O88738 (O88738_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Ubiquitin-conjugating enzyme EMBL CAA76720.1

Gene names

Name:

Birc6 MGI 1276108

Organism

Mus musculus (Mouse) EMBL CAA76720.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	4845 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological process	anti-apoptosis Inferred from mutant phenotype. Source: MGI labyrinthine layer development Inferred from mutant phenotype. Source: MGI positive regulation of cell proliferation Inferred from mutant phenotype. Source: MGI spongiotrophoblast layer development Inferred from mutant phenotype. Source: MGI
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro membrane fraction Inferred from direct assay Ref.1. Source: MGI
Molecular function	ubiquitin-protein ligase activity Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O88738 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 35C585F73B8CF84C	FASTA	4,845	528,424
	10 20 30 40 50 60 MAAAAAEASG PSCSSAAAAA GAGAAGVSEW LVLRDGCMRC DADGLHSLSY HPALNAILAV 70 80 90 100 110 120 TSRGTIKVID GTSGATLQAS ALSAKPGGQV KCQYISAVDK VIFVDDYAVG CRKDLNGILL 130 140 150 160 170 180 LDTALQTPVS KQDDVVQLEL PVTEAQQLLS ACIEKIDVSS TEGYDLFITQ LKDGLKNISH 190 200 210 220 230 240 ETAANHKVAK WATVTFHLPH HVLKSIASAI VNELKKINQN VAALPVASSV MDRLSYLLPS 250 260 270 280 290 300 ARPELGVGPG RSVDRALMYS EANRRETFTS WPHVGYRWAQ PDPMAQAGFY HQPASSGDDR 310 320 330 340 350 360 AMCFTCSVCL VCWEPTDEPW SEHERHSPNC PFVKGEHTQN VPLSVTLATS PAQLPSADGA 370 380 390 400 410 420 DRIACFGSGS CPQFLAAATK RGKICIWDVS KLMKVHLKFE INAYDPAIVQ QLILSGDPSS 430 440 450 460 470 480 GVDSRRPTLA WLEDSSSCSD IPKLEGDSDD LLEDSDSEEH SRSDSVTGHT SQKEAMEVSL 490 500 510 520 530 540 DITALSILQQ PEKLQWEIVA NVLEDTVKDL EELGANPSLT NSKSEKTKEK HQEQHNIPFP 550 560 570 580 590 600 CLLAGGLLTY KSPATSPISS NSHRSLDGLS RTQGESISEQ GSTDNESCTN SELNSPLVRR 610 620 630 640 650 660 TLPVLLLYSI KESDEKAGKI FSQMNNIMSK SLHDDGFTVP QIIEMELDNQ EQLLLQDPPV 670 680 690 700 710 720 TYIQQFADAA ASLTSPDSEK WNSVFPKPGT LVQCLRLPKF AEEETLCIDS ITPCADGIHL 730 740 750 760 770 780 LVGLRTCSVE SLSAINQVEA LNNLNKLNSA LCNRRKGDLE SNLAVVNGAN ISVIQHESPA 790 800 810 820 830 840 DVPEHLLIRP EQRNVVSGGY LVLYKMNYTT RIVTLEEEPV KIQHIKDPQD TITSLILLPP 850 860 870 880 890 900 DILDNREDDC EEPAEEMQLA SKNGIEREKK SDISTLGHLV VTTQGGYVKV LDLSNFEILA 910 920 930 940 950 960 KVEPPKKEGT EEQDTFVSVI YCSGTDRLCA CTKGGELHFL QIGGTCDDID EADILVDGSL 970 980 990 1000 1010 1020 SKGIEPALEG SRPLSNPSSP GISGVELLVD QPFTLEILTS LVELTRFETL TPRFSATVPP 1030 1040 1050 1060 1070 1080 CWVEVQQEQQ QRRHPQHLHQ QHHGDAAQHT RTWKLQTDSN SWDEHVFELV LPKACMVGHV 1090 1100 1110 1120 1130 1140 DFKFVLNSNI TSVPQIQVTL LKNKAPGLGK ANALNIEVEH NGNPSLVDLN EEMHHMDVEE 1150 1160 1170 1180 1190 1200 SQCLRLCPFL EDHKEDILCG PVWLASGLDL SGHAGMLTLT SPKLVKGMAG GKYRSFLIHV 1210 1220 1230 1240 1250 1260 KAVSDRGAAD EMCSSGLRPV VRLPSLKQQG HKGYSLASLL AKVAAGKEKS SNVKNENAGG 1270 