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Protein

C3a anaphylatoxin chemotactic receptor

Gene

C3AR1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

GO - Molecular functioni

  • C3a anaphylatoxin receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C3a anaphylatoxin chemotactic receptor
Short name:
C3AR
Short name:
C3a-R
Gene namesi
Name:C3AR1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4623Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 5711CytoplasmicSequence analysisAdd
BLAST
Transmembranei58 – 8023Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini81 – 9616ExtracellularSequence analysisAdd
BLAST
Transmembranei97 – 11822Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini119 – 13921CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 331171ExtracellularSequence analysisAdd
BLAST
Transmembranei332 – 35120Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini352 – 36817CytoplasmicSequence analysisAdd
BLAST
Transmembranei369 – 39123Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini392 – 40817ExtracellularSequence analysisAdd
BLAST
Transmembranei409 – 42921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini430 – 47546CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 475475C3a anaphylatoxin chemotactic receptorPRO_0000069201Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 172PROSITE-ProRule annotation
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence analysis
Modified residuei174 – 1741SulfotyrosineBy similarity
Modified residuei183 – 1831SulfotyrosineBy similarity
Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence analysis
Glycosylationi292 – 2921N-linked (GlcNAc...)Sequence analysis
Modified residuei450 – 4501PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Sulfation

Expressioni

Tissue specificityi

Expressed in the heart, kidney, lung, liver, peritoneal macrophages and spleen.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000019559.

Structurei

3D structure databases

ProteinModelPortaliO88680.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUVF. Eukaryota.
ENOG410YBJQ. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000261616.
HOVERGENiHBG002433.
InParanoidiO88680.
OMAiLWVAGLK.
OrthoDBiEOG7PGDQQ.
TreeFamiTF330976.

Family and domain databases

InterProiIPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 2 hits.
PTHR24225:SF28. PTHR24225:SF28. 2 hits.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O88680-1) [UniParc]FASTAAdd to basket

Also known as: gpC3aR-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESSSAETNS TGLHLEPQYQ PETILAMAIL GLTFVLGLPG NGLVLWVAGL
60 70 80 90 100
KMRRTVNTVW FLHLTVADFV CCLSLPFSMA HLALRGYWPY GEILCKFIPT
110 120 130 140 150
VIIFNMFASV FLLTAISLDR CLMVLKPIWC QNHRNVRTAC IICGCIWLVA
160 170 180 190 200
FVLCIPVFVY RETFTLENHT ICTYNFSPGS FDYLDYAYDR DAWGYGTPDP
210 220 230 240 250
IVQLPGEMEH RSDPSSFQTQ DGPWSVTTTL YSQTSQRPSE DSFHMDSAKL
260 270 280 290 300
SGQGKYVDVV LPTNLCGLPM EENRTNTLHN AAFLSSDLDV SNATQKCLST
310 320 330 340 350
PEPPQDFWDD LSPFTHEYRT PRLLKVITFT RLVVGFLLPM IIMVACYTLI
360 370 380 390 400
IFRMRRVRVV KSWNKALHLA MVVVTIFLIC WAPYHVFGVL ILFINPESRV
410 420 430 440 450
GAALLSWDHV SIALASANSC FNPFLYALLG RDLRKRVRQS MKGILEAAFS
460 470
EDISKSTSFI QAKAFSEKHS LSTNV
Length:475
Mass (Da):53,570
Last modified:November 1, 1998 - v1
Checksum:i0D6FFF5627A53330
GO
Isoform 2 (identifier: O88680-2) [UniParc]FASTAAdd to basket

Also known as: gpC3aR-S

The sequence of this isoform differs from the canonical sequence as follows:
     254-288: Missing.

Show »
Length:440
Mass (Da):49,755
Checksum:i660001D31C1B7731
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21E → D in AAC36503 (PubMed:9743361).Curated
Sequence conflicti357 – 3571V → A in AAC36503 (PubMed:9743361).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei254 – 28835Missing in isoform 2. 1 PublicationVSP_010628Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006402 Genomic DNA. Translation: CAA07002.1.
U86378 mRNA. Translation: AAC36503.1.
RefSeqiNP_001166589.1. NM_001173118.1.

Genome annotation databases

EnsembliENSCPOT00000009625; ENSCPOP00000019559; ENSCPOG00000026687. [O88680-1]
GeneIDi100379246.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006402 Genomic DNA. Translation: CAA07002.1.
U86378 mRNA. Translation: AAC36503.1.
RefSeqiNP_001166589.1. NM_001173118.1.

3D structure databases

ProteinModelPortaliO88680.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000019559.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000009625; ENSCPOP00000019559; ENSCPOG00000026687. [O88680-1]
GeneIDi100379246.

Organism-specific databases

CTDi719.

Phylogenomic databases

eggNOGiENOG410IUVF. Eukaryota.
ENOG410YBJQ. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000261616.
HOVERGENiHBG002433.
InParanoidiO88680.
OMAiLWVAGLK.
OrthoDBiEOG7PGDQQ.
TreeFamiTF330976.

Family and domain databases

InterProiIPR001644. Anaphtx_C3AR1.
IPR002234. Anphylx_rcpt.
IPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 2 hits.
PTHR24225:SF28. PTHR24225:SF28. 2 hits.
PfamiPF00001. 7tm_1. 2 hits.
[Graphical view]
PRINTSiPR01104. ANPHYLATOXNR.
PR01060. C3ANPHYLTXNR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor."
    Lienenklaus S., Ames R.S., Tornetta M.A., Sarau H.M., Foley J.J., Crass T., Sohns B., Raffetseder U., Grove M., Hoelzer A., Klos A., Koehl J., Bautsch W.
    J. Immunol. 161:2089-2093(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  2. "Molecular cloning of two isoforms of the guinea pig C3a anaphylatoxin receptor: alternative splicing in the large extracellular loop."
    Fukuoka Y., Ember J.A., Hugli T.E.
    J. Immunol. 161:2977-2984(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    Strain: Hartley.
    Tissue: Spleen.

Entry informationi

Entry nameiC3AR_CAVPO
AccessioniPrimary (citable) accession number: O88680
Secondary accession number(s): Q9QWG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.