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O88708

- ORC4_MOUSE

UniProt

O88708 - ORC4_MOUSE

Protein

Origin recognition complex subunit 4

Gene

Orc4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 By similarity. Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA replication origin binding Source: Ensembl
    3. nucleoside-triphosphatase activity Source: InterPro

    GO - Biological processi

    1. DNA replication Source: MGI
    2. DNA replication initiation Source: Ensembl

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_204269. E2F-enabled inhibition of pre-replication complex formation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Origin recognition complex subunit 4
    Gene namesi
    Name:Orc4
    Synonyms:Orc4l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1347043. Orc4.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear origin of replication recognition complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Origin recognition complex subunit 4PRO_0000127088Add
    BLAST

    Proteomic databases

    PRIDEiO88708.

    PTM databases

    PhosphoSiteiO88708.

    Expressioni

    Gene expression databases

    ArrayExpressiO88708.
    BgeeiO88708.
    GenevestigatoriO88708.

    Interactioni

    Subunit structurei

    Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase By similarity. Interacts with DBF4.By similarity1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliO88708.
    SMRiO88708. Positions 59-212.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ORC4 family.Curated

    Phylogenomic databases

    eggNOGiNOG289784.
    GeneTreeiENSGT00390000016542.
    HOGENOMiHOG000007226.
    HOVERGENiHBG000253.
    InParanoidiQ91V62.
    KOiK02606.
    OMAiFQKFIQR.
    OrthoDBiEOG72NRPZ.
    TreeFamiTF101094.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR016527. ORC4.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PIRSFiPIRSF007858. ORC4. 1 hit.
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O88708-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSRKTKSNA HAECLSQVQR ILRERFCHHS PHSNLFGVQV QYKHLIELLK    50
    RTAIYGESNS VLIVGPRGSG KTTLLNHALK ELMEIEVSEN VIQVHLNGLL 100
    QTNEKIALKE ITRQLNLDNV VEDKVFGSFA ENLSFLLEAL QKGDRTSSCP 150
    VIFILDEFDI FAHQKNQTLL YNLFDISQSA QTPVAVIGLT CRLDILELLE 200
    KRVKSRFSHR QIHLMNSFDF PQYLKIFKEQ LSLPAEFPDK AFAERWNENV 250
    HCLSEDSTVL EVLQKHFSVN KNLQSLHMLL MLALNRVTVS HPFMTSADLM 300
    EAQHMCSLDS KANIVHGLSV LEICLIIAMK HLNDIYEEEP FNFQMVYNEF 350
    QKFIQRKAHS VYNFEKPVVM KAFEHLQQLE LIKPVERTSV NSQREYQLVK 400
    LLLDNTQIMN ALQKYSNCPT DVRQWATSSL SWL 433
    Length:433
    Mass (Da):49,982
    Last modified:July 27, 2011 - v2
    Checksum:i9857AB8CCF41982D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti141 – 1411Q → K in CAA76188. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16386 mRNA. Translation: CAA76188.1.
    AJ003140 mRNA. Translation: CAA05896.1.
    AK010258 mRNA. Translation: BAB26801.1.
    AK147823 mRNA. Translation: BAE28161.1.
    AK169291 mRNA. Translation: BAE41048.1.
    AL732317 Genomic DNA. Translation: CAM14876.1.
    CH466519 Genomic DNA. Translation: EDL26871.1.
    BC015072 mRNA. Translation: AAH15072.1.
    BC019748 mRNA. Translation: AAH19748.1.
    CCDSiCCDS16022.1.
    RefSeqiNP_036088.3. NM_011958.3.
    XP_006498126.1. XM_006498063.1.
    XP_006498127.1. XM_006498064.1.
    XP_006498128.1. XM_006498065.1.
    UniGeneiMm.291059.
    Mm.314338.

    Genome annotation databases

    EnsembliENSMUST00000028098; ENSMUSP00000028098; ENSMUSG00000026761.
    GeneIDi26428.
    KEGGimmu:26428.
    UCSCiuc008jpp.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y16386 mRNA. Translation: CAA76188.1 .
    AJ003140 mRNA. Translation: CAA05896.1 .
    AK010258 mRNA. Translation: BAB26801.1 .
    AK147823 mRNA. Translation: BAE28161.1 .
    AK169291 mRNA. Translation: BAE41048.1 .
    AL732317 Genomic DNA. Translation: CAM14876.1 .
    CH466519 Genomic DNA. Translation: EDL26871.1 .
    BC015072 mRNA. Translation: AAH15072.1 .
    BC019748 mRNA. Translation: AAH19748.1 .
    CCDSi CCDS16022.1.
    RefSeqi NP_036088.3. NM_011958.3.
    XP_006498126.1. XM_006498063.1.
    XP_006498127.1. XM_006498064.1.
    XP_006498128.1. XM_006498065.1.
    UniGenei Mm.291059.
    Mm.314338.

    3D structure databases

    ProteinModelPortali O88708.
    SMRi O88708. Positions 59-212.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O88708.

    Proteomic databases

    PRIDEi O88708.

    Protocols and materials databases

    DNASUi 26428.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028098 ; ENSMUSP00000028098 ; ENSMUSG00000026761 .
    GeneIDi 26428.
    KEGGi mmu:26428.
    UCSCi uc008jpp.2. mouse.

    Organism-specific databases

    CTDi 5000.
    MGIi MGI:1347043. Orc4.

    Phylogenomic databases

    eggNOGi NOG289784.
    GeneTreei ENSGT00390000016542.
    HOGENOMi HOG000007226.
    HOVERGENi HBG000253.
    InParanoidi Q91V62.
    KOi K02606.
    OMAi FQKFIQR.
    OrthoDBi EOG72NRPZ.
    TreeFami TF101094.

    Enzyme and pathway databases

    Reactomei REACT_204269. E2F-enabled inhibition of pre-replication complex formation.

    Miscellaneous databases

    NextBioi 304469.
    PROi O88708.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O88708.
    Bgeei O88708.
    Genevestigatori O88708.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR016527. ORC4.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PIRSFi PIRSF007858. ORC4. 1 hit.
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex."
      Komrskova T., Yang H., Gavin K., Pappin P., Canas B., Kobayashi R., Hunt T., Stillman B.
      Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex."
      Springer J., Kneissl M., Putter V., Grummt F.
      Chromosoma 108:243-249(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Heart.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N and FVB/N-3.
      Tissue: Liver and Mammary tumor.
    7. "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells."
      Kneissl M., Puetter V., Szalay A.A., Grummt F.
      J. Mol. Biol. 327:111-128(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DBF4.

    Entry informationi

    Entry nameiORC4_MOUSE
    AccessioniPrimary (citable) accession number: O88708
    Secondary accession number(s): Q91V62, Q9QYX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3