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O88738 (BIRC6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Baculoviral IAP repeat-containing protein 6

EC=6.3.2.-
Alternative name(s):
BIR repeat-containing ubiquitin-conjugating enzyme
Short name=BRUCE
Ubiquitin-conjugating BIR domain enzyme apollon
Short name=APOLLON
Gene names
Name:Birc6
Synonyms:Kiaa1289
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length4882 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Required for normal placenta development. Ref.1 Ref.5 Ref.6

Enzyme regulation

Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9 By similarity.

Subunit structure

Homodimer. Binds the activated, processed forms of CASP3, CASP6 and CASP7. Interacts with RNF41, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8 By similarity. Interacts with CASP9, DIABLO/SMAC and HTRA2. Ref.6

Subcellular location

Golgi apparatustrans-Golgi network membrane By similarity. Midbody By similarity. Endosome By similarity. Cytoplasmcytoskeletonspindle pole By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Note: Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis By similarity.

Tissue specificity

Widely expressed. Highly expressed in the brain and kidney. Ref.1

Domain

The BIR domain is essential for its antiapoptotic function and is important for binding to DIABLO/SMAC and CASP9 By similarity.

Post-translational modification

Ubiquitinated. Ubiquitination is mediated by the RNF41 E3 ligase and leads to proteasomal degradation, impairing inhibition of apoptosis. Deubiquitinated by USP8/UBPY By similarity.

Disruption phenotype

Mice exhibit perinatal lethality and growth deficiencies, which are linked to a defect in proper placental development. Ref.5

Sequence similarities

In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family.

Contains 1 BIR repeat.

Sequence caution

The sequence BAC32373.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC37801.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAA76720.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processApoptosis
Cell cycle
Cell division
Mitosis
Ubl conjugation pathway
   Cellular componentCytoplasm
Cytoskeleton
Endosome
Golgi apparatus
Membrane
   Coding sequence diversityAlternative splicing
   Molecular functionLigase
Protease inhibitor
Thiol protease inhibitor
   PTMPhosphoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

labyrinthine layer development

Inferred from mutant phenotype Ref.5. Source: MGI

mitotic nuclear division

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of apoptotic process

Inferred from mutant phenotype Ref.6. Source: MGI

negative regulation of endopeptidase activity

Inferred from sequence or structural similarity. Source: GOC

placenta development

Inferred from mutant phenotype Ref.5. Source: UniProtKB

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 15887267. Source: MGI

protein ubiquitination

Inferred by curator Ref.1. Source: MGI

regulation of cell proliferation

Inferred from mutant phenotype Ref.5. Source: MGI

regulation of cytokinesis

Inferred from sequence or structural similarity. Source: UniProtKB

spongiotrophoblast layer development

Inferred from mutant phenotype Ref.5. Source: MGI

   Cellular_componentendosome

Inferred from sequence or structural similarity. Source: UniProtKB

membrane

Inferred from direct assay Ref.1. Source: MGI

microtubule organizing center

Inferred from sequence or structural similarity. Source: UniProtKB

midbody

Inferred from sequence or structural similarity. Source: UniProtKB

spindle pole

Inferred from electronic annotation. Source: UniProtKB-SubCell

trans-Golgi network

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functioncysteine-type endopeptidase inhibitor activity

Inferred from sequence or structural similarity. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 15314180. Source: UniProtKB

ubiquitin-protein transferase activity

Inferred from direct assay Ref.1. Source: MGI

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O88738-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O88738-2)

The sequence of this isoform differs from the canonical sequence as follows:
     2212-2220: Missing.
Isoform 3 (identifier: O88738-3)

The sequence of this isoform differs from the canonical sequence as follows:
     2057-2062: Missing.
     2212-2220: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 48824882Baculoviral IAP repeat-containing protein 6
PRO_0000416247

Regions

Repeat292 – 36271BIR
Region4592 – 4720129Ubiquitin-conjugating By similarity
Compositional bias1669 – 169729Ala-rich
Compositional bias2203 – 22064Poly-Ala
Compositional bias2406 – 24105Poly-Leu
Compositional bias2694 – 26974Poly-Ser
Compositional bias2759 – 27646Poly-Ser
Compositional bias4445 – 44506Poly-Glu

