOG7VTDM2.
TreeFamiTF105357.

Family and domain databases

Gene3Di1.10.1170.10. 1 hit.
2.130.10.10. 4 hits.
3.10.110.10. 1 hit.
InterProiIPR001370. BIR.
IPR022103. BIRC6.
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00653. BIR. 1 hit.
PF12356. DUF3643. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view]
SMARTiSM00238. BIR. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 4 hits.
SSF54495. SSF54495. 1 hit.
PROSITEiPS50143. BIR_REPEAT_2. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O88738-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVTGCGAAPP GTVTERLPSV IVLSAGRKMA AAAAEASGPS CSSAAAAAGA     50
GAAGVSEWLV LRDGCMRCDA DGLHSLSYHP ALNAILAVTS RGTIKVIDGT 100
SGATLQASAL SAKPGGQVKC QYISAVDKVI FVDDYAVGCR KDLNGILLLD 150
TALQTPVSKQ DDVVQLELPV TEAQQLLSAC IEKIDVSSTE GYDLFITQLK 200
DGLKNTSHET AANHKVAKWA TVTFHLPHHV LKSIASAIVN ELKKINQNVA 250
ALPVASSVMD RLSYLLPSAR PELGVGPGRS VDRALMYSEA NRRETFTSWP 300
HVGYRWAQPD PMAQAGFYHQ PASSGDDRAM CFTCSVCLVC WEPTDEPWSE 350
HERHSPNCPF VKGEHTQNVP LSVTLATSPA QLPSADGADR IACFGSGSCP 400
QFLAAATKRG KICIWDVSKL MKVHLKFEIN AYDPAIVQQL ILSGDPSSGV 450
DSRRPTLAWL EDSSSCSDIP KLEGDSDDLL EDSDSEEHSR SDSVTGHTSQ 500
KEAMEVSLDI TALSILQQPE KLQWEIVANV LEDTVKDLEE LGANPSLTNS 550
KSEKTKEKHQ EQHNIPFPCL LAGGLLTYKS PATSPISSNS HRSLDGLSRT 600
QGESISEQGS TDNESCTNSE LNSPLVRRTL PVLLLYSIKE SDEKAGKIFS 650
QMNNIMSKSL HDDGFTVPQI IEMELDNQEQ LLLQDPPVTY IQQFADAAAS 700
LTSPDSEKWN SVFPKPGALV QCLRLPKFAE EETLCIDSIT PCADGIHLLV 750
GLRTCSVESL SAINQVEALN NLNKLNSALC NRRKGDLESN LAVVNGANIS 800
VIQHESPADV PEHLLIRPEQ RNVVSGGYLV LYKMNYTTRI VTLEEEPVKI 850
QHIKDPQDTI TSLILLPPDI LDNREDDCEE PAEEMQLASK NGIEREKKSD 900
ISTLGHLVVT TQGGYVKVLD LSNFEILAKV EPPKKEGTEE QDTFVSVIYC 950
SGTDRLCACT KGGELHFLQI GGTCDDIDEA DILVDGSLSK GIEPALEGSR 1000
PLSNPSSPGI SGVELLVDQP FTLEILTSLV ELTRFETLTP RFSATVPPCW 1050
VEVQQEQQQR RHPQHLHQQH HGDAAQHTRT WKLQTDSNSW DEHVFELVLP 1100
KACMVGHVDF KFVLNSNITS VPQIQVTLLK NKAPGLGKAN ALNIEVEHNG 1150
NPSLVDLNEE MHHMDVEESQ CLRLCPFLED HKEDILCGPV WLASGLDLSG 1200
HAGMLTLTSP KLVKGMAGGK YRSFLIHVKA VSDRGAADEM CSSGLRPVVR 1250
LPSLKQQGHK GYSLASLLAK VAAGKEKSSN VKNENAGGTR KSENLRGCDL 1300
LQEVSVTIRR FKKTSICKER VQRCAMLQFS EFHEKLLNTL CRRSDDGQVT 1350
EHAQSLVLDA LCWLAGVHSN GSGSSKEGNE CLLSKTRKCL SDIVRVCFFE 1400