1280 1290 1300 1310 1320 TRKSENLRGC DLLQEVSVTI RRFKKTSICK ERVQRCAMLQ FSEFHEKLLN TLCRRSDDGQ 1330 1340 1350 1360 1370 1380 VTEHAQSLVL DALCWLAGVH SNGSGSSKEG NECLLSKTRK CLSDIVRVCF FEAGRSIAHK 1390 1400 1410 1420 1430 1440 CARFLALCIS NGKCEPCQPG FGSVLLKALL DNMCFLPAAA TGGSVYWYFV LLNYVKDEDL 1450 1460 1470 1480 1490 1500 AGCSTACAAL LTAVSRQLQD RLTPLEALLQ TRYGLYSSPF DPVLFDLEMS GSSWKTVYSS 1510 1520 1530 1540 1550 1560 STAVQSDEID LSDVLSGNGR VSSCTAAEGS FTSLTGLLEV EPLHFTCVST SDGTRIERDD 1570 1580 1590 1600 1610 1620 ASTFTVSSFG VPPAVGGLSS GTVGEASTAL SSAAQVALQS LSHAMASAEQ QLQVLQEKQQ 1630 1640 1650 1660 1670 1680 QLLKLQQQKA KLEAKLHQTT AAAAAAASAA AAAAAGPVHN AVPSNPVAAP GFFIHPSDVI 1690 1700 1710 1720 1730 1740 PPTPKTTPLF MTPPLTPPNE AVSVVINAEL AQLFPGSVID PPAVNLAAQN KNSSKSRMNP 1750 1760 1770 1780 1790 1800 LGSGLALAIS HASHFLQPPP HQSIIIERMH SGARRFVTLD FGRPILLTDV LIPTCGDLAS 1810 1820 1830 1840 1850 1860 LSIDIWTLGE EVDGRRLVVA TDISTHSLIL HDLIPPPVCR FMKITVIGRY GSTNARAKIP 1870 1880 1890 1900 1910 1920 LGFYYGHSYI LPWESELKLM HDPLRGEGES ASQPEIDQHL AMMVALQEDI QCRYNLACHR 1930 1940 1950 1960 1970 1980 LEALLQSIDL PPLNSANNAQ YFLRKPDKAV EEDSRVFSAY QDCIQLQLQL NLAHNAVQRL 1990 2000 2010 2020 2030 2040 KVAIGASRKL LNETSGPEDL IQTSSTEQLR TIVRYLLDTL LSLLHSSNGH SVPAVLQSTF 2050 2060 2070 2080 2090 2100 HAQACEELFK HLCISGTPKI RLHTGLLLVQ LCGGERWWRQ FLSNVLQELY NSEQLLIFPQ 2110 2120 2130 2140 2150 2160 DRVFMLLSCI GQRSLSNSGV LESLLNLLDN LLSPLQPELS MHRRTEGVLD IPMISWVVML 2170 2180 2190 2200 2210 2220 VSRLLDYVAT VEDEAAAAKK PLNGNQWSFI NNNLHTQNLN RSSKGGSSLD RLYSRKIRKQ 2230 2240 2250 2260 2270 2280 LVHHKQQLNL LKAKQKALVE QMEKEKIQSN KGSSYKLLVE QAKLKQATSK HFKDLIRLRR 2290 2300 2310 2320 2330 2340 TAEWSRSNLD TEVTTTKESP EIEPLPFTLA HDRCISVVQK LVLFLLSMDF TCHADLLLFV 2350 2360 2370 2380 2390 2400 CKVLARIANA TRPTIHLCEI VNEPQLERLL LLLVGTDFNR GDISWGGAWA QYSLTCMLQD 2410 2420 2430 2440 2450 2460 ILAGELLAPV AAEAMEEGTV SEDVGATAGD SDDSLQQSPA QLLETIDEPL THEIAGTPPL 2470 2480 2490 2500 2510 2520 SSLEKDKEID LELLQDLMEV DIDPLDIDLE KDPLAAKVFK PISSTWYDYW GADYGTYNYN 2530 2540 2550 2560 2570 2580 PYIGGLGMPV AKPPSNTEKN GSQTVSVSVS QALDARLEVG LEQQAELMLK MMSTLEADSI 2590 2600 2610 2620 2630 2640 LQALTNTSPT FSQSPTGTDD SLLGNLQPAN QNSQLMIQLS SVPMLNVCFN KLFSMLQVHH 2650 2660 2670 2680 2690 2700 VQLESLLQLW LTLSLNSSSS GNKENGADIF LYNANRIPVI SLNQASIASF LTVLAWYPNT 2710 2720 2730 2740 2750 2760 LLRTWCLVLH SLTLMTNMQL NSGSSSSIGI QETTAHLLVS DPNLIHVLVK FLSGTSPHGT 2770 2780 2790 2800 2810 2820 NQHSPQVGPT ATQAMQEFLT RLQVHLSSTC PQIFSELLLK LIHILSTERG AFQTGQGPLD 2830 2840 2850 2860 2870 2880 AQVKLLEFTL EQNFEVVSVS TISAVIESVT FLVHHYITCS DKVMSRSGSD SSAGARACFG 2890 2900 2910 2920 2930 2940 GLFANLIRPG DAKAVCGEMT RDQLMFDLLK LVNILVQLPL SSNREYSARV SVTTNTTDSV 2950 2960 2970 2980 2990 3000 SDEEKVSGGK DVNGSSASIP GSPACVADLV LANQQIMSQI LSALGLCNSS AMAMIIGASG 3010 3020 3030 3040 3050 3060 LHLTKHENFH GGLDAISVGD GLFTILTTLS KKASTVHMML QPILTYMACG