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Protein

Origin recognition complex subunit 4

Gene

Orc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity). Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • DNA replication Source: MGI
  • DNA replication initiation Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-176187 Activation of ATR in response to replication stress
R-MMU-68616 Assembly of the ORC complex at the origin of replication
R-MMU-68689 CDC6 association with the ORC:origin complex
R-MMU-68827 CDT1 association with the CDC6:ORC:origin complex
R-MMU-68867 Assembly of the pre-replicative complex
R-MMU-68949 Orc1 removal from chromatin
R-MMU-68962 Activation of the pre-replicative complex

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 4
Gene namesi
Name:Orc4
Synonyms:Orc4l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1347043 Orc4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001270881 – 433Origin recognition complex subunit 4Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7N6-methyllysineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

EPDiO88708
MaxQBiO88708
PaxDbiO88708
PeptideAtlasiO88708
PRIDEiO88708

PTM databases

iPTMnetiO88708
PhosphoSitePlusiO88708

Expressioni

Gene expression databases

BgeeiENSMUSG00000026761
ExpressionAtlasiO88708 baseline and differential
GenevisibleiO88708 MM

Interactioni

Subunit structurei

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (By similarity). Interacts with DBF4 (PubMed:12614612). Interacts with POLQ (By similarity).By similarity1 Publication

Protein-protein interaction databases

ComplexPortaliCPX-1915 Nuclear origin of replication recognition complex
CORUMiO88708
STRINGi10090.ENSMUSP00000028098

Structurei

3D structure databases

ProteinModelPortaliO88708
SMRiO88708
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ORC4 family.Curated

Phylogenomic databases

eggNOGiKOG2228 Eukaryota
ENOG410XSK0 LUCA
GeneTreeiENSGT00390000016542
HOGENOMiHOG000007226
HOVERGENiHBG000253
InParanoidiO88708
KOiK02606
OMAiKWNENVQ
OrthoDBiEOG091G0842
TreeFamiTF101094

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR016527 ORC4
IPR032705 ORC4_C
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF14629 ORC4_C, 1 hit
PIRSFiPIRSF007858 ORC4, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

O88708-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRKTKSNA HAECLSQVQR ILRERFCHHS PHSNLFGVQV QYKHLIELLK
60 70 80 90 100
RTAIYGESNS VLIVGPRGSG KTTLLNHALK ELMEIEVSEN VIQVHLNGLL
110 120 130 140 150
QTNEKIALKE ITRQLNLDNV VEDKVFGSFA ENLSFLLEAL QKGDRTSSCP
160 170 180 190 200
VIFILDEFDI FAHQKNQTLL YNLFDISQSA QTPVAVIGLT CRLDILELLE
210 220 230 240 250
KRVKSRFSHR QIHLMNSFDF PQYLKIFKEQ LSLPAEFPDK AFAERWNENV
260 270 280 290 300
HCLSEDSTVL EVLQKHFSVN KNLQSLHMLL MLALNRVTVS HPFMTSADLM
310 320 330 340 350
EAQHMCSLDS KANIVHGLSV LEICLIIAMK HLNDIYEEEP FNFQMVYNEF
360 370 380 390 400
QKFIQRKAHS VYNFEKPVVM KAFEHLQQLE LIKPVERTSV NSQREYQLVK
410 420 430
LLLDNTQIMN ALQKYSNCPT DVRQWATSSL SWL
Length:433
Mass (Da):49,982
Last modified:July 27, 2011 - v2
Checksum:i9857AB8CCF41982D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141Q → K in CAA76188 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y16386 mRNA Translation: CAA76188.1
AJ003140 mRNA Translation: CAA05896.1
AK010258 mRNA Translation: BAB26801.1
AK147823 mRNA Translation: BAE28161.1
AK169291 mRNA Translation: BAE41048.1
AL732317 Genomic DNA Translation: CAM14876.1
CH466519 Genomic DNA Translation: EDL26871.1
BC015072 mRNA Translation: AAH15072.1
BC019748 mRNA Translation: AAH19748.1
CCDSiCCDS16022.1
RefSeqiNP_036088.3, NM_011958.3
XP_006498126.1, XM_006498063.3
XP_006498127.1, XM_006498064.3
XP_006498128.1, XM_006498065.3
UniGeneiMm.291059
Mm.314338

Genome annotation databases

EnsembliENSMUST00000028098; ENSMUSP00000028098; ENSMUSG00000026761
GeneIDi26428
KEGGimmu:26428
UCSCiuc008jpp.2 mouse

Similar proteinsi

Entry informationi

Entry nameiORC4_MOUSE
AccessioniPrimary (citable) accession number: O88708
Secondary accession number(s): Q91V62, Q9QYX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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