AGRSIAHKCA RFLALCISNG KCEPCQPGFG SVLLKALLDN MCFLPAAATG 1450
GSVYWYFVLL NYVKDEDLAG CSTACAALLT AVSRQLQDRL TPLEALLQTR 1500
YGLYSSPFDP VLFDLEMSGS SWKTVYSSST AVQSDEIDLS DVLSGNGRVS 1550
SCTAAEGSFT SLTGLLEVEP LHFTCVSTSD GTRIERDDAS TFTVSSFGVP 1600
PAVGGLSSGT VGEASTALSS AAQVALQSLS HAMASAEQQL QVLQEKQQQL 1650
LKLQQQKAKL EAKLHQTTAA AAAAASAAAA AAAGPVHNAV PSNPVAAPGF 1700
FIHPSDVIPP TPKTTPLFMT PPLTPPNEAV SVVINAELAQ LFPGSVIDPP 1750
AVNLAAQNKN SSKSRMNPLG SGLALAISHA SHFLQPPPHQ SIIIERMHSG 1800
ARRFVTLDFG RPILLTDVLI PTCGDLASLS IDIWTLGEEV DGRRLVVATD 1850
ISTHSLILHD LIPPPVCRFM KITVIGRYGS TNARAKIPLG FYYGHSYILP 1900
WESELKLMHD PLRGEGESAS QPEIDQHLAM MVALQEDIQC RYNLACHRLE 1950
ALLQSIDLPP LNSANNAQYF LRKPDKAVEE DSRVFSAYQD CIQLQLQLNL 2000
AHNAVQRLKV AIGASRKLLN ETSGPEDLIQ TSSTEQLRTI VRYLLDTLLS 2050
LLHSSNGHSV PAVLQSTFHA QACEELFKHL CISGTPKIRL HTGLLLVQLC 2100
GGERWWGQFL SNVLQELYNS EQLLIFPQDR VFMLLSCIGQ RSLSNSGVLE 2150
SLLNLLDNLL SPLQPELSMH RRTEGVLDIP MISWVVMLVS RLLDYVATVE 2200
DEAAAAKKPL NGKDRERFLT GNQWSFINNN LHTQNLNRSS KGGSSLDRLY 2250
SRKIRKQLVH HKQQLNLLKA KQKALVEQME KEKIQSNKGS SYKLLVEQAK 2300
LKQATSKHFK DLIRLRRTAE WSRSNLDTEV TTTKESPEIE PLPFTLAHDR 2350
CISVVQKLVL FLLSMDFTCH ADLLLFVCKV LARIANATRP TIHLCEIVNE 2400
PQLERLLLLL VGTDFNRGDI SWGGAWAQYS LTCMLQDILA GELLAPVAAE 2450
AMEECTVSED VGATAGDSDD SLQQSPAQLL ETIDEPLTHE IAGTPPLSSL 2500
EKDKEIDLEL LQDLMEVDID PLDIDLEKDP LAAKVFKPIS STWYDYWGAD 2550
YGTYNYNPYI GGLGMPVAKP PSNTEKNGSQ TVSVSVSQAL DARLEVGLEQ 2600
QAELMLKMMS TLEADSILQA LTNTSPTFSQ SPTGTDDSLL GNLQPANQNS 2650
QLMIQLSSVP MLNVCFNKLF SMLQVHHVQL ESLLQLWLTL SLNSSSSGNK 2700
ENGADIFLYN ANRIPVISLN QASIASFLTV LAWYPNTLLR TWCLVLHSLT 2750
LMTNMQLNSG SSSSIGIQET TAHLLVSDPN LIHVLVKFLS GTSPHGTNQH 2800
SPQVGPTATQ AMQEFLTRLQ VHLSSTCPQI FSELLLKLIH ILSTERGAFQ 2850
TGQGPLDAQV KLLEFTLEQN FEVVSVSTIS AVIESVTFLV HHYITCSDKV 2900
MSRSGSDSSA GARACFGGLF ANLIRPGDAK AVCGEMTRDQ LMFDLLKLVN 2950
ILVQLPLSSN REYSARVSVT TNTTDSVSDE EKVSGGKDVN GSSASTPGSP 3000
ACVADLVLAN QQIMSQILSA LGLCNSSAMA MIIGASGLHL TKHENFHGGL 3050
DAISVGDGLF TILTTLSKKA STVHMMLQPI LTYMACGYMG RQGSLATCQL 3100
SEPLLWFILR VLDTSDALKA FHDMGGVQLI CNNMVTSTRA IVNTARSMVS 3150
TIMKFLDSGP NKAVDSTLKT RILASEPDNA EGIHNFAPLG TITSSSPTAQ 3200