Sites

Active site46911Glycyl thioester intermediate By similarity

Amino acid modifications

Modified residue4831Phosphoserine By similarity

Natural variations

Alternative sequence2057 – 20626Missing in isoform 3.
VSP_042536
Alternative sequence2212 – 22209Missing in isoform 2 and isoform 3.
VSP_042537

Experimental info

Sequence conflict2061T → I in CAA76720. Ref.1
Sequence conflict5521S → R in BAC37801. Ref.3
Sequence conflict7181A → T in CAA76720. Ref.1
Sequence conflict21071G → R in CAA76720. Ref.1
Sequence conflict24551C → G in CAA76720. Ref.1
Sequence conflict29961T → I in CAA76720. Ref.1
Sequence conflict32141R → K in BAC35061. Ref.3
Sequence conflict32631S → T in CAA76720. Ref.1
Sequence conflict39511M → V in CAA76720. Ref.1
Sequence conflict39661I → V in CAA76720. Ref.1
Sequence conflict43831V → M in CAA76720. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 21, 2012. Version 2.
Checksum: 6F804ACFA3AFA211

FASTA4,882532,170
        10         20         30         40         50         60 
MVTGCGAAPP GTVTERLPSV IVLSAGRKMA AAAAEASGPS CSSAAAAAGA GAAGVSEWLV 

        70         80         90        100        110        120 
LRDGCMRCDA DGLHSLSYHP ALNAILAVTS RGTIKVIDGT SGATLQASAL SAKPGGQVKC 

       130        140        150        160        170        180 
QYISAVDKVI FVDDYAVGCR KDLNGILLLD TALQTPVSKQ DDVVQLELPV TEAQQLLSAC 

       190        200        210        220        230        240 
IEKIDVSSTE GYDLFITQLK DGLKNTSHET AANHKVAKWA TVTFHLPHHV LKSIASAIVN 

       250        260        270        280        290        300 
ELKKINQNVA ALPVASSVMD RLSYLLPSAR PELGVGPGRS VDRALMYSEA NRRETFTSWP 

       310        320        330        340        350        360 
HVGYRWAQPD PMAQAGFYHQ PASSGDDRAM CFTCSVCLVC WEPTDEPWSE HERHSPNCPF 

       370        380        390        400        410        420 
VKGEHTQNVP LSVTLATSPA QLPSADGADR IACFGSGSCP QFLAAATKRG KICIWDVSKL 

       430        440        450        460        470        480 
MKVHLKFEIN AYDPAIVQQL ILSGDPSSGV DSRRPTLAWL EDSSSCSDIP KLEGDSDDLL 

       490        500        510        520        530        540 
EDSDSEEHSR SDSVTGHTSQ KEAMEVSLDI TALSILQQPE KLQWEIVANV LEDTVKDLEE 

       550        560        570        580        590        600 
LGANPSLTNS KSEKTKEKHQ EQHNIPFPCL LAGGLLTYKS PATSPISSNS HRSLDGLSRT 

       610        620        630        640        650        660 
QGESISEQGS TDNESCTNSE LNSPLVRRTL PVLLLYSIKE SDEKAGKIFS QMNNIMSKSL 

       670        680        690        700        710        720 
HDDGFTVPQI IEMELDNQEQ LLLQDPPVTY IQQFADAAAS LTSPDSEKWN SVFPKPGALV 

       730        740        750        760        770        780 
QCLRLPKFAE EETLCIDSIT PCADGIHLLV GLRTCSVESL SAINQVEALN NLNKLNSALC 

       790        800        810        820        830        840 
NRRKGDLESN LAVVNGANIS VIQHESPADV PEHLLIRPEQ RNVVSGGYLV LYKMNYTTRI 

       850        860        870        880        890        900 
VTLEEEPVKI QHIKDPQDTI TSLILLPPDI LDNREDDCEE PAEEMQLASK NGIEREKKSD 

       910        920        930        940        950        960 
ISTLGHLVVT TQGGYVKVLD LSNFEILAKV EPPKKEGTEE QDTFVSVIYC SGTDRLCACT 

       970        980        990       1000       1010       1020 
KGGELHFLQI GGTCDDIDEA DILVDGSLSK GIEPALEGSR PLSNPSSPGI SGVELLVDQP 

      1030       1040       1050       1060       1070       1080 
FTLEILTSLV ELTRFETLTP RFSATVPPCW VEVQQEQQQR RHPQHLHQQH HGDAAQHTRT 

