Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vasopressin V2 receptor

Gene

Avpr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • I-kappaB kinase/NF-kappaB signaling Source: MGI
  • interferon-gamma production Source: MGI
  • negative regulation of renal sodium excretion Source: Ensembl
  • negative regulation of urine volume Source: Ensembl
  • positive regulation of cell proliferation Source: Ensembl
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of systemic arterial blood pressure Source: Ensembl
  • response to cytokine Source: MGI
  • telencephalon development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-388479. Vasopressin-like receptors.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V2 receptor
Short name:
V2R
Alternative name(s):
AVPR V2
Antidiuretic hormone receptor
Renal-type arginine vasopressin receptor
Gene namesi
Name:Avpr2
Synonyms:V2r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:88123. Avpr2.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence analysisAdd
BLAST
Transmembranei39 – 6325Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini64 – 7714CytoplasmicSequence analysisAdd
BLAST
Transmembranei78 – 9821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini99 – 11315ExtracellularSequence analysisAdd
BLAST
Transmembranei114 – 13522Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini136 – 15924CytoplasmicSequence analysisAdd
BLAST
Transmembranei160 – 18021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini181 – 20020ExtracellularSequence analysisAdd
BLAST
Transmembranei201 – 22020Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini221 – 27151CytoplasmicSequence analysisAdd
BLAST
Transmembranei272 – 29322Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini294 – 30815ExtracellularSequence analysisAdd
BLAST
Transmembranei309 – 32820Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini329 – 37143CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Vasopressin V2 receptorPRO_0000070209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence analysis
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence analysis
Lipidationi341 – 3411S-palmitoyl cysteineBy similarity
Lipidationi342 – 3421S-palmitoyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO88721.
PRIDEiO88721.

PTM databases

PhosphoSiteiO88721.

Expressioni

Gene expression databases

BgeeiO88721.
CleanExiMM_AVPR2.
ExpressionAtlasiO88721. baseline and differential.
GenevisibleiO88721. MM.

Interactioni

Subunit structurei

Interacts with ARRDC4. Identified in a complex containing at least ARRDC4, V2R and HGS.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033765.

Structurei

3D structure databases

ProteinModelPortaliO88721.
SMRiO88721. Positions 14-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiO88721.
KOiK04228.
OMAiGGARWNR.
OrthoDBiEOG7Z69CP.
PhylomeDBiO88721.
TreeFamiTF106499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000161. Vprsn_rcpt_V2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00898. VASOPRSNV2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88721-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILVSTTSAV PGALSSPSSP SNSSQEELLD DRDPLLVRAE LALLSTIFVA
60 70 80 90 100
VALSNGLVLG ALIRRGRRGR WAPMHVFISH LCLADLAVAL FQVLPQLAWD
110 120 130 140 150
ATDRFHGPDA LCRAVKYLQM VGMYASSYMI LAMTLDRHRA ICRPMLAYRH
160 170 180 190 200
GGGARWNRPV LVAWAFSLLL SLPQLFIFAQ RDVGNGSGVF DCWARFAEPW
210 220 230 240 250
GLRAYVTWIA LMVFVAPALG IAACQVLIFR EIHASLVPGP SERAGRRRRG
260 270 280 290 300
HRTGSPSEGA HVSAAMAKTV RMTLVIVIVY VLCWAPFFLV QLWAAWDPEA
310 320 330 340 350
PLERPPFVLL MLLASLNSCT NPWIYASFSS SVSSELRSLL CCAQRHTTHS
360 370
LGPQDESCAT ASSSLMKDTP S
Length:371
Mass (Da):40,645
Last modified:November 1, 1998 - v1
Checksum:iF2E7CBEA1113FD5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006691 Genomic DNA. Translation: CAA07187.1.
AF133093 Genomic DNA. No translation available.
AJ310753 mRNA. Translation: CAC34589.1.
CCDSiCCDS30216.1.
RefSeqiNP_062277.1. NM_019404.2.
XP_006527819.1. XM_006527756.2.
UniGeneiMm.383171.

Genome annotation databases

EnsembliENSMUST00000033765; ENSMUSP00000033765; ENSMUSG00000031390.
GeneIDi12000.
KEGGimmu:12000.
UCSCiuc009tmx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006691 Genomic DNA. Translation: CAA07187.1.
AF133093 Genomic DNA. No translation available.
AJ310753 mRNA. Translation: CAC34589.1.
CCDSiCCDS30216.1.
RefSeqiNP_062277.1. NM_019404.2.
XP_006527819.1. XM_006527756.2.
UniGeneiMm.383171.

3D structure databases

ProteinModelPortaliO88721.
SMRiO88721. Positions 14-339.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033765.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO88721.

Proteomic databases

PaxDbiO88721.
PRIDEiO88721.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033765; ENSMUSP00000033765; ENSMUSG00000031390.
GeneIDi12000.
KEGGimmu:12000.
UCSCiuc009tmx.1. mouse.

Organism-specific databases

CTDi554.
MGIiMGI:88123. Avpr2.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiO88721.
KOiK04228.
OMAiGGARWNR.
OrthoDBiEOG7Z69CP.
PhylomeDBiO88721.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiR-MMU-388479. Vasopressin-like receptors.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.

Miscellaneous databases

NextBioi280189.
PROiO88721.
SOURCEiSearch...

Gene expression databases

BgeeiO88721.
CleanExiMM_AVPR2.
ExpressionAtlasiO88721. baseline and differential.
GenevisibleiO88721. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR000161. Vprsn_rcpt_V2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00898. VASOPRSNV2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure and functional expression of the mouse vasopressin V2 receptor gene."
    Guenther G., Eichhorst J., Krause G., Rosenthal W., Oksche A.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJ.
  2. "Comparative sequence analysis of the mouse L1cam locus and the corresponding region of human Xq28."
    Platzer M., Brenner V., Reichwald K., Wiehe T., Oksche A., Rosenthal A.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Species differences in vasopressin V2 receptors: mRNA tissue distribution and functional properties of the human and murine receptors."
    Oksche A., Leder G., Rosenthal W.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJ.
    Tissue: Kidney.

Entry informationi

Entry nameiV2R_MOUSE
AccessioniPrimary (citable) accession number: O88721
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.