PAEVLLQATP PHRRARSAAW SYIFLPEEAW CDLTIHLPSA VLLKEIHIQP 3250
HLASLATCPS SVSVEVSADG VNMLPLSTPV VTSGLTYIKI QLVKAEVASA 3300
VCLRLHRPRD ASTLGLSQIK LLGLTAFGTT SSATVNNPFL PSEDQVSKTS 3350
IGWLRLLHHC LTHISDLEGM MASAAAPTAN LLQTCAALLM SPYCGMHSPN 3400
IEVVLVKIGL QSTRIGLKLI DILLRNCAAS GSDPTDLNSP LLFGRLNGLS 3450
SDSTIDILYQ LGTTQDPGTK DRIQALLKWV SDSAKMAALK RSGRMNYMCP 3500
SSSAVEYGLL MPSPSHLHCV AAILWHSYEL LVEYDLPALL DRELFELLFN 3550
WSMSLPCNVV LKKAVDSLLC SMCHIHPNYF SLLMGWMGII PPPVQCHHRL 3600
SMTDDSKKQD LSSSLTDDSK NAQAPLSLTE SHLATLASSS QSPEAIKQLL 3650
DSGLPSLLVR SLASFCFSHI SYSESIAQSV DNSQDKLRRH HVPQHCNKMP 3700
ITADLVAPIL RFLTEVGNSH IMKDWLGGSE VNPLWTALLF LLCHSGSTAG 3750
GHNLGAQQSS TRSASHSSAT TTVLTTQQRT AIENATVAFF LQCISCHPNN 3800
QKLMAQVLCE LFQTAPQRGS LPTSGNISGF VRRLFLQLML EDEKVTMFLQ 3850
SPCPLYKGRI NATSHVIQHP MFGAGHKFRT LHLPVSTTLS DVLDRVSDTP 3900
SITAKLISEQ KDDKEKKNHE EKEKVKAENG FQDNYSVVVA SGLKSQSKRA 3950
MASTPPRPPS RRGRTIPDKI GSASSSADAA SKIITVPVFH LFHRLLAGQP 4000
LPAEMTLAQL LTLLYDRKLP QGYRSIDLTV KLGSKVITDP SLSKTDSFKR 4050
LHPEKDHGDL VGSCPEDEAL TPSDECMDGV LDESLLETCP IQSPLQVFAG 4100
MGGLALIAER LPMLYPEVIQ QVSAPVIAST TQEKPKDSDQ FEWVTIEQSG 4150
ELVYEAPETI AAEPPPVKSA VQATSPIPAH SLAAFGLFLR LPGYAEVLLK 4200
ERKHAQCLLR LVLGVTDDGE GSHILQSPSA NVLPTLPFHV LRSLFSATPL 4250
TTDDGVLLRR MALEIGALHL ILVCLSALSH HAPRVPNSSL SQTEPQVSNS 4300
HNPTSAEEQQ LYWAKGTGFG TGSTASGWDV EQALTKQRLE EEHVTCLLQV 4350
LASYINPMSG AVNGEAQASP ESRAQNSSAL PSVLLELLSQ SCLIPAMSSY 4400
LRNDSVLDMA RHVPLYRALL ELLRAIASCT SMVPLLLPLS TENGEEEEDE 4450
QSECQTSVGT LLAKMKTCVD TYTNRLRSKR ENVKAGVKPD APDQEPEGLA 4500
LLVPDIQRTA EIVHAATANL RQANQEKKLG EYSKKVVMKP KPLSVLKSLE 4550
EKYVAVMKKL QFDTFEMVSE DDDGKLGFKV NYHYMSQVKN ANDANSAARA 4600
RRLAQEAVTL STSLPLSSSS SVFVRCDEER LDIMKVLITG PADTPYANGC 4650
FEFDVYFPQD YPSSPPLVNL ETTGGHSVRF NPNLYNDGKV CLSILNTWHG 4700
RPEEKWNPQT SSFLQVLVSV QSLILVAEPY FNEPGYERSR GTPSGTQSSR 4750
EYDGNIRQAT VKWAMLEQIR NPSPCFKEVI HKHFYLKRIE LMAQCEEWIA 4800
DIQQYSSDKR VGRTMSHHAA ALKRHTAQLR EELLKLPCPE GLDPDIEDAS 4850
PVCRATAGAE DTLTHDHVNP SSSKDLPSDF QL 4882
Length:4,882
Mass (Da):532,170
Last modified:March 21, 2012 - v2
Checksum:i6F804ACFA3AFA211
GO
Isoform 2 (identifier: O88738-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2212-2220: Missing.