YMGRQGSLAT 3070 3080 3090 3100 3110 3120 CQLSEPLLWF ILRVLDTSDA LKAFHDMGGV QLICNNMVTS TRAIVNTARS MVSTIMKFLD 3130 3140 3150 3160 3170 3180 SGPNKAVDST LKTRILASEP DNAEGIHNFA PLGTITSSSP TAQPAEVLLQ ATPPHRRARS 3190 3200 3210 3220 3230 3240 AAWSYIFLPE EAWCDLTIHL PSAVLLKEIH IQPHLASLAT CPSSVTVEVS ADGVNMLPLS 3250 3260 3270 3280 3290 3300 TPVVTSGLTY IKIQLVKAEV ASAVCLRLHR PRDASTLGLS QIKLLGLTAF GTTSSATVNN 3310 3320 3330 3340 3350 3360 PFLPSEDQVS KTSIGWLRLL HHCLTHISDL EGMMASAAAP TANLLQTCAA LLMSPYCGMH 3370 3380 3390 3400 3410 3420 SPNIEVVLVK IGLQSTRIGL KLIDILLRNC AASGSDPTDL NSPLLFGRLN GLSSDSTIDI 3430 3440 3450 3460 3470 3480 LYQLGTTQDP GTKDRIQALL KWVSDSAKMA ALKRSGRMNY MCPSSSAVEY GLLMPSPSHL 3490 3500 3510 3520 3530 3540 HCVAAILWHS YELLVEYDLP ALLDRELFEL LFNWSMSLPC NVVLKKAVDS LLCSMCHIHP 3550 3560 3570 3580 3590 3600 NYFSLLMGWM GIIPPPVQCH HRLSMTDDSK KQDLSSSLTD DSKNAQAPLS LTESHLATLA 3610 3620 3630 3640 3650 3660 SSSQSPEAIK QLLDSGLPSL LVRSLASFCF SHISYSESIA QSVDNSQDKL RRHHVPQHCN 3670 3680 3690 3700 3710 3720 KMPITADLVA PILRFLTEVG NSHIMKDWLG GSEVNPLWTA LLFLLCHSGS TAGGHNLGAQ 3730 3740 3750 3760 3770 3780 QSSTRSASHS SATTTVLTTQ QRTAIENATV AFFLQCISCH PNNQKLMAQV LCELFQTAPQ 3790 3800 3810 3820 3830 3840 RGSLPTSGNI SGFVRRLFLQ LMLEDEKVTM FLQSPCPLYK GRINATSHVI QHPMFGAGHK 3850 3860 3870 3880 3890 3900 FRTLHLPVST TLSDVLDRVS DTPSITAKLI SEQKDDKEKK NHEEKEKVKA ENGFQDNYSV 3910 3920 3930 3940 3950 3960 VVASGLKSQS KRAVASTPPR PPSRRGRTVP DKIGSASSSA DAASKIITVP VFHLFHRLLA 3970 3980 3990 4000 4010 4020 GQPLPAEMTL AQLLTLLYDR KLPQGYRSID LTVKLGSKVI TDPSLSKTDS FKRLHPEKDH 4030 4040 4050 4060 4070 4080 GDLVGSCPED EALTPSDECM DGVLDESLLE TCPIQSPLQV FAGMGGLALI AERLPMLYPE 4090 4100 4110 4120 4130 4140 VIQQVSAPVI ASTTQEKPKD SDQFEWVTIE QSGELVYEAP ETIAAEPPPV KSAVQATSPI 4150 4160 4170 4180 4190 4200 PAHSLAAFGL FLRLPGYAEV LLKERKHAQC LLRLVLGVTD DGEGSHILQS PSANVLPTLP 4210 4220 4230 4240 4250 4260 FHVLRSLFSA TPLTTDDGVL LRRMALEIGA LHLILVCLSA LSHHAPRVPN SSLSQTEPQV 4270 4280 4290 4300 4310 4320 SNSHNPTSAE EQQLYWAKGT GFGTGSTASG WDVEQALTKQ RLEEEHVTCL LQVLASYINP 4330 4340 4350 4360 4370 4380 MSGAVNGEAQ ASPESRAQNS SALPSMLLEL LSQSCLIPAM SSYLRNDSVL DMARHVPLYR 4390 4400 4410 4420 4430 4440 ALLELLRAIA SCTSMVPLLL PLSTENGEEE EDEQSECQTS VGTLLAKMKT CVDTYTNRLR 4450 4460 4470 4480 4490 4500 SKRENVKAGV KPDAPDQEPE GLALLVPDIQ RTAEIVHAAT ANLRQANQEK KLGEYSKKVV 4510 4520 4530 4540 4550 4560 MKPKPLSVLK SLEEKYVAVM KKLQFDTFEM VSEDDDGKLG FKVNYHYMSQ VKNANDANSA 4570 4580 4590 4600 4610 4620 ARARRLAQEA VTLSTSLPLS SSSSVFVRCD EERLDIMKVL ITGPADTPYA NGCFEFDVYF 4630 4640 4650 4660 4670 4680 PQDYPSSPPL VNLETTGGHS VRFNPNLYND GKVCLSILNT WHGRPEEKWN PQTSSFLQVL 4690 4700 4710 4720 4730 4740 VSVQSLILVA EPYFNEPGYE RSRGTPSGTQ SSREYDGNIR QATVKWAMLE QIRNPSPCFK 4750 4760 4770 4780 4790 4800 EVIHKHFYLK RIELMAQCEE WIADIQQYSS DKRVGRTMSH HAAALKRHTA QLREELLKLP 4810 4820 4830 4840 CPEGLDPDIE DASPVCRATA GAEDTLTHDH VNPSSSKDLP SDFQL