      1090       1100       1110       1120       1130       1140 
WKLQTDSNSW DEHVFELVLP KACMVGHVDF KFVLNSNITS VPQIQVTLLK NKAPGLGKAN 

      1150       1160       1170       1180       1190       1200 
ALNIEVEHNG NPSLVDLNEE MHHMDVEESQ CLRLCPFLED HKEDILCGPV WLASGLDLSG 

      1210       1220       1230       1240       1250       1260 
HAGMLTLTSP KLVKGMAGGK YRSFLIHVKA VSDRGAADEM CSSGLRPVVR LPSLKQQGHK 

      1270       1280       1290       1300       1310       1320 
GYSLASLLAK VAAGKEKSSN VKNENAGGTR KSENLRGCDL LQEVSVTIRR FKKTSICKER 

      1330       1340       1350       1360       1370       1380 
VQRCAMLQFS EFHEKLLNTL CRRSDDGQVT EHAQSLVLDA LCWLAGVHSN GSGSSKEGNE 

      1390       1400       1410       1420       1430       1440 
CLLSKTRKCL SDIVRVCFFE AGRSIAHKCA RFLALCISNG KCEPCQPGFG SVLLKALLDN 

      1450       1460       1470       1480       1490       1500 
MCFLPAAATG GSVYWYFVLL NYVKDEDLAG CSTACAALLT AVSRQLQDRL TPLEALLQTR 

      1510       1520       1530       1540       1550       1560 
YGLYSSPFDP VLFDLEMSGS SWKTVYSSST AVQSDEIDLS DVLSGNGRVS SCTAAEGSFT 

      1570       1580       1590       1600       1610       1620 
SLTGLLEVEP LHFTCVSTSD GTRIERDDAS TFTVSSFGVP PAVGGLSSGT VGEASTALSS 

      1630       1640       1650       1660       1670       1680 
AAQVALQSLS HAMASAEQQL QVLQEKQQQL LKLQQQKAKL EAKLHQTTAA AAAAASAAAA 

      1690       1700       1710       1720       1730       1740 
AAAGPVHNAV PSNPVAAPGF FIHPSDVIPP TPKTTPLFMT PPLTPPNEAV SVVINAELAQ 

      1750       1760       1770       1780       1790       1800 
LFPGSVIDPP AVNLAAQNKN SSKSRMNPLG SGLALAISHA SHFLQPPPHQ SIIIERMHSG 

      1810       1820       1830       1840       1850       1860 
ARRFVTLDFG RPILLTDVLI PTCGDLASLS IDIWTLGEEV DGRRLVVATD ISTHSLILHD 

      1870       1880       1890       1900       1910       1920 
LIPPPVCRFM KITVIGRYGS TNARAKIPLG FYYGHSYILP WESELKLMHD PLRGEGESAS 

      1930       1940       1950       1960       1970       1980 
QPEIDQHLAM MVALQEDIQC RYNLACHRLE ALLQSIDLPP LNSANNAQYF LRKPDKAVEE 

      1990       2000       2010       2020       2030       2040 
DSRVFSAYQD CIQLQLQLNL AHNAVQRLKV AIGASRKLLN ETSGPEDLIQ TSSTEQLRTI 

      2050       2060       2070       2080       2090       2100 
VRYLLDTLLS LLHSSNGHSV PAVLQSTFHA QACEELFKHL CISGTPKIRL HTGLLLVQLC 

      2110       2120       2130       2140       2150       2160 
GGERWWGQFL SNVLQELYNS EQLLIFPQDR VFMLLSCIGQ RSLSNSGVLE SLLNLLDNLL 

      2170       2180       2190       2200       2210       2220 
SPLQPELSMH RRTEGVLDIP MISWVVMLVS RLLDYVATVE DEAAAAKKPL NGKDRERFLT 

      2230       2240       2250       2260       2270       2280 
GNQWSFINNN LHTQNLNRSS KGGSSLDRLY SRKIRKQLVH HKQQLNLLKA KQKALVEQME 

      2290       2300       2310       2320       2330       2340 
KEKIQSNKGS SYKLLVEQAK LKQATSKHFK DLIRLRRTAE WSRSNLDTEV TTTKESPEIE 