Show »
Length:4,873
Mass (Da):531,067
Checksum:i58562C9F94576EF2
GO
Isoform 3 (identifier: O88738-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2057-2062: Missing.
     2212-2220: Missing.

Show »
Length:4,867
Mass (Da):530,518
Checksum:iA6386423866153B0
GO

Sequence cautioni

The sequence BAC32373.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC37801.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAA76720.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2057 – 20626Missing in isoform 3. VSP_042536
Alternative sequencei2212 – 22209Missing in isoform 2 and isoform 3. VSP_042537

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti206 – 2061T → I in CAA76720. 1 Publication
Sequence conflicti552 – 5521S → R in BAC37801. 1 Publication
Sequence conflicti718 – 7181A → T in CAA76720. 1 Publication
Sequence conflicti2107 – 21071G → R in CAA76720. 1 Publication
Sequence conflicti2455 – 24551C → G in CAA76720. 1 Publication
Sequence conflicti2996 – 29961T → I in CAA76720. 1 Publication
Sequence conflicti3214 – 32141R → K in BAC35061. 1 Publication
Sequence conflicti3263 – 32631S → T in CAA76720. 1 Publication
Sequence conflicti3951 – 39511M → V in CAA76720. 1 Publication
Sequence conflicti3966 – 39661I → V in CAA76720. 1 Publication
Sequence conflicti4383 – 43831V → M in CAA76720. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y17267 mRNA. Translation: CAA76720.1. Different initiation.
AC098726 Genomic DNA. No translation available.
AC154442 Genomic DNA. No translation available.
AK041241 mRNA. Translation: BAC30874.1.
AK045446 mRNA. Translation: BAC32373.1. Different initiation.
AK052612 mRNA. Translation: BAC35061.1.
AK079995 mRNA. Translation: BAC37801.1. Different initiation.
AK173143 Transcribed RNA. Translation: BAD32421.1.
CCDSiCCDS37693.2. [O88738-2]
PIRiT31067.
RefSeqiNP_031592.3. NM_007566.3. [O88738-2]
UniGeneiMm.442564.
Mm.447926.