References

[1]	"A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors." Hauser H.P., Bardroff M., Pyrowolakis G., Jentsch S. J. Cell Biol. 141:1415-1422(1998) [PubMed: 9628897] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	Jentsch S.P. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y17267 mRNA. Translation: CAA76720.1.
IPI	IPI00134095.
PIR	T31067.
RefSeq	NP_031592.2. NM_007566.2.
UniGene	Mm.290908. Mm.447926.
3D structure databases
HSSP	HSSP built from PDB template 1I3O based on UniProtKB P98170.
ProteinModelPortal	O88738.
SMR	O88738. Positions 4509-4806.
ModBase	Search...
Protein-protein interaction databases
IntAct	O88738. 7 interactions.
MINT	MINT-4105645.
STRING	O88738.
Protein family/group databases
MEROPS	I32.006.
PTM databases
PhosphoSite	O88738.
Proteomic databases
PRIDE	O88738.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	12211.
KEGG	mmu:12211.
UCSC	uc008doe.1. mouse.
Organism-specific databases
CTD	57448.
MGI	MGI:1276108. Birc6.
Phylogenomic databases
eggNOG	roNOG04204.
HOGENOM	HBG355747.
HOVERGEN	HBG050691.
InParanoid	O88738.
OrthoDB	EOG4DJJVH.
Gene expression databases
ArrayExpress	O88738.
Genevestigator	O88738.
Family and domain databases
InterPro	IPR001370. BIR. IPR022103. DUF3643. IPR000608. UBQ-conjugat_E2. IPR016135. UBQ-conjugating_enzyme/RWD. IPR015943. WD40/YVTN_repeat-like_dom. [Graphical view]
Gene3D	G3DSA:1.10.1170.10. BIR. 1 hit. G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit. G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 4 hits.
KO	K10586.
Pfam	PF00653. BIR. 1 hit. PF12356. DUF3643. 1 hit. PF00179. UQ_con. 1 hit. [Graphical view]
SMART	SM00238. BIR. 1 hit. [Graphical view]
SUPFAM	SSF54495. UBQ-conjugat/RWD-like. 1 hit.
PROSITE	PS50143. BIR_REPEAT_2. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	280605.
SOURCE	Search...

Entry information

Entry name

O88738_MOUSE

Accession

Primary (citable) accession number: O88738

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1998
Last sequence update:	November 1, 1998
Last modified:	November 16, 2011
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)