      2350       2360       2370       2380       2390       2400 
PLPFTLAHDR CISVVQKLVL FLLSMDFTCH ADLLLFVCKV LARIANATRP TIHLCEIVNE 

      2410       2420       2430       2440       2450       2460 
PQLERLLLLL VGTDFNRGDI SWGGAWAQYS LTCMLQDILA GELLAPVAAE AMEECTVSED 

      2470       2480       2490       2500       2510       2520 
VGATAGDSDD SLQQSPAQLL ETIDEPLTHE IAGTPPLSSL EKDKEIDLEL LQDLMEVDID 

      2530       2540       2550       2560       2570       2580 
PLDIDLEKDP LAAKVFKPIS STWYDYWGAD YGTYNYNPYI GGLGMPVAKP PSNTEKNGSQ 

      2590       2600       2610       2620       2630       2640 
TVSVSVSQAL DARLEVGLEQ QAELMLKMMS TLEADSILQA LTNTSPTFSQ SPTGTDDSLL 

      2650       2660       2670       2680       2690       2700 
GNLQPANQNS QLMIQLSSVP MLNVCFNKLF SMLQVHHVQL ESLLQLWLTL SLNSSSSGNK 

      2710       2720       2730       2740       2750       2760 
ENGADIFLYN ANRIPVISLN QASIASFLTV LAWYPNTLLR TWCLVLHSLT LMTNMQLNSG 

      2770       2780       2790       2800       2810       2820 
SSSSIGIQET TAHLLVSDPN LIHVLVKFLS GTSPHGTNQH SPQVGPTATQ AMQEFLTRLQ 

      2830       2840       2850       2860       2870       2880 
VHLSSTCPQI FSELLLKLIH ILSTERGAFQ TGQGPLDAQV KLLEFTLEQN FEVVSVSTIS 

      2890       2900       2910       2920       2930       2940 
AVIESVTFLV HHYITCSDKV MSRSGSDSSA GARACFGGLF ANLIRPGDAK AVCGEMTRDQ 

      2950       2960       2970       2980       2990       3000 
LMFDLLKLVN ILVQLPLSSN REYSARVSVT TNTTDSVSDE EKVSGGKDVN GSSASTPGSP 

      3010       3020       3030       3040       3050       3060 
ACVADLVLAN QQIMSQILSA LGLCNSSAMA MIIGASGLHL TKHENFHGGL DAISVGDGLF 

      3070       3080       3090       3100       3110       3120 
TILTTLSKKA STVHMMLQPI LTYMACGYMG RQGSLATCQL SEPLLWFILR VLDTSDALKA 

      3130       3140       3150       3160       3170       3180 
FHDMGGVQLI CNNMVTSTRA IVNTARSMVS TIMKFLDSGP NKAVDSTLKT RILASEPDNA 

      3190       3200       3210       3220       3230       3240 
EGIHNFAPLG TITSSSPTAQ PAEVLLQATP PHRRARSAAW SYIFLPEEAW CDLTIHLPSA 

      3250       3260       3270       3280       3290       3300 
VLLKEIHIQP HLASLATCPS SVSVEVSADG VNMLPLSTPV VTSGLTYIKI QLVKAEVASA 

      3310       3320       3330       3340       3350       3360 
VCLRLHRPRD ASTLGLSQIK LLGLTAFGTT SSATVNNPFL PSEDQVSKTS IGWLRLLHHC 

      3370       3380       3390       3400       3410       3420 
LTHISDLEGM MASAAAPTAN LLQTCAALLM SPYCGMHSPN IEVVLVKIGL QSTRIGLKLI 

      3430       3440       3450       3460       3470       3480 
DILLRNCAAS GSDPTDLNSP LLFGRLNGLS SDSTIDILYQ LGTTQDPGTK DRIQALLKWV 

      3490       3500       3510       3520       3530       3540 
SDSAKMAALK RSGRMNYMCP SSSAVEYGLL MPSPSHLHCV AAILWHSYEL LVEYDLPALL 

      3550       3560       3570       3580       3590       3600 
DRELFELLFN WSMSLPCNVV LKKAVDSLLC SMCHIHPNYF SLLMGWMGII PPPVQCHHRL 

      3610       3620       3630       3640       3650       3660 
SMTDDSKKQD LSSSLTDDSK NAQAPLSLTE SHLATLASSS QSPEAIKQLL DSGLPSLLVR 

