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O88736

- DHB7_MOUSE

UniProt

O88736 - DHB7_MOUSE

Protein

3-keto-steroid reductase

Gene

Hsd17b7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Responsible for the reduction of the keto group on the C-3 of sterols.

    Catalytic activityi

    A 3-beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH.
    17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei171 – 1711SubstrateBy similarity
    Active sitei193 – 1931Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 158NADSequence Analysis

    GO - Molecular functioni

    1. 3-keto sterol reductase activity Source: MGI
    2. estradiol 17-beta-dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cholesterol biosynthetic process Source: MGI
    2. estrogen biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

    Keywords - Ligandi

    NAD, NADP

    Enzyme and pathway databases

    ReactomeiREACT_208531. Cholesterol biosynthesis.
    UniPathwayiUPA00769.
    UPA00770; UER00758.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-keto-steroid reductase (EC:1.1.1.270)
    Alternative name(s):
    17-beta-hydroxysteroid dehydrogenase 7
    Short name:
    17-beta-HSD 7
    Estradiol 17-beta-dehydrogenase 7 (EC:1.1.1.62)
    Gene namesi
    Name:Hsd17b7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1330808. Hsd17b7.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3343343-keto-steroid reductasePRO_0000054587Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiO88736.
    PaxDbiO88736.
    PRIDEiO88736.

    PTM databases

    PhosphoSiteiO88736.

    Expressioni

    Tissue specificityi

    Most abundant in ovaries of pregnant animals. Present also in nonpregnant animals in ovaries, mammary gland, liver, kidney and testis.

    Gene expression databases

    ArrayExpressiO88736.
    BgeeiO88736.
    CleanExiMM_HSD17B7.
    GenevestigatoriO88736.

    Interactioni

    Protein-protein interaction databases

    BioGridi200436. 1 interaction.
    IntActiO88736. 1 interaction.
    MINTiMINT-1862744.

    Structurei

    3D structure databases

    ProteinModelPortaliO88736.
    SMRiO88736. Positions 3-250.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 229229ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini251 – 33484CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei230 – 25021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1028.
    GeneTreeiENSGT00390000013340.
    HOGENOMiHOG000253921.
    HOVERGENiHBG058236.
    KOiK13373.
    OMAiCHSDNPS.
    OrthoDBiEOG7S4X6D.
    TreeFamiTF105433.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.

    Sequencei

    Sequence statusi: Complete.

    O88736-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKVVLITGA SSGIGLALCG RLLAEDDDLH LCLACRNLSK ARAVRDTLLA    50
    SHPSAEVSIV QMDVSSLQSV VRGAEEVKQK FQRLDYLYLN AGILPNPQFN 100
    LKAFFCGIFS RNVIHMFTTA EGILTQNDSV TADGLQEVFE TNLFGHFILI 150
    RELEPLLCHA DNPSQLIWTS SRNAKKANFS LEDIQHSKGP EPYSSSKYAT 200
    DLLNVALNRN FNQKGLYSSV MCPGVVMTNM TYGILPPFIW TLLLPIMWLL 250
    RFFVNALTVT PYNGAEALVW LFHQKPESLN PLTKYASATS GFGTNYVTGQ 300
    KMDIDEDTAE KFYEVLLELE KRVRTTVQKS DHPS 334
    Length:334
    Mass (Da):37,317
    Last modified:November 1, 1998 - v1
    Checksum:iE05F0716465BC160
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti160 – 1601A → V in CAC88119. 1 PublicationCurated
    Sequence conflicti160 – 1601A → V in BC011464. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y15733 mRNA. Translation: CAA75742.1.
    AJ291459
    , AJ291460, AJ291461, AJ291463, AJ291465, AJ291466, AJ291464, AJ291462 Genomic DNA. Translation: CAC88119.1.
    AK028380 mRNA. Translation: BAC25918.1.
    AK050211 mRNA. Translation: BAC34124.1.
    BC011464 mRNA. No translation available.
    AF367475 Genomic DNA. Translation: AAM21211.1.
    CCDSiCCDS35766.1.
    RefSeqiNP_034606.3. NM_010476.3.
    UniGeneiMm.12882.

    Genome annotation databases

    EnsembliENSMUST00000027989; ENSMUSP00000027989; ENSMUSG00000026675.
    GeneIDi15490.
    KEGGimmu:15490.
    UCSCiuc007dlp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y15733 mRNA. Translation: CAA75742.1 .
    AJ291459
    , AJ291460 , AJ291461 , AJ291463 , AJ291465 , AJ291466 , AJ291464 , AJ291462 Genomic DNA. Translation: CAC88119.1 .
    AK028380 mRNA. Translation: BAC25918.1 .
    AK050211 mRNA. Translation: BAC34124.1 .
    BC011464 mRNA. No translation available.
    AF367475 Genomic DNA. Translation: AAM21211.1 .
    CCDSi CCDS35766.1.
    RefSeqi NP_034606.3. NM_010476.3.
    UniGenei Mm.12882.

    3D structure databases

    ProteinModelPortali O88736.
    SMRi O88736. Positions 3-250.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200436. 1 interaction.
    IntActi O88736. 1 interaction.
    MINTi MINT-1862744.

    PTM databases

    PhosphoSitei O88736.

    Proteomic databases

    MaxQBi O88736.
    PaxDbi O88736.
    PRIDEi O88736.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027989 ; ENSMUSP00000027989 ; ENSMUSG00000026675 .
    GeneIDi 15490.
    KEGGi mmu:15490.
    UCSCi uc007dlp.1. mouse.

    Organism-specific databases

    CTDi 51478.
    MGIi MGI:1330808. Hsd17b7.

    Phylogenomic databases

    eggNOGi COG1028.
    GeneTreei ENSGT00390000013340.
    HOGENOMi HOG000253921.
    HOVERGENi HBG058236.
    KOi K13373.
    OMAi CHSDNPS.
    OrthoDBi EOG7S4X6D.
    TreeFami TF105433.

    Enzyme and pathway databases

    UniPathwayi UPA00769 .
    UPA00770 ; UER00758 .
    Reactomei REACT_208531. Cholesterol biosynthesis.

    Miscellaneous databases

    NextBioi 288362.
    PROi O88736.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O88736.
    Bgeei O88736.
    CleanExi MM_HSD17B7.
    Genevestigatori O88736.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    ProtoNeti Search...

    Publicationsi

    1. "Expression cloning of a novel estrogenic mouse 17 beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (m17HSD7), previously described as a prolactin receptor-associated protein (PRAP) in rat."
      Nokelainen P., Peltoketo H., Vihko R., Vihko P.
      Mol. Endocrinol. 12:1048-1059(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Mammary gland.
    2. "Characterization of mouse 17beta-hydroxysteroid dehydrogenase type 7 gene."
      Nokelainen P., Vihko P.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Liver and Placenta.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    5. "Characterization of mouse gene for 17-beta-hydroxysteroid dehydrogenase type 7."
      Ohnesorg T., Adamski J.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 1-301.

    Entry informationi

    Entry nameiDHB7_MOUSE
    AccessioniPrimary (citable) accession number: O88736
    Secondary accession number(s): Q8K5C9, Q921L1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3