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Protein

3-keto-steroid reductase

Gene

Hsd17b7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the reduction of the keto group on the C-3 of sterols.

Catalytic activityi

A 3-beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH.
17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.

Pathwayi: estrogen biosynthesis

This protein is involved in the pathway estrogen biosynthesis, which is part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway estrogen biosynthesis and in Steroid biosynthesis.

Pathwayi: zymosterol biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes zymosterol from lanosterol.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Lanosterol 14-alpha demethylase (Cyp51a1)
  2. no protein annotated in this organism
  3. Methylsterol monooxygenase 1 (Msmo1)
  4. Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (Nsdhl)
  5. 3-keto-steroid reductase (Hsd17b7)
  6. no protein annotated in this organism
This subpathway is part of the pathway zymosterol biosynthesis, which is itself part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes zymosterol from lanosterol, the pathway zymosterol biosynthesis and in Steroid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei171SubstrateBy similarity1
Active sitei193Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 15NADSequence analysis8

GO - Molecular functioni

  • 3-keto sterol reductase activity Source: MGI
  • estradiol 17-beta-dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  • cholesterol biosynthetic process Source: MGI
  • estrogen biosynthetic process Source: UniProtKB-UniPathway

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis
LigandNAD, NADP

Enzyme and pathway databases

BRENDAi1.1.1.270 3474
1.1.1.62 3474
ReactomeiR-MMU-191273 Cholesterol biosynthesis
UniPathwayiUPA00769
UPA00770; UER00758

Chemistry databases

SwissLipidsiSLP:000001215

Names & Taxonomyi

Protein namesi
Recommended name:
3-keto-steroid reductase (EC:1.1.1.270)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase 7
Short name:
17-beta-HSD 7
Estradiol 17-beta-dehydrogenase 7 (EC:1.1.1.62)
Gene namesi
Name:Hsd17b7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1330808 Hsd17b7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 229ExtracellularSequence analysisAdd BLAST229
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 334CytoplasmicSequence analysisAdd BLAST84

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000545871 – 3343-keto-steroid reductaseAdd BLAST334

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi229N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO88736
MaxQBiO88736
PaxDbiO88736
PeptideAtlasiO88736
PRIDEiO88736

PTM databases

iPTMnetiO88736
PhosphoSitePlusiO88736
SwissPalmiO88736

Expressioni

Tissue specificityi

Most abundant in ovaries of pregnant animals. Present also in nonpregnant animals in ovaries, mammary gland, liver, kidney and testis.

Gene expression databases

BgeeiENSMUSG00000026675
CleanExiMM_HSD17B7
ExpressionAtlasiO88736 baseline and differential
GenevisibleiO88736 MM

Interactioni

Protein-protein interaction databases

BioGridi200436, 1 interactor
IntActiO88736, 1 interactor
STRINGi10090.ENSMUSP00000027989

Structurei

3D structure databases

ProteinModelPortaliO88736
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1478 Eukaryota
ENOG410XPNE LUCA
GeneTreeiENSGT00390000013340
HOGENOMiHOG000253921
HOVERGENiHBG058236
InParanoidiO88736
KOiK13373
OMAiHPGIFTS
TreeFamiTF105433

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
SUPFAMiSSF51735 SSF51735, 2 hits

Sequencei

Sequence statusi: Complete.

O88736-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKVVLITGA SSGIGLALCG RLLAEDDDLH LCLACRNLSK ARAVRDTLLA
60 70 80 90 100
SHPSAEVSIV QMDVSSLQSV VRGAEEVKQK FQRLDYLYLN AGILPNPQFN
110 120 130 140 150
LKAFFCGIFS RNVIHMFTTA EGILTQNDSV TADGLQEVFE TNLFGHFILI
160 170 180 190 200
RELEPLLCHA DNPSQLIWTS SRNAKKANFS LEDIQHSKGP EPYSSSKYAT
210 220 230 240 250
DLLNVALNRN FNQKGLYSSV MCPGVVMTNM TYGILPPFIW TLLLPIMWLL
260 270 280 290 300
RFFVNALTVT PYNGAEALVW LFHQKPESLN PLTKYASATS GFGTNYVTGQ
310 320 330
KMDIDEDTAE KFYEVLLELE KRVRTTVQKS DHPS
Length:334
Mass (Da):37,317
Last modified:November 1, 1998 - v1
Checksum:iE05F0716465BC160
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160A → V in CAC88119 (Ref. 2) Curated1
Sequence conflicti160A → V in BC011464 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15733 mRNA Translation: CAA75742.1
AJ291459
, AJ291460, AJ291461, AJ291463, AJ291465, AJ291466, AJ291464, AJ291462 Genomic DNA Translation: CAC88119.1
AK028380 mRNA Translation: BAC25918.1
AK050211 mRNA Translation: BAC34124.1
BC011464 mRNA No translation available.
AF367475 Genomic DNA Translation: AAM21211.1
CCDSiCCDS35766.1
RefSeqiNP_034606.3, NM_010476.3
UniGeneiMm.12882

Genome annotation databases

EnsembliENSMUST00000027989; ENSMUSP00000027989; ENSMUSG00000026675
GeneIDi15490
KEGGimmu:15490
UCSCiuc007dlp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDHB7_MOUSE
AccessioniPrimary (citable) accession number: O88736
Secondary accession number(s): Q8K5C9, Q921L1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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