      3670       3680       3690       3700       3710       3720 
SLASFCFSHI SYSESIAQSV DNSQDKLRRH HVPQHCNKMP ITADLVAPIL RFLTEVGNSH 

      3730       3740       3750       3760       3770       3780 
IMKDWLGGSE VNPLWTALLF LLCHSGSTAG GHNLGAQQSS TRSASHSSAT TTVLTTQQRT 

      3790       3800       3810       3820       3830       3840 
AIENATVAFF LQCISCHPNN QKLMAQVLCE LFQTAPQRGS LPTSGNISGF VRRLFLQLML 

      3850       3860       3870       3880       3890       3900 
EDEKVTMFLQ SPCPLYKGRI NATSHVIQHP MFGAGHKFRT LHLPVSTTLS DVLDRVSDTP 

      3910       3920       3930       3940       3950       3960 
SITAKLISEQ KDDKEKKNHE EKEKVKAENG FQDNYSVVVA SGLKSQSKRA MASTPPRPPS 

      3970       3980       3990       4000       4010       4020 
RRGRTIPDKI GSASSSADAA SKIITVPVFH LFHRLLAGQP LPAEMTLAQL LTLLYDRKLP 

      4030       4040       4050       4060       4070       4080 
QGYRSIDLTV KLGSKVITDP SLSKTDSFKR LHPEKDHGDL VGSCPEDEAL TPSDECMDGV 

      4090       4100       4110       4120       4130       4140 
LDESLLETCP IQSPLQVFAG MGGLALIAER LPMLYPEVIQ QVSAPVIAST TQEKPKDSDQ 

      4150       4160       4170       4180       4190       4200 
FEWVTIEQSG ELVYEAPETI AAEPPPVKSA VQATSPIPAH SLAAFGLFLR LPGYAEVLLK 

      4210       4220       4230       4240       4250       4260 
ERKHAQCLLR LVLGVTDDGE GSHILQSPSA NVLPTLPFHV LRSLFSATPL TTDDGVLLRR 

      4270       4280       4290       4300       4310       4320 
MALEIGALHL ILVCLSALSH HAPRVPNSSL SQTEPQVSNS HNPTSAEEQQ LYWAKGTGFG 

      4330       4340       4350       4360       4370       4380 
TGSTASGWDV EQALTKQRLE EEHVTCLLQV LASYINPMSG AVNGEAQASP ESRAQNSSAL 

      4390       4400       4410       4420       4430       4440 
PSVLLELLSQ SCLIPAMSSY LRNDSVLDMA RHVPLYRALL ELLRAIASCT SMVPLLLPLS 

      4450       4460       4470       4480       4490       4500 
TENGEEEEDE QSECQTSVGT LLAKMKTCVD TYTNRLRSKR ENVKAGVKPD APDQEPEGLA 

      4510       4520       4530       4540       4550       4560 
LLVPDIQRTA EIVHAATANL RQANQEKKLG EYSKKVVMKP KPLSVLKSLE EKYVAVMKKL 

      4570       4580       4590       4600       4610       4620 
QFDTFEMVSE DDDGKLGFKV NYHYMSQVKN ANDANSAARA RRLAQEAVTL STSLPLSSSS 

      4630       4640       4650       4660       4670       4680 
SVFVRCDEER LDIMKVLITG PADTPYANGC FEFDVYFPQD YPSSPPLVNL ETTGGHSVRF 

      4690       4700       4710       4720       4730       4740 
NPNLYNDGKV CLSILNTWHG RPEEKWNPQT SSFLQVLVSV QSLILVAEPY FNEPGYERSR 

      4750       4760       4770       4780       4790       4800 
GTPSGTQSSR EYDGNIRQAT VKWAMLEQIR NPSPCFKEVI HKHFYLKRIE LMAQCEEWIA 

      4810       4820       4830       4840       4850       4860 
DIQQYSSDKR VGRTMSHHAA ALKRHTAQLR EELLKLPCPE GLDPDIEDAS PVCRATAGAE 

      4870       4880 
DTLTHDHVNP SSSKDLPSDF QL 

« Hide

Isoform 2 [UniParc].

Checksum: 58562C9F94576EF2
Show »

FASTA4,873531,067
Isoform 3 [UniParc].

