O88684 (O88684_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Bone moorphogenic protein-7 EMBL BAA31853.1

Gene names

Name:

Bmp7 RGD 620743

Organism

Rattus norvegicus (Rat) EMBL BAA31853.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	141 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the TGF-beta family. RuleBase RU000354

Ontologies

Keywords
Cellular component	Secreted SAAS SAAS001839
Molecular function	Growth factor RuleBase RU000354 SAAS SAAS001839
PTM	Disulfide bond SAAS SAAS001839
Gene Ontology (GO)
Biological_process	BMP signaling pathway Inferred from electronic annotation. Source: Compara SMAD protein signal transduction Inferred from electronic annotation. Source: Compara axon guidance Inferred from electronic annotation. Source: Compara branching involved in salivary gland morphogenesis Inferred from electronic annotation. Source: Compara branching morphogenesis of an epithelial tube Inferred from electronic annotation. Source: Compara embryonic camera-type eye morphogenesis Inferred from electronic annotation. Source: Compara embryonic limb morphogenesis Inferred from electronic annotation. Source: Compara embryonic pattern specification Inferred from electronic annotation. Source: Compara embryonic skeletal joint morphogenesis Inferred from electronic annotation. Source: Compara epithelial cell differentiation Inferred from electronic annotation. Source: Compara mesenchymal cell differentiation Inferred from electronic annotation. Source: Compara mesenchyme development Inferred from sequence or structural similarity. Source: UniProtKB mesoderm formation Inferred from electronic annotation. Source: Compara mesonephros development Inferred from electronic annotation. Source: Compara metanephric mesenchymal cell proliferation involved in metanephros development Inferred from electronic annotation. Source: Compara metanephric mesenchyme morphogenesis Inferred from electronic annotation. Source: Compara monocyte aggregation Inferred from electronic annotation. Source: Compara negative regulation of MAP kinase activity Inferred from electronic annotation. Source: Compara negative regulation of Notch signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of glomerular mesangial cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of mitosis Inferred from electronic annotation. Source: Compara negative regulation of neurogenesis Inferred from electronic annotation. Source: Compara negative regulation of neuron differentiation Inferred from electronic annotation. Source: Compara negative regulation of prostatic bud formation Inferred from electronic annotation. Source: Compara negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara nephrogenic mesenchyme morphogenesis Inferred from electronic annotation. Source: Compara odontogenesis of dentin-containing tooth Inferred from electronic annotation. Source: Compara pathway-restricted SMAD protein phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of bone mineralization Inferred from electronic annotation. Source: Compara positive regulation of dendrite development Inferred from electronic annotation. Source: Compara positive regulation of heterotypic cell-cell adhesion Inferred from electronic annotation. Source: Compara positive regulation of hyaluranon cable assembly Inferred from electronic annotation. Source: Compara positive regulation of neuron differentiation Inferred from electronic annotation. Source: Compara positive regulation of osteoblast differentiation Inferred from electronic annotation. Source: Compara positive regulation of peptidyl-threonine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara protein localization to nucleus Inferred from electronic annotation. Source: Compara regulation of branching involved in prostate gland morphogenesis Inferred from electronic annotation. Source: Compara steroid hormone mediated signaling pathway Inferred from electronic annotation. Source: Compara ureteric bud development Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	extracellular space Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAA31853.1
	Non-terminal residue	141	1	EMBL BAA31853.1

Sequences

	Sequence		Length	Mass (Da)
	O88684 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 1A02FA2213F39812	FASTA	141	15,850
	10 20 30 40 50 60 MVAFFKATEV HLRSIRSTGG KQRSQNRSKT PKNQEALRMA SVAENSSSDQ RQACKKHELY 70 80 90 100 110 120 VSFRDLGWQD WIIAPEGYAA YYCEGECAFP LNSYMNATNH AIVQTLVHFI NPDTVPKPCC 130 140 APTQLNAISV LYFDDSSNVI L

References

[1]

"Transcripts for two members of the transforming growth factor-beta superfamily BMP-3 and BMP-7 are expressed in developing rat embryos." Takahashi H., Ikeda T. Dev. Dyn. 207:439-449(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Wistar EMBL BAA31853.1. Tissue: Whole body EMBL BAA31853.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D29769 mRNA. Translation: BAA31853.1.
IPI	IPI00357998.
UniGene	Rn.18030.
3D structure databases
HSSP	HSSP built from PDB template 1M4U based on UniProtKB P18075.
ProteinModelPortal	O88684.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000009656.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG272883.
HOVERGEN	HBG004860.
InParanoid	O88684.
OrthoDB	EOG4GB76H.
Gene expression databases
Genevestigator	O88684.
Family and domain databases
InterPro	IPR002405. Inhibin_asu. IPR001839. TGF-b_C. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
PANTHER	PTHR11848. PTHR11848. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. [Graphical view]
PRINTS	PR00669. INHIBINA.
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O88684_RAT

Accession

Primary (citable) accession number: O88684

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1998
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)