Genome annotation databases

EnsembliENSMUST00000180037; ENSMUSP00000136329; ENSMUSG00000024073. [O88738-2]
ENSMUST00000182133; ENSMUSP00000138693; ENSMUSG00000024073. [O88738-3]
ENSMUST00000182597; ENSMUSP00000138333; ENSMUSG00000024073. [O88738-1]
GeneIDi12211.
KEGGimmu:12211.
UCSCiuc008doe.1. mouse. [O88738-1]
uc008dof.1. mouse. [O88738-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y17267 mRNA. Translation: CAA76720.1 . Different initiation.
AC098726 Genomic DNA. No translation available.
AC154442 Genomic DNA. No translation available.
AK041241 mRNA. Translation: BAC30874.1 .
AK045446 mRNA. Translation: BAC32373.1 . Different initiation.
AK052612 mRNA. Translation: BAC35061.1 .
AK079995 mRNA. Translation: BAC37801.1 . Different initiation.
AK173143 Transcribed RNA. Translation: BAD32421.1 .
CCDSi CCDS37693.2. [O88738-2 ]
PIRi T31067.
RefSeqi NP_031592.3. NM_007566.3. [O88738-2 ]
UniGenei Mm.442564.
Mm.447926.

3D structure databases

ProteinModelPortali O88738.
SMRi O88738. Positions 4546-4843.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O88738. 10 interactions.
MINTi MINT-4105645.

Protein family/group databases

MEROPSi I32.006.

PTM databases

PhosphoSitei O88738.

Proteomic databases

MaxQBi O88738.
PaxDbi O88738.
PRIDEi O88738.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000180037 ; ENSMUSP00000136329 ; ENSMUSG00000024073 . [O88738-2 ]
ENSMUST00000182133 ; ENSMUSP00000138693 ; ENSMUSG00000024073 . [O88738-3 ]
ENSMUST00000182597 ; ENSMUSP00000138333 ; ENSMUSG00000024073 . [O88738-1 ]
GeneIDi 12211.
KEGGi mmu:12211.
UCSCi uc008doe.1. mouse. [O88738-1 ]
uc008dof.1. mouse. [O88738-2 ]

Organism-specific databases

CTDi 57448.
MGIi MGI:1276108. Birc6.
Rougei Search...

Phylogenomic databases

eggNOGi COG5078.
GeneTreei ENSGT00730000110680.
HOGENOMi HOG000168828.
HOVERGENi HBG050691.
InParanoidi O88738.
KOi K10586.
OMAi GHVDFKF.
OrthoDBi EOG7VTDM2.
TreeFami TF105357.

Miscellaneous databases

ChiTaRSi BIRC6. mouse.
NextBioi 280605.
PROi O88738.
SOURCEi Search...

Gene expression databases

ArrayExpressi O88738.
Bgeei O88738.
Genevestigatori O88738.

Family and domain databases

Gene3Di 1.10.1170.10. 1 hit.
2.130.10.10. 4 hits.
3.10.110.10. 1 hit.
InterProi IPR001370. BIR.
IPR022103. BIRC6.
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00653. BIR. 1 hit.
PF12356. DUF3643. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view ]
SMARTi SM00238. BIR. 1 hit.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 4 hits.
SSF54495. SSF54495. 1 hit.
PROSITEi PS50143. BIR_REPEAT_2. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors."
    Hauser H.P., Bardroff M., Pyrowolakis G., Jentsch S.
    J. Cell Biol. 141:1415-1422(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Aorta and Vein.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-893; 3091-3912 AND 4121-4523.
    Strain: C57BL/6J.
    Tissue: Aorta, Corpora quadrigemina, Kidney and Vein.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1905-3034 (ISOFORM 3).
    Tissue: Brain.
  5. "BRUCE, a giant E2/E3 ubiquitin ligase and inhibitor of apoptosis protein of the trans-Golgi network, is required for normal placenta development and mouse survival."
    Lotz K., Pyrowolakis G., Jentsch S.
    Mol. Cell. Biol. 24:9339-9350(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  6. "Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function."
    Hao Y., Sekine K., Kawabata A., Nakamura H., Ishioka T., Ohata H., Katayama R., Hashimoto C., Zhang X., Noda T., Tsuruo T., Naito M.
    Nat. Cell Biol. 6:849-860(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, INTERACTION WITH HTRA2; CASP9 AND DIABLO/SMAC.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiBIRC6_MOUSE
AccessioniPrimary (citable) accession number: O88738
Secondary accession number(s): E9PYU6
, Q69ZM5, Q8BNX0, Q8BR72, Q8BRV7, Q8C737
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: March 21, 2012
Last modified: September 3, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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