Checksum: A6386423866153B0
Show »

FASTA4,867530,518

References

« Hide 'large scale' references
[1]"A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors."
Hauser H.P., Bardroff M., Pyrowolakis G., Jentsch S.
J. Cell Biol. 141:1415-1422(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY.
Strain: C57BL/6J.
Tissue: Aorta and Vein.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-893; 3091-3912 AND 4121-4523.
Strain: C57BL/6J.
Tissue: Aorta, Corpora quadrigemina, Kidney and Vein.
[4]"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1905-3034 (ISOFORM 3).
Tissue: Brain.
[5]"BRUCE, a giant E2/E3 ubiquitin ligase and inhibitor of apoptosis protein of the trans-Golgi network, is required for normal placenta development and mouse survival."
Lotz K., Pyrowolakis G., Jentsch S.
Mol. Cell. Biol. 24:9339-9350(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
[6]"Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function."
Hao Y., Sekine K., Kawabata A., Nakamura H., Ishioka T., Ohata H., Katayama R., Hashimoto C., Zhang X., Noda T., Tsuruo T., Naito M.
Nat. Cell Biol. 6:849-860(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT, INTERACTION WITH HTRA2; CASP9 AND DIABLO/SMAC.
[7]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y17267 mRNA. Translation: CAA76720.1. Different initiation.
AC098726 Genomic DNA. No translation available.
AC154442 Genomic DNA. No translation available.
AK041241 mRNA. Translation: BAC30874.1.
AK045446 mRNA. Translation: BAC32373.1. Different initiation.
AK052612 mRNA. Translation: BAC35061.1.
AK079995 mRNA. Translation: BAC37801.1. Different initiation.
AK173143 Transcribed RNA. Translation: BAD32421.1.
CCDSCCDS37693.2. [O88738-2]
PIRT31067.
RefSeqNP_031592.3. NM_007566.3. [O88738-2]
UniGeneMm.442564.
Mm.447926.

3D structure databases

ProteinModelPortalO88738.
SMRO88738. Positions 4546-4843.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO88738. 10 interactions.
MINTMINT-4105645.

Protein family/group databases

MEROPSI32.006.

PTM databases

PhosphoSiteO88738.

Proteomic databases

MaxQBO88738.
PaxDbO88738.
PRIDEO88738.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000180037; ENSMUSP00000136329; ENSMUSG00000024073. [O88738-2]
ENSMUST00000182133; ENSMUSP00000138693; ENSMUSG00000024073. [O88738-3]
ENSMUST00000182597; ENSMUSP00000138333; ENSMUSG00000024073. [O88738-1]
GeneID12211.
KEGGmmu:12211.
UCSCuc008doe.1. mouse. [O88738-1]
uc008dof.1. mouse. [O88738-2]

Organism-specific databases

CTD57448.
MGIMGI:1276108. Birc6.
RougeSearch...

Phylogenomic databases

eggNOGCOG5078.
GeneTreeENSGT00730000110680.
HOGENOMHOG000168828.
HOVERGENHBG050691.
InParanoidO88738.
KOK10586.
OMAGHVDFKF.
OrthoDBEOG7VTDM2.
TreeFamTF105357.

Gene expression databases

ArrayExpressO88738.
BgeeO88738.
GenevestigatorO88738.

Family and domain databases

Gene3D1.10.1170.10. 1 hit.
2.130.10.10. 4 hits.
3.10.110.10. 1 hit.
InterProIPR001370. BIR.
IPR022103. BIRC6.
IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00653. BIR. 1 hit.
PF12356. DUF3643. 1 hit.
PF00179. UQ_con. 1 hit.
[Graphical view]
SMARTSM00238. BIR. 1 hit.
[Graphical view]
SUPFAMSSF50978. SSF50978. 4 hits.
SSF54495. SSF54495. 1 hit.
PROSITEPS50143. BIR_REPEAT_2. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBIRC6. mouse.
NextBio280605.
PROO88738.
SOURCESearch...

Entry information

Entry nameBIRC6_MOUSE
AccessionPrimary (citable) accession number: O88738
Secondary accession number(s): E9PYU6 expand/collapse secondary AC list , Q69ZM5, Q8BNX0, Q8BR72, Q8BRV7, Q8C737
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: March 21, 2012
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot