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Protein
Submitted name:

CNR2

Gene

Pcdha6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesionSAAS annotation

Keywords - Ligandi

CalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
CNR2Imported
Gene namesi
Name:Pcdha6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1298367. Pcdha6.

Subcellular locationi

  • Cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500416084730 – 946Sequence analysisAdd BLAST917

PTM databases

iPTMnetiO88690.
PhosphoSitePlusiO88690.

Interactioni

Protein-protein interaction databases

MINTiMINT-113936.

Structurei

3D structure databases

ProteinModelPortaliO88690.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 133CadherinInterPro annotationAdd BLAST106
Domaini157 – 242CadherinInterPro annotationAdd BLAST86
Domaini243 – 350CadherinInterPro annotationAdd BLAST108
Domaini351 – 455CadherinInterPro annotationAdd BLAST105
Domaini456 – 565CadherinInterPro annotationAdd BLAST110
Domaini581 – 678CadherinInterPro annotationAdd BLAST98

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOGENOMiHOG000220892.
HOVERGENiHBG054878.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O88690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFTTEGRLG TRCMLLSLLL LAAWEAGSGQ LHYSVPEEPK HGTFVGRIAQ
60 70 80 90 100
DLGLELTELV PRLFRVASKD RGDLLEVNLQ NGILFVNSRI DREELCGRSV
110 120 130 140 150
ECSIHLEVIV DRPLQVFHVE VEVRDINDNP PVFSVKEQRM LIYESRLPDS
160 170 180 190 200
LFPLEGASDA DVGLNSMLTY KLSPSEYFGL DVKSNSDGNK QIRLLLKKSL
210 220 230 240 250
DREDAPEHKL LLTATDGGKP ELTGSVQLLV TVLDVNDNAP TFQHPEYEVR
260 270 280 290 300
ILENSDNGTT VIRLNASDKD EGTNSAISYS FNRLVPPKTL EQFSIDADTG
310 320 330 340 350
EIITQGNLDF EQVDVYKIHV DATDKGHPPM VGHCTVLVKV LDENDNVPQI
360 370 380 390 400
TLTSLSLPVR EDAALSTVIA LISVSDLDSG SNGQVTCSLS PHVPFKLVST
410 420 430 440 450
FKNYYSLVLD SALDRETTAD YQVVVTARDG GSPSLWTTAS VSVEVADVND
460 470 480 490 500
NAPSFAQPDY TVFVKENNPP GAHIFTVSAM DADAQENALV SYSLVERRVG
510 520 530 540 550
ERLLSSYVSV HAESGKVFAL QPLDHEELEL LQFQVSARDA GVPALGSNVT
560 570 580 590 600
LQVFVLDEND NAPTLLGPWT PGSGGVVSEL VSPSVGAGQV VTKVRAVDAD
610 620 630 640 650
SGYNAWLSYE LHPLAGGTRS LFRVGLYTGE ISTTRALEEA DAPRHRLLVL
660 670 680 690 700
VKDHGEPALI ATATVLVSLV ENSQTPKASS RAQGATGQEV SLVNVNVYLI
710 720 730 740 750
IAICAVSSLL VLTLMVYTAL RCSVPPTEGV CGAGKPVLVC SSAVGSWSYS
760 770 780 790 800
QQRRQKVCSG EGPPKTDLMA FSPSLPPCPV VGEHQDLNDD HCSRPRQPNP
810 820 830 840 850
DWRYSASLRA GMHSSVHLEE AGILRAGPGG PDQQWPTVSS ATPEPEAGEV
860 870 880 890 900
SPPVGAGVNS NSWTFKYGPG NPKQSGPGEL PDKFIIPGSP AIISIRQEPA
910 920 930 940
NNQIDKSDFI TFGKKEETKK KKKKKKGNKT QEKKEKGNST TDNSDQ
Length:946
Mass (Da):102,313
Last modified:November 1, 1998 - v1
Checksum:iB580BF4284E9EBEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86917 mRNA. Translation: BAA29046.1.
UniGeneiMm.308500.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86917 mRNA. Translation: BAA29046.1.
UniGeneiMm.308500.

3D structure databases

ProteinModelPortaliO88690.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-113936.

PTM databases

iPTMnetiO88690.
PhosphoSitePlusiO88690.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1298367. Pcdha6.

Phylogenomic databases

HOGENOMiHOG000220892.
HOVERGENiHBG054878.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO88690_MOUSE
AccessioniPrimary (citable) accession number: O88690
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.