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Protein

Vasopressin V2 receptor

Gene

Avpr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-388479. Vasopressin-like receptors.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-MMU-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V2 receptor
Short name:
V2R
Alternative name(s):
AVPR V2
Antidiuretic hormone receptor
Renal-type arginine vasopressin receptor
Gene namesi
Name:Avpr2
Synonyms:V2r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:88123. Avpr2.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 63Helical; Name=1Sequence analysisAdd BLAST25
Topological domaini64 – 77CytoplasmicSequence analysisAdd BLAST14
Transmembranei78 – 98Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini99 – 113ExtracellularSequence analysisAdd BLAST15
Transmembranei114 – 135Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini136 – 159CytoplasmicSequence analysisAdd BLAST24
Transmembranei160 – 180Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini181 – 200ExtracellularSequence analysisAdd BLAST20
Transmembranei201 – 220Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini221 – 271CytoplasmicSequence analysisAdd BLAST51
Transmembranei272 – 293Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini294 – 308ExtracellularSequence analysisAdd BLAST15
Transmembranei309 – 328Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini329 – 371CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702091 – 371Vasopressin V2 receptorAdd BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22N-linked (GlcNAc...)Sequence analysis1
Glycosylationi185N-linked (GlcNAc...)Sequence analysis1
Lipidationi341S-palmitoyl cysteineBy similarity1
Lipidationi342S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO88721.
PRIDEiO88721.

PTM databases

PhosphoSitePlusiO88721.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031390.
CleanExiMM_AVPR2.
ExpressionAtlasiO88721. baseline and differential.
GenevisibleiO88721. MM.

Interactioni

Subunit structurei

Interacts with ARRDC4. Identified in a complex containing at least ARRDC4, V2R and HGS.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033765.

Structurei

3D structure databases

ProteinModelPortaliO88721.
SMRiO88721.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiO88721.
KOiK04228.
OMAiGGARWNR.
OrthoDBiEOG091G0DB6.
PhylomeDBiO88721.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000161. Vprsn_rcpt_V2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00898. VASOPRSNV2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88721-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILVSTTSAV PGALSSPSSP SNSSQEELLD DRDPLLVRAE LALLSTIFVA
60 70 80 90 100
VALSNGLVLG ALIRRGRRGR WAPMHVFISH LCLADLAVAL FQVLPQLAWD
110 120 130 140 150
ATDRFHGPDA LCRAVKYLQM VGMYASSYMI LAMTLDRHRA ICRPMLAYRH
160 170 180 190 200
GGGARWNRPV LVAWAFSLLL SLPQLFIFAQ RDVGNGSGVF DCWARFAEPW
210 220 230 240 250
GLRAYVTWIA LMVFVAPALG IAACQVLIFR EIHASLVPGP SERAGRRRRG
260 270 280 290 300
HRTGSPSEGA HVSAAMAKTV RMTLVIVIVY VLCWAPFFLV QLWAAWDPEA
310 320 330 340 350
PLERPPFVLL MLLASLNSCT NPWIYASFSS SVSSELRSLL CCAQRHTTHS
360 370
LGPQDESCAT ASSSLMKDTP S
Length:371
Mass (Da):40,645
Last modified:November 1, 1998 - v1
Checksum:iF2E7CBEA1113FD5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006691 Genomic DNA. Translation: CAA07187.1.
AF133093 Genomic DNA. No translation available.
AJ310753 mRNA. Translation: CAC34589.1.
CCDSiCCDS30216.1.
RefSeqiNP_062277.1. NM_019404.2.
XP_006527819.1. XM_006527756.3.
UniGeneiMm.383171.

Genome annotation databases

EnsembliENSMUST00000033765; ENSMUSP00000033765; ENSMUSG00000031390.
GeneIDi12000.
KEGGimmu:12000.
UCSCiuc009tmx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006691 Genomic DNA. Translation: CAA07187.1.
AF133093 Genomic DNA. No translation available.
AJ310753 mRNA. Translation: CAC34589.1.
CCDSiCCDS30216.1.
RefSeqiNP_062277.1. NM_019404.2.
XP_006527819.1. XM_006527756.3.
UniGeneiMm.383171.

3D structure databases

ProteinModelPortaliO88721.
SMRiO88721.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033765.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiO88721.

Proteomic databases

PaxDbiO88721.
PRIDEiO88721.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033765; ENSMUSP00000033765; ENSMUSG00000031390.
GeneIDi12000.
KEGGimmu:12000.
UCSCiuc009tmx.1. mouse.

Organism-specific databases

CTDi554.
MGIiMGI:88123. Avpr2.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiO88721.
KOiK04228.
OMAiGGARWNR.
OrthoDBiEOG091G0DB6.
PhylomeDBiO88721.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiR-MMU-388479. Vasopressin-like receptors.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-MMU-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

PROiO88721.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031390.
CleanExiMM_AVPR2.
ExpressionAtlasiO88721. baseline and differential.
GenevisibleiO88721. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000161. Vprsn_rcpt_V2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00898. VASOPRSNV2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV2R_MOUSE
AccessioniPrimary (citable) accession number: